Modular Metal–Organic Polyhedra Superassembly: From Molecular‐Level Design to Targeted Drug Delivery

Journal Article · 30 January 2019 · Advanced Materials

DOI: https://doi.org/10.1002/adma.201806774 · OSTI ID:1493080

Zhu, Wei ^[1]; Guo, Jimin ^[1]; Ju, Yi ^[2]; Serda, Rita E. ^[3]; Croissant, Jonas G. ^[1]; Shang, Jin ^[4]; Coker, Eric ^[5]; Agola, Jacob Ongudi ^[1]; Zhong, Qi‐Zhi ^[2]; Ping, Yuan ^[6]; Caruso, Frank ^[2]; Brinker, C. Jeffrey  ^[1]

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1. Center for Micro‐Engineered Materials Department of Chemical and Biological Engineering The University of New Mexico Albuquerque NM 87131 USA
2. ARC Centre of Excellence in Convergent Bio–Nano Science and Technology and The Department of Chemical Engineering The University of Melbourne Parkville Victoria 3010 Australia
3. Department of Internal Medicine Molecular Medicine The University of New Mexico Albuquerque NM 87131 USA
4. School of Energy and Environment City University of Hong Kong Tat Chee Avenue Kowloon Hong Kong SAR P. R. China
5. Sandia National Laboratories Applied Optical/Plasma Sciences P.O. Box 5800, MS 1411 Albuquerque NM 87185‐1411 USA
6. College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 P. R. China

Abstract Targeted drug delivery remains at the forefront of biomedical research but remains a challenge to date. Herein, the first superassembly of nanosized metal–organic polyhedra (MOP) and their biomimetic coatings of lipid bilayers are described to synergistically combine the advantages of micelles and supramolecular coordination cages for targeted drug delivery. The superassembly technique affords unique hydrophobic features that endow individual MOP to act as nanobuilding blocks and enable their superassembly into larger and well‐defined nanocarriers with homogeneous sizes over a broad range of diameters. Various cargos are controllably loaded into the MOP with high payloads, and the nanocages are then superassembled to form multidrug delivery systems. Additionally, functional nanoparticles are introduced into the superassemblies via a one‐pot process for versatile bioapplications. The MOP superassemblies are surface‐engineered with epidermal growth factor receptors and can be targeted to cancer cells. In vivo studies indicated the assemblies to have a substantial circulation half‐life of 5.6 h and to undergo renal clearance—characteristics needed for nanomedicines.

• Sponsoring Organization: USDOE
• Grant/Contract Number: NA0003525
• OSTI ID: 1493080
• Journal Information: Advanced Materials, Journal Name: Advanced Materials Journal Issue: 12 Vol. 31; ISSN 0935-9648
• Publisher: Wiley Blackwell (John Wiley & Sons)Copyright Statement
• Country of Publication: Germany
• Language: English