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Title: The impact of positron range on PET resolution, evaluated with phantoms and PHITS Monte Carlo simulations for conventional and non-conventional radionuclides

Journal Article · · Molecular Imaging and Biology
 [1];  [2];  [1];  [3];  [2];  [4];  [4];  [3]
  1. Memorial Sloan Kettering Cancer Center, New York, NY (United States)
  2. Brookhaven National Lab. (BNL), Upton, NY (United States)
  3. Memorial Sloan Kettering Cancer Center, New York, NY (United States); Weill Cornell Medical College, New York, NY (United States)
  4. Univ. of Alabama at Birmingham, Birmingham, AL (United States)
+ Show Author Affiliations

The increasing interest and availability of non-standard positron-emitting radionuclides has heightened the relevance of radionuclide choice in the development and optimization of new positron emission tomography (PET) imaging procedures, both in preclinical research and clinical practice. Differences in achievable resolution arising from positron range can largely influence application suitability of each radionuclide, especially in small-ring preclinical PET where system blurring factors due to annihilation photon acollinearity and detector geometry are less significant. Here, some resolution degradation can be mitigated with appropriate range corrections implemented during image reconstruction, the quality of which is contingent on an accurate characterization of positron range.

Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Nuclear Physics (NP) (SC-26)
Grant/Contract Number:
SC0012704
OSTI ID:
1495012
Report Number(s):
BNL--211279-2019-JAAM
Journal Information:
Molecular Imaging and Biology, Journal Name: Molecular Imaging and Biology Journal Issue: 1 Vol. 22; ISSN 1536-1632
Publisher:
SpringerCopyright Statement
Country of Publication:
United States
Language:
English

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Cited By (2)

Comparison of Quantification of Target-Specific Accumulation of [18F]F-siPSMA-14 in the HET-CAM Model and in Mice Using PET/MRI other January 2021
Minimization of parallax error in positron emission tomography using depth of interaction capable detectors: methods and apparatus journal October 2019

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43 PARTICLE ACCELERATORS
Monte Carlo simulation
PET
PHITS
phantom
point spread function
positron range
spatial resolution