Xenotransplantation in China: Present status
- Health Management Center Sichuan Academy of Medical Science &, Sichuan Provincial People’s Hospital Chengdu China, School of Medicine University of Electronic Science and Technology of China Chengdu China, Department of Pharmacy Sichuan Academy of Medical Science &, Sichuan Provincial People's Hospital Chengdu China
- School of Medicine University of Electronic Science and Technology of China Chengdu China
- Organ Transplant and Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province Sichuan Academy of an Transplant Science &, Sichuan Provincial People’s Hospital Chengdu China
- Department of Pharmacy Chengdu Military General Hospital Chengdu China
Abstract The main obstacle to organ transplantation is the shortage of organs from deceased individuals. Especially in China, the ratio of patients on the waiting list versus the transplant recipients is 30:1. Therefore, there is an urgent need for organ donors. Genetically modified pig organs have proved to be a new source for xenotransplantation, and Chinese scientists have made considerable progress in this area during recent years. In this paper, we review four important aspects of the xenotransplantation field in China. First, a large variety of genetically modified pigs have been generated by Chinese scientists: all these genetically modified pigs and the purpose of these modifications will be summarized. Second, the preclinical research in pig‐to‐nonhuman primate xenotransplantation is outlined. The survival time and major biochemical parameters for the xenografts are summarized. Third, regarding the bench‐to‐bed approach, more suitable organs have been developed for xenotransplantation in humans, and in particular, pig islet transplantation into diabetic patients as well as pig‐to‐human cornea and skin transplantation. Fourth, we briefly address the regulations and prospects for recruiting xenotransplantation experts in China. Based on recent progress, we anticipate that genetically modified pigs will offer suitable organs for the treatment of end‐stage organ diseases in humans in the near future. Given the recent influx of world‐renowned scientists in xenotransplantation to China, our country will definitely become one of the major centers of xenotransplantation research and development in the world.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1494207
- Journal Information:
- Xenotransplantation, Journal Name: Xenotransplantation Journal Issue: 1 Vol. 26; ISSN 0908-665X
- Publisher:
- Wiley-BlackwellCopyright Statement
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
Xenotransplantation in Asia
Construction of EMSC-islet co-localizing composites for xenogeneic porcine islet transplantation