IL‐10 derived from M2 macrophage promotes cancer stemness via JAK1/STAT1/NF‐κB/Notch1 pathway in non‐small cell lung cancer
Abstract
Tumor‐associated macrophages (TAMs), key immune cells in the tumor microenvironment, are shown to be closely correlated with the progression of non‐small cell lung cancer (NSCLC). Cancer stem cells (CSCs) can contribute to NSCLC progression as well. We aimed to clarify whether TAMs promote the progression of NSCLC by mainly affecting the activities of CSCs. We found that TAM‐like cells promoted CSC‐like properties in NSCLC cells in vitro , which was mediated by TAM‐derived IL‐10. TAM‐derived IL‐10 promoted CSC‐like properties of NSCLC cells through JAK1/STAT1/NF‐κB/Notch1 signaling. Blockade of IL‐10/JAK1 signaling inhibited TAM‐mediated NSCLC tumor growth in vivo , and the TAM‐mediated expression of CSC‐related and mesenchymal‐related genes in NSCLC. Lastly, expression levels of these signaling molecules were significantly correlated with survival of NSCLC patients. Therefore, IL‐10/JAK1 signaling might be a potential therapeutic target for NSCLC treatment.
- Authors:
-
[7]
- Biotherapy Center The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan People's Republic of China, Department of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan People's Republic of China, Key Laboratory for Tumor Immunology and Biotherapy of Henan Province Zhengzhou Henan People's Republic of China
- Biotherapy Center The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan People's Republic of China, Key Laboratory for Tumor Immunology and Biotherapy of Henan Province Zhengzhou Henan People's Republic of China, School of Life Sciences Zhengzhou University Zhengzhou Henan People's Republic of China
- Department of Radiology Orthopaedic Hospital of Zhengzhou City Zhengzhou Henan People's Republic of China
- Department of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan People's Republic of China, Key Laboratory for Tumor Immunology and Biotherapy of Henan Province Zhengzhou Henan People's Republic of China
- Department of Hematology/Oncology, School of Medicine Northwestern University Chicago IL
- Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, College of Medicine University of Cincinnati Cincinnati OH
- Biotherapy Center The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan People's Republic of China, Department of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan People's Republic of China, Key Laboratory for Tumor Immunology and Biotherapy of Henan Province Zhengzhou Henan People's Republic of China, School of Life Sciences Zhengzhou University Zhengzhou Henan People's Republic of China
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1493929
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- International Journal of Cancer
- Additional Journal Information:
- Journal Name: International Journal of Cancer Journal Volume: 145 Journal Issue: 4; Journal ID: ISSN 0020-7136
- Publisher:
- Wiley Blackwell (John Wiley & Sons)
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Yang, Li, Dong, Ying, Li, Yanjun, Wang, Dong, Liu, Shasha, Wang, Dan, Gao, Qun, Ji, Shaofei, Chen, Xinfeng, Lei, Qingyang, Jiang, Wenyi, Wang, Liping, Zhang, Bin, Yu, Jane J., and Zhang, Yi. IL‐10 derived from M2 macrophage promotes cancer stemness via JAK1/STAT1/NF‐κB/Notch1 pathway in non‐small cell lung cancer. United States: N. p., 2019.
Web. doi:10.1002/ijc.32151.
Yang, Li, Dong, Ying, Li, Yanjun, Wang, Dong, Liu, Shasha, Wang, Dan, Gao, Qun, Ji, Shaofei, Chen, Xinfeng, Lei, Qingyang, Jiang, Wenyi, Wang, Liping, Zhang, Bin, Yu, Jane J., & Zhang, Yi. IL‐10 derived from M2 macrophage promotes cancer stemness via JAK1/STAT1/NF‐κB/Notch1 pathway in non‐small cell lung cancer. United States. https://doi.org/10.1002/ijc.32151
Yang, Li, Dong, Ying, Li, Yanjun, Wang, Dong, Liu, Shasha, Wang, Dan, Gao, Qun, Ji, Shaofei, Chen, Xinfeng, Lei, Qingyang, Jiang, Wenyi, Wang, Liping, Zhang, Bin, Yu, Jane J., and Zhang, Yi. Thu .
"IL‐10 derived from M2 macrophage promotes cancer stemness via JAK1/STAT1/NF‐κB/Notch1 pathway in non‐small cell lung cancer". United States. https://doi.org/10.1002/ijc.32151.
@article{osti_1493929,
title = {IL‐10 derived from M2 macrophage promotes cancer stemness via JAK1/STAT1/NF‐κB/Notch1 pathway in non‐small cell lung cancer},
author = {Yang, Li and Dong, Ying and Li, Yanjun and Wang, Dong and Liu, Shasha and Wang, Dan and Gao, Qun and Ji, Shaofei and Chen, Xinfeng and Lei, Qingyang and Jiang, Wenyi and Wang, Liping and Zhang, Bin and Yu, Jane J. and Zhang, Yi},
abstractNote = {Tumor‐associated macrophages (TAMs), key immune cells in the tumor microenvironment, are shown to be closely correlated with the progression of non‐small cell lung cancer (NSCLC). Cancer stem cells (CSCs) can contribute to NSCLC progression as well. We aimed to clarify whether TAMs promote the progression of NSCLC by mainly affecting the activities of CSCs. We found that TAM‐like cells promoted CSC‐like properties in NSCLC cells in vitro , which was mediated by TAM‐derived IL‐10. TAM‐derived IL‐10 promoted CSC‐like properties of NSCLC cells through JAK1/STAT1/NF‐κB/Notch1 signaling. Blockade of IL‐10/JAK1 signaling inhibited TAM‐mediated NSCLC tumor growth in vivo , and the TAM‐mediated expression of CSC‐related and mesenchymal‐related genes in NSCLC. Lastly, expression levels of these signaling molecules were significantly correlated with survival of NSCLC patients. Therefore, IL‐10/JAK1 signaling might be a potential therapeutic target for NSCLC treatment.},
doi = {10.1002/ijc.32151},
journal = {International Journal of Cancer},
number = 4,
volume = 145,
place = {United States},
year = {Thu Feb 07 00:00:00 EST 2019},
month = {Thu Feb 07 00:00:00 EST 2019}
}
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