skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Progress in multiple genetically modified minipigs for xenotransplantation in China

Authors:
 [1];  [2];  [2];  [3];  [4];  [1]
  1. Organ Transplant and Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province Sichuan Academy of an Transplant Science &, Sichuan Provincial People’s Hospital Chengdu China
  2. School of Medicine University of Electronic Science and Technology of China Chengdu China
  3. Chengdu Clonorgan Biotechnology Co., LTD Chengdu China
  4. Health Management Center Sichuan Academy of Medical Science &, Sichuan Provincial People’s Hospital Chengdu China
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1494959
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Xenotransplantation
Additional Journal Information:
Journal Name: Xenotransplantation Journal Volume: 26 Journal Issue: 1; Journal ID: ISSN 0908-665X
Publisher:
Wiley-Blackwell
Country of Publication:
Country unknown/Code not available
Language:
English

Citation Formats

Pan, Dengke, Liu, Ting, Lei, Tiantian, Zhu, Huibin, Wang, Yi, and Deng, Shaoping. Progress in multiple genetically modified minipigs for xenotransplantation in China. Country unknown/Code not available: N. p., 2019. Web. https://doi.org/10.1111/xen.12492.
Pan, Dengke, Liu, Ting, Lei, Tiantian, Zhu, Huibin, Wang, Yi, & Deng, Shaoping. Progress in multiple genetically modified minipigs for xenotransplantation in China. Country unknown/Code not available. https://doi.org/10.1111/xen.12492
Pan, Dengke, Liu, Ting, Lei, Tiantian, Zhu, Huibin, Wang, Yi, and Deng, Shaoping. Mon . "Progress in multiple genetically modified minipigs for xenotransplantation in China". Country unknown/Code not available. https://doi.org/10.1111/xen.12492.
@article{osti_1494959,
title = {Progress in multiple genetically modified minipigs for xenotransplantation in China},
author = {Pan, Dengke and Liu, Ting and Lei, Tiantian and Zhu, Huibin and Wang, Yi and Deng, Shaoping},
abstractNote = {},
doi = {10.1111/xen.12492},
journal = {Xenotransplantation},
number = 1,
volume = 26,
place = {Country unknown/Code not available},
year = {2019},
month = {2}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1111/xen.12492

Citation Metrics:
Cited by: 5 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Recent investigations into pig antigen and anti-pig antibody expression
journal, November 2015

  • Byrne, Guerard W.; McGregor, Christopher G. A.; Breimer, Michael E.
  • International Journal of Surgery, Vol. 23
  • DOI: 10.1016/j.ijsu.2015.07.724

Controlling coagulation dysregulation in xenotransplantation
journal, January 2011

  • Cowan, Peter J.; Robson, Simon C.; dʼApice, Anthony JF
  • Current Opinion in Organ Transplantation, Vol. 16, Issue 2
  • DOI: 10.1097/MOT.0b013e3283446c65

Initial study of α1,3-galactosyltransferase gene-knockout/CD46 pig full-thickness corneal xenografts in rhesus monkeys
journal, January 2017

  • Dong, Xiaojuan; Hara, Hidetaka; Wang, Ying
  • Xenotransplantation, Vol. 24, Issue 1
  • DOI: 10.1111/xen.12282

Current cellular immunological hurdles in pig-to-primate xenotransplantation
journal, June 2009


Genetically Modified Pigs as Organ Donors for Xenotransplantation
journal, July 2017

  • Hryhorowicz, Magdalena; Zeyland, Joanna; Słomski, Ryszard
  • Molecular Biotechnology, Vol. 59, Issue 9-10
  • DOI: 10.1007/s12033-017-0024-9

Cytokine profiles in Tibetan macaques following α-1,3-galactosyltransferase-knockout pig liver xenotransplantation
journal, July 2017

  • Zhang, Zhuochao; Li, Xiao; Zhang, Hong
  • Xenotransplantation, Vol. 24, Issue 5
  • DOI: 10.1111/xen.12321

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9, editorial commentary
journal, November 2017

  • Scobie, Linda; Denner, Joachim; Schuurman, Henk-Jan
  • Xenotransplantation, Vol. 24, Issue 6
  • DOI: 10.1111/xen.12363

The C3-Activator System: an Alternate Pathway of Complement Activation
journal, September 1971

  • Götze, Otto; Müller-Eberhard, Hans J.
  • Journal of Experimental Medicine, Vol. 134, Issue 3
  • DOI: 10.1084/jem.134.3.90

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9
journal, August 2017


Recombinant pig TFPI efficiently regulates human tissue factor pathways
journal, May 2008


Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen
journal, September 2014

  • Byrne, Guerard W.; Du, Zeji; Stalboerger, Paul
  • Xenotransplantation, Vol. 21, Issue 6
  • DOI: 10.1111/xen.12124

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)
journal, October 2015


PERV inactivation is necessary to guarantee absence of pig-to-patient PERVs transmission in xenotransplantation
journal, November 2017

  • Güell, Marc; Niu, Dong; Kan, Yinan
  • Xenotransplantation, Vol. 24, Issue 6
  • DOI: 10.1111/xen.12366

Coagulation dysregulation as a barrier to xenotransplantation in the primate
journal, June 2009

  • Lin, Chih Che; Cooper, David K. C.; Dorling, Anthony
  • Transplant Immunology, Vol. 21, Issue 2, p. 75-80
  • DOI: 10.1016/j.trim.2008.10.008

Complement Activation in Acute Humoral Renal Allograft Rejection: Diagnostic Significance of C4d Deposits in Peritubular Capillaries
journal, October 1999

  • Collins, A. Bernard; Schneeberger, Eveline E.; Pascual, Manuel A.
  • Journal of the American Society of Nephrology, Vol. 10, Issue 10
  • DOI: 10.1681/ASN.V10102208

China to halt using executed prisoners’ organs for transplants: a step in the right direction in medical ethics
journal, April 2015


The sequence and analysis of a Chinese pig genome
journal, November 2012


Role for CD47-SIRP  signaling in xenograft rejection by macrophages
journal, March 2007

  • Ide, K.; Wang, H.; Tahara, H.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 12
  • DOI: 10.1073/pnas.0609661104

Long-Term Controlled Normoglycemia in Diabetic Non-Human Primates After Transplantation with hCD46 Transgenic Porcine Islets
journal, December 2009


B4GALNT2 and xenotransplantation: A newly appreciated xenogeneic antigen
journal, March 2018

  • Byrne, Guerard; Ahmad-Villiers, Saadullah; Du, Zeji
  • Xenotransplantation, Vol. 25, Issue 5
  • DOI: 10.1111/xen.12394

Multiple Groups of Novel Retroviral Genomes in Pigs and Related Species
journal, March 2001


Targeted disruption of the α1,3-galactosyltransferase gene in cloned pigs
journal, March 2002

  • Dai, Yifan; Vaught, Todd D.; Boone, Jeremy
  • Nature Biotechnology, Vol. 20, Issue 3
  • DOI: 10.1038/nbt0302-251

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein
journal, July 2015

  • Azimzadeh, Agnes M.; Kelishadi, Sean S.; Ezzelarab, Mohamed B.
  • Xenotransplantation, Vol. 22, Issue 4
  • DOI: 10.1111/xen.12176

Genetic modifications of pigs for medicine and agriculture
journal, June 2011

  • Whyte, Jeffrey J.; Prather, Randall S.
  • Molecular Reproduction and Development, Vol. 78, Issue 10-11
  • DOI: 10.1002/mrd.21333

Highly Efficient Generation of GGTA1 Biallelic Knockout Inbred Mini-Pigs with TALENs
journal, December 2013


Human membrane cofactor protein (MCP, CD 46) protects transgenic pig hearts from hyperacute rejection in primates
journal, February 2001


The generation of transgenic pigs as potential organ donors for humans
journal, September 1995

  • Cozzi, Emanuele; White, David J. G.
  • Nature Medicine, Vol. 1, Issue 9
  • DOI: 10.1038/nm0995-964

Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T-cell immune response and immune status
journal, August 2013

  • Hara, Hidetaka; Witt, William; Crossley, Tanner
  • Immunology, Vol. 140, Issue 1
  • DOI: 10.1111/imm.12107

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
journal, April 2016

  • Mohiuddin, Muhammad M.; Singh, Avneesh K.; Corcoran, Philip C.
  • Nature Communications, Vol. 7, Issue 1
  • DOI: 10.1038/ncomms11138

Distribution and expression of porcine endogenous retroviruses in multi-transgenic pigs generated for xenotransplantation
journal, March 2009


Biodiversity of pig breeds from China and Europe estimated from pooled DNA samples: differences in microsatellite variation between two areas of domestication
journal, December 2007

  • Megens, Hendrik-Jan; Crooijmans, Richard P. M. A.; Cristobal, Magali San
  • Genetics Selection Evolution, Vol. 40, Issue 1
  • DOI: 10.1051/gse:2007039

Pig BMSCs Transfected with Human TFPI Combat Species Incompatibility and Regulate the Human TF Pathway <b><i>in Vitro</i></b> and in a Rodent Model
journal, January 2015

  • Ji, Hongchen; Li, Xiao; Yue, Shuqiang
  • Cellular Physiology and Biochemistry, Vol. 36, Issue 1
  • DOI: 10.1159/000374067

Antibody-mediated xenograft injury: Mechanisms and protective strategies
journal, June 2009


Clinical xenotransplantation: the next medical revolution?
journal, February 2012


Disordered regulation of coagulation and platelet activation in xenotransplantation
journal, August 2000


Characterization of Transgenic pigs Expressing Functionally Active Human cd59 on Cardiac Endothelium
journal, January 1996


Production and characterization of transgenic pigs expressing porcine CTLA4-Ig
journal, November 2009