Probiotic Lactobacillus acidophilus Strain INMIA 9602 Er 317/402 Administration Reduces the Numbers of Candida albicans and Abundance of Enterobacteria in the Gut Microbiota of Familial Mediterranean Fever Patients

doi:10.3389/fimmu.2018.01426

Title: Probiotic Lactobacillus acidophilus Strain INMIA 9602 Er 317/402 Administration Reduces the Numbers of Candida albicans and Abundance of Enterobacteria in the Gut Microbiota of Familial Mediterranean Fever Patients

Full Record
Other Related Research

Abstract

Intestinal microorganisms play a crucial role in health and disease. The disruption of host–microbiota homeostasis has been reported to occur not only during disease development but also as a result of medication. Familial Mediterranean fever (FMF) is an inflammatory genetic disease characterized by elevated systemic reactivity against the commensal gut microbiota and high levels of Candida albicans in the gut. This study’s major objective was to investigate the effects of commercial probiotic Narine on the relative abundance of gut bacteria (specifically, enterobacteria, lactobacilli, Staphylococcus aureus, and enterococci) of C. albicans carrier and non-carrier FMF patients in remission. Our main finding indicates that the probiotic reduces numbers of C. albicans and abundance of enterobacteria in male and female patients of C. albicans carriers and non-carriers. It has pivotal effect on Enterococcus faecalis: increase in male non-carriers and decrease in female ones regardless of C. albicans status. No effect was seen for Lactobacillus and S. aureus. Our data suggest that M694V/V726A pyrin inflammasome mutations leading to FMF disease may contribute to gender-specific differences in microbial community structure in FMF patients. The study’s secondary objective was to elucidate the gender-specific differences in the gut’s microbial community of FMF patients. The tendency was detectedmore »« less

Authors:

Pepoyan, Astghik ^[1]; Balayan, Marine ^[2]; Manvelyan, Anahit ^[1]; Galstyan, Lilit ^[3]; Pepoyan, Sofi ^[2]; Petrosyan, Susanna ^[4]; Tsaturyan, Vardan ^[3]; Kamiya, Shigeru ^[5]; Torok, Tamas ^[6]; Chikindas, Michael ^[7]

Armenian National Agrarian Univ., Yerevan (Armenia). Dept. of Food Safety and Biotechnology
International Association for Human and Animals Health Improvement, Yerevan (Armenia)
Yerevan State Medical Univ., Yerevan (Armenia)
Armenian National Agrarian Univ., Yerevan (Armenia)
Kyorin Univ., Tokyo (Japan). School of Medicine
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Rutgers Univ., New Brunswick, NJ (United States). Health Promoting Naturals Lab. School of Environmental and Biological Sciences

Publication Date:: 2018-06-26

Research Org.:: Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Armenian National Agrarian Univ., Yerevan (Armenia); International Association for Human and Animals Health Improvement, Yerevan (Armenia)

Sponsoring Org.:: USDOE National Nuclear Security Administration (NNSA), Office of Defense Nuclear Nonproliferation (NA-20); International Science and Technology Center (ISTC)

OSTI Identifier:: 1489661

Grant/Contract Number:: AC02-05CH11231; A-1980; A-2134

Resource Type:: Accepted Manuscript

Journal Name:: Frontiers in Immunology

Additional Journal Information:: Journal Volume: 9; Journal ID: ISSN 1664-3224

Publisher:: Frontiers Research Foundation

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES; familial Mediterranean fever; M694V/V726A mutations; gut microbiota; gender; Candida albicans; Lactobacillus acidophilus INMIA 9602 Er 317/402; Enteroccocus faecalis; Enterobacteriaceae

Citation Formats


                    Pepoyan, Astghik, Balayan, Marine, Manvelyan, Anahit, Galstyan, Lilit, Pepoyan, Sofi, Petrosyan, Susanna, Tsaturyan, Vardan, Kamiya, Shigeru, Torok, Tamas, and Chikindas, Michael. Probiotic Lactobacillus acidophilus Strain INMIA 9602 Er 317/402 Administration Reduces the Numbers of Candida albicans and Abundance of Enterobacteria in the Gut Microbiota of Familial Mediterranean Fever Patients.  United States: N. p., 2018. 
        Web.  doi:10.3389/fimmu.2018.01426.

Copy to clipboard


                    Pepoyan, Astghik, Balayan, Marine, Manvelyan, Anahit, Galstyan, Lilit, Pepoyan, Sofi, Petrosyan, Susanna, Tsaturyan, Vardan, Kamiya, Shigeru, Torok, Tamas, & Chikindas, Michael. Probiotic Lactobacillus acidophilus Strain INMIA 9602 Er 317/402 Administration Reduces the Numbers of Candida albicans and Abundance of Enterobacteria in the Gut Microbiota of Familial Mediterranean Fever Patients.  United States.  doi:10.3389/fimmu.2018.01426.

Copy to clipboard


                    Pepoyan, Astghik, Balayan, Marine, Manvelyan, Anahit, Galstyan, Lilit, Pepoyan, Sofi, Petrosyan, Susanna, Tsaturyan, Vardan, Kamiya, Shigeru, Torok, Tamas, and Chikindas, Michael. Tue .  
        "Probiotic Lactobacillus acidophilus Strain INMIA 9602 Er 317/402 Administration Reduces the Numbers of Candida albicans and Abundance of Enterobacteria in the Gut Microbiota of Familial Mediterranean Fever Patients".  United States.  doi:10.3389/fimmu.2018.01426.  https://www.osti.gov/servlets/purl/1489661.

Copy to clipboard


                    
@article{osti_1489661,

  title        = {Probiotic Lactobacillus acidophilus Strain INMIA 9602 Er 317/402 Administration Reduces the Numbers of Candida albicans and Abundance of Enterobacteria in the Gut Microbiota of Familial Mediterranean Fever Patients},

  author       = {Pepoyan, Astghik and Balayan, Marine and Manvelyan, Anahit and Galstyan, Lilit and Pepoyan, Sofi and Petrosyan, Susanna and Tsaturyan, Vardan and Kamiya, Shigeru and Torok, Tamas and Chikindas, Michael},

  abstractNote = {Intestinal microorganisms play a crucial role in health and disease. The disruption of host–microbiota homeostasis has been reported to occur not only during disease development but also as a result of medication. Familial Mediterranean fever (FMF) is an inflammatory genetic disease characterized by elevated systemic reactivity against the commensal gut microbiota and high levels of Candida albicans in the gut. This study’s major objective was to investigate the effects of commercial probiotic Narine on the relative abundance of gut bacteria (specifically, enterobacteria, lactobacilli, Staphylococcus aureus, and enterococci) of C. albicans carrier and non-carrier FMF patients in remission. Our main finding indicates that the probiotic reduces numbers of C. albicans and abundance of enterobacteria in male and female patients of C. albicans carriers and non-carriers. It has pivotal effect on Enterococcus faecalis: increase in male non-carriers and decrease in female ones regardless of C. albicans status. No effect was seen for Lactobacillus and S. aureus. Our data suggest that M694V/V726A pyrin inflammasome mutations leading to FMF disease may contribute to gender-specific differences in microbial community structure in FMF patients. The study’s secondary objective was to elucidate the gender-specific differences in the gut’s microbial community of FMF patients. The tendency was detected for higher counts of enterobacteria in female FMF subjects. However, the small number of patients of these groups preclude from conclusive statements, pointing at the need for additional investigations with appropriate for statistical analysis groups of subjects involved in the study.},

  doi          = {10.3389/fimmu.2018.01426},

  journal      = {Frontiers in Immunology},

  number       = ,

  volume       = 9,

  place        = {United States},

  year         = {2018},

  month        = {6}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (DOE)

Publisher's Version of Record

DOI: 10.3389/fimmu.2018.01426

Other availability

Search WorldCat to find libraries that may hold this journal

Citation Metrics:

Cited by: 2 works

Citation information provided by
Web of Science

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

Uniparental disomy of chromosome 16 in offsprings of Familial Mediterranean Fever (FMF) patients treated with colchicine

Journal Article Korenstein, A. ; Avivi, L. ; Ravia, Y. - American Journal of Human Genetics

Uniparental disomy (UPD), an altered mode of Mendelian inheritance, may reveal expression of recessive alleles due to the loss of heterozygosity, as well as imprinted genes. The mechanism causing UPD can be best elucidated in offsprings of individuals at high risk for chromosomal non-disjunction. Such individuals are Familial Mediterranean Fever (FMF) patients, who are routinely treated with the antimitotic agent colchicine, and, therefore, are expected to be at an increased risk for aneuploidy. A dominant mode of inheritance was observed in four FMF offsprings having one parent exhibiting the FMF phenotype (homozygote recessive) while the other was free of themore »« less
Complete Genome Sequence of $Lactobacillus$ $plantarum$ Oregon-R-modENCODE Strain BDGP2 Isolated from $Drosophila$ $melanogaster$ Gut

Journal Article Wan, Kenneth H. ; Yu, Charles ; Park, Soo ; ... - Genome Announcements

$Lactobacillus$ $plantarum$ Oregon-R-modENCODE strain BDGP2 was isolated from the gut of $Drosophila$ $melanogaster$ for functional host microbial interaction studies. Here, the complete genome comprised a single circular genome of 3,407,160 bp, with a G+C content of 44%, and four plasmids.
DOI: 10.1128/genomeA.01155-17

Full Text Available
Investigating intestinal permeability and gut microbiota roles in acute coronary syndrome patients

Journal Article Alhmoud, Tarik ; Kumar, Anand ; Lo, Chien-Chi ; ... - Human Microbiome Journal

Acute Coronary Syndrome (ACS) is a prime cause of morbidity and mortality. Perturbed gutmicrobiota (dysbiosis) and increased intestinal permeability (leaky-gut) with translocation of bacterial antigens, play critical role in obesity and metabolic syndrome, which are also major ACS risk factors. Additionally, Trimethylamine-N-Oxide (TMAO), a metabolite produced by phylum Proteobacteria in gut is implicated in developing ACS. As Proteobacteria is a major source of translocated antigen lipopolysaccharides (LPS), we hypothesized that ACS patients have leaky-gut condition characterized by dysbiosis with increased Proteobacteria, leading to elevated blood levels of TMAO and LPS. Methods: In a pilot case-control study, we enrolled 19 ACSmore »« less
DOI: 10.1016/j.humic.2019.100059

Full Text Available
Evaluation of β-galactosidase from Lactobacillus acidophilus as biocatalyst for galacto-oligosaccharides synthesis: Product structural characterization and enzyme immobilization

Journal Article Carevic, Milica ; Vukasinovic-Sekulic, Maja ; Corovic, Marija ; ... - Journal of Bioscience and Bioengineering

β-Galactosidase is an important industrial enzyme that catalyzes reaction of lactose hydrolysis and recently more interesting reaction of transgalactosylation, yielding a highly valuable group of prebiotic compounds named galacto-oligosaccharides (GOS). In this paper, parameters for achieving high yields of tailor-made GOS using crude β-galactosidase obtained from Lactobacillus acidophilus ATCC 4356, probiotic bacteria regarded as safe for human consumption, were optimized. At the same time, detailed structural elucidation of obtained GOS was conducted, and it was concluded that β-galactosidase from L. acidophilus shows a particular specificity towards the formation of β-(1 → 6) glycosidic bonds. In order to develop more stablemore »« less
Cited by 1
DOI: 10.1016/j.jbiosc.2018.06.003

Full Text Available
β-(1,3)-Glucan Unmasking in Some Candida albicans Mutants Correlates with Increases in Cell Wall Surface Roughness and Decreases in Cell Wall Elasticity

Journal Article Hasim, Sahar ; Allison, David P. ; Retterer, Scott T. ; ... - Infection and Immunity

Candida albicans is among the most common human fungal pathogens, causing a broad range of infections, including life-threatening systemic infections. The cell wall of C. albicans is the interface between the fungus and the innate immune system. The cell wall is composed of an outer layer enriched in mannosylated glycoproteins (mannan) and an inner layer enriched in β-(1,3)-glucan and chitin. Detection of C. albicans by Dectin-1, a C-type signaling lectin specific for β-(1,3)-glucan, is important for the innate immune system to recognize systemic fungal infections. Increased exposure of β-(1,3)-glucan to the immune system occurs when the mannan layer is alteredmore »« less
Cited by 5
DOI: 10.1128/IAI.00601-16

Full Text Available

Similar Records