skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Litters of self-replicating origami cross-tiles

Abstract

Self-replication and exponential growth are ubiquitous in nature but until recently there were few examples of artificial self-replication. Often replication is a templated process where a parent produces a single offspring, doubling the population in each generation. Many species however produce more than one offspring at a time, enabling faster population growth and higher probability of species perpetuation. We have made a system of cross-shaped origami tiles that yields a number of offspring, four to eight or more, depending on the concentration of monomer units to be assembled. The parent dimer template serves as a seed to crystallize a one-dimensional crystal, a ladder. The ladder rungs are then UV–cross-linked and the offspring are then released by heating, to yield a litter of autonomous daughters. In the complement study, we also optimize the growth conditions to speed up the process and yield a 10 3 increase in the growth rate for the single-offspring replication system. Self-replication and exponential growth of autonomous motifs is useful for fundamental studies of selection and evolution as well as for materials design, fabrication, and directed evolution. Methods that increase the growth rate, the primary evolutionary drive, not only speed up experiments but provide additional mechanisms formore » evolving materials toward desired functionalities.« less

Authors:
; ORCiD logo; ; ; ;
Publication Date:
Research Org.:
Energy Frontier Research Centers (EFRC) (United States). Center for Bio-Inspired Energy Science (CBES); Northwestern Univ., Evanston, IL (United States); New York Univ. (NYU), NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1491910
Alternate Identifier(s):
OSTI ID: 1566666
Grant/Contract Number:  
SC0007991; SC0000989
Resource Type:
Published Article
Journal Name:
Proceedings of the National Academy of Sciences of the United States of America
Additional Journal Information:
Journal Name: Proceedings of the National Academy of Sciences of the United States of America Journal Volume: 116 Journal Issue: 6; Journal ID: ISSN 0027-8424
Publisher:
Proceedings of the National Academy of Sciences
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; catalysis (homogeneous), solar (photovoltaic), bio-inspired, charge transport, mesostructured materials, materials and chemistry by design, synthesis (novel materials), synthesis (self-assembly)

Citation Formats

Zhuo, Rebecca, Zhou, Feng, He, Xiaojin, Sha, Ruojie, Seeman, Nadrian C., and Chaikin, Paul M. Litters of self-replicating origami cross-tiles. United States: N. p., 2019. Web. doi:10.1073/pnas.1812793116.
Zhuo, Rebecca, Zhou, Feng, He, Xiaojin, Sha, Ruojie, Seeman, Nadrian C., & Chaikin, Paul M. Litters of self-replicating origami cross-tiles. United States. doi:10.1073/pnas.1812793116.
Zhuo, Rebecca, Zhou, Feng, He, Xiaojin, Sha, Ruojie, Seeman, Nadrian C., and Chaikin, Paul M. Wed . "Litters of self-replicating origami cross-tiles". United States. doi:10.1073/pnas.1812793116.
@article{osti_1491910,
title = {Litters of self-replicating origami cross-tiles},
author = {Zhuo, Rebecca and Zhou, Feng and He, Xiaojin and Sha, Ruojie and Seeman, Nadrian C. and Chaikin, Paul M.},
abstractNote = {Self-replication and exponential growth are ubiquitous in nature but until recently there were few examples of artificial self-replication. Often replication is a templated process where a parent produces a single offspring, doubling the population in each generation. Many species however produce more than one offspring at a time, enabling faster population growth and higher probability of species perpetuation. We have made a system of cross-shaped origami tiles that yields a number of offspring, four to eight or more, depending on the concentration of monomer units to be assembled. The parent dimer template serves as a seed to crystallize a one-dimensional crystal, a ladder. The ladder rungs are then UV–cross-linked and the offspring are then released by heating, to yield a litter of autonomous daughters. In the complement study, we also optimize the growth conditions to speed up the process and yield a 10 3 increase in the growth rate for the single-offspring replication system. Self-replication and exponential growth of autonomous motifs is useful for fundamental studies of selection and evolution as well as for materials design, fabrication, and directed evolution. Methods that increase the growth rate, the primary evolutionary drive, not only speed up experiments but provide additional mechanisms for evolving materials toward desired functionalities.},
doi = {10.1073/pnas.1812793116},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
number = 6,
volume = 116,
place = {United States},
year = {2019},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1073/pnas.1812793116

Save / Share:

Works referenced in this record:

Exponential growth and selection in self-replicating materials from DNA origami rafts
journal, September 2017

  • He, Xiaojin; Sha, Ruojie; Zhuo, Rebecca
  • Nature Materials, Vol. 16, Issue 10
  • DOI: 10.1038/nmat4986

Chemical self-replication of palindromic duplex DNA
journal, May 1994


Robust self-replication of combinatorial information via crystal growth and scission
journal, April 2012

  • Schulman, R.; Yurke, B.; Winfree, E.
  • Proceedings of the National Academy of Sciences, Vol. 109, Issue 17
  • DOI: 10.1073/pnas.1117813109

Surface-promoted replication and exponential amplification of DNA analogues
journal, November 1998

  • Luther, A.; Brandsch, R.; von Kiedrowski, G.
  • Nature, Vol. 396, Issue 6708
  • DOI: 10.1038/24343

Towards self-replicating materials of DNA-functionalized colloids
journal, January 2009

  • Leunissen, Mirjam E.; Dreyfus, Rémi; Sha, Roujie
  • Soft Matter, Vol. 5, Issue 12
  • DOI: 10.1039/b817679e

Ribozyme-Catalyzed Transcription of an Active Ribozyme
journal, April 2011


Spontaneous network formation among cooperative RNA replicators
journal, October 2012

  • Vaidya, Nilesh; Manapat, Michael L.; Chen, Irene A.
  • Nature, Vol. 491, Issue 7422
  • DOI: 10.1038/nature11549

Exponential self-replication enabled through a fibre elongation/breakage mechanism
journal, June 2015

  • Colomb-Delsuc, Mathieu; Mattia, Elio; Sadownik, Jan W.
  • Nature Communications, Vol. 6, Issue 1
  • DOI: 10.1038/ncomms8427

Self-replication of information-bearing nanoscale patterns
journal, October 2011

  • Wang, Tong; Sha, Ruojie; Dreyfus, Rémi
  • Nature, Vol. 478, Issue 7368
  • DOI: 10.1038/nature10500

Self-Sustained Replication of an RNA Enzyme
journal, February 2009


Exponential growth by cross-catalytic cleavage of deoxyribozymogens
journal, May 2003

  • Levy, M.; Ellington, A. D.
  • Proceedings of the National Academy of Sciences, Vol. 100, Issue 11
  • DOI: 10.1073/pnas.1130145100

Studies in Molecular Replication
journal, July 1994

  • Wintner, Edward A.; Conn, M. Morgan; Rebek, Julius Jr.
  • Accounts of Chemical Research, Vol. 27, Issue 7
  • DOI: 10.1021/ar00043a003

Nonenzymatic Template-Directed RNA Synthesis Inside Model Protocells
journal, November 2013


Crystalline Two-Dimensional DNA-Origami Arrays
journal, November 2010

  • Liu, Wenyan; Zhong, Hong; Wang, Risheng
  • Angewandte Chemie International Edition, Vol. 50, Issue 1
  • DOI: 10.1002/anie.201005911

Chemical copying of connectivity
journal, November 2002

  • Eckardt, Lars Henning; Naumann, Kai; Matthias Pankau, Wolf
  • Nature, Vol. 420, Issue 6913
  • DOI: 10.1038/420286a

Escalation of polymerization in a thermal gradient
journal, April 2013

  • Mast, C. B.; Schink, S.; Gerland, U.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 20
  • DOI: 10.1073/pnas.1303222110

Emergence of symbiosis in peptide self-replication through a hypercyclic network
journal, December 1997

  • Lee, David H.; Severin, Kay; Yokobayashi, Yohei
  • Nature, Vol. 390, Issue 6660
  • DOI: 10.1038/37569

Self-replication of DNA rings
journal, May 2015

  • Kim, Junghoon; Lee, Junwye; Hamada, Shogo
  • Nature Nanotechnology, Vol. 10, Issue 6
  • DOI: 10.1038/nnano.2015.87

In vivo cloning of artificial DNA nanostructures
journal, October 2008

  • Lin, C.; Rinker, S.; Wang, X.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 46
  • DOI: 10.1073/pnas.0805416105

Folding DNA to create nanoscale shapes and patterns
journal, March 2006


Ultrafast Reversible Photo-Cross-Linking Reaction: Toward in Situ DNA Manipulation
journal, August 2008

  • Yoshimura, Yoshinaga; Fujimoto, Kenzo
  • Organic Letters, Vol. 10, Issue 15
  • DOI: 10.1021/ol801112j

Synthesizing life
journal, January 2001

  • Szostak, Jack W.; Bartel, David P.; Luisi, P. Luigi
  • Nature, Vol. 409, Issue 6818
  • DOI: 10.1038/35053176