Structural Characterization of Pan-Ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein

Milligan, Jacob C.; Parekh, Diptiben V.; Fuller, Katherine M.; Igarashi, Manabu; Takada, Ayato; Saphire, Erica Ollmann

doi:10.1093/infdis/jiy532

Title: Structural Characterization of Pan-Ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein

Journal Article · 09 September 2018 · Journal of Infectious Diseases

DOI: https://doi.org/10.1093/infdis/jiy532 · OSTI ID:1490125

^[1]; Parekh, Diptiben V. ^[1]; Fuller, Katherine M. ^[1]; Igarashi, Manabu ^[2]; Takada, Ayato ^[2];

^[3]

Department of Immunology and Microbiology, La Jolla, California
Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
Department of Immunology and Microbiology, La Jolla, California, Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1490125

Journal Information:: Journal of Infectious Diseases, Journal Name: Journal of Infectious Diseases Journal Issue: 3 Vol. 219; ISSN 0022-1899

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United States

Language:: English

References (13)

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Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability Zhao, Xuelian; Howell, Katie A.; He, Shihua Cell, Vol. 169, Issue 5 https://doi.org/10.1016/j.cell.2017.04.038	journal	May 2017
Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site Howell, Katie A.; Qiu, Xiangguo; Brannan, Jennifer M. Cell Reports, Vol. 15, Issue 7 https://doi.org/10.1016/j.celrep.2016.04.026	journal	May 2016
Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor Lee, Jeffrey E.; Fusco, Marnie L.; Hessell, Ann J. Nature, Vol. 454, Issue 7201 https://doi.org/10.1038/nature07082	journal	July 2008
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp Qiu, Xiangguo; Wong, Gary; Audet, Jonathan Nature, Vol. 514, Issue 7520 https://doi.org/10.1038/nature13777	journal	August 2014
Structures of Ebola virus GP and sGP in complex with therapeutic antibodies Pallesen, Jesper; Murin, Charles D.; de Val, Natalia Nature Microbiology, Vol. 1, Issue 9 https://doi.org/10.1038/nmicrobiol.2016.128	journal	August 2016
Discovery of an antibody for pan-ebolavirus therapy Furuyama, Wakako; Marzi, Andrea; Nanbo, Asuka Scientific Reports, Vol. 6, Issue 1 https://doi.org/10.1038/srep20514	journal	February 2016
Ebola vaccines in clinical trial: The promising candidates Wang, Yuxiao; Li, Jingxin; Hu, Yuemei Human Vaccines & Immunotherapeutics, Vol. 13, Issue 1 https://doi.org/10.1080/21645515.2016.1225637	journal	November 2016
Neglected filoviruses Burk, Robin; Bollinger, Laura; Johnson, Joshua C. FEMS Microbiology Reviews, Vol. 40, Issue 4 https://doi.org/10.1093/femsre/fuw010	journal	June 2016
Development of an Immunochromatography Assay (QuickNavi-Ebola) to Detect Multiple Species of Ebolaviruses Yoshida, Reiko; Muramatsu, Shino; Akita, Hiroshi Journal of Infectious Diseases, Vol. 214, Issue suppl 3 https://doi.org/10.1093/infdis/jiw252	journal	July 2016
Development of Clinical-Stage Human Monoclonal Antibodies That Treat Advanced Ebola Virus Disease in Nonhuman Primates Pascal, Kristen E.; Dudgeon, Drew; Trefry, John C. The Journal of Infectious Diseases, Vol. 218, Issue suppl_5 https://doi.org/10.1093/infdis/jiy285	journal	May 2018
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010
Structural and molecular basis for Ebola virus neutralization by protective human antibodies Misasi, J.; Gilman, M. S. A.; Kanekiyo, M. Science, Vol. 351, Issue 6279 https://doi.org/10.1126/science.aad6117	journal	February 2016

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