Copper‐Mediated Aminoquinoline‐Directed Radiofluorination of Aromatic C−H Bonds with K 18 F
- Department of Radiology University of Michigan 1301 Catherine St Ann Arbor MI 48109 USA
- Department of Chemistry The University of Michigan 930 North University Ave Ann Arbor MI 48109 USA
Abstract A Cu‐mediated ortho ‐C−H radiofluorination of aromatic carboxylic acids that are protected as 8‐aminoquinoline benzamides is described. The method uses K 18 F and is compatible with a wide range of functional groups. The reaction is showcased in the high specific activity automated synthesis of the RARβ2 agonist [ 18 F]AC261066.
- Sponsoring Organization:
- USDOE
- Grant/Contract Number:
- SC0012484
- OSTI ID:
- 1493376
- Journal Information:
- Angewandte Chemie, Journal Name: Angewandte Chemie Vol. 131 Journal Issue: 10; ISSN 0044-8249
- Publisher:
- Wiley Blackwell (John Wiley & Sons)Copyright Statement
- Country of Publication:
- Germany
- Language:
- English
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