skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium

Abstract

We employ an advanced 3D computational model of the head with high anatomical fidelity, together with measured tissue properties, to assess the consequences of dynamic loading to the head in two distinct modes: head rotation and head extension. We use a subject-specific computational head model, using the material point method, built from T1 magnetic resonance images, and considering the anisotropic properties of the white matter which can predict strains in the brain under large rotational accelerations. The material model now includes the shear anisotropy of the white matter. We validate the model under head rotation and head extension motions using live human data, and advance a prior version of the model to include biofidelic falx and tentorium. Furthermore we then examine the consequences of incorporating the falx and tentorium in terms of the predictions from the computational head model.

Authors:
 [1]; ORCiD logo [1];  [2];  [1];  [2];  [3];  [1];  [4]; ORCiD logo [1]
+ Show Author Affiliations
  1. Johns Hopkins Univ., Baltimore, MD (United States)
  2. The Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD (United States)
  3. National Institutes of Health Clinical Center, Bethesda, MD (United States)
  4. Washington Univ. in St. Louis, St. Louis, MO (United States)
Publication Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
National Institutes of Health (NIH); USDOE
OSTI Identifier:
1495175
Report Number(s):
LA-UR-19-20972
Journal ID: ISSN 0090-6964
Grant/Contract Number:  
89233218CNA000001
Resource Type:
Accepted Manuscript
Journal Name:
Annals of Biomedical Engineering
Additional Journal Information:
Journal Name: Annals of Biomedical Engineering; Journal ID: ISSN 0090-6964
Publisher:
Springer
Country of Publication:
United States
Language:
English
Subject:
61 RADIATION PROTECTION AND DOSIMETRY; brain; tbi; material point method; dynamic impact; soft matter; brain modeling; in vivo experiments; validation

Citation Formats

Lu, Y. -C., Daphalapurkar, Nitin P., Knutsen, A. K., Glaister, J., Pham, D. L., Butman, J. A., Prince, J. L., Bayly, P. V., and Ramesh, K. T. A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium. United States: N. p., 2019. Web. doi:10.1007/s10439-019-02226-z.
Copy to clipboard
Lu, Y. -C., Daphalapurkar, Nitin P., Knutsen, A. K., Glaister, J., Pham, D. L., Butman, J. A., Prince, J. L., Bayly, P. V., & Ramesh, K. T. A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium. United States. doi:10.1007/s10439-019-02226-z.
Copy to clipboard
Lu, Y. -C., Daphalapurkar, Nitin P., Knutsen, A. K., Glaister, J., Pham, D. L., Butman, J. A., Prince, J. L., Bayly, P. V., and Ramesh, K. T. Thu . "A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium". United States. doi:10.1007/s10439-019-02226-z. https://www.osti.gov/servlets/purl/1495175.
Copy to clipboard
@article{osti_1495175,
title = {A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium},
author = {Lu, Y. -C. and Daphalapurkar, Nitin P. and Knutsen, A. K. and Glaister, J. and Pham, D. L. and Butman, J. A. and Prince, J. L. and Bayly, P. V. and Ramesh, K. T.},
abstractNote = {We employ an advanced 3D computational model of the head with high anatomical fidelity, together with measured tissue properties, to assess the consequences of dynamic loading to the head in two distinct modes: head rotation and head extension. We use a subject-specific computational head model, using the material point method, built from T1 magnetic resonance images, and considering the anisotropic properties of the white matter which can predict strains in the brain under large rotational accelerations. The material model now includes the shear anisotropy of the white matter. We validate the model under head rotation and head extension motions using live human data, and advance a prior version of the model to include biofidelic falx and tentorium. Furthermore we then examine the consequences of incorporating the falx and tentorium in terms of the predictions from the computational head model.},
doi = {10.1007/s10439-019-02226-z},
journal = {Annals of Biomedical Engineering},
number = ,
volume = ,
place = {United States},
year = {2019},
month = {2}
}
Copy to clipboard
Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI:  10.1007/s10439-019-02226-z
Copyright Statement
Other availability
Search WorldCat Search WorldCat to find libraries that may hold this journal
Citation Metrics:
Cited by: 1 work
Citation information provided by
Web of Science
Save / Share:
Export Metadata
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.

Works referenced in this record:

Measurements of mechanical anisotropy in brain tissue and implications for transversely isotropic material models of white matter
journal, July 2013

  • Feng, Yuan; Okamoto, Ruth J.; Namani, Ravi
  • Journal of the Mechanical Behavior of Biomedical Materials, Vol. 23
  • DOI: 10.1016/j.jmbbm.2013.04.007

Deformation of the Human Brain Induced by Mild Acceleration
journal, August 2005

Anisotropic constitutive equations and experimental tensile behavior of brain tissue
journal, November 2005

  • Velardi, F.; Fraternali, F.; Angelillo, M.
  • Biomechanics and Modeling in Mechanobiology, Vol. 5, Issue 1
  • DOI: 10.1007/s10237-005-0007-9

Epidemiology of Traumatic Brain Injury in Eastern China, 2004: A Prospective Large Case Study
journal, January 2008

  • Wu, Xing; Hu, Jin; Zhuo, Liangfu
  • The Journal of Trauma: Injury, Infection, and Critical Care, Vol. 64, Issue 5
  • DOI: 10.1097/TA.0b013e318165c803

A micromechanical hyperelastic modeling of brain white matter under large deformation
journal, July 2009

  • Karami, G.; Grundman, N.; Abolfathi, N.
  • Journal of the Mechanical Behavior of Biomedical Materials, Vol. 2, Issue 3
  • DOI: 10.1016/j.jmbbm.2008.08.003

Measurement of viscoelastic properties in multiple anatomical regions of acute rat brain tissue slices
journal, January 2014

  • Lee, S. J.; King, M. A.; Sun, J.
  • Journal of the Mechanical Behavior of Biomedical Materials, Vol. 29
  • DOI: 10.1016/j.jmbbm.2013.08.026

A Finite Element Study of the Dynamic Response of Brain Based on Two Parasagittal Slice Models
journal, January 2015

  • Song, Xuewei; Wang, Cong; Hu, Hao
  • Computational and Mathematical Methods in Medicine, Vol. 2015
  • DOI: 10.1155/2015/816405

Automatic falx cerebri and tentorium cerebelli segmentation from magnetic resonance images
conference, March 2017

  • Glaister, Jeffrey; Carass, Aaron; Pham, Dzung L.
  • SPIE Medical Imaging, SPIE Proceedings
  • DOI: 10.1117/12.2255640

Regional, Directional, and Age-Dependent Properties of the Brain Undergoing Large Deformation
journal, March 2002

  • Prange, Michael T.; Margulies, Susan S.
  • Journal of Biomechanical Engineering, Vol. 124, Issue 2
  • DOI: 10.1115/1.1449907

A Multiscale Computational Approach to Estimating Axonal Damage under Inertial Loading of the Head
journal, January 2013

  • Wright, Rika M.; Post, Andrew; Hoshizaki, Blaine
  • Journal of Neurotrauma, Vol. 30, Issue 2
  • DOI: 10.1089/neu.2012.2418

Advances in Understanding of Experimental Concussion Mechanisms
conference, December 1969

  • Hodgson, V. R.; Thomas, L. M.; Gurdjian, E. S.
  • 13th Stapp Car Crash Conference (1969), SAE Technical Paper Series
  • DOI: 10.4271/690796

A robust anisotropic hyperelastic formulation for the modelling of soft tissue
journal, November 2014

  • Nolan, D. R.; Gower, A. L.; Destrade, M.
  • Journal of the Mechanical Behavior of Biomedical Materials, Vol. 39
  • DOI: 10.1016/j.jmbbm.2014.06.016

Mechanics of head Injuries
journal, October 1943

Neck Flexion Induces Larger Deformation of the Brain Than Extension at a Rotational Acceleration, Closed Head Trauma
journal, January 2014

  • Hansson, Hans-Arne; Krave, Ulrika; Höjer, Svante
  • Advances in Neuroscience, Vol. 2014
  • DOI: 10.1155/2014/945869

A systematic review of brain injury epidemiology in Europe
journal, November 2005

Simulation of dynamic crack growth using the generalized interpolation material point (GIMP) method
journal, February 2007

  • Daphalapurkar, Nitin P.; Lu, Hongbing; Coker, Demir
  • International Journal of Fracture, Vol. 143, Issue 1
  • DOI: 10.1007/s10704-007-9051-z

A Three-Dimensional Computational Human Head Model That Captures Live Human Brain Dynamics
journal, July 2017

  • Ganpule, Shailesh; Daphalapurkar, Nitin P.; Ramesh, Kaliat T.
  • Journal of Neurotrauma, Vol. 34, Issue 13
  • DOI: 10.1089/neu.2016.4744

A biomechanical model for the analysis of the cervical spine in static postures
journal, January 1991

Influence of FE model variability in predicting brain motion and intracranial pressure changes in head impact simulations
journal, August 2004

  • Horgan, T. J.; Gilchrist, M. D.
  • International Journal of Crashworthiness, Vol. 9, Issue 4
  • DOI: 10.1533/ijcr.2004.0299

A Proposed Injury Threshold for Mild Traumatic Brain Injury
journal, April 2004

  • Zhang, Liying; Yang, King H.; King, Albert I.
  • Journal of Biomechanical Engineering, Vol. 126, Issue 2
  • DOI: 10.1115/1.1691446

Development of a Finite Element Human Head Model Partially Validated With Thirty Five Experimental Cases
journal, September 2013

  • Mao, Haojie; Zhang, Liying; Jiang, Binhui
  • Journal of Biomechanical Engineering, Vol. 135, Issue 11
  • DOI: 10.1115/1.4025101

Dynamic response of bone and muscle tissue.
journal, July 1966

Hyperelastic modelling of arterial layers with distributed collagen fibre orientations
journal, September 2005

  • Gasser, T. Christian; Ogden, Ray W.; Holzapfel, Gerhard A.
  • Journal of The Royal Society Interface, Vol. 3, Issue 6
  • DOI: 10.1098/rsif.2005.0073

An anisotropic hyperelastic constitutive model of brain white matter in biaxial tension and structural–mechanical relationships
journal, September 2016

  • Labus, Kevin M.; Puttlitz, Christian M.
  • Journal of the Mechanical Behavior of Biomedical Materials, Vol. 62
  • DOI: 10.1016/j.jmbbm.2016.05.003

The peculiar properties of the falx and tentorium in brain injury biomechanics
journal, July 2017

Parametric Comparisons of Intracranial Mechanical Responses from Three Validated Finite Element Models of the Human Head
journal, September 2013

  • Ji, Songbai; Ghadyani, Hamidreza; Bolander, Richard P.
  • Annals of Biomedical Engineering, Vol. 42, Issue 1
  • DOI: 10.1007/s10439-013-0907-2

A convected particle domain interpolation technique to extend applicability of the material point method for problems involving massive deformations
journal, March 2011

  • Sadeghirad, A.; Brannon, R. M.; Burghardt, J.
  • International Journal for Numerical Methods in Engineering, Vol. 86, Issue 12
  • DOI: 10.1002/nme.3110

Effect of bulk modulus on deformation of the brain under rotational accelerations
journal, December 2017

Coupled B-snake grids and constrained thin-plate splines for analysis of 2-D tissue deformations from tagged MRI
journal, June 1998

  • Amini, A. A.; Curwen, R. W.
  • IEEE Transactions on Medical Imaging, Vol. 17, Issue 3
  • DOI: 10.1109/42.712124

Isometric Strength of the Cervical Flexor, Extensor, and Rotator Muscles in 220 Healthy Females Aged 20 to 59 Years
journal, July 2006

  • Salo, Petri K.; Ylinen, Jari J.; Mälkiä, Esko A.
  • Journal of Orthopaedic & Sports Physical Therapy, Vol. 36, Issue 7
  • DOI: 10.2519/jospt.2006.2122

Improved measurement of brain deformation during mild head acceleration using a novel tagged MRI sequence
journal, November 2014

An axonal strain injury criterion for traumatic brain injury
journal, April 2011

  • Wright, Rika M.; Ramesh, K. T.
  • Biomechanics and Modeling in Mechanobiology, Vol. 11, Issue 1-2
  • DOI: 10.1007/s10237-011-0307-1

The Lucite Calvarium—A Method for Direct Observation of the Brain
journal, November 1946

Underwater Explosions
journal, October 1948

  • Cole, Robert H.; Weller, Royal
  • Physics Today, Vol. 1, Issue 6
  • DOI: 10.1063/1.3066176

In vivo brain viscoelastic properties measured by magnetic resonance elastography
journal, August 2008

  • Green, Michael A.; Bilston, Lynne E.; Sinkus, Ralph
  • NMR in Biomedicine, Vol. 21, Issue 7
  • DOI: 10.1002/nbm.1254

Automatic tracking of SPAMM grid and the estimation of deformation parameters from cardiac MR images
journal, March 1994

  • Kumar, S.; Goldgof, D.
  • IEEE Transactions on Medical Imaging, Vol. 13, Issue 1
  • DOI: 10.1109/42.276150

The impact of traumatic brain injuries: A global perspective
journal, December 2007

  • Hyder, Adnan A.; Wunderlich, Colleen A.; Puvanachandra, Prasanthi
  • NeuroRehabilitation, Vol. 22, Issue 5
  • DOI: 10.3233/NRE-2007-22502

Anthropometry for WorldSID A World-Harmonized Midsize Male Side Impact Crash Dummy
conference, June 2000

  • Moss, S.; Wang, Z.; Salloum, M.
  • Government/Industry Meeting, SAE Technical Paper Series
  • DOI: 10.4271/2000-01-2202
    [ × clear filter / sort ]

    Similar records in OSTI.GOV collections: