Ribosome-induced RNA conformational changes in a viral 3'-UTR sense and regulate translation levels

Hartwick, Erik W.; Costantino, David A.; MacFadden, Andrea; Nix, Jay C.; Tian, Siqi; Das, Rhiju; Kieft, Jeffrey S.

doi:10.1038/s41467-018-07542-x

Title: Ribosome-induced RNA conformational changes in a viral 3'-UTR sense and regulate translation levels

Journal Article · 28 November 2018 · Nature Communications

DOI: https://doi.org/10.1038/s41467-018-07542-x · OSTI ID:1493274

Hartwick, Erik W. ^[1]; Costantino, David A. ^[2]; MacFadden, Andrea ^[2]; Nix, Jay C. ^[3]; Tian, Siqi ^[4];

^[4];

^[2]

Univ. of Colorado, Denver, CO (United States); Univ. of Colorado Denver School of Medicine, Aurora, CO (United States)
Univ. of Colorado Denver School of Medicine, Aurora, CO (United States)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Stanford Univ., Stanford, CA (United States)

Structured RNA elements, programmed RNA conformational changes, and interactions between different RNA domains underlie many modes of regulating gene expression, mandating studies to understand the foundational principles that govern these phenomena. Exploring the structured 3' untranslated region (UTR) of a viral RNA, we discovered that different contexts of the 3'-UTR confer different abilities to enhance translation of an associated open reading frame. In one context, ribosome-induced conformational changes in a ‘sensor’ RNA domain affect a separate RNA ‘functional’ domain, altering translation efficiency. The structure of the entire 3'-UTR reveals that structurally distinct domains use a spine of continuously stacked bases and a strut-like linker to create a conduit for communication within the higher-order architecture. Furthermore, this 3'-UTR RNA illustrates how RNA can use programmed conformational changes to sense the translation status of an upstream open reading frame, then create a tuned functional response by communicating that information to other RNA elements.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1493274

Journal Information:: Nature Communications, Journal Name: Nature Communications Journal Issue: 1 Vol. 9; ISSN 2041-1723

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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G ₂ -quadruplex in the 3’UTR of IE180 regulates Pseudorabies virus replication by enhancing gene expression Zhang, Yashu; Liu, Sisi; Jiang, Hui RNA Biology, Vol. 17, Issue 6 https://doi.org/10.1080/15476286.2020.1731664	journal	March 2020

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