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Title: C–H 18 F-fluorination of 8-methylquinolines with Ag[ 18 F]F

Abstract

This report describes a Pd-mediated C–H radiofluorination of 8-methylquinoline derivatives with no-carrier-added Ag[ 18 F]F. Fluorination of 10 examples in up to 21% RCY and high molar activity is reported, as well as automation of the process in a radiochemistry synthesis module.

Authors:
ORCiD logo [1]; ORCiD logo [1];  [2]; ORCiD logo [2]; ORCiD logo [1]; ORCiD logo [2]; ORCiD logo [1]
  1. Department of Radiology, University of Michigan, Ann Arbor, USA
  2. Department of Chemistry, University of Michigan, Ann Arbor, USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1495071
Grant/Contract Number:  
SC0012484
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Chemical Communications
Additional Journal Information:
Journal Name: Chemical Communications Journal Volume: 55 Journal Issue: 20; Journal ID: ISSN 1359-7345
Publisher:
Royal Society of Chemistry (RSC)
Country of Publication:
United Kingdom
Language:
English

Citation Formats

Lee, So Jeong, Brooks, Allen F., Ichiishi, Naoko, Makaravage, Katarina J., Mossine, Andrew V., Sanford, Melanie S., and Scott, Peter J. H. C–H 18 F-fluorination of 8-methylquinolines with Ag[ 18 F]F. United Kingdom: N. p., 2019. Web. doi:10.1039/C9CC00641A.
Lee, So Jeong, Brooks, Allen F., Ichiishi, Naoko, Makaravage, Katarina J., Mossine, Andrew V., Sanford, Melanie S., & Scott, Peter J. H. C–H 18 F-fluorination of 8-methylquinolines with Ag[ 18 F]F. United Kingdom. doi:10.1039/C9CC00641A.
Lee, So Jeong, Brooks, Allen F., Ichiishi, Naoko, Makaravage, Katarina J., Mossine, Andrew V., Sanford, Melanie S., and Scott, Peter J. H. Tue . "C–H 18 F-fluorination of 8-methylquinolines with Ag[ 18 F]F". United Kingdom. doi:10.1039/C9CC00641A.
@article{osti_1495071,
title = {C–H 18 F-fluorination of 8-methylquinolines with Ag[ 18 F]F},
author = {Lee, So Jeong and Brooks, Allen F. and Ichiishi, Naoko and Makaravage, Katarina J. and Mossine, Andrew V. and Sanford, Melanie S. and Scott, Peter J. H.},
abstractNote = {This report describes a Pd-mediated C–H radiofluorination of 8-methylquinoline derivatives with no-carrier-added Ag[ 18 F]F. Fluorination of 10 examples in up to 21% RCY and high molar activity is reported, as well as automation of the process in a radiochemistry synthesis module.},
doi = {10.1039/C9CC00641A},
journal = {Chemical Communications},
number = 20,
volume = 55,
place = {United Kingdom},
year = {2019},
month = {3}
}

Journal Article:
Free Publicly Available Full Text
This content will become publicly available on February 12, 2020
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