Evaluation of 72Se/72As generator and production of 72Se for supplying 72As as a potential PET imaging radionuclide

Feng, Yutian; Phipps, Michael D.; Phelps, Tim E.; Okoye, Nkemakonam C.; Baumeister, Jakob E.; Wycoff, Donald E.; Dorman, Eric F.; Wooten, A. Lake; Vlasenko, Vladislav; Berendzen, Ashley F.; Wilbur, D. Scott; Hoffman, Timothy J.; Cutler, Cathy S.; Ketring, Alan R.; Jurisson, Silvia S.

doi:10.1016/j.apradiso.2018.10.026

Title: Evaluation of ⁷²Se/⁷²As generator and production of ⁷²Se for supplying ⁷²As as a potential PET imaging radionuclide

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Abstract

Here, positron-emitting ⁷²As is the PET imaging counterpart for beta-emitting ⁷⁷As. Its parent, no carrier added (n.c.a.) ⁷²Se, was produced for a ⁷²Se/⁷²As generator by irradiating an enriched ^7°Ge metal-graphite target via the ⁷⁰Ge(α, 2 n)⁷²Se reaction. Target dissolution used a fast, environmentally friendly method with 93% radioactivity recovery. Chromatographic parameters of the ⁷²Se/⁷²As generator were evaluated, the eluted n.c.a. ⁷²As was characterized with a phantom imaging study, and the previously reported trithiol and aryl-dithiol ligand systems were radiolabeled with the separated n.c.a. ⁷²As in high yield.

Authors:

Feng, Yutian ^[1]; Phipps, Michael D. ^[1]; Phelps, Tim E. ^[1]; Okoye, Nkemakonam C. ^[1]; Baumeister, Jakob E. ^[1]; Wycoff, Donald E. ^[1]; Dorman, Eric F. ^[2]; Wooten, A. Lake ^[2]; Vlasenko, Vladislav ^[2]; Berendzen, Ashley F. ^[3]; Wilbur, D. Scott ^[2]; Hoffman, Timothy J. ^[3]; Cutler, Cathy S. ^[4]; Ketring, Alan R. ^[5]; Jurisson, Silvia S. ^[6]

Univ. of Missouri, Columbia, MO (United States)
Univ. of Washington, Seattle, WA (United States)
Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO (United States)
Brookhaven National Lab. (BNL), Upton, NY (United States)
Univ. of Missouri Research Reactor Center, Columbia, MO (United States)
Univ. of Missouri, Columbia, MO (United States); Univ. of Missouri Research Reactor Center, Columbia, MO (United States)

Publication Date:: Tue Oct 30 00:00:00 EDT 2018

Research Org.:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Nuclear Physics (NP)

OSTI Identifier:: 1489747

Alternate Identifier(s):: OSTI ID: 1636700

Report Number(s):: BNL-210844-2019-JAAM
Journal ID: ISSN 0969-8043

Grant/Contract Number:: SC0012704; SC0003851; SC0010283

Resource Type:: Accepted Manuscript

Journal Name:: Applied Radiation and Isotopes

Additional Journal Information:: Journal Volume: 143; Journal Issue: C; Journal ID: ISSN 0969-8043

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Subject:: 43 PARTICLE ACCELERATORS; 72Se; 72As; 72Se/72As generator; 70Ge target; Alpha irradiation; Radiolabeling

Citation Formats


                    Feng, Yutian, Phipps, Michael D., Phelps, Tim E., Okoye, Nkemakonam C., Baumeister, Jakob E., Wycoff, Donald E., Dorman, Eric F., Wooten, A. Lake, Vlasenko, Vladislav, Berendzen, Ashley F., Wilbur, D. Scott, Hoffman, Timothy J., Cutler, Cathy S., Ketring, Alan R., and Jurisson, Silvia S. Evaluation of 72Se/72As generator and production of 72Se for supplying 72As as a potential PET imaging radionuclide.  United States: N. p., 2018. 
Web.  doi:10.1016/j.apradiso.2018.10.026.

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                    Feng, Yutian, Phipps, Michael D., Phelps, Tim E., Okoye, Nkemakonam C., Baumeister, Jakob E., Wycoff, Donald E., Dorman, Eric F., Wooten, A. Lake, Vlasenko, Vladislav, Berendzen, Ashley F., Wilbur, D. Scott, Hoffman, Timothy J., Cutler, Cathy S., Ketring, Alan R., & Jurisson, Silvia S. Evaluation of 72Se/72As generator and production of 72Se for supplying 72As as a potential PET imaging radionuclide.  United States.  https://doi.org/10.1016/j.apradiso.2018.10.026

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                    Feng, Yutian, Phipps, Michael D., Phelps, Tim E., Okoye, Nkemakonam C., Baumeister, Jakob E., Wycoff, Donald E., Dorman, Eric F., Wooten, A. Lake, Vlasenko, Vladislav, Berendzen, Ashley F., Wilbur, D. Scott, Hoffman, Timothy J., Cutler, Cathy S., Ketring, Alan R., and Jurisson, Silvia S. Tue .  
"Evaluation of 72Se/72As generator and production of 72Se for supplying 72As as a potential PET imaging radionuclide".  United States.  https://doi.org/10.1016/j.apradiso.2018.10.026.  https://www.osti.gov/servlets/purl/1489747.

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@article{osti_1489747,

  title        = {Evaluation of 72Se/72As generator and production of 72Se for supplying 72As as a potential PET imaging radionuclide},

  author       = {Feng, Yutian and Phipps, Michael D. and Phelps, Tim E. and Okoye, Nkemakonam C. and Baumeister, Jakob E. and Wycoff, Donald E. and Dorman, Eric F. and Wooten, A. Lake and Vlasenko, Vladislav and Berendzen, Ashley F. and Wilbur, D. Scott and Hoffman, Timothy J. and Cutler, Cathy S. and Ketring, Alan R. and Jurisson, Silvia S.},

  abstractNote = {Here, positron-emitting 72As is the PET imaging counterpart for beta-emitting 77As. Its parent, no carrier added (n.c.a.) 72Se, was produced for a 72Se/72As generator by irradiating an enriched 7°Ge metal-graphite target via the 70Ge(α, 2 n)72Se reaction. Target dissolution used a fast, environmentally friendly method with 93% radioactivity recovery. Chromatographic parameters of the 72Se/72As generator were evaluated, the eluted n.c.a. 72As was characterized with a phantom imaging study, and the previously reported trithiol and aryl-dithiol ligand systems were radiolabeled with the separated n.c.a. 72As in high yield.},

  doi          = {10.1016/j.apradiso.2018.10.026},

  journal      = {Applied Radiation and Isotopes},

  number       = C,

  volume       = 143,

  place        = {United States},

  year         = {Tue Oct 30 00:00:00 EDT 2018},

  month        = {Tue Oct 30 00:00:00 EDT 2018}

}

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https://doi.org/10.1016/j.apradiso.2018.10.026

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Title: Evaluation of 72Se/72As generator and production of 72Se for supplying 72As as a potential PET imaging radionuclide

Abstract

Citation Formats

Title: Evaluation of ⁷²Se/⁷²As generator and production of ⁷²Se for supplying ⁷²As as a potential PET imaging radionuclide