Versatility of the adenovirus-vectored foot-and-mouth disease vaccine platform across multiple foot-and-mouth disease virus serotypes and topotypes using a vaccine dose representative of the AdtA24 conditionally licensed vaccine
Abstract
We investigated the serotype- and topotype versatility of a replication-deficient human adenovirus serotype 5 vectored foot-and-mouth disease (FMD) vaccine platform (AdtFMD). Sixteen AdtFMD recombinant subunit monovalent vaccines targeting twelve distinct FMD virus (FMDV) serotype/topotypes in FMD Regional Pools I-VII were constructed. The AdtA24 serotype conditionally licensed vaccine served as the basis for vaccine design and target dose for cattle clinical trials. Several vaccines contained an additional RGD motif genetic insertion in the adenovector fiber knob, and/or a full-length 2B gene insertion in the FMDV P1 gene cassette. In 13 of the 22 efficacy studies conducted, naïve control and AdtFMD vaccinated cattle were challenged intradermolingually at 2 weeks post-vaccination using a FMDV strain homologous to the AdtFMD vaccine strain. Each of the 16 AdtFMD vaccines were immunogenic based on the presence of homologous neutralizing antibodies in the serum of approximately 90% of total vaccinates (n = 375) on the day of challenge. Importantly, for 75% of vaccines tested, the effective dose that conferred 100% protection against clinical FMD was identical to or in some cases lower than, the minimum protective dose for the conditionally licensed AdtA24 vaccine formulated with ENABL® adjuvant. Results also confirmed the capability of the AdtFMD vaccine platformmore »
- Authors:
-
- Plum Island Animal Disease Center, Greenport, NY (United States)
- GenVec, Inc., Gaithersburg, MD (United States)
- Plum Island Animal Disease Center Research Participation Program, Oak Ridge, TN (United States). Oak Ridge Institute for Science and Education
- Plum Island Animal Disease Center, Greenport, NY (United States); Plum Island Animal Disease Center Research Participation Program, Oak Ridge, TN (United States). Oak Ridge Institute for Science and Education
- Publication Date:
- Research Org.:
- Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1494688
- Grant/Contract Number:
- AC05-06OR23100; HSHQPD-07-X-00003; HSHQDC-14-F-00035; HSHQDC-8-C-00011; HSHQDC-12-C-00127
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Vaccine
- Additional Journal Information:
- Journal Volume: 36; Journal Issue: 48; Journal ID: ISSN 0264-410X
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; Foot-and-mouth disease virus; Recombinant human adenovirus vectored vaccine; Serotype; Vaccine efficacy; DIVA; Cattle
Citation Formats
Barrera, José, Brake, David A., Schutta, Christopher, Ettyreddy, Damodar, Kamicker, Barbara J., Rasmussen, Max V., Bravo de Rueda, Carla, Zurita, Mariceny, Pisano, Melia, Hurtle, William, Brough, Douglas E., Butman, Bryan T., Harper, Bruce G., and Neilan, John G. Versatility of the adenovirus-vectored foot-and-mouth disease vaccine platform across multiple foot-and-mouth disease virus serotypes and topotypes using a vaccine dose representative of the AdtA24 conditionally licensed vaccine. United States: N. p., 2018.
Web. doi:10.1016/j.vaccine.2018.10.031.
Barrera, José, Brake, David A., Schutta, Christopher, Ettyreddy, Damodar, Kamicker, Barbara J., Rasmussen, Max V., Bravo de Rueda, Carla, Zurita, Mariceny, Pisano, Melia, Hurtle, William, Brough, Douglas E., Butman, Bryan T., Harper, Bruce G., & Neilan, John G. Versatility of the adenovirus-vectored foot-and-mouth disease vaccine platform across multiple foot-and-mouth disease virus serotypes and topotypes using a vaccine dose representative of the AdtA24 conditionally licensed vaccine. United States. https://doi.org/10.1016/j.vaccine.2018.10.031
Barrera, José, Brake, David A., Schutta, Christopher, Ettyreddy, Damodar, Kamicker, Barbara J., Rasmussen, Max V., Bravo de Rueda, Carla, Zurita, Mariceny, Pisano, Melia, Hurtle, William, Brough, Douglas E., Butman, Bryan T., Harper, Bruce G., and Neilan, John G. Sat .
"Versatility of the adenovirus-vectored foot-and-mouth disease vaccine platform across multiple foot-and-mouth disease virus serotypes and topotypes using a vaccine dose representative of the AdtA24 conditionally licensed vaccine". United States. https://doi.org/10.1016/j.vaccine.2018.10.031. https://www.osti.gov/servlets/purl/1494688.
@article{osti_1494688,
title = {Versatility of the adenovirus-vectored foot-and-mouth disease vaccine platform across multiple foot-and-mouth disease virus serotypes and topotypes using a vaccine dose representative of the AdtA24 conditionally licensed vaccine},
author = {Barrera, José and Brake, David A. and Schutta, Christopher and Ettyreddy, Damodar and Kamicker, Barbara J. and Rasmussen, Max V. and Bravo de Rueda, Carla and Zurita, Mariceny and Pisano, Melia and Hurtle, William and Brough, Douglas E. and Butman, Bryan T. and Harper, Bruce G. and Neilan, John G.},
abstractNote = {We investigated the serotype- and topotype versatility of a replication-deficient human adenovirus serotype 5 vectored foot-and-mouth disease (FMD) vaccine platform (AdtFMD). Sixteen AdtFMD recombinant subunit monovalent vaccines targeting twelve distinct FMD virus (FMDV) serotype/topotypes in FMD Regional Pools I-VII were constructed. The AdtA24 serotype conditionally licensed vaccine served as the basis for vaccine design and target dose for cattle clinical trials. Several vaccines contained an additional RGD motif genetic insertion in the adenovector fiber knob, and/or a full-length 2B gene insertion in the FMDV P1 gene cassette. In 13 of the 22 efficacy studies conducted, naïve control and AdtFMD vaccinated cattle were challenged intradermolingually at 2 weeks post-vaccination using a FMDV strain homologous to the AdtFMD vaccine strain. Each of the 16 AdtFMD vaccines were immunogenic based on the presence of homologous neutralizing antibodies in the serum of approximately 90% of total vaccinates (n = 375) on the day of challenge. Importantly, for 75% of vaccines tested, the effective dose that conferred 100% protection against clinical FMD was identical to or in some cases lower than, the minimum protective dose for the conditionally licensed AdtA24 vaccine formulated with ENABL® adjuvant. Results also confirmed the capability of the AdtFMD vaccine platform to differentiate infected from vaccinated animals (DIVA) across the five FMDV serotypes evaluated. Collectively, this comprehensive set of FMD cattle vaccine dose ranging studies highlights the serotype- and topotype versatility of the AdtFMD vaccine platform for further development, licensure, and application in FMD outbreak control and disease eradication efforts.},
doi = {10.1016/j.vaccine.2018.10.031},
journal = {Vaccine},
number = 48,
volume = 36,
place = {United States},
year = {Sat Oct 13 00:00:00 EDT 2018},
month = {Sat Oct 13 00:00:00 EDT 2018}
}
Web of Science
Figures / Tables:
Works referenced in this record:
Use of a portable real-time reverse transcriptasepolymerase chain reaction assay for rapid detection of foot-and-mouth disease virus
journal, June 2002
- Callahan, Johnny D.; Brown, Fred; Osorio, Fernando A.
- Journal of the American Veterinary Medical Association, Vol. 220, Issue 11
Recombinant human adenovirus-5 expressing capsid proteins of Indian vaccine strains of foot-and-mouth disease virus elicits effective antibody response in cattle
journal, May 2017
- Sreenivasa, B. P.; Mohapatra, J. K.; Pauszek, S. J.
- Veterinary Microbiology, Vol. 203
Adenovirus-vectored foot-and-mouth disease vaccine confers early and full protection against FMDV O1 Manisa in swine
journal, February 2017
- Fernandez-Sainz, Ignacio; Medina, Gisselle N.; Ramirez-Medina, Elizabeth
- Virology, Vol. 502
Emergence of Foot-and-Mouth Disease Virus SAT 2 in Egypt During 2012
journal, October 2012
- Ahmed, H. A.; Salem, S. A. H.; Habashi, A. R.
- Transboundary and Emerging Diseases, Vol. 59, Issue 6
Review of the Global Distribution of Foot-and-Mouth Disease Virus from 2007 to 2014
journal, May 2015
- Brito, B. P.; Rodriguez, L. L.; Hammond, J. M.
- Transboundary and Emerging Diseases, Vol. 64, Issue 2
Multiple efficacy studies of an adenovirus-vectored foot-and-mouth disease virus serotype A24 subunit vaccine in cattle using homologous challenge
journal, June 2016
- Schutta, Christopher; Barrera, José; Pisano, Melia
- Vaccine, Vol. 34, Issue 27
Efficacy of a high-potency multivalent foot-and-mouth disease virus vaccine in cattle against heterologous challenge with a field virus from the emerging A/ASIA/G-VII lineage
journal, March 2018
- Waters, Ryan; Ludi, Anna B.; Fowler, Veronica L.
- Vaccine, Vol. 36, Issue 14
Efficacy of a high quality O1/Campos foot-and-mouth disease vaccine upon challenge with a heterologous Korean O Mya98 lineage virus in pigs
journal, March 2018
- Galdo Novo, S.; Malirat, V.; Maradei, E. D.
- Vaccine, Vol. 36, Issue 12
Use of ENABL® adjuvant to increase the potency of an adenovirus-vectored foot-and-mouth disease virus serotype A subunit vaccine
journal, February 2018
- Barrera, José; Schutta, Christopher; Pisano, Melia
- Vaccine, Vol. 36, Issue 8
DetailedAnalysis of the CD8 + T-Cell Response followingAdenovirusVaccination
journal, December 2003
- Yang, Teng Chih; Dayball, Kelley; Wan, Yong Hong
- Journal of Virology, Vol. 77, Issue 24
The need for improved vaccines against foot-and-mouth disease
journal, April 2018
- de los Santos, Teresa; Diaz-San Segundo, Fayna; Rodriguez, Luis L.
- Current Opinion in Virology, Vol. 29
Experimental infections using the foot-and-mouth disease virus O/JPN/2010 in animals administered a vaccine preserved for emergency use in Japan
journal, January 2017
- Fukai, Katsuhiko; Nishi, Tatsuya; Shimada, Nobuaki
- Journal of Veterinary Medical Science, Vol. 79, Issue 1
Correction for LaRocco et al., A Continuous Bovine Kidney Cell Line Constitutively Expressing Bovine α V β 6 Integrin Has Increased Susceptibility to Foot-and-Mouth Disease Virus
journal, January 2015
- LaRocco, Michael; Krug, Peter W.; Kramer, Ed
- Journal of Clinical Microbiology, Vol. 53, Issue 2
Development of Replication-Defective Adenovirus Serotype 5 Containing the Capsid and 3C Protease Coding Regions of Foot-and-Mouth Disease Virus as a Vaccine Candidate
journal, October 1999
- Mayr, Gregory A.; Chinsangaram, Jarasvech; Grubman, Marvin J.
- Virology, Vol. 263, Issue 2
Protection to homologous and heterologous challenge in pigs immunized with vaccine against foot-and-mouth disease type O caused an epidemic in East Asia during 2010/2011
journal, April 2014
- Park, Jeong-Nam; Lee, Seo-Yong; Chu, Jia-Qi
- Vaccine, Vol. 32, Issue 16
Global Foot-and-Mouth Disease Research Update and Gap Analysis: 2 - Epidemiology, Wildlife and Economics
journal, June 2016
- Knight-Jones, T. J. D.; Robinson, L.; Charleston, B.
- Transboundary and Emerging Diseases, Vol. 63
Characterization of foot-and-mouth disease virus from outbreaks in Ecuador during 2009–2010 and cross-protection studies with the vaccine strain in use in the region
journal, October 2011
- Maradei, Eduardo; Perez Beascoechea, Claudia; Malirat, Viviana
- Vaccine, Vol. 29, Issue 46
An improved, rapid competitive ELISA using a novel conserved 3B epitope for the detection of serum antibodies to foot-and-mouth disease virus
journal, June 2018
- Chung, Chungwon J.; Clavijo, Alfonso; Bounpheng, Mangkey A.
- Journal of Veterinary Diagnostic Investigation, Vol. 30, Issue 5
Update on epidemiology and control of Foot and Mouth Disease - A menace to international trade and global animal enterprise
journal, January 2012
- Depa, P.; Dimri, Umesh; Sharma, Mc
- Veterinary World, Vol. 5, Issue 11
Foot-and-Mouth Disease Impact on Smallholders - What Do We Know, What Don't We Know and How Can We Find Out More?
journal, May 2016
- Knight-Jones, T. J. D.; McLaws, M.; Rushton, J.
- Transboundary and Emerging Diseases, Vol. 64, Issue 4
Safety profile of a replication-deficient human adenovirus-vectored foot-and-mouth disease virus serotype A24 subunit vaccine in cattle
journal, October 2017
- Barrera, J.; Brake, D. A.; Kamicker, B. J.
- Transboundary and Emerging Diseases, Vol. 65, Issue 2
Epidemiology of the Foot-and-Mouth Disease Serotype O Epidemic of November 2010 to April 2011 in the Republic Of Korea
journal, June 2013
- Yoon, H.; Yoon, S. -S.; Kim, Y. -J.
- Transboundary and Emerging Diseases, Vol. 62, Issue 3
Genetic characterisation of the recent foot-and-mouth disease virus subtype A/IRN/2005
journal, January 2007
- Klein, Joern; Hussain, Manzoor; Ahmad, Munir
- Virology Journal, Vol. 4, Issue 1
Retrospective evaluation of foot-and-mouth disease vaccine effectiveness in Turkey
journal, April 2014
- Knight-Jones, T. J. D.; Bulut, A. N.; Gubbins, S.
- Vaccine, Vol. 32, Issue 16
Foot-and-Mouth Disease Virus Serotype A in Egypt
journal, October 2007
- Knowles, Nick J.; Wadsworth, Jemma; Reid, Scott M.
- Emerging Infectious Diseases, Vol. 13, Issue 10
Efficacy of a high potency O1 Manisa monovalent vaccine against heterologous challenge with a FMDV O Mya98 lineage virus in pigs 4 and 7 days post vaccination
journal, June 2015
- Wilna, Vosloo; Hong, Nguyen Thi Thu; Geoffrey, Fosgate T.
- Vaccine, Vol. 33, Issue 24
Protection induced by a commercial bivalent vaccine against Foot-and-Mouth Disease 2010 field virus from Ecuador
journal, July 2016
- Duque, Hernando; Naranjo, Jose; Carrillo, Consuelo
- Vaccine, Vol. 34, Issue 35
Multimodel Inference: Understanding AIC and BIC in Model Selection
journal, November 2004
- Burnham, Kenneth P.; Anderson, David R.
- Sociological Methods & Research, Vol. 33, Issue 2
Delivery of a foot-and-mouth disease virus empty capsid subunit antigen with nonstructural protein 2B improves protection of swine
journal, October 2008
- Pena, Lindomar; Moraes, Mauro Pires; Koster, Marla
- Vaccine, Vol. 26, Issue 45
Longevity of protection in cattle following immunisation with emergency FMD A22 serotype vaccine from the UK strategic reserve
journal, March 2010
- Cox, Sarah J.; Veronica Carr, B.; Parida, Satya
- Vaccine, Vol. 28, Issue 11
Evaluation of a Fiber-Modified Adenovirus Vector Vaccine against Foot-and-Mouth Disease in Cattle
journal, November 2015
- Medina, Gisselle N.; Montiel, Nestor; Diaz-San Segundo, Fayna
- Clinical and Vaccine Immunology, Vol. 23, Issue 2
Selection of vaccine strains for serotype O foot-and-mouth disease viruses (2007–2012) circulating in Southeast Asia, East Asia and Far East
journal, December 2017
- Mahapatra, Mana; Upadhyaya, Sasmita; Aviso, Sharie
- Vaccine, Vol. 35, Issue 51
Protective effects of high-potency FMDV O 1 Manisa monovalent vaccine in cattle challenged with FMDV O/SKR/2010 at 7 or 4 days post vaccination
journal, September 2017
- Horsington, Jacquelyn; Perez, Claudia Beascoechea; Maradei, Eduardo
- Vaccine, Vol. 35, Issue 38
Recent Spread of a New Strain (A-Iran-05) of Foot-and-Mouth Disease Virus Type A in the Middle East
journal, June 2009
- Knowles, N. J.; Nazem Shirazi, M. H.; Wadsworth, J.
- Transboundary and Emerging Diseases, Vol. 56, Issue 5
A gene transfer vector-cell line system for complete functional complementation of adenovirus early regions E1 and E4
journal, September 1996
- Brough, D. E.; Lizonova, A.; Hsu, C.
- Journal of Virology, Vol. 70, Issue 9
Works referencing / citing this record:
Biological Function and Application of Picornaviral 2B Protein: A New Target for Antiviral Drug Development
journal, June 2019
- Li, Zengbin; Zou, Zixiao; Jiang, Zeju
- Viruses, Vol. 11, Issue 6
Biological Function and Application of Picornaviral 2B Protein: A New Target for Antiviral Drug Development
journal, June 2019
- Li, Zengbin; Zou, Zixiao; Jiang, Zeju
- Viruses, Vol. 11, Issue 6
Figures / Tables found in this record: