A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium

Lu, Y. -C.; Daphalapurkar, Nitin P.; Knutsen, A. K.; Glaister, J.; Pham, D. L.; Butman, J. A.; Prince, J. L.; Bayly, P. V.; Ramesh, K. T.

doi:10.1007/s10439-019-02226-z

Title: A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium

Journal Article · 13 February 2019 · Annals of Biomedical Engineering

DOI: https://doi.org/10.1007/s10439-019-02226-z · OSTI ID:1495175

Lu, Y. -C. ^[1];

^[1]; Knutsen, A. K. ^[2]; Glaister, J. ^[1]; Pham, D. L. ^[2]; Butman, J. A. ^[3]; Prince, J. L. ^[1]; Bayly, P. V. ^[4];

^[1]

Johns Hopkins Univ., Baltimore, MD (United States)
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD (United States)
National Institutes of Health Clinical Center, Bethesda, MD (United States)
Washington Univ. in St. Louis, St. Louis, MO (United States)

We employ an advanced 3D computational model of the head with high anatomical fidelity, together with measured tissue properties, to assess the consequences of dynamic loading to the head in two distinct modes: head rotation and head extension. We use a subject-specific computational head model, using the material point method, built from T1 magnetic resonance images, and considering the anisotropic properties of the white matter which can predict strains in the brain under large rotational accelerations. The material model now includes the shear anisotropy of the white matter. We validate the model under head rotation and head extension motions using live human data, and advance a prior version of the model to include biofidelic falx and tentorium. Furthermore we then examine the consequences of incorporating the falx and tentorium in terms of the predictions from the computational head model.

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Research Organization:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: National Institutes of Health; USDOE

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 1495175

Report Number(s):: LA-UR--19-20972

Journal Information:: Annals of Biomedical Engineering, Journal Name: Annals of Biomedical Engineering Journal Issue: 9 Vol. 47; ISSN 0090-6964

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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Nonlinear Dynamical Behavior of the Deep White Matter during Head Impact Abderezaei, Javid; Zhao, Wei; Grijalva, Carissa L. Physical Review Applied, Vol. 12, Issue 1 https://doi.org/10.1103/physrevapplied.12.014058	journal	July 2019

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Title: A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium

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