DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: G protein‐coupled estrogen receptor activates cell type‐specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes

ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [2]
  1. CICS‐UBI – Health Sciences Research Centre University of Beira Interior Covilhã Portugal
  2. CICS‐UBI – Health Sciences Research Centre University of Beira Interior Covilhã Portugal, Faculty of Health Sciences University of Beira Interior Covilhã Portugal
Publication Date:
Sponsoring Org.:
OSTI Identifier:
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Journal of Neurochemistry
Additional Journal Information:
Journal Name: Journal of Neurochemistry Journal Volume: 149 Journal Issue: 1; Journal ID: ISSN 0022-3042
Country of Publication:
United Kingdom

Citation Formats

Roque, Cláudio, Mendes‐Oliveira, Julieta, and Baltazar, Graça. G protein‐coupled estrogen receptor activates cell type‐specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes. United Kingdom: N. p., 2019. Web. doi:10.1111/jnc.14648.
Roque, Cláudio, Mendes‐Oliveira, Julieta, & Baltazar, Graça. G protein‐coupled estrogen receptor activates cell type‐specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes. United Kingdom.
Roque, Cláudio, Mendes‐Oliveira, Julieta, and Baltazar, Graça. Mon . "G protein‐coupled estrogen receptor activates cell type‐specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes". United Kingdom.
title = {G protein‐coupled estrogen receptor activates cell type‐specific signaling pathways in cortical cultures: relevance to the selective loss of astrocytes},
author = {Roque, Cláudio and Mendes‐Oliveira, Julieta and Baltazar, Graça},
abstractNote = {},
doi = {10.1111/jnc.14648},
journal = {Journal of Neurochemistry},
number = 1,
volume = 149,
place = {United Kingdom},
year = {2019},
month = {1}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Citation Metrics:
Cited by: 17 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER
journal, September 2009

GPR30 estrogen receptor agonists induce mechanical hyperalgesia in the rat
journal, April 2008

Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis
journal, September 2009

GPER Agonist G1 Attenuates Neuroinflammation and Dopaminergic Neurodegeneration in Parkinson Disease
journal, January 2017

  • Guan, Jing; Yang, Beibei; Fan, Yi
  • Neuroimmunomodulation, Vol. 24, Issue 1
  • DOI: 10.1159/000478908

GPR30 Regulates Glutamate Transporter GLT-1 Expression in Rat Primary Astrocytes
journal, May 2012

  • Lee, Eunsook; Sidoryk-Wêgrzynowicz, Marta; Wang, Ning
  • Journal of Biological Chemistry, Vol. 287, Issue 32
  • DOI: 10.1074/jbc.M112.341867

Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues
journal, May 2009

  • Hazell, Georgina G. J.; Yao, Song T.; Roper, James A.
  • Journal of Endocrinology, Vol. 202, Issue 2
  • DOI: 10.1677/JOE-09-0066

Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications
journal, May 2007

Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association
journal, February 2011

Estradiol-mediated ERK phosphorylation and apoptosis in vascular smooth muscle cells requires GPR 30
journal, November 2009

  • Ding, Qingming; Gros, Robert; Limbird, Lee E.
  • American Journal of Physiology-Cell Physiology, Vol. 297, Issue 5
  • DOI: 10.1152/ajpcell.00185.2009

Estrogen Enhances Neurogenesis and Behavioral Recovery after Stroke
journal, July 2010

  • Li, Jun; Siegel, Matt; Yuan, Mike
  • Journal of Cerebral Blood Flow & Metabolism, Vol. 31, Issue 2
  • DOI: 10.1038/jcbfm.2010.181

GPER1/GPR30 Activation Improves Neuronal Survival Following Global Cerebral Ischemia Induced by Cardiac Arrest in Mice
journal, September 2012

Estrogen Signaling through the Transmembrane G Protein–Coupled Receptor GPR30
journal, March 2008

Vasodilation in Response to the GPR30 Agonist G-1 is Not Different From Estradiol in the mRen2.Lewis Female Rat
journal, January 2011

  • Lindsey, Sarah H.; Carver, Kyle A.; Prossnitz, Eric R.
  • Journal of Cardiovascular Pharmacology, Vol. 57, Issue 5
  • DOI: 10.1097/FJC.0b013e3182135f1c

GPER expressed on microglia mediates the anti-inflammatory effect of estradiol in ischemic stroke
journal, March 2016

  • Zhao, Tian-Zhi; Ding, Qian; Hu, Jun
  • Brain and Behavior, Vol. 6, Issue 4
  • DOI: 10.1002/brb3.449

17β-Estradiol activates GPER- and ESR1-dependent pathways inducing apoptosis in GC-2 cells, a mouse spermatocyte-derived cell line
journal, May 2012

  • Chimento, Adele; Sirianni, Rosa; Casaburi, Ivan
  • Molecular and Cellular Endocrinology, Vol. 355, Issue 1
  • DOI: 10.1016/j.mce.2012.01.017

Estrogen destabilizes microtubules through an ion-conductivity-independent TRPV1 pathway: TRPV1-C-terminus regulates microtubule stability
journal, May 2011

Cloning of Human cDNA Encoding a Novel Heptahelix Receptor Expressed in Burkitt's Lymphoma and Widely Distributed in Brain and Peripheral Tissues
journal, November 1996

  • Owman, Christer; Blay, Pilar; Nilsson, Christer
  • Biochemical and Biophysical Research Communications, Vol. 228, Issue 2
  • DOI: 10.1006/bbrc.1996.1654

Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions
journal, March 2007

  • Suzuki, S.; Brown, C. M.; Dela Cruz, C. D.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 14
  • DOI: 10.1073/pnas.0610394104

G protein-coupled estrogen receptor 1-mediated effects in the rat myometrium
journal, November 2011

  • Tica, Andrei A.; Dun, Erica C.; Tica, Oana S.
  • American Journal of Physiology-Cell Physiology, Vol. 301, Issue 5
  • DOI: 10.1152/ajpcell.00501.2010

GPER: A new tool to protect dopaminergic neurons?
journal, October 2015

  • Bessa, Agustina; Campos, Filipa Lopes; Videira, Rita Alexandra
  • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1852, Issue 10
  • DOI: 10.1016/j.bbadis.2015.07.004

Estrogen receptors mediate rapid activation of phospholipase C pathway in the rat endometrium
journal, December 2011

The Role of Calcium in the Regulation of Apoptosis
journal, October 1997

  • McConkey, David J.; Orrenius, Sten
  • Biochemical and Biophysical Research Communications, Vol. 239, Issue 2
  • DOI: 10.1006/bbrc.1997.7409

Membrane Estrogen Receptor Regulates Experimental Autoimmune Encephalomyelitis through Up-regulation of Programmed Death 1
journal, February 2009

Stroke Increases G Protein-Coupled Estrogen Receptor Expression in the Brain of Male but Not Female Mice
journal, January 2013

  • Broughton, Brad R. S.; Brait, Vanessa H.; Guida, Elizabeth
  • Neurosignals, Vol. 21, Issue 3-4
  • DOI: 10.1159/000338019

Activation of G protein-coupled estrogen receptor 1 (GPER-1) ameliorates blood-brain barrier permeability after global cerebral ischemia in ovariectomized rats
journal, August 2016

  • Lu, Dan; Qu, Yan; Shi, Fei
  • Biochemical and Biophysical Research Communications, Vol. 477, Issue 2
  • DOI: 10.1016/j.bbrc.2016.06.044

NAD Induces Astrocyte Calcium Flux and Cell Death by ART2 and P2X7 Pathway
journal, September 2012

Estrogen Replacement Therapy for Stroke
journal, January 2014

Synthetic Estrogen Derivatives Demonstrate the Functionality of Intracellular GPR30
journal, July 2007

  • Revankar, Chetana M.; Mitchell, Hugh D.; Field, Angela S.
  • ACS Chemical Biology, Vol. 2, Issue 8
  • DOI: 10.1021/cb700072n

GPER activation is effective in protecting against inflammation-induced nigral dopaminergic loss and motor function impairment
journal, August 2017

  • Mendes-Oliveira, Julieta; Lopes Campos, Filipa; Videira, Rita Alexandra
  • Brain, Behavior, and Immunity, Vol. 64
  • DOI: 10.1016/j.bbi.2017.04.016

Estrogens and Experimental Ischemic Stroke: A Systematic Review
journal, January 2006

  • Gibson, Claire L.; Gray, Laura J.; Murphy, Sean P.
  • Journal of Cerebral Blood Flow & Metabolism, Vol. 26, Issue 9
  • DOI: 10.1038/sj.jcbfm.9600270

Insights into Rapid Modulation of Neuroplasticity by Brain Estrogens
journal, August 2013

  • Srivastava, Deepak P.; Woolfrey, Kevin M.; Penzes, Peter
  • Pharmacological Reviews, Vol. 65, Issue 4
  • DOI: 10.1124/pr.111.005272

Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system
journal, May 2007

  • Brailoiu, E.; Dun, S. L.; Brailoiu, G. C.
  • Journal of Endocrinology, Vol. 193, Issue 2
  • DOI: 10.1677/JOE-07-0017

Ameliorative effect of membrane-associated estrogen receptor G protein coupled receptor 30 activation on object recognition memory in mouse models of Alzheimer's disease
journal, July 2016

  • Kubota, Takashi; Matsumoto, Hiroshi; Kirino, Yutaka
  • Journal of Pharmacological Sciences, Vol. 131, Issue 3
  • DOI: 10.1016/j.jphs.2016.06.005

Estrogen neuroprotection and the critical period hypothesis
journal, January 2012

Oestrogen and Nigrostriatal Dopaminergic Neurodegeneration: Animal Models and Clinical Reports of Parkinson'S Disease
journal, July 2007

A novel method for culturing stellate astrocytes reveals spatially distinct Ca 2+ signaling and vesicle recycling in astrocytic processes
journal, December 2016

  • Wolfes, Anne C.; Ahmed, Saheeb; Awasthi, Ankit
  • The Journal of General Physiology, Vol. 149, Issue 1
  • DOI: 10.1085/jgp.201611607

17β-Estradiol Inhibits Oxidative Stress-Induced Apoptosis in Keratinocytes by Promoting Bcl-2 Expression
journal, December 2003

G Protein-Coupled Estrogen Receptor-Selective Ligands Modulate Endometrial Tumor Growth
journal, January 2013

  • Petrie, Whitney K.; Dennis, Megan K.; Hu, Chelin
  • Obstetrics and Gynecology International, Vol. 2013
  • DOI: 10.1155/2013/472720

Anti-inflammatory effect of selective estrogen receptor modulators (SERMs) in microglial cells
journal, May 2005

In vivo effects of a GPR30 antagonist
journal, May 2009

  • Dennis, Megan K.; Burai, Ritwik; Ramesh, Chinnasamy
  • Nature Chemical Biology, Vol. 5, Issue 6
  • DOI: 10.1038/nchembio.168

Antidepressants, sertraline and paroxetine, increase calcium influx and induce mitochondrial damage-mediated apoptosis of astrocytes
journal, December 2017

Extra-nuclear estrogen receptor GPR30 regulates serotonin function in rat hypothalamus
journal, February 2009

A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling
journal, March 2005

Estrogen biology: New insights into GPER function and clinical opportunities
journal, May 2014

  • Prossnitz, Eric R.; Barton, Matthias
  • Molecular and Cellular Endocrinology, Vol. 389, Issue 1-2
  • DOI: 10.1016/j.mce.2014.02.002

Binding and activation of the seven-transmembrane estrogen receptor GPR30 by environmental estrogens: A potential novel mechanism of endocrine disruption
journal, December 2006

  • Thomas, Peter; Dong, Jing
  • The Journal of Steroid Biochemistry and Molecular Biology, Vol. 102, Issue 1-5
  • DOI: 10.1016/j.jsbmb.2006.09.017

Estrogen and non-genomic upregulation of voltage-gated Na+ channel activity in MDA-MB-231 human breast cancer cells: Role in adhesion
journal, April 2010

  • Fraser, Scott P.; Ozerlat-Gunduz, Iley; Onkal, Rustem
  • Journal of Cellular Physiology, Vol. 224, Issue 2
  • DOI: 10.1002/jcp.22154

Virtual and biomolecular screening converge on a selective agonist for GPR30
journal, March 2006

  • Bologa, Cristian G.; Revankar, Chetana M.; Young, Susan M.
  • Nature Chemical Biology, Vol. 2, Issue 4
  • DOI: 10.1038/nchembio775

A novel putative G-protein-coupled receptor expressed in lung, heart and lymphoid tissue
journal, April 1997

Protein Kinase C δ Activates the MEK-ERK Pathway in a Manner Independent of Ras and Dependent on Raf
journal, September 1996

  • Ueda, Yoshihiko; Hirai, Syu-ichi; Osada, Shin-ichi
  • Journal of Biological Chemistry, Vol. 271, Issue 38
  • DOI: 10.1074/jbc.271.38.23512

Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formation
journal, August 2008

The G-protein-coupled estrogen receptor GPER in health and disease
journal, August 2011

Astrocyte apoptosis: implications for neuroprotection
journal, February 2004

Apoptotic effect of ethanol is potentiated by caffeine-induced calcium release in rat astrocytes
journal, January 2006

Primary culture of cellular subtypes from postnatal mouse for in vitro studies of oxygen glucose deprivation
journal, August 2011

Impact of Astrocytes on the Injury Induced by In Vitro Ischemia
journal, March 2017

Activation of the Novel Estrogen Receptor G Protein-Coupled Receptor 30 (GPR30) at the Plasma Membrane
journal, July 2007

Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines
journal, April 2010

  • Gillies, Glenda E.; McArthur, Simon
  • Pharmacological Reviews, Vol. 62, Issue 2
  • DOI: 10.1124/pr.109.002071

Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia
journal, May 2009

  • Dun, Siok L.; Brailoiu, G. Cristina; Gao, Xin
  • Journal of Neuroscience Research, Vol. 87, Issue 7
  • DOI: 10.1002/jnr.21980

JNK1 regulates histone acetylation in trigeminal neurons following chemical stimulation
journal, November 2008

  • Wu, Jing; Zhang, Xuan; Nauta, Haring J.
  • Biochemical and Biophysical Research Communications, Vol. 376, Issue 4
  • DOI: 10.1016/j.bbrc.2008.09.073

Involvement of Na + -Ca 2+ Exchanger in Reperfusion-induced Delayed Cell Death of Cultured Rat Astrocytes
journal, May 1996

Neuroprotective effects of estrogens following ischemic stroke
journal, July 2009

  • Suzuki, Shotaro; Brown, Candice M.; Wise, Phyllis M.
  • Frontiers in Neuroendocrinology, Vol. 30, Issue 2
  • DOI: 10.1016/j.yfrne.2009.04.007

17β-Estradiol Stimulates the Growth of Human Keratinocytes by Inducing Cyclin D2 Expression
journal, August 2004

Discovery of Three Novel G-Protein-Coupled Receptor Genes
journal, January 1998

Sex-Dependent Effects of G Protein–Coupled Estrogen Receptor Activity on Outcome After Ischemic Stroke
journal, March 2014

Cloning of cDNAs Encoding G Protein-Coupled Receptor Expressed in Human Endothelial Cells Exposed to Fluid Shear Stress
journal, November 1997

  • Takada, Yoshio; Kato, Chihiro; Kondo, Shuhei
  • Biochemical and Biophysical Research Communications, Vol. 240, Issue 3
  • DOI: 10.1006/bbrc.1997.7734

Reprint of ”GPR30 mediates estrogen rapid signaling and neuroprotection”
journal, May 2014

  • Tang, Hui; Zhang, Quanguang; Yang, Licai
  • Molecular and Cellular Endocrinology, Vol. 389, Issue 1-2
  • DOI: 10.1016/j.mce.2014.05.005

What Is the Role of Astrocyte Calcium in Neurophysiology?
journal, September 2008