Does co-transcriptional regulation of alternative splicing mediate plant stress responses?
Abstract
Plants display exquisite control over gene expression to elicit appropriate responses under normal and stress conditions. Alternative splicing (AS) of pre-mRNAs, a process that generates two or more transcripts from multi-exon genes, adds another layer of regulation to fine-tune condition-specific gene expression in animals and plants. However, exactly how plants control splice isoform ratios and the timing of this regulation in response to environmental signals remains elusive. In mammals, recent evidence indicate that epigenetic and epitranscriptome changes, such as DNA methylation, chromatin modifications and RNA methylation, regulate RNA polymerase II processivity, co-transcriptional splicing, and stability and translation efficiency of splice isoforms. In plants, the role of epigenetic modifications in regulating transcription rate and mRNA abundance under stress is beginning to emerge. However, the mechanisms by which epigenetic and epitranscriptomic modifications regulate AS and translation efficiency require further research. Dynamic changes in the chromatin landscape in response to stress may provide a scaffold around which gene expression, AS and translation are orchestrated. Finally, we discuss CRISPR/Cas-based strategies for engineering chromatin architecture to manipulate AS patterns (or splice isoforms levels) to obtain insight into the epigenetic regulation of AS.
- Authors:
-
[3];
[1];
[1]
- School of Human and Life Sciences, Canterbury Christ Church University, Canterbury, CT1 1QU, UK
- Department of Biology and Program in Cell and Molecular Biology, Colorado State University, Fort Collins, CO 80523-1878, USA
- Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences - BOKU, Muthgasse 18, 1190 Vienna, Austria
- Publication Date:
- Research Org.:
- Colorado State Univ., Fort Collins, CO (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- OSTI Identifier:
- 1495855
- Alternate Identifier(s):
- OSTI ID: 1611510
- Grant/Contract Number:
- SC0010733
- Resource Type:
- Published Article
- Journal Name:
- Nucleic Acids Research
- Additional Journal Information:
- Journal Name: Nucleic Acids Research Journal Volume: 47 Journal Issue: 6; Journal ID: ISSN 0305-1048
- Publisher:
- Oxford University Press
- Country of Publication:
- United Kingdom
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; 54 ENVIRONMENTAL SCIENCES; Biochemistry & Molecular Biology
Citation Formats
Jabre, Ibtissam, Reddy, Anireddy S. N., Kalyna, Maria, Chaudhary, Saurabh, Khokhar, Waqas, Byrne, Lee J., Wilson, Cornelia M., and Syed, Naeem H. Does co-transcriptional regulation of alternative splicing mediate plant stress responses?. United Kingdom: N. p., 2019.
Web. doi:10.1093/nar/gkz121.
Jabre, Ibtissam, Reddy, Anireddy S. N., Kalyna, Maria, Chaudhary, Saurabh, Khokhar, Waqas, Byrne, Lee J., Wilson, Cornelia M., & Syed, Naeem H. Does co-transcriptional regulation of alternative splicing mediate plant stress responses?. United Kingdom. https://doi.org/10.1093/nar/gkz121
Jabre, Ibtissam, Reddy, Anireddy S. N., Kalyna, Maria, Chaudhary, Saurabh, Khokhar, Waqas, Byrne, Lee J., Wilson, Cornelia M., and Syed, Naeem H. Fri .
"Does co-transcriptional regulation of alternative splicing mediate plant stress responses?". United Kingdom. https://doi.org/10.1093/nar/gkz121.
@article{osti_1495855,
title = {Does co-transcriptional regulation of alternative splicing mediate plant stress responses?},
author = {Jabre, Ibtissam and Reddy, Anireddy S. N. and Kalyna, Maria and Chaudhary, Saurabh and Khokhar, Waqas and Byrne, Lee J. and Wilson, Cornelia M. and Syed, Naeem H.},
abstractNote = {Plants display exquisite control over gene expression to elicit appropriate responses under normal and stress conditions. Alternative splicing (AS) of pre-mRNAs, a process that generates two or more transcripts from multi-exon genes, adds another layer of regulation to fine-tune condition-specific gene expression in animals and plants. However, exactly how plants control splice isoform ratios and the timing of this regulation in response to environmental signals remains elusive. In mammals, recent evidence indicate that epigenetic and epitranscriptome changes, such as DNA methylation, chromatin modifications and RNA methylation, regulate RNA polymerase II processivity, co-transcriptional splicing, and stability and translation efficiency of splice isoforms. In plants, the role of epigenetic modifications in regulating transcription rate and mRNA abundance under stress is beginning to emerge. However, the mechanisms by which epigenetic and epitranscriptomic modifications regulate AS and translation efficiency require further research. Dynamic changes in the chromatin landscape in response to stress may provide a scaffold around which gene expression, AS and translation are orchestrated. Finally, we discuss CRISPR/Cas-based strategies for engineering chromatin architecture to manipulate AS patterns (or splice isoforms levels) to obtain insight into the epigenetic regulation of AS.},
doi = {10.1093/nar/gkz121},
journal = {Nucleic Acids Research},
number = 6,
volume = 47,
place = {United Kingdom},
year = {Fri Feb 22 00:00:00 EST 2019},
month = {Fri Feb 22 00:00:00 EST 2019}
}
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