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Title: The impact of positron range on PET resolution, evaluated with phantoms and PHITS Monte Carlo simulations for conventional and non-conventional radionuclides

Abstract

The increasing interest and availability of non-standard positron-emitting radionuclides has heightened the relevance of radionuclide choice in the development and optimization of new positron emission tomography (PET) imaging procedures, both in preclinical research and clinical practice. Differences in achievable resolution arising from positron range can largely influence application suitability of each radionuclide, especially in small-ring preclinical PET where system blurring factors due to annihilation photon acollinearity and detector geometry are less significant. Here, some resolution degradation can be mitigated with appropriate range corrections implemented during image reconstruction, the quality of which is contingent on an accurate characterization of positron range.

Authors:
 [1];  [2];  [1];  [3];  [2];  [4];  [4];  [3]
  1. Memorial Sloan Kettering Cancer Center, New York, NY (United States)
  2. Brookhaven National Lab. (BNL), Upton, NY (United States)
  3. Memorial Sloan Kettering Cancer Center, New York, NY (United States); Weill Cornell Medical College, New York, NY (United States)
  4. Univ. of Alabama at Birmingham, Birmingham, AL (United States)
Publication Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Nuclear Physics (NP)
OSTI Identifier:
1495012
Report Number(s):
BNL-211279-2019-JAAM
Journal ID: ISSN 1536-1632
Grant/Contract Number:  
SC0012704
Resource Type:
Accepted Manuscript
Journal Name:
Molecular Imaging and Biology
Additional Journal Information:
Journal Volume: 22; Journal Issue: 1; Journal ID: ISSN 1536-1632
Publisher:
Springer
Country of Publication:
United States
Language:
English
Subject:
43 PARTICLE ACCELERATORS; PET; positron range; spatial resolution; Monte Carlo simulation; PHITS; phantom; point spread function

Citation Formats

Carter, Lukas M., Cutler, Cathy S., Kesner, A., Pratt, E. C., Sanders, V. A., Massicano, A. V. F., Lapi, S. E., and Lewis, Jason S. The impact of positron range on PET resolution, evaluated with phantoms and PHITS Monte Carlo simulations for conventional and non-conventional radionuclides. United States: N. p., 2019. Web. doi:10.1007/s11307-019-01337-2.
Carter, Lukas M., Cutler, Cathy S., Kesner, A., Pratt, E. C., Sanders, V. A., Massicano, A. V. F., Lapi, S. E., & Lewis, Jason S. The impact of positron range on PET resolution, evaluated with phantoms and PHITS Monte Carlo simulations for conventional and non-conventional radionuclides. United States. doi:10.1007/s11307-019-01337-2.
Carter, Lukas M., Cutler, Cathy S., Kesner, A., Pratt, E. C., Sanders, V. A., Massicano, A. V. F., Lapi, S. E., and Lewis, Jason S. Fri . "The impact of positron range on PET resolution, evaluated with phantoms and PHITS Monte Carlo simulations for conventional and non-conventional radionuclides". United States. doi:10.1007/s11307-019-01337-2. https://www.osti.gov/servlets/purl/1495012.
@article{osti_1495012,
title = {The impact of positron range on PET resolution, evaluated with phantoms and PHITS Monte Carlo simulations for conventional and non-conventional radionuclides},
author = {Carter, Lukas M. and Cutler, Cathy S. and Kesner, A. and Pratt, E. C. and Sanders, V. A. and Massicano, A. V. F. and Lapi, S. E. and Lewis, Jason S.},
abstractNote = {The increasing interest and availability of non-standard positron-emitting radionuclides has heightened the relevance of radionuclide choice in the development and optimization of new positron emission tomography (PET) imaging procedures, both in preclinical research and clinical practice. Differences in achievable resolution arising from positron range can largely influence application suitability of each radionuclide, especially in small-ring preclinical PET where system blurring factors due to annihilation photon acollinearity and detector geometry are less significant. Here, some resolution degradation can be mitigated with appropriate range corrections implemented during image reconstruction, the quality of which is contingent on an accurate characterization of positron range.},
doi = {10.1007/s11307-019-01337-2},
journal = {Molecular Imaging and Biology},
number = 1,
volume = 22,
place = {United States},
year = {2019},
month = {2}
}

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