skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Structural Characterization of Pan-Ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein

Authors:
ORCiD logo [1];  [1];  [1];  [2];  [2]; ORCiD logo [3]
  1. Department of Immunology and Microbiology, La Jolla, California
  2. Division of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan
  3. Department of Immunology and Microbiology, La Jolla, California, Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1490125
Alternate Identifier(s):
OSTI ID: 1478451
Grant/Contract Number:  
[AC02-06CH11357]
Resource Type:
Published Article
Journal Name:
Journal of Infectious Diseases
Additional Journal Information:
[Journal Name: Journal of Infectious Diseases Journal Volume: 219 Journal Issue: 3]; Journal ID: ISSN 0022-1899
Publisher:
Oxford University Press
Country of Publication:
United States
Language:
English

Citation Formats

Milligan, Jacob C., Parekh, Diptiben V., Fuller, Katherine M., Igarashi, Manabu, Takada, Ayato, and Saphire, Erica Ollmann. Structural Characterization of Pan-Ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein. United States: N. p., 2018. Web. doi:10.1093/infdis/jiy532.
Milligan, Jacob C., Parekh, Diptiben V., Fuller, Katherine M., Igarashi, Manabu, Takada, Ayato, & Saphire, Erica Ollmann. Structural Characterization of Pan-Ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein. United States. doi:10.1093/infdis/jiy532.
Milligan, Jacob C., Parekh, Diptiben V., Fuller, Katherine M., Igarashi, Manabu, Takada, Ayato, and Saphire, Erica Ollmann. Mon . "Structural Characterization of Pan-Ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein". United States. doi:10.1093/infdis/jiy532.
@article{osti_1490125,
title = {Structural Characterization of Pan-Ebolavirus Antibody 6D6 Targeting the Fusion Peptide of the Surface Glycoprotein},
author = {Milligan, Jacob C. and Parekh, Diptiben V. and Fuller, Katherine M. and Igarashi, Manabu and Takada, Ayato and Saphire, Erica Ollmann},
abstractNote = {},
doi = {10.1093/infdis/jiy532},
journal = {Journal of Infectious Diseases},
number = [3],
volume = [219],
place = {United States},
year = {2018},
month = {9}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1093/infdis/jiy532

Citation Metrics:
Cited by: 4 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability
journal, May 2017


Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses
journal, May 2017


Discovery of an antibody for pan-ebolavirus therapy
journal, February 2016

  • Furuyama, Wakako; Marzi, Andrea; Nanbo, Asuka
  • Scientific Reports, Vol. 6, Issue 1
  • DOI: 10.1038/srep20514

Ebola vaccines in clinical trial: The promising candidates
journal, November 2016


Development of Clinical-Stage Human Monoclonal Antibodies That Treat Advanced Ebola Virus Disease in Nonhuman Primates
journal, May 2018

  • Pascal, Kristen E.; Dudgeon, Drew; Trefry, John C.
  • The Journal of Infectious Diseases, Vol. 218, Issue suppl_5
  • DOI: 10.1093/infdis/jiy285

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
journal, August 2014

  • Qiu, Xiangguo; Wong, Gary; Audet, Jonathan
  • Nature, Vol. 514, Issue 7520
  • DOI: 10.1038/nature13777

Development of an Immunochromatography Assay (QuickNavi-Ebola) to Detect Multiple Species of Ebolaviruses
journal, July 2016

  • Yoshida, Reiko; Muramatsu, Shino; Akita, Hiroshi
  • Journal of Infectious Diseases, Vol. 214, Issue suppl 3
  • DOI: 10.1093/infdis/jiw252

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site
journal, May 2016


Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor
journal, July 2008

  • Lee, Jeffrey E.; Fusco, Marnie L.; Hessell, Ann J.
  • Nature, Vol. 454, Issue 7201
  • DOI: 10.1038/nature07082

Neglected filoviruses
journal, June 2016

  • Burk, Robin; Bollinger, Laura; Johnson, Joshua C.
  • FEMS Microbiology Reviews, Vol. 40, Issue 4
  • DOI: 10.1093/femsre/fuw010

Structural and molecular basis for Ebola virus neutralization by protective human antibodies
journal, February 2016


PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

Structures of Ebola virus GP and sGP in complex with therapeutic antibodies
journal, August 2016