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Title: A Bismuth Metal–Organic Framework as a Contrast Agent for X-ray Computed Tomography

Abstract

A new bismuth metal–organic framework (MOF), bismuth-NU901 (Bi-NU-901), featuring the scu topology and a pore with a diameter of ~11 Å, was solvothermally synthesized, and its use as an X-ray computed tomography (CT) contrast agent was tested. X-ray CT is a common diagnostic method used in the medical field. Inside the body, contrast media enhance the distinction between tissues and organs of similar density. Bi-NU-901 consists of eight connected Bi 6 nodes and tetratopic 1,3,5,8-( p-benzoate)pyrene linkers (TBAPy). Numerous material characterization studies including powder X-ray diffraction (PXRD), scanning transmission electron microscopy (STEM), and DFT pore size distribution support the scu structure. Additionally, given the framework’s high density of nontoxic heavy atoms, Bi-NU-901 was evaluated as an X-ray computed tomography (CT) agent. Importantly, in vitro studies revealed this new bismuth MOF demonstrates p7 times better contrast intensity compared to a zirconium MOF featuring the same topology and ~14 times better contrast than a commercially available CT contrast agent. Furthermore these results suggest bismuth MOFs may be promising CT contrast agents.

Authors:
ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [1]; ORCiD logo [1];  [1];  [1]; ORCiD logo [1]; ORCiD logo [3];  [3]; ORCiD logo [1];  [4]; ORCiD logo [1]; ORCiD logo [1]
  1. Northwestern Univ., Evanston, IL (United States)
  2. Northwestern Univ., Evanston, IL (United States); Nanjing Tech Univ., Nanjing (China)
  3. Univ. of Liverpool, Liverpool (United Kingdom)
  4. Nanjing Tech Univ., Nanjing (China)
Publication Date:
Research Org.:
Univ. of Notre Dame, Notre Dame, IN (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1497853
Grant/Contract Number:  
NA0003763
Resource Type:
Accepted Manuscript
Journal Name:
ACS Applied Bio Materials
Additional Journal Information:
Journal Volume: 2; Journal Issue: 3; Journal ID: ISSN 2576-6422
Publisher:
ACS Publications
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; bismuth; contrast agent; metal−organic frameworks; X-ray computed tomography

Citation Formats

Robison, Lee, Zhang, Lin, Drout, Riki J., Li, Peng, Haney, Chad R., Brikha, Anlil, Noh, Hyunho, Mehdi, B. Layla, Browning, Nigel D., Dravid, Vinayak P., Cui, Qun, Islamoglu, Timur, and Farha, Omar K. A Bismuth Metal–Organic Framework as a Contrast Agent for X-ray Computed Tomography. United States: N. p., 2019. Web. doi:10.1021/acsabm.8b00778.
Robison, Lee, Zhang, Lin, Drout, Riki J., Li, Peng, Haney, Chad R., Brikha, Anlil, Noh, Hyunho, Mehdi, B. Layla, Browning, Nigel D., Dravid, Vinayak P., Cui, Qun, Islamoglu, Timur, & Farha, Omar K. A Bismuth Metal–Organic Framework as a Contrast Agent for X-ray Computed Tomography. United States. doi:10.1021/acsabm.8b00778.
Robison, Lee, Zhang, Lin, Drout, Riki J., Li, Peng, Haney, Chad R., Brikha, Anlil, Noh, Hyunho, Mehdi, B. Layla, Browning, Nigel D., Dravid, Vinayak P., Cui, Qun, Islamoglu, Timur, and Farha, Omar K. Fri . "A Bismuth Metal–Organic Framework as a Contrast Agent for X-ray Computed Tomography". United States. doi:10.1021/acsabm.8b00778.
@article{osti_1497853,
title = {A Bismuth Metal–Organic Framework as a Contrast Agent for X-ray Computed Tomography},
author = {Robison, Lee and Zhang, Lin and Drout, Riki J. and Li, Peng and Haney, Chad R. and Brikha, Anlil and Noh, Hyunho and Mehdi, B. Layla and Browning, Nigel D. and Dravid, Vinayak P. and Cui, Qun and Islamoglu, Timur and Farha, Omar K.},
abstractNote = {A new bismuth metal–organic framework (MOF), bismuth-NU901 (Bi-NU-901), featuring the scu topology and a pore with a diameter of ~11 Å, was solvothermally synthesized, and its use as an X-ray computed tomography (CT) contrast agent was tested. X-ray CT is a common diagnostic method used in the medical field. Inside the body, contrast media enhance the distinction between tissues and organs of similar density. Bi-NU-901 consists of eight connected Bi6 nodes and tetratopic 1,3,5,8-(p-benzoate)pyrene linkers (TBAPy). Numerous material characterization studies including powder X-ray diffraction (PXRD), scanning transmission electron microscopy (STEM), and DFT pore size distribution support the scu structure. Additionally, given the framework’s high density of nontoxic heavy atoms, Bi-NU-901 was evaluated as an X-ray computed tomography (CT) agent. Importantly, in vitro studies revealed this new bismuth MOF demonstrates p7 times better contrast intensity compared to a zirconium MOF featuring the same topology and ~14 times better contrast than a commercially available CT contrast agent. Furthermore these results suggest bismuth MOFs may be promising CT contrast agents.},
doi = {10.1021/acsabm.8b00778},
journal = {ACS Applied Bio Materials},
number = 3,
volume = 2,
place = {United States},
year = {2019},
month = {2}
}

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This content will become publicly available on February 15, 2020
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