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Title: Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae

The substantial research efforts into lignocellulosic biofuels have generated an abundance of valuable knowledge and technologies for metabolic engineering. In particular, these investments have led to a vast growth in proficiency of engineering the yeast Saccharomyces cerevisiae for consuming lignocellulosic sugars, enabling the simultaneous assimilation of multiple carbon sources, and producing a large variety of value-added products by introduction of heterologous metabolic pathways. While microbial conversion of cellulosic sugars into large-volume low-value biofuels is not currently economically feasible, there may still be opportunities to produce other value-added chemicals as regulation of cellulosic sugar metabolism is quite different from glucose metabolism. Furthermore, this review summarizes these recent advances with an emphasis on employing engineered yeast for the bioconversion of lignocellulosic sugars into a variety of non-ethanol value-added products.
Authors:
 [1] ;  [1] ;  [1]
  1. Univ. of Illinois at Urbana-Champaign, Urbana, IL (United States)
Publication Date:
Grant/Contract Number:
SC0018420
Type:
Accepted Manuscript
Journal Name:
Bioresource Technology
Additional Journal Information:
Journal Volume: 260; Journal Issue: C; Journal ID: ISSN 0960-8524
Publisher:
Elsevier
Research Org:
Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), Urbana, IL (United States)
Sponsoring Org:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Saccharomyces cerevisiae; metabolic engineering; synthetic biology; fermentation; lignocellulosic biofuels
OSTI Identifier:
1489217

Lane, Stephan, Dong, Jia, and Jin, Yong -Su. Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae. United States: N. p., Web. doi:10.1016/j.biortech.2018.04.013.
Lane, Stephan, Dong, Jia, & Jin, Yong -Su. Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae. United States. doi:10.1016/j.biortech.2018.04.013.
Lane, Stephan, Dong, Jia, and Jin, Yong -Su. 2018. "Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae". United States. doi:10.1016/j.biortech.2018.04.013. https://www.osti.gov/servlets/purl/1489217.
@article{osti_1489217,
title = {Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae},
author = {Lane, Stephan and Dong, Jia and Jin, Yong -Su},
abstractNote = {The substantial research efforts into lignocellulosic biofuels have generated an abundance of valuable knowledge and technologies for metabolic engineering. In particular, these investments have led to a vast growth in proficiency of engineering the yeast Saccharomyces cerevisiae for consuming lignocellulosic sugars, enabling the simultaneous assimilation of multiple carbon sources, and producing a large variety of value-added products by introduction of heterologous metabolic pathways. While microbial conversion of cellulosic sugars into large-volume low-value biofuels is not currently economically feasible, there may still be opportunities to produce other value-added chemicals as regulation of cellulosic sugar metabolism is quite different from glucose metabolism. Furthermore, this review summarizes these recent advances with an emphasis on employing engineered yeast for the bioconversion of lignocellulosic sugars into a variety of non-ethanol value-added products.},
doi = {10.1016/j.biortech.2018.04.013},
journal = {Bioresource Technology},
number = C,
volume = 260,
place = {United States},
year = {2018},
month = {4}
}