DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Peptoid drug discovery and optimization via surface X‐ray scattering

 [1];  [2]; ORCiD logo [3]
  1. Howard Hughes Medical Institute Northwestern University Evanston Illinois
  2. Howard Hughes Medical Institute University of California Los Angeles California
  3. Center for the Molecular Study of Condensed Soft Matter and Department of Physics Illinois Institute of Technology Chicago Illinois
Publication Date:
Sponsoring Org.:
OSTI Identifier:
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Additional Journal Information:
Journal Name: Biopolymers Journal Volume: 110 Journal Issue: 6; Journal ID: ISSN 0006-3525
Wiley Blackwell (John Wiley & Sons)
Country of Publication:
United States

Citation Formats

Andreev, Konstantin, Martynowycz, Michael W., and Gidalevitz, David. Peptoid drug discovery and optimization via surface X‐ray scattering. United States: N. p., 2019. Web. doi:10.1002/bip.23274.
Andreev, Konstantin, Martynowycz, Michael W., & Gidalevitz, David. Peptoid drug discovery and optimization via surface X‐ray scattering. United States.
Andreev, Konstantin, Martynowycz, Michael W., and Gidalevitz, David. Wed . "Peptoid drug discovery and optimization via surface X‐ray scattering". United States.
title = {Peptoid drug discovery and optimization via surface X‐ray scattering},
author = {Andreev, Konstantin and Martynowycz, Michael W. and Gidalevitz, David},
abstractNote = {},
doi = {10.1002/bip.23274},
journal = {Biopolymers},
number = 6,
volume = 110,
place = {United States},
year = {2019},
month = {3}

Works referenced in this record:

Cell Membranes: The Lipid Perspective
journal, November 2011

Triangular prism-shaped β-peptoid helices as unique biomimetic scaffolds
journal, May 2015

  • Laursen, Jonas S.; Harris, Pernille; Fristrup, Peter
  • Nature Communications, Vol. 6, Issue 1
  • DOI: 10.1038/ncomms8013

Antibiotic resistance—the need for global solutions
journal, December 2013

Protegrin interaction with lipid monolayers: grazing incidence X-ray diffraction and X-ray reflectivity study
journal, January 2008

  • Neville, Frances; Ishitsuka, Yuji; Hodges, Chris S.
  • Soft Matter, Vol. 4, Issue 8
  • DOI: 10.1039/b718295c

Alzheimer's disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide
journal, October 2016

  • Kumar, Deepak Kumar Vijaya; Eimer, William A.; Tanzi, Rudolph E.
  • Neurodegenerative Disease Management, Vol. 6, Issue 5
  • DOI: 10.2217/nmt-2016-0035

Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides
journal, February 2008

  • Chongsiriwatana, N. P.; Patch, J. A.; Czyzewski, A. M.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 8
  • DOI: 10.1073/pnas.0708254105

Antimicrobial peptides of multicellular organisms
journal, January 2002

Development and use of an atomistic CHARMM-based forcefield for peptoid simulation
journal, November 2013

  • Mirijanian, Dina T.; Mannige, Ranjan V.; Zuckermann, Ronald N.
  • Journal of Computational Chemistry, Vol. 35, Issue 5
  • DOI: 10.1002/jcc.23478

Omadacycline: development of a novel aminomethylcycline antibiotic for treating drug-resistant bacterial infections
journal, October 2016

  • Villano, Stephen; Steenbergen, Judith; Loh, Evan
  • Future Microbiology, Vol. 11, Issue 11
  • DOI: 10.2217/fmb-2016-0100

TAM Receptor Tyrosine Kinases in Cancer Drug Resistance
journal, May 2017

Insights into Signaling and the Functional Complexity of Biological Membranes
journal, August 2017

Liposomes as a Model for the Biological Membrane: Studies on Daunorubicin Bilayer Interaction
journal, January 2012

  • Matos, Carla; Moutinho, Carla; Lobão, Paulo
  • The Journal of Membrane Biology, Vol. 245, Issue 2
  • DOI: 10.1007/s00232-011-9414-2

Recombinant production of antimicrobial peptides in Escherichia coli: A review
journal, December 2011

Novel Antimicrobial Peptides with High Anticancer Activity and Selectivity
journal, May 2015

Lateral pressure in membranes
journal, October 1996

Lipid Organization of the Plasma Membrane
journal, October 2014

  • Ingólfsson, Helgi I.; Melo, Manuel N.; van Eerden, Floris J.
  • Journal of the American Chemical Society, Vol. 136, Issue 41
  • DOI: 10.1021/ja507832e

Epitaxial τ phase MnAl thin films on MgO (001) with thickness-dependent magnetic anisotropy
journal, November 2011

  • Cui, Yishen; Yin, Wenjing; Chen, Wei
  • Journal of Applied Physics, Vol. 110, Issue 10
  • DOI: 10.1063/1.3663435

High-Throughput Sequencing of Peptoids and Peptide−Peptoid Hybrids by Partial Edman Degradation and Mass Spectrometry
journal, March 2009

  • Thakkar, Amit; Cohen, Allison S.; Connolly, Michael D.
  • Journal of Combinatorial Chemistry, Vol. 11, Issue 2
  • DOI: 10.1021/cc8001734

Lipid domains in bacterial membranes and the action of antimicrobial agents
journal, January 2009

  • Epand, Richard M.; Epand, Raquel F.
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1788, Issue 1
  • DOI: 10.1016/j.bbamem.2008.08.023

Determination of the total charge in the cell walls of Gram-positive bacteria
journal, June 1997

  • van der Wal, Albert; Norde, Willem; Zehnder, Alexander J. B.
  • Colloids and Surfaces B: Biointerfaces, Vol. 9, Issue 1-2
  • DOI: 10.1016/S0927-7765(96)01340-9

Impurity controlled phase transitions of phospholipid monolayers
journal, July 1984

  • L�sche, M.; M�hwald, H.
  • European Biophysics Journal, Vol. 11, Issue 1
  • DOI: 10.1007/BF00253856

Unnecessary Antibiotics for Acute Respiratory Tract Infections: Association With Care Setting and Patient Demographics
journal, January 2016

  • Barlam, Tamar F.; Soria-Saucedo, Rene; Cabral, Howard J.
  • Open Forum Infectious Diseases, Vol. 3, Issue 1
  • DOI: 10.1093/ofid/ofw045

New FDA approved antibacterial drugs: 2015-2017
journal, April 2018

  • Andrei, Stefan; Valeanu, Liana; Chirvasuta, Radu
  • Discoveries, Vol. 6, Issue 1
  • DOI: 10.15190/d.2018.1

Membrane lipids: where they are and how they behave
journal, February 2008

  • van Meer, Gerrit; Voelker, Dennis R.; Feigenson, Gerald W.
  • Nature Reviews Molecular Cell Biology, Vol. 9, Issue 2
  • DOI: 10.1038/nrm2330

Barrel-Stave Model or Toroidal Model? A Case Study on Melittin Pores
journal, September 2001

Hydrophobic Interactions Modulate Peptide Cell Specificity
journal, February 2018

  • Andreev, Konstantin; Martynowycz, Michael W.; Huang, Mia L.
  • Biophysical Journal, Vol. 114, Issue 3
  • DOI: 10.1016/j.bpj.2017.11.2514

The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins
journal, April 2010

  • van Wijk, Sjoerd J. L.; Timmers, H. T. Marc
  • The FASEB Journal, Vol. 24, Issue 4
  • DOI: 10.1096/fj.09-136259

PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer
journal, February 2018

Top-down strategies for the structural elucidation of intact gram-negative bacterial endotoxins
journal, January 2014

  • O'Brien, John P.; Needham, Brittany D.; Brown, Dusty B.
  • Chem. Sci., Vol. 5, Issue 11
  • DOI: 10.1039/C4SC01034E

In situ characterization of lipid A interaction with antimicrobial peptides using surface X-ray scattering
journal, February 2006

  • Neville, Frances; Hodges, Chris S.; Liu, Chao
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1758, Issue 2
  • DOI: 10.1016/j.bbamem.2006.01.025

Toroidal pores formed by antimicrobial peptides show significant disorder
journal, October 2008

  • Sengupta, Durba; Leontiadou, Hari; Mark, Alan E.
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1778, Issue 10
  • DOI: 10.1016/j.bbamem.2008.06.007

α-Peptide/β-Peptoid Chimeras
journal, April 2007

  • Olsen, Christian A.; Bonke, Gitte; Vedel, Line
  • Organic Letters, Vol. 9, Issue 8
  • DOI: 10.1021/ol070316c

Biophysical Interactions with Model Lipid Membranes: Applications in Drug Discovery and Drug Delivery
journal, May 2009

  • Peetla, Chiranjeevi; Stine, Andrew; Labhasetwar, Vinod
  • Molecular Pharmaceutics, Vol. 6, Issue 5
  • DOI: 10.1021/mp9000662

Cardiolipin, a major phospholipid of gram-positive bacteria that is not readily extractable
journal, November 1980

  • Filgueiras, M. H.; den Kamp, J. A. F. Op
  • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol. 620, Issue 2
  • DOI: 10.1016/0005-2760(80)90215-5

Learning from Host-Defense Peptides: Cationic, Amphipathic Peptoids with Potent Anticancer Activity
journal, February 2014

Degradation of naturally occurring and engineered antimicrobial peptides by proteases
journal, January 2011

  • Moncla, Bernard J.; Pryke, Kara; Rohan, Lisa Cencia
  • Advances in Bioscience and Biotechnology, Vol. 02, Issue 06
  • DOI: 10.4236/abb.2011.26059

Bovine pulmonary surfactant: Chemical composition and physical properties
journal, August 1983

  • Yu, Sue; Harding, Paul G. R.; Smith, Norman
  • Lipids, Vol. 18, Issue 8
  • DOI: 10.1007/BF02535391

Drug Resistance in Cancer: An Overview
journal, September 2014

The role of lipids in pulmonary surfactant
journal, November 1998

  • Veldhuizen, Ruud; Nag, Kaushik; Orgeig, Sandra
  • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1408, Issue 2-3
  • DOI: 10.1016/S0925-4439(98)00061-1

Precise determination of tilt angles by x-ray diffraction and reflection with arachidic acid monolayers
journal, October 1991

Helical Peptoid Mimics of Magainin-2 Amide
journal, October 2003

  • Patch, James A.; Barron, Annelise E.
  • Journal of the American Chemical Society, Vol. 125, Issue 40
  • DOI: 10.1021/ja037320d

Genetic Linkage and Horizontal Gene Transfer, the Roots of the Antibiotic Multi -Resistance Problem
journal, December 2006

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis
journal, March 2018

Model membrane systems and their applications
journal, December 2007

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease
journal, May 2016

  • Kumar, Deepak Kumar Vijaya; Choi, Se Hoon; Washicosky, Kevin J.
  • Science Translational Medicine, Vol. 8, Issue 340
  • DOI: 10.1126/scitranslmed.aaf1059

Antimicrobial resistance in humans, livestock and the wider environment
journal, June 2015

  • Woolhouse, Mark; Ward, Melissa; van Bunnik, Bram
  • Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 370, Issue 1670
  • DOI: 10.1098/rstb.2014.0083

Control of cell selectivity of antimicrobial peptides
journal, August 2009

Difference in surface properties between Escherichia coli and Staphylococcus aureus as revealed by electrophoretic mobility measurements
journal, August 1995

A comparative study on the interactions of SMAP-29 with lipid monolayers
journal, May 2010

  • Neville, Frances; Ivankin, Andrey; Konovalov, Oleg
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1798, Issue 5
  • DOI: 10.1016/j.bbamem.2009.09.017

Thermodynamic relationships for mixed insoluble monolayers
journal, March 1966

Cyclization Improves Membrane Permeation by Antimicrobial Peptoids
journal, November 2016

Potential role of antimicrobial peptides in the early onset of Alzheimer's disease
journal, January 2015

  • Welling, Mick M.; Nabuurs, Rob J. A.; van der Weerd, Louise
  • Alzheimer's & Dementia, Vol. 11, Issue 1
  • DOI: 10.1016/j.jalz.2013.12.020

DNA-tethered membranes formed by giant vesicle rupture
journal, October 2009

  • Chung, Minsub; Lowe, Randall D.; Chan, Yee-Hung M.
  • Journal of Structural Biology, Vol. 168, Issue 1
  • DOI: 10.1016/j.jsb.2009.06.015

Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010-2011
journal, May 2016

  • Fleming-Dutra, Katherine E.; Hersh, Adam L.; Shapiro, Daniel J.
  • JAMA, Vol. 315, Issue 17
  • DOI: 10.1001/jama.2016.4151

Modification of Salmonella Lipopolysaccharides Prevents the Outer Membrane Penetration of Novobiocin
journal, December 2015

  • Nobre, Thatyane M.; Martynowycz, Michael W.; Andreev, Konstantin
  • Biophysical Journal, Vol. 109, Issue 12
  • DOI: 10.1016/j.bpj.2015.10.013

Structure-Activity Relationship Study of Novel Peptoids That Mimic the Structure of Antimicrobial Peptides
journal, May 2015

  • Mojsoska, Biljana; Zuckermann, Ronald N.; Jenssen, Håvard
  • Antimicrobial Agents and Chemotherapy, Vol. 59, Issue 7
  • DOI: 10.1128/AAC.00237-15

Membrane lipid homeostasis in bacteria
journal, March 2008

  • Zhang, Yong-Mei; Rock, Charles O.
  • Nature Reviews Microbiology, Vol. 6, Issue 3
  • DOI: 10.1038/nrmicro1839

Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis
journal, December 1992

  • Zuckermann, Ronald N.; Kerr, Janice M.; Kent, Stephen B. H.
  • Journal of the American Chemical Society, Vol. 114, Issue 26
  • DOI: 10.1021/ja00052a076

On the nature of the lipid monolayer phase transition
journal, January 1984

Phospholipid monolayers between fluid and solid states
journal, September 1987

Peptoid Backbone Flexibilility Dictates Its Interaction with Water and Surfaces: A Molecular Dynamics Investigation
journal, January 2018

Oncogenic mutations of ALK kinase in neuroblastoma
journal, October 2008

  • Chen, Yuyan; Takita, Junko; Choi, Young Lim
  • Nature, Vol. 455, Issue 7215
  • DOI: 10.1038/nature07399

Cardiolipins and biomembrane function
journal, March 1992

Peptoids: a modular approach to drug discovery.
journal, October 1992

  • Simon, R. J.; Kania, R. S.; Zuckermann, R. N.
  • Proceedings of the National Academy of Sciences, Vol. 89, Issue 20
  • DOI: 10.1073/pnas.89.20.9367

Effect of side chain hydrophobicity and cationic charge on antimicrobial activity and cytotoxicity of helical peptoids
journal, January 2018

  • Lee, Jiyoun; Kang, Dahyun; Choi, Jieun
  • Bioorganic & Medicinal Chemistry Letters, Vol. 28, Issue 2
  • DOI: 10.1016/j.bmcl.2017.11.034

Mechanism of membrane perturbation by the HIV-1 gp41 membrane-proximal external region and its modulation by cholesterol
journal, November 2012

  • Ivankin, Andrey; Apellániz, Beatriz; Gidalevitz, David
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1818, Issue 11
  • DOI: 10.1016/j.bbamem.2012.06.002

The influence of molecular structure on the oxidation of aliphatic hydrocarbons
journal, May 1953

Charge asymmetry in the proteins of the outer membrane
journal, June 2013

Synchrotron x-ray diffraction and reflection studies of arachidic acid monolayers at the air-water interface
journal, April 1989

  • Kjaer, K.; Als-Nielsen, J.; Helm, C. A.
  • The Journal of Physical Chemistry, Vol. 93, Issue 8
  • DOI: 10.1021/j100345a063

Cyclic Peptoids
journal, March 2007

  • Shin, Sung Bin Y.; Yoo, Barney; Todaro, Louis J.
  • Journal of the American Chemical Society, Vol. 129, Issue 11
  • DOI: 10.1021/ja066960o

Lipid monolayers: why use half a membrane to characterize protein-membrane interactions?
journal, August 1999

Seamless Proteins Tie Up Their Loose Ends
journal, March 2006

Lipid map of the mammalian cell
journal, December 2010

  • van Meer, G.; de Kroon, A. I. P. M.
  • Journal of Cell Science, Vol. 124, Issue 1
  • DOI: 10.1242/jcs.071233

Early Evolution of Membrane Lipids: How did the Lipid Divide Occur?
journal, January 2011

Proteolytic Degradation of Human Antimicrobial Peptide LL-37 by Bacillus anthracis May Contribute to Virulence
journal, June 2006

  • Thwaite, J. E.; Hibbs, S.; Titball, R. W.
  • Antimicrobial Agents and Chemotherapy, Vol. 50, Issue 7
  • DOI: 10.1128/AAC.01488-05

Membrane-Proximal External HIV-1 gp41 Motif Adapted for Destabilizing the Highly Rigid Viral Envelope
journal, November 2011

Evolution and development of model membranes for physicochemical and functional studies of the membrane lateral heterogeneity
journal, October 2018

  • Morigaki, Kenichi; Tanimoto, Yasushi
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1860, Issue 10
  • DOI: 10.1016/j.bbamem.2018.03.010

Phospholipid Monolayers Probed by Vibrational Sum Frequency Spectroscopy: Instability of Unsaturated Phospholipids
journal, May 2010

  • Liljeblad, Jonathan F. D.; Bulone, Vincent; Tyrode, Eric
  • Biophysical Journal, Vol. 98, Issue 10
  • DOI: 10.1016/j.bpj.2010.02.009

Peptoid Macrocycles: Making the Rounds with Peptidomimetic Oligomers
journal, April 2010

  • Yoo, Barney; Shin, Sung Bin Y.; Huang, Mia Lace
  • Chemistry - A European Journal, Vol. 16, Issue 19
  • DOI: 10.1002/chem.200903549

Asymmetrical Distribution and Artifactual Reorientation of Lipopolysaccharide in the Outer Membrane Bilayer of Salmonella typhimurium
journal, February 1975

Mitochondria-Targeting Peptoids
journal, March 2018

The early evolution of lipid membranes and the three domains of life
journal, June 2012

  • Lombard, Jonathan; López-García, Purificación; Moreira, David
  • Nature Reviews Microbiology, Vol. 10, Issue 7
  • DOI: 10.1038/nrmicro2815

Peptoids successfully inhibit the growth of gram negative E. coli causing substantial membrane damage
journal, February 2017

  • Mojsoska, Biljana; Carretero, Gustavo; Larsen, Sylvester
  • Scientific Reports, Vol. 7, Issue 1
  • DOI: 10.1038/srep42332

X-ray diffraction and scattering on disordered systems using synchrotron radiation
journal, April 1983

Static and dynamic lipid asymmetry in cell membranes
journal, February 1991

Peptidomimetic design
journal, January 1998

A Superliquid in Two Dimensions and a First‐Order Change in a Condensed Monolayer I. Energy, Compressibility, and Order of Phase Transformations
journal, May 1942

  • Harkins, William D.; Copeland, L. E.
  • The Journal of Chemical Physics, Vol. 10, Issue 5
  • DOI: 10.1063/1.1723720

Asymmetric localization of lipopolysaccharides on the outer membrane of Salmonella typhimurium
journal, March 1980

Mechanisms of Drug Resistance in Cancer Chemotherapy
journal, January 2005

  • Luqmani, Y. A.
  • Medical Principles and Practice, Vol. 14, Issue 1
  • DOI: 10.1159/000086183

Amphiphilic Cyclic Peptoids That Exhibit Antimicrobial Activity by Disrupting Staphylococcus aureus Membranes : Amphiphilic Cyclic Peptoids
journal, April 2013

  • Huang, Mia L.; Benson, Meredith A.; Shin, Sung Bin Y.
  • European Journal of Organic Chemistry, Vol. 2013, Issue 17
  • DOI: 10.1002/ejoc.201300077

journal, September 1917

  • Langmuir, Irving
  • Journal of the American Chemical Society, Vol. 39, Issue 9
  • DOI: 10.1021/ja02254a006

X-Ray Diffraction Study of the Ge(001) Reconstructed Surface
journal, April 1981

A carpet-based mechanism for direct antimicrobial peptide activity against vaccinia virus membranes
journal, November 2010

Synchrotron X-ray Studies of Rapidly Evolving Morphology of Self-Assembled Nanoparticle Films under Lateral Compression
journal, November 2013

  • Dai, Yeling; Lin, Binhua; Meron, Mati
  • Langmuir, Vol. 29, Issue 46
  • DOI: 10.1021/la403252d

Multilevel populations and the evolution of antibiotic resistance through horizontal gene transfer
journal, September 2011

Structure of the inverted hexagonal (HII) phase, and non-lamellar phase transitions of lipids
journal, February 1990

Membrane lipidome of an epithelial cell line
journal, January 2011

  • Sampaio, Julio L.; Gerl, Mathias J.; Klose, Christian
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 5
  • DOI: 10.1073/pnas.1019267108

Formation of Solid-Supported Lipid Bilayers:  An Integrated View
journal, April 2006

  • Richter, Ralf P.; Bérat, Rémi; Brisson, Alain R.
  • Langmuir, Vol. 22, Issue 8
  • DOI: 10.1021/la052687c

EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib
journal, February 2005

  • Kobayashi, Susumu; Boggon, Titus J.; Dayaram, Tajhal
  • New England Journal of Medicine, Vol. 352, Issue 8
  • DOI: 10.1056/NEJMoa044238

What's so special about cholesterol?
journal, November 2004

Interaction of antimicrobial peptide protegrin with biomembranes
journal, May 2003

  • Gidalevitz, D.; Ishitsuka, Y.; Muresan, A. S.
  • Proceedings of the National Academy of Sciences, Vol. 100, Issue 11
  • DOI: 10.1073/pnas.0934731100

Hydrophobic interactions modulate antimicrobial peptoid selectivity towards anionic lipid membranes
journal, June 2018

  • Andreev, Konstantin; Martynowycz, Michael W.; Huang, Mia L.
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1860, Issue 6
  • DOI: 10.1016/j.bbamem.2018.03.021

Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications
journal, March 2017

Peptide Hydrophobicity Controls the Activity and Selectivity of Magainin 2 Amide in Interaction with Membranes
journal, May 1997

  • Wieprecht, Torsten; Dathe, Margitta; Beyermann, Michael
  • Biochemistry, Vol. 36, Issue 20
  • DOI: 10.1021/bi9619987

Role of the Conformational Rigidity in the Design of Biomimetic Antimicrobial Compounds
journal, September 2010

  • Ivankin, Andrey; Livne, Liran; Mor, Amram
  • Angewandte Chemie International Edition, Vol. 49, Issue 45
  • DOI: 10.1002/anie.201003104

Membrane Interactions of Antimicrobial Peptoids - Restriction of Conformational Flexibility as a Strategy to Enhance Activity
journal, January 2013

Drug Resistance and Gene Transfer Mechanisms in Respiratory/Oral Bacteria
journal, June 2018

A Continuum of Anionic Charge: Structures and Functions of D-Alanyl-Teichoic Acids in Gram-Positive Bacteria
journal, December 2003

X-Ray Diffraction in Crystals, Imperfect Crystals, and Amorphous Bodies.
journal, January 1965

  • Borie, Bernard
  • Journal of the American Chemical Society, Vol. 87, Issue 1
  • DOI: 10.1021/ja01079a041

Solid supported lipid bilayers from artificial and natural lipid mixtures – long-term stable, homogeneous and reproducible
journal, January 2015

  • Möller, Isabelle; Seeger, Stefan
  • Journal of Materials Chemistry B, Vol. 3, Issue 29
  • DOI: 10.1039/C5TB00437C

Langmuir monolayers to study interactions at model membrane surfaces
journal, February 2003

Bacterial membrane lipids: diversity in structures and pathways
journal, April 2015

  • Sohlenkamp, Christian; Geiger, Otto
  • FEMS Microbiology Reviews, Vol. 40, Issue 1
  • DOI: 10.1093/femsre/fuv008

Guanidino groups greatly enhance the action of antimicrobial peptidomimetics against bacterial cytoplasmic membranes
journal, October 2014

  • Andreev, Konstantin; Bianchi, Christopher; Laursen, Jonas S.
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1838, Issue 10
  • DOI: 10.1016/j.bbamem.2014.05.022

Synthesis of DNA-Binding Peptoids
journal, May 2015

Structure and phase transitions in Langmuir monolayers
journal, April 1999

  • Kaganer, Vladimir M.; Möhwald, Helmuth; Dutta, Pulak
  • Reviews of Modern Physics, Vol. 71, Issue 3
  • DOI: 10.1103/RevModPhys.71.779

Mechanisms of Cancer Drug Resistance
journal, February 2002

Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050?
journal, November 2016

Antimicrobial peptides modulate long-term memory
journal, October 2018

Analysis of Antimicrobial-Triggered Membrane Depolarization Using Voltage Sensitive Dyes
journal, April 2016

  • te Winkel, J. Derk; Gray, Declan A.; Seistrup, Kenneth H.
  • Frontiers in Cell and Developmental Biology, Vol. 4
  • DOI: 10.3389/fcell.2016.00029

Correlations of Cationic Charges with Salt Sensitivity and Microbial Specificity of Cystine-stabilized β-Strand Antimicrobial Peptides
journal, October 2002

  • Tam, James P.; Lu, Yi-An; Yang, Jin-Long
  • Journal of Biological Chemistry, Vol. 277, Issue 52
  • DOI: 10.1074/jbc.M208429200

In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents
journal, February 2016

Amphiphiles Self-Assembly: Basic Concepts and Future Perspectives of Supramolecular Approaches
journal, January 2015

  • Lombardo, Domenico; Kiselev, Mikhail A.; Magazù, Salvatore
  • Advances in Condensed Matter Physics, Vol. 2015
  • DOI: 10.1155/2015/151683

Antimicrobial peptides in toroidal and cylindrical pores
journal, August 2010

  • Mihajlovic, Maja; Lazaridis, Themis
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1798, Issue 8
  • DOI: 10.1016/j.bbamem.2010.04.004

A Comparison of Linear and Cyclic Peptoid Oligomers as Potent Antimicrobial Agents
journal, September 2011

  • Huang, Mia Lace; Shin, Sung Bin Y.; Benson, Meredith A.
  • ChemMedChem, Vol. 7, Issue 1
  • DOI: 10.1002/cmdc.201100358

Exploring the links between peptoid antibacterial activity and toxicity
journal, January 2017

  • Bolt, H. L.; Eggimann, G. A.; Jahoda, C. A. B.
  • MedChemComm, Vol. 8, Issue 5
  • DOI: 10.1039/C6MD00648E

Self-assembly of ultra-small micelles from amphiphilic lipopeptoids
journal, January 2017

  • Lau, King Hang Aaron; Castelletto, Valeria; Kendall, Thomas
  • Chemical Communications, Vol. 53, Issue 13
  • DOI: 10.1039/C6CC09888F

Describing the Mechanism of Antimicrobial Peptide Action with the Interfacial Activity Model
journal, August 2010

Cellular processing of platinum anticancer drugs
journal, March 2005

  • Wang, Dong; Lippard, Stephen J.
  • Nature Reviews Drug Discovery, Vol. 4, Issue 4
  • DOI: 10.1038/nrd1691

Ordering in Lipid Monolayers Studied by Synchrotron X-Ray Diffraction and Fluorescence Microscopy
journal, May 1987

De novo structure prediction and experimental characterization of folded peptoid oligomers
journal, August 2012

  • Butterfoss, G. L.; Yoo, B.; Jaworski, J. N.
  • Proceedings of the National Academy of Sciences, Vol. 109, Issue 36
  • DOI: 10.1073/pnas.1209945109

From antimicrobial to anticancer peptides. A review
journal, January 2013

  • Gaspar, Diana; Veiga, A. Salomé; Castanho, Miguel A. R. B.
  • Frontiers in Microbiology, Vol. 4
  • DOI: 10.3389/fmicb.2013.00294

A comparative study of the phase transitions of phospholipid bilayers and monolayers
journal, October 1979

Molecular arrangement in condensed monolayer phases
journal, January 1978

An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection
journal, January 2018

Peptides with Dual Antimicrobial and Anticancer Activities
journal, February 2017

Comparative Study of Poloxamer Insertion into Lipid Monolayers
journal, March 2003

  • Maskarinec, Stacey A.; Lee, Ka Yee C.
  • Langmuir, Vol. 19, Issue 5
  • DOI: 10.1021/la026175z

Sequence-specific polypeptoids: A diverse family of heteropolymers with stable secondary structure
journal, April 1998

  • Kirshenbaum, K.; Barron, A. E.; Goldsmith, R. A.
  • Proceedings of the National Academy of Sciences, Vol. 95, Issue 8
  • DOI: 10.1073/pnas.95.8.4303

Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
journal, March 2005

Antibiotics in late clinical development
journal, June 2017

Do β -Defensins and Other Antimicrobial Peptides Play a Role in Neuroimmune Function and Neurodegeneration?
journal, January 2012

  • Williams, Wesley M.; Castellani, Rudy J.; Weinberg, Aaron
  • The Scientific World Journal, Vol. 2012
  • DOI: 10.1100/2012/905785

The role of cationic antimicrobial peptides in innate host defences
journal, September 2000

Structural and Dynamical Characteristics of Peptoid Oligomers with Achiral Aliphatic Side Chains Studied by Molecular Dynamics Simulation
journal, September 2011

  • Park, Sung Hyun; Szleifer, Igal
  • The Journal of Physical Chemistry B, Vol. 115, Issue 37
  • DOI: 10.1021/jp2025957

Cellular uptake and membrane-destabilising properties of α-peptide/β-peptoid chimeras: lessons for the design of new cell-penetrating peptides
journal, November 2008

  • Foged, Camilla; Franzyk, Henrik; Bahrami, Shervin
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1778, Issue 11
  • DOI: 10.1016/j.bbamem.2008.06.020

Antimicrobial peptides are degraded by the cytosolic proteases of human erythrocytes
journal, December 2017

  • Starr, Charles G.; Wimley, William C.
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1859, Issue 12
  • DOI: 10.1016/j.bbamem.2017.09.008

Antimicrobial peptide mimics for improved therapeutic properties
journal, August 2009

Solid supported lipid membranes: New concepts for the biomimetic functionalization of solid surfaces
journal, June 2008

  • Knoll, W.; Naumann, R.; Friedrich, M.
  • Biointerphases, Vol. 3, Issue 2
  • DOI: 10.1116/1.2913612

Surface Tension
journal, March 1891

Few novel antibiotics in the pipeline, WHO warns
journal, September 2017

Kdo 2 -Lipid A of Escherichia coli , a defined endotoxin that activates macrophages via TLR-4
journal, February 2006

  • Raetz, Christian R. H.; Garrett, Teresa A.; Reynolds, C. Michael
  • Journal of Lipid Research, Vol. 47, Issue 5
  • DOI: 10.1194/jlr.M600027-JLR200

Relation between various phospholipase actions on human red cell membranes and the interfacial phospholipid pressure in monolayers
journal, September 1975

  • Demel, R. A.; Geurts van Kessel, W. S. M.; Zwaal, R. F. A.
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 406, Issue 1
  • DOI: 10.1016/0005-2736(75)90045-0

Interactions between membrane sterols and phospholipids in model mammalian and fungi cellular membranes — A Langmuir monolayer study
journal, March 2009

Role of the Cyclization in De Novo Design of Antimicrobial Peptide Mimics
journal, January 2012

Intracellular biomass flocculation as a key mechanism of rapid bacterial killing by cationic, amphipathic antimicrobial peptides and peptoids
journal, December 2017

  • Chongsiriwatana, Nathaniel P.; Lin, Jennifer S.; Kapoor, Rinki
  • Scientific Reports, Vol. 7, Issue 1
  • DOI: 10.1038/s41598-017-16180-0