Highly selective and sensitive macrocycle-based dinuclear foldamer for fluorometric and colorimetric sensing of citrate in water

doi:10.1038/s41598-017-18322-w

Title: Highly selective and sensitive macrocycle-based dinuclear foldamer for fluorometric and colorimetric sensing of citrate in water

Abstract

The selective detection of citrate anions is essential for various biological functions in living systems. A quantitative assessment of citrate is required for the diagnosis of various diseases in the human body; however, it is extremely challenging to develop efficient fluorescence and color-detecting molecular probes for sensing citrate in water. Herein, we report a macrocycle-based dinuclear foldamer (1) assembled with eosin Y (EY) that has been studied for anion binding by fluorescence and colorimetric techniques in water at neutral pH. Results from the fluorescence titrations reveal that the 1·EY ensemble strongly binds citrate anions, showing remarkable selectivity over a wide range of inorganic and carboxylate anions. The addition of citrate anions to the 1·EY adduct led to a large fluorescence enhancement, displaying a detectable color change under both visible and UV light in water up to 2 μmol. The biocompatibility of 1·EY as an intracellular carrier in a biological system was evaluated on primary human foreskin fibroblast (HF) cells, showing an excellent cell viability. The strong binding properties of the ensemble allow it to be used as a highly sensitive, detective probe for biologically relevant citrate anions in various applications.

Authors:

Rhaman, Md Mhahabubur ^[1]; Hasan, Mohammad H. ^[2]; Alamgir, Azmain ^[1]; Xu, Lihua ^[3]; Powell, Douglas R. ^[4];

^[3];

^[2]; Hossain, Md. Alamgir ^[1]

Jackson State Univ, Jackson, MS (United States)
Univ. of Mississippi Medical Center, Jackson, MS (United States)
Univ. of California, Riverside, CA (United States)
Univ. of Oklahoma, Norman, OK (United States)

Publication Date:: 2018-01-10

Research Org.:: Univ. of California, Riverside, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1500015

Grant/Contract Number:: SC0016269

Resource Type:: Accepted Manuscript

Journal Name:: Scientific Reports

Additional Journal Information:: Journal Volume: 8; Journal Issue: 1; Journal ID: ISSN 2045-2322

Publisher:: Nature Publishing Group

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

Citation Formats


                    Rhaman, Md Mhahabubur, Hasan, Mohammad H., Alamgir, Azmain, Xu, Lihua, Powell, Douglas R., Wong, Bryan M., Tandon, Ritesh, and Hossain, Md. Alamgir. Highly selective and sensitive macrocycle-based dinuclear foldamer for fluorometric and colorimetric sensing of citrate in water.  United States: N. p., 2018. 
        Web.  doi:10.1038/s41598-017-18322-w.

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                    Rhaman, Md Mhahabubur, Hasan, Mohammad H., Alamgir, Azmain, Xu, Lihua, Powell, Douglas R., Wong, Bryan M., Tandon, Ritesh, & Hossain, Md. Alamgir. Highly selective and sensitive macrocycle-based dinuclear foldamer for fluorometric and colorimetric sensing of citrate in water.  United States.  doi:10.1038/s41598-017-18322-w.

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                    Rhaman, Md Mhahabubur, Hasan, Mohammad H., Alamgir, Azmain, Xu, Lihua, Powell, Douglas R., Wong, Bryan M., Tandon, Ritesh, and Hossain, Md. Alamgir. Wed .  
        "Highly selective and sensitive macrocycle-based dinuclear foldamer for fluorometric and colorimetric sensing of citrate in water".  United States.  doi:10.1038/s41598-017-18322-w.  https://www.osti.gov/servlets/purl/1500015.

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@article{osti_1500015,

  title        = {Highly selective and sensitive macrocycle-based dinuclear foldamer for fluorometric and colorimetric sensing of citrate in water},

  author       = {Rhaman, Md Mhahabubur and Hasan, Mohammad H. and Alamgir, Azmain and Xu, Lihua and Powell, Douglas R. and Wong, Bryan M. and Tandon, Ritesh and Hossain, Md. Alamgir},

  abstractNote = {The selective detection of citrate anions is essential for various biological functions in living systems. A quantitative assessment of citrate is required for the diagnosis of various diseases in the human body; however, it is extremely challenging to develop efficient fluorescence and color-detecting molecular probes for sensing citrate in water. Herein, we report a macrocycle-based dinuclear foldamer (1) assembled with eosin Y (EY) that has been studied for anion binding by fluorescence and colorimetric techniques in water at neutral pH. Results from the fluorescence titrations reveal that the 1·EY ensemble strongly binds citrate anions, showing remarkable selectivity over a wide range of inorganic and carboxylate anions. The addition of citrate anions to the 1·EY adduct led to a large fluorescence enhancement, displaying a detectable color change under both visible and UV light in water up to 2 μmol. The biocompatibility of 1·EY as an intracellular carrier in a biological system was evaluated on primary human foreskin fibroblast (HF) cells, showing an excellent cell viability. The strong binding properties of the ensemble allow it to be used as a highly sensitive, detective probe for biologically relevant citrate anions in various applications.},

  doi          = {10.1038/s41598-017-18322-w},

  journal      = {Scientific Reports},

  number       = 1,

  volume       = 8,

  place        = {United States},

  year         = {2018},

  month        = {1}

}

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DOI: 10.1038/s41598-017-18322-w

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Works referenced in this record:

Highly Selective Oligonucleotide-Based Sensor for Mercury(II) in Aqueous Solutions
journal, August 2004

Ono, Akira; Togashi, Humika
Angewandte Chemie International Edition, Vol. 43, Issue 33, p. 4300-4302
DOI: 10.1002/anie.200454172

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Title: Highly selective and sensitive macrocycle-based dinuclear foldamer for fluorometric and colorimetric sensing of citrate in water

Abstract

Citation Formats

Highly Selective Oligonucleotide-Based Sensor for Mercury(II) in Aqueous Solutions journal, August 2004

Highly Selective Oligonucleotide-Based Sensor for Mercury(II) in Aqueous Solutions
journal, August 2004