Radiation exposure and longitudinal changes in peripheral monocytes over 50 years: the Adult Health Study of atomic‐bomb survivors
Abstract
Summary Enhanced inflammatory responses have been suggested decades after radiation exposure in atomic‐bomb survivors, but cellular and molecular alterations related to prolonged inflammation remain unclear. This study, utilizing longitudinal haematological data over 50 years for 14 000 persons, investigated whether radiation exposure promoted the relative increase in peripheral myeloid cells, known as an aging‐associated indicator of low‐grade inflammation. Statistical modelling was performed with a linear mixed‐effects model for leucocyte subsets, together with a proportional hazards regression model for all‐cause mortality. We found that age trends in lymphocyte, neutrophil and monocyte percentages or counts differed before versus after age 60 years. Radiation dose was associated with monocyte percentages and counts, but not with the lymphoid‐myeloid cell ratio. Radiation effects on monocytes were stronger after versus before age 60 years. Increases in monocyte percentages and counts were associated with higher risk of all‐cause mortality. Studies of chromosomal aberrations have shown a clonal expansion of haematopoietic stem cells among atomic‐bomb survivors. Therefore, radiation exposure might accelerate aging‐associated clonal haematopoiesis, which could result in a long‐lasting elevation of circulating monocytes.
- Authors:
-
[1];
[3];
- Department of Molecular Biosciences Radiation Effects Research Foundation Hiroshima Japan
- Department of Statistics Radiation Effects Research Foundation Hiroshima Japan
- Department of Clinical Studies Radiation Effects Research Foundation Hiroshima Japan, Department of Pathology Kurume University School of Medicine Kurume Fukuoka
- Department of Clinical Studies Radiation Effects Research Foundation Nagasaki Japan
- Department of Clinical Studies Radiation Effects Research Foundation Hiroshima Japan
- Publication Date:
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1490763
- Resource Type:
- Publisher's Accepted Manuscript
- Journal Name:
- British Journal of Haematology
- Additional Journal Information:
- Journal Name: British Journal of Haematology Journal Volume: 185 Journal Issue: 1; Journal ID: ISSN 0007-1048
- Publisher:
- Wiley-Blackwell
- Country of Publication:
- United Kingdom
- Language:
- English
Citation Formats
Yoshida, Kengo, French, Benjamin, Yoshida, Noriaki, Hida, Ayumi, Ohishi, Waka, and Kusunoki, Yoichiro. Radiation exposure and longitudinal changes in peripheral monocytes over 50 years: the Adult Health Study of atomic‐bomb survivors. United Kingdom: N. p., 2019.
Web. doi:10.1111/bjh.15750.
Yoshida, Kengo, French, Benjamin, Yoshida, Noriaki, Hida, Ayumi, Ohishi, Waka, & Kusunoki, Yoichiro. Radiation exposure and longitudinal changes in peripheral monocytes over 50 years: the Adult Health Study of atomic‐bomb survivors. United Kingdom. https://doi.org/10.1111/bjh.15750
Yoshida, Kengo, French, Benjamin, Yoshida, Noriaki, Hida, Ayumi, Ohishi, Waka, and Kusunoki, Yoichiro. Sun .
"Radiation exposure and longitudinal changes in peripheral monocytes over 50 years: the Adult Health Study of atomic‐bomb survivors". United Kingdom. https://doi.org/10.1111/bjh.15750.
@article{osti_1490763,
title = {Radiation exposure and longitudinal changes in peripheral monocytes over 50 years: the Adult Health Study of atomic‐bomb survivors},
author = {Yoshida, Kengo and French, Benjamin and Yoshida, Noriaki and Hida, Ayumi and Ohishi, Waka and Kusunoki, Yoichiro},
abstractNote = {Summary Enhanced inflammatory responses have been suggested decades after radiation exposure in atomic‐bomb survivors, but cellular and molecular alterations related to prolonged inflammation remain unclear. This study, utilizing longitudinal haematological data over 50 years for 14 000 persons, investigated whether radiation exposure promoted the relative increase in peripheral myeloid cells, known as an aging‐associated indicator of low‐grade inflammation. Statistical modelling was performed with a linear mixed‐effects model for leucocyte subsets, together with a proportional hazards regression model for all‐cause mortality. We found that age trends in lymphocyte, neutrophil and monocyte percentages or counts differed before versus after age 60 years. Radiation dose was associated with monocyte percentages and counts, but not with the lymphoid‐myeloid cell ratio. Radiation effects on monocytes were stronger after versus before age 60 years. Increases in monocyte percentages and counts were associated with higher risk of all‐cause mortality. Studies of chromosomal aberrations have shown a clonal expansion of haematopoietic stem cells among atomic‐bomb survivors. Therefore, radiation exposure might accelerate aging‐associated clonal haematopoiesis, which could result in a long‐lasting elevation of circulating monocytes.},
doi = {10.1111/bjh.15750},
journal = {British Journal of Haematology},
number = 1,
volume = 185,
place = {United Kingdom},
year = {Sun Jan 13 00:00:00 EST 2019},
month = {Sun Jan 13 00:00:00 EST 2019}
}
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