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Title: A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium

Abstract

We employ an advanced 3D computational model of the head with high anatomical fidelity, together with measured tissue properties, to assess the consequences of dynamic loading to the head in two distinct modes: head rotation and head extension. We use a subject-specific computational head model, using the material point method, built from T1 magnetic resonance images, and considering the anisotropic properties of the white matter which can predict strains in the brain under large rotational accelerations. The material model now includes the shear anisotropy of the white matter. We validate the model under head rotation and head extension motions using live human data, and advance a prior version of the model to include biofidelic falx and tentorium. Furthermore we then examine the consequences of incorporating the falx and tentorium in terms of the predictions from the computational head model.

Authors:
 [1]; ORCiD logo [1];  [2];  [1];  [2];  [3];  [1];  [4]; ORCiD logo [1]
+ Show Author Affiliations
  1. Johns Hopkins Univ., Baltimore, MD (United States)
  2. The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD (United States)
  3. National Institutes of Health Clinical Center, Bethesda, MD (United States)
  4. Washington Univ. in St. Louis, St. Louis, MO (United States)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
National Institutes of Health (NIH); USDOE
OSTI Identifier:
1495175
Report Number(s):
LA-UR-19-20972
Journal ID: ISSN 0090-6964
Grant/Contract Number:  
89233218CNA000001
Resource Type:
Accepted Manuscript
Journal Name:
Annals of Biomedical Engineering
Additional Journal Information:
Journal Volume: 47; Journal Issue: 9; Journal ID: ISSN 0090-6964
Publisher:
Springer
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; brain; tbi; material point method; dynamic impact; soft matter; brain modeling; in vivo experiments; validation

Citation Formats

Lu, Y. -C., Daphalapurkar, Nitin P., Knutsen, A. K., Glaister, J., Pham, D. L., Butman, J. A., Prince, J. L., Bayly, P. V., and Ramesh, K. T. A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium. United States: N. p., 2019. Web. https://doi.org/10.1007/s10439-019-02226-z.
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Lu, Y. -C., Daphalapurkar, Nitin P., Knutsen, A. K., Glaister, J., Pham, D. L., Butman, J. A., Prince, J. L., Bayly, P. V., & Ramesh, K. T. A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium. United States. https://doi.org/10.1007/s10439-019-02226-z
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Lu, Y. -C., Daphalapurkar, Nitin P., Knutsen, A. K., Glaister, J., Pham, D. L., Butman, J. A., Prince, J. L., Bayly, P. V., and Ramesh, K. T. Thu . "A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium". United States. https://doi.org/10.1007/s10439-019-02226-z. https://www.osti.gov/servlets/purl/1495175.
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@article{osti_1495175,
title = {A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium},
author = {Lu, Y. -C. and Daphalapurkar, Nitin P. and Knutsen, A. K. and Glaister, J. and Pham, D. L. and Butman, J. A. and Prince, J. L. and Bayly, P. V. and Ramesh, K. T.},
abstractNote = {We employ an advanced 3D computational model of the head with high anatomical fidelity, together with measured tissue properties, to assess the consequences of dynamic loading to the head in two distinct modes: head rotation and head extension. We use a subject-specific computational head model, using the material point method, built from T1 magnetic resonance images, and considering the anisotropic properties of the white matter which can predict strains in the brain under large rotational accelerations. The material model now includes the shear anisotropy of the white matter. We validate the model under head rotation and head extension motions using live human data, and advance a prior version of the model to include biofidelic falx and tentorium. Furthermore we then examine the consequences of incorporating the falx and tentorium in terms of the predictions from the computational head model.},
doi = {10.1007/s10439-019-02226-z},
journal = {Annals of Biomedical Engineering},
number = 9,
volume = 47,
place = {United States},
year = {2019},
month = {2}
}
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    Works referencing / citing this record:

    Nonlinear Dynamical Behavior of the Deep White Matter during Head Impact
    journal, July 2019

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