An avian influenza virus A(H7N9) reassortant that recently emerged in the United States with low pathogenic phenotype does not efficiently infect swine

Journal Article · 12 February 2019 · Influenza and Other Respiratory Viruses

DOI: https://doi.org/10.1111/irv.12631 · OSTI ID:1494770

Powell, Joshua D.  ^[1]; Abente, Eugenio J. ^[1]; Torchetti, Mia K. ^[2]; Killian, Mary L. ^[2]; Vincent, Amy L.  ^[1]

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1. Virus and Prion Research Unit Agricultural Research Service National Animal Disease Center U.S. Department of Agriculture Ames Iowa
2. National Veterinary Services Laboratories, Veterinary Services U.S. Department of Agriculture Ames Iowa

In 2017, outbreaks of low and highly pathogenic avian H7N9 viruses were reported in four States in the United States. In total, over 270 000 birds died or were culled, causing significant economic loss. The potential for avian‐to‐swine transmission of the U.S. avian H7N9 was unknown. In an experimental challenge in swine using a representative low pathogenic H7N9 (A/chicken/Tennessee/17‐007431‐3/2017; LPAI TN /17) isolated from these events, no infectious virus in the upper and minimal virus in the lower respiratory tract was detected, nor was lung pathology or evidence of transmission in pigs observed, indicating that the virus cannot efficiently infect swine.

• Sponsoring Organization: USDOE
• Grant/Contract Number: NONE; AC05-06OR23100
• OSTI ID: 1494770
• Journal Information: Influenza and Other Respiratory Viruses, Journal Name: Influenza and Other Respiratory Viruses Journal Issue: 3 Vol. 13; ISSN 1750-2640
• Publisher: Wiley-BlackwellCopyright Statement
• Country of Publication: Country unknown/Code not available
• Language: English