Comparative electrophysiological evaluation of hippocampal function following repeated inhalation exposures to JP-8, Jet A, JP-5, and the synthetic Fischer Tropsch fuel
Abstract
Exposure to fuels continues to be a concern in both military and general populations. The aim of this study was to examine effects of in vivo rat repeated exposures to different types of jet fuel utilizing microelectrode arrays for comparative electrophysiological (EP) measurements in hippocampal slices. Animals were exposed to increasing concentrations of four jet fuels, Jet Propellant (JP)-8, Jet A, JP-5, or synthetic Fischer Tropsch (FT) fuel via whole-body inhalation for 20 d (6 hr/d, 5 d/week for 28 d) and synaptic transmission as well as behavioral performance were assessed. Our behavioral studies indicated no significant changes in behavioral performance in animals exposed to JP-8, Jet A, or JP-5. A significant deviation in learning pattern during the Morris water maze task was observed in rats exposed to the highest concentration of FT (2000 mg/m3). There were also significant differences in the EP profile of hippocampal neurons from animals exposed to JP-8, Jet A, JP-5, or FT compared to control air. However, these differences were not consistent across fuels or dose dependent. As expected, patterns of EP alterations in brain slices from JP-8 and Jet A exposures were more similar compared to those from JP-5 and FT. Further longitudinal investigationsmore »
- Authors:
-
- Naval Medical Research Unit Dayton (NAMRU-D), Wright-Patterson Air Force Base, Dayton, OH (United States); Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States)
- Naval Medical Research Unit Dayton (NAMRU-D), Wright-Patterson Air Force Base, Dayton, OH (United States)
- Naval Medical Research Unit Dayton (NAMRU-D), Wright-Patterson Air Force Base, Dayton, OH (United States); cCAMRIS International, Bethesda, MD (United States)
- Publication Date:
- Research Org.:
- Oak Ridge Inst. for Science and Education (ORISE), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1494675
- Grant/Contract Number:
- WUN H1320
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Journal of Toxicology and Environmental Health: Part A
- Additional Journal Information:
- Journal Volume: 81; Journal Issue: 10; Journal ID: ISSN 1528-7394
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 54 ENVIRONMENTAL SCIENCES
Citation Formats
Rohan, Joyce G., McInturf, Shawn M., Miklasevich, Molly K., Gut, Chester P., Grimm, Michael D., Reboulet, James E., Howard, William R., and Mumy, Karen L. Comparative electrophysiological evaluation of hippocampal function following repeated inhalation exposures to JP-8, Jet A, JP-5, and the synthetic Fischer Tropsch fuel. United States: N. p., 2018.
Web. doi:10.1080/15287394.2018.1437097.
Rohan, Joyce G., McInturf, Shawn M., Miklasevich, Molly K., Gut, Chester P., Grimm, Michael D., Reboulet, James E., Howard, William R., & Mumy, Karen L. Comparative electrophysiological evaluation of hippocampal function following repeated inhalation exposures to JP-8, Jet A, JP-5, and the synthetic Fischer Tropsch fuel. United States. https://doi.org/10.1080/15287394.2018.1437097
Rohan, Joyce G., McInturf, Shawn M., Miklasevich, Molly K., Gut, Chester P., Grimm, Michael D., Reboulet, James E., Howard, William R., and Mumy, Karen L. Fri .
"Comparative electrophysiological evaluation of hippocampal function following repeated inhalation exposures to JP-8, Jet A, JP-5, and the synthetic Fischer Tropsch fuel". United States. https://doi.org/10.1080/15287394.2018.1437097. https://www.osti.gov/servlets/purl/1494675.
@article{osti_1494675,
title = {Comparative electrophysiological evaluation of hippocampal function following repeated inhalation exposures to JP-8, Jet A, JP-5, and the synthetic Fischer Tropsch fuel},
author = {Rohan, Joyce G. and McInturf, Shawn M. and Miklasevich, Molly K. and Gut, Chester P. and Grimm, Michael D. and Reboulet, James E. and Howard, William R. and Mumy, Karen L.},
abstractNote = {Exposure to fuels continues to be a concern in both military and general populations. The aim of this study was to examine effects of in vivo rat repeated exposures to different types of jet fuel utilizing microelectrode arrays for comparative electrophysiological (EP) measurements in hippocampal slices. Animals were exposed to increasing concentrations of four jet fuels, Jet Propellant (JP)-8, Jet A, JP-5, or synthetic Fischer Tropsch (FT) fuel via whole-body inhalation for 20 d (6 hr/d, 5 d/week for 28 d) and synaptic transmission as well as behavioral performance were assessed. Our behavioral studies indicated no significant changes in behavioral performance in animals exposed to JP-8, Jet A, or JP-5. A significant deviation in learning pattern during the Morris water maze task was observed in rats exposed to the highest concentration of FT (2000 mg/m3). There were also significant differences in the EP profile of hippocampal neurons from animals exposed to JP-8, Jet A, JP-5, or FT compared to control air. However, these differences were not consistent across fuels or dose dependent. As expected, patterns of EP alterations in brain slices from JP-8 and Jet A exposures were more similar compared to those from JP-5 and FT. Further longitudinal investigations are needed to determine if these EP effects are transient or persistent. Such studies may dictate if and how one may use EP measurements to indicate potential susceptibility to neurological impairments, particularly those that result from inhalation exposure to chemicals or mixtures.},
doi = {10.1080/15287394.2018.1437097},
journal = {Journal of Toxicology and Environmental Health: Part A},
number = 10,
volume = 81,
place = {United States},
year = {Fri Mar 02 00:00:00 EST 2018},
month = {Fri Mar 02 00:00:00 EST 2018}
}
Web of Science
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