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Title: Comparative electrophysiological evaluation of hippocampal function following repeated inhalation exposures to JP-8, Jet A, JP-5, and the synthetic Fischer Tropsch fuel

Abstract

Exposure to fuels continues to be a concern in both military and general populations. The aim of this study was to examine effects of in vivo rat repeated exposures to different types of jet fuel utilizing microelectrode arrays for comparative electrophysiological (EP) measurements in hippocampal slices. Animals were exposed to increasing concentrations of four jet fuels, Jet Propellant (JP)-8, Jet A, JP-5, or synthetic Fischer Tropsch (FT) fuel via whole-body inhalation for 20 d (6 hr/d, 5 d/week for 28 d) and synaptic transmission as well as behavioral performance were assessed. Our behavioral studies indicated no significant changes in behavioral performance in animals exposed to JP-8, Jet A, or JP-5. A significant deviation in learning pattern during the Morris water maze task was observed in rats exposed to the highest concentration of FT (2000 mg/m 3). There were also significant differences in the EP profile of hippocampal neurons from animals exposed to JP-8, Jet A, JP-5, or FT compared to control air. However, these differences were not consistent across fuels or dose dependent. As expected, patterns of EP alterations in brain slices from JP-8 and Jet A exposures were more similar compared to those from JP-5 and FT. Further longitudinalmore » investigations are needed to determine if these EP effects are transient or persistent. Such studies may dictate if and how one may use EP measurements to indicate potential susceptibility to neurological impairments, particularly those that result from inhalation exposure to chemicals or mixtures.« less

Authors:
ORCiD logo [1];  [2];  [3];  [3];  [3];  [3];  [2];  [2]
  1. Naval Medical Research Unit Dayton (NAMRU-D), Wright-Patterson Air Force Base, Dayton, OH (United States); Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States)
  2. Naval Medical Research Unit Dayton (NAMRU-D), Wright-Patterson Air Force Base, Dayton, OH (United States)
  3. Naval Medical Research Unit Dayton (NAMRU-D), Wright-Patterson Air Force Base, Dayton, OH (United States); cCAMRIS International, Bethesda, MD (United States)
Publication Date:
Research Org.:
Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1494675
Grant/Contract Number:  
WUN H1320
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Toxicology and Environmental Health: Part A
Additional Journal Information:
Journal Volume: 81; Journal Issue: 10; Journal ID: ISSN 1528-7394
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES

Citation Formats

Rohan, Joyce G., McInturf, Shawn M., Miklasevich, Molly K., Gut, Chester P., Grimm, Michael D., Reboulet, James E., Howard, William R., and Mumy, Karen L. Comparative electrophysiological evaluation of hippocampal function following repeated inhalation exposures to JP-8, Jet A, JP-5, and the synthetic Fischer Tropsch fuel. United States: N. p., 2018. Web. doi:10.1080/15287394.2018.1437097.
Rohan, Joyce G., McInturf, Shawn M., Miklasevich, Molly K., Gut, Chester P., Grimm, Michael D., Reboulet, James E., Howard, William R., & Mumy, Karen L. Comparative electrophysiological evaluation of hippocampal function following repeated inhalation exposures to JP-8, Jet A, JP-5, and the synthetic Fischer Tropsch fuel. United States. doi:10.1080/15287394.2018.1437097.
Rohan, Joyce G., McInturf, Shawn M., Miklasevich, Molly K., Gut, Chester P., Grimm, Michael D., Reboulet, James E., Howard, William R., and Mumy, Karen L. Fri . "Comparative electrophysiological evaluation of hippocampal function following repeated inhalation exposures to JP-8, Jet A, JP-5, and the synthetic Fischer Tropsch fuel". United States. doi:10.1080/15287394.2018.1437097. https://www.osti.gov/servlets/purl/1494675.
@article{osti_1494675,
title = {Comparative electrophysiological evaluation of hippocampal function following repeated inhalation exposures to JP-8, Jet A, JP-5, and the synthetic Fischer Tropsch fuel},
author = {Rohan, Joyce G. and McInturf, Shawn M. and Miklasevich, Molly K. and Gut, Chester P. and Grimm, Michael D. and Reboulet, James E. and Howard, William R. and Mumy, Karen L.},
abstractNote = {Exposure to fuels continues to be a concern in both military and general populations. The aim of this study was to examine effects of in vivo rat repeated exposures to different types of jet fuel utilizing microelectrode arrays for comparative electrophysiological (EP) measurements in hippocampal slices. Animals were exposed to increasing concentrations of four jet fuels, Jet Propellant (JP)-8, Jet A, JP-5, or synthetic Fischer Tropsch (FT) fuel via whole-body inhalation for 20 d (6 hr/d, 5 d/week for 28 d) and synaptic transmission as well as behavioral performance were assessed. Our behavioral studies indicated no significant changes in behavioral performance in animals exposed to JP-8, Jet A, or JP-5. A significant deviation in learning pattern during the Morris water maze task was observed in rats exposed to the highest concentration of FT (2000 mg/m3). There were also significant differences in the EP profile of hippocampal neurons from animals exposed to JP-8, Jet A, JP-5, or FT compared to control air. However, these differences were not consistent across fuels or dose dependent. As expected, patterns of EP alterations in brain slices from JP-8 and Jet A exposures were more similar compared to those from JP-5 and FT. Further longitudinal investigations are needed to determine if these EP effects are transient or persistent. Such studies may dictate if and how one may use EP measurements to indicate potential susceptibility to neurological impairments, particularly those that result from inhalation exposure to chemicals or mixtures.},
doi = {10.1080/15287394.2018.1437097},
journal = {Journal of Toxicology and Environmental Health: Part A},
number = 10,
volume = 81,
place = {United States},
year = {2018},
month = {3}
}

Journal Article:
Free Publicly Available Full Text
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Cited by: 1 work
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Figures / Tables:

Table 1 Table 1: Jet Fuel Constituents for Jet A, JP-8, JP-5, and FT. Analysis Was Performed Using the Striebich et al. (2014) Method. All Values Are in % by Weight

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    Works referencing / citing this record:

    Toxicity and occupational exposure assessment for Fischer-Tropsch synthetic paraffinic kerosene
    journal, July 2018

    • Mattie, David R.; Sterner, Teresa R.; Reddy, Gunda
    • Journal of Toxicology and Environmental Health, Part A, Vol. 81, Issue 16
    • DOI: 10.1080/15287394.2018.1490675

      Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.