Redox activity goes organic [Superoxide dismutase mimics: Redox activity goes organic]

Cabelli, Diane E.

doi:10.1038/s41557-018-0180-y

Title: Redox activity goes organic [Superoxide dismutase mimics: Redox activity goes organic]

Abstract

Superoxide dismutase mimics can help regulate the levels of O₂^•– in the body, but typically rely on redox-active metals that are toxic in their free form. Here, a complex featuring a redox-active quinol moiety complexed to a redox-inactive zinc centre has been shown to catalyse O₂^•– dismutation.

Authors:

Cabelli, Diane E. ^[1]

Brookhaven National Lab. (BNL), Upton, NY (United States)

Publication Date:: Wed Nov 21 00:00:00 EST 2018

Research Org.:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

OSTI Identifier:: 1491151

Report Number(s):: BNL-210858-2019-JAAM
Journal ID: ISSN 1755-4330

Grant/Contract Number:: SC0012704

Resource Type:: Accepted Manuscript

Journal Name:: Nature Chemistry

Additional Journal Information:: Journal Volume: 10; Journal Issue: 12; Journal ID: ISSN 1755-4330

Publisher:: Nature Publishing Group

Country of Publication:: United States

Language:: English

Subject:: 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY

Citation Formats


                    Cabelli, Diane E. Redox activity goes organic [Superoxide dismutase mimics: Redox activity goes organic].  United States: N. p., 2018. 
Web.  doi:10.1038/s41557-018-0180-y.

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                    Cabelli, Diane E. Redox activity goes organic [Superoxide dismutase mimics: Redox activity goes organic].  United States.  https://doi.org/10.1038/s41557-018-0180-y

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                    Cabelli, Diane E. Wed .  
"Redox activity goes organic [Superoxide dismutase mimics: Redox activity goes organic]".  United States.  https://doi.org/10.1038/s41557-018-0180-y.  https://www.osti.gov/servlets/purl/1491151.

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@article{osti_1491151,

  title        = {Redox activity goes organic [Superoxide dismutase mimics: Redox activity goes organic]},

  author       = {Cabelli, Diane E.},

  abstractNote = {Superoxide dismutase mimics can help regulate the levels of O2•– in the body, but typically rely on redox-active metals that are toxic in their free form. Here, a complex featuring a redox-active quinol moiety complexed to a redox-inactive zinc centre has been shown to catalyse O2•– dismutation.},

  doi          = {10.1038/s41557-018-0180-y},

  journal      = {Nature Chemistry},

  number       = 12,

  volume       = 10,

  place        = {United States},

  year         = {Wed Nov 21 00:00:00 EST 2018},

  month        = {Wed Nov 21 00:00:00 EST 2018}

}

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https://doi.org/10.1038/s41557-018-0180-y

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Works referenced in this record:

Manganese superoxide dismutase, MnSOD and its mimics
journal, May 2012

Miriyala, Sumitra; Spasojevic, Ivan; Tovmasyan, Artak
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1822, Issue 5
DOI: 10.1016/j.bbadis.2011.12.002

Superoxide Dismutases and Superoxide Reductases
journal, January 2014

Sheng, Yuewei; Abreu, Isabel A.; Cabelli, Diane E.
Chemical Reviews, Vol. 114, Issue 7
DOI: 10.1021/cr4005296

Superoxide dismutase activity enabled by a redox-active ligand rather than metal
journal, October 2018

Ward, Meghan B.; Scheitler, Andreas; Yu, Meng
Nature Chemistry, Vol. 10, Issue 12
DOI: 10.1038/s41557-018-0137-1

Activation of superoxide dismutases: Putting the metal to the pedal
journal, July 2006

Culotta, Valeria Cizewski; Yang, Mei; O'Halloran, Thomas V.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1763, Issue 7
DOI: 10.1016/j.bbamcr.2006.05.003

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Similar Records

Title: Redox activity goes organic [Superoxide dismutase mimics: Redox activity goes organic]

Abstract

Citation Formats

Manganese superoxide dismutase, MnSOD and its mimics journal, May 2012

Superoxide Dismutases and Superoxide Reductases journal, January 2014

Superoxide dismutase activity enabled by a redox-active ligand rather than metal journal, October 2018

Activation of superoxide dismutases: Putting the metal to the pedal journal, July 2006

Manganese superoxide dismutase, MnSOD and its mimics
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journal, October 2018

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