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Title: Nanofiber-Based Total Internal Reflection Microscopy for Characterizing Colloidal Systems at the Microscale

Abstract

Bulk colloidal interactions are dictated by the physical properties of individual particles dispersed in solution. However, for many applications it remains challenging to predict system-level colloidal behavior. Comprehensive characterization typically requires disparate techniques that can observe correlations between microscale particle–surface interactions and physical properties of the particles. In this work, we present a unique tin dioxide (SnO2) nanofiber-based total internal reflection microscopy (TIRM) method to efficiently characterize colloidal behavior as a function of particle-level properties in complex fluidic conditions. We develop and model the device physics to understand the physical underpinnings of the raw device data and then use these models to design proof-of-concept experiments to verify device function. Statistical trends in the data collected from a nominal system of 80 nm gold nanoparticles correspond to theoretical predictions as we vary key design parameters such as particle size, surface charge, and solution ionic strength. Lastly, we consider the practical limitations of the technique gleaned from our studies and offer suggestions for utilizing the platform to quantitatively analyze nonideal colloidal systems with distributed or heterogeneous system parameters.

Authors:
 [1];  [1];  [2]; ORCiD logo [1]; ORCiD logo [1]
  1. Univ. of California, San Diego, CA (United States)
  2. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1497303
Report Number(s):
LLNL-JRNL-733749
Journal ID: ISSN 1932-7447; 885613
Grant/Contract Number:  
AC52-07NA27344
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Physical Chemistry. C
Additional Journal Information:
Journal Volume: 122; Journal Issue: 38; Journal ID: ISSN 1932-7447
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Villanueva, Joshua T., Huang, Qian, Fischer, Nicholas O., Arya, Gaurav, and Sirbuly, Donald J. Nanofiber-Based Total Internal Reflection Microscopy for Characterizing Colloidal Systems at the Microscale. United States: N. p., 2018. Web. doi:10.1021/acs.jpcc.8b03167.
Villanueva, Joshua T., Huang, Qian, Fischer, Nicholas O., Arya, Gaurav, & Sirbuly, Donald J. Nanofiber-Based Total Internal Reflection Microscopy for Characterizing Colloidal Systems at the Microscale. United States. doi:10.1021/acs.jpcc.8b03167.
Villanueva, Joshua T., Huang, Qian, Fischer, Nicholas O., Arya, Gaurav, and Sirbuly, Donald J. Tue . "Nanofiber-Based Total Internal Reflection Microscopy for Characterizing Colloidal Systems at the Microscale". United States. doi:10.1021/acs.jpcc.8b03167. https://www.osti.gov/servlets/purl/1497303.
@article{osti_1497303,
title = {Nanofiber-Based Total Internal Reflection Microscopy for Characterizing Colloidal Systems at the Microscale},
author = {Villanueva, Joshua T. and Huang, Qian and Fischer, Nicholas O. and Arya, Gaurav and Sirbuly, Donald J.},
abstractNote = {Bulk colloidal interactions are dictated by the physical properties of individual particles dispersed in solution. However, for many applications it remains challenging to predict system-level colloidal behavior. Comprehensive characterization typically requires disparate techniques that can observe correlations between microscale particle–surface interactions and physical properties of the particles. In this work, we present a unique tin dioxide (SnO2) nanofiber-based total internal reflection microscopy (TIRM) method to efficiently characterize colloidal behavior as a function of particle-level properties in complex fluidic conditions. We develop and model the device physics to understand the physical underpinnings of the raw device data and then use these models to design proof-of-concept experiments to verify device function. Statistical trends in the data collected from a nominal system of 80 nm gold nanoparticles correspond to theoretical predictions as we vary key design parameters such as particle size, surface charge, and solution ionic strength. Lastly, we consider the practical limitations of the technique gleaned from our studies and offer suggestions for utilizing the platform to quantitatively analyze nonideal colloidal systems with distributed or heterogeneous system parameters.},
doi = {10.1021/acs.jpcc.8b03167},
journal = {Journal of Physical Chemistry. C},
number = 38,
volume = 122,
place = {United States},
year = {2018},
month = {9}
}

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