Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae

Lane, Stephan; Dong, Jia; Jin, Yong -Su

doi:10.1016/j.biortech.2018.04.013

Title: Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae

Journal Article · 07 April 2018 · Bioresource Technology

DOI: https://doi.org/10.1016/j.biortech.2018.04.013 · OSTI ID:1489217

Lane, Stephan ^[1]; Dong, Jia ^[1]; Jin, Yong -Su ^[1]

Univ. of Illinois at Urbana-Champaign, Urbana, IL (United States)

The substantial research efforts into lignocellulosic biofuels have generated an abundance of valuable knowledge and technologies for metabolic engineering. In particular, these investments have led to a vast growth in proficiency of engineering the yeast Saccharomyces cerevisiae for consuming lignocellulosic sugars, enabling the simultaneous assimilation of multiple carbon sources, and producing a large variety of value-added products by introduction of heterologous metabolic pathways. While microbial conversion of cellulosic sugars into large-volume low-value biofuels is not currently economically feasible, there may still be opportunities to produce other value-added chemicals as regulation of cellulosic sugar metabolism is quite different from glucose metabolism. Furthermore, this review summarizes these recent advances with an emphasis on employing engineered yeast for the bioconversion of lignocellulosic sugars into a variety of non-ethanol value-added products.

View Accepted Manuscript (DOE)

View Accepted Manuscript (Publisher)

Cite

Export

Save

Research Organization:: Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), Urbana, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0018420

OSTI ID:: 1489217

Alternate ID(s):: OSTI ID: 1991832; OSTI ID: 2396777

Journal Information:: Bioresource Technology, Vol. 260, Issue C; ISSN 0960-8524

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

References (129)

Modification of metabolic pathways of Saccharomyces cerevisiae by the expression of lactate dehydrogenase and deletion of pyruvate decarboxylase genes for the lactic acid fermentation at low pH value Adachi, Eri; Torigoe, Mikiko; Sugiyama, Minetaka Journal of Fermentation and Bioengineering, Vol. 86, Issue 3 https://doi.org/10.1016/S0922-338X(98)80131-1	journal	January 1998
Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols Avalos, José L.; Fink, Gerald R.; Stephanopoulos, Gregory Nature Biotechnology, Vol. 31, Issue 4 https://doi.org/10.1038/nbt.2509	journal	February 2013
Deletion of the HXK2 gene in Saccharomyces cerevisiae enables mixed sugar fermentation of glucose and galactose in oxygen-limited conditions Bae, Yi-Hyun; Kweon, Dae-Hyuk; Park, Yong-Cheol Process Biochemistry, Vol. 49, Issue 4 https://doi.org/10.1016/j.procbio.2014.01.030	journal	April 2014
Eco-friendly dry chemo-mechanical pretreatments of lignocellulosic biomass: Impact on energy and yield of the enzymatic hydrolysis Barakat, Abdellatif; Chuetor, Santi; Monlau, Florian Applied Energy, Vol. 113 https://doi.org/10.1016/j.apenergy.2013.07.015	journal	January 2014
Xylose reductase from Pichia stipitis with altered coenzyme preference improves ethanolic xylose fermentation by recombinant Saccharomyces cerevisiae Bengtsson, Oskar; Hahn-Hägerdal, Bärbel; Gorwa-Grauslund, Marie F. Biotechnology for Biofuels, Vol. 2, Issue 1 https://doi.org/10.1186/1754-6834-2-9	journal	January 2009
Modeling simultaneous glucose and xylose uptake in Saccharomyces cerevisiae from kinetics and gene expression of sugar transporters Bertilsson, Magnus; Andersson, Jonas; Lidén, Gunnar Bioprocess and Biosystems Engineering, Vol. 31, Issue 4 https://doi.org/10.1007/s00449-007-0169-1	journal	November 2007
Arabinose and xylose fermentation by recombinant Saccharomyces cerevisiae expressing a fungal pentose utilization pathway Bettiga, Maurizio; Bengtsson, Oskar; Hahn-Hägerdal, Bärbel Microbial Cell Factories, Vol. 8, Issue 1 https://doi.org/10.1186/1475-2859-8-40	journal	January 2009
Advances in metabolic engineering of yeast Saccharomyces cerevisiae for production of chemicals Borodina, Irina; Nielsen, Jens Biotechnology Journal, Vol. 9, Issue 5 https://doi.org/10.1002/biot.201300445	journal	February 2014
Isobutanol production from d -xylose by recombinant Saccharomyces cerevisiae Brat, Dawid; Boles, Eckhard FEMS Yeast Research, Vol. 13, Issue 2 https://doi.org/10.1111/1567-1364.12028	journal	January 2013
Functional Expression of a Bacterial Xylose Isomerase in Saccharomyces cerevisiae Brat, D.; Boles, E.; Wiedemann, B. Applied and Environmental Microbiology, Vol. 75, Issue 8 https://doi.org/10.1128/AEM.02522-08	journal	February 2009
Miscanthus : a fast-growing crop for biofuels and chemicals production : A fast-growing crop for biofuels and chemicals production Brosse, Nicolas; Dufour, Anthony; Meng, Xianzhi Biofuels, Bioproducts and Biorefining, Vol. 6, Issue 5 https://doi.org/10.1002/bbb.1353	journal	July 2012
The role of redox balances in the anaerobic fermentation of xylose by yeasts Bruinenberg, Peter M.; Bot, Peter H. M.; Dijken, Johannes P. European Journal of Applied Microbiology and Biotechnology, Vol. 18, Issue 5 https://doi.org/10.1007/BF00500493	journal	January 1983
Dynamic response of the expression of hxt1, hxt5 and hxt7 transport proteins in Saccharomyces cerevisiae to perturbations in the extracellular glucose concentration Buziol, S.; Warth, L.; Magario, I. Journal of Biotechnology, Vol. 134, Issue 3-4 https://doi.org/10.1016/j.jbiotec.2008.02.002	journal	April 2008
Exploring xylose metabolism in Spathaspora species: XYL1.2 from Spathaspora passalidarum as the key for efficient anaerobic xylose fermentation in metabolic engineered Saccharomyces cerevisiae Cadete, Raquel M.; de las Heras, Alejandro M.; Sandström, Anders G. Biotechnology for Biofuels, Vol. 9, Issue 1 https://doi.org/10.1186/s13068-016-0570-6	journal	August 2016
Transcriptional profiling reveals molecular basis and novel genetic targets for improved resistance to multiple fermentation inhibitors in Saccharomyces cerevisiae Chen, Yingying; Sheng, Jiayuan; Jiang, Tao Biotechnology for Biofuels, Vol. 9, Issue 1 https://doi.org/10.1186/s13068-015-0418-5	journal	January 2016
Enhanced production of 2,3‐butanediol in pyruvate decarboxylase‐deficient Saccharomyces cerevisiae through optimizing ratio of glucose/galactose Choi, Eun‐Ji; Kim, Jin‐Woo; Kim, Soo‐Jung Biotechnology Journal, Vol. 11, Issue 11 https://doi.org/10.1002/biot.201600042	journal	September 2016
Overcoming inefficient cellobiose fermentation by cellobiose phosphorylase in the presence of xylose Chomvong, Kulika; Kordić, Vesna; Li, Xin Biotechnology for Biofuels, Vol. 7, Issue 1 https://doi.org/10.1186/1754-6834-7-85	journal	January 2014
Control of lactate production by Saccharomyces cerevisiae expressing a bacterial LDH gene Colombié, S.; Dequin, S.; Sablayrolles, J. M. Enzyme and Microbial Technology, Vol. 33, Issue 1 https://doi.org/10.1016/S0141-0229(03)00082-6	journal	July 2003
Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae Conrad, Michaela; Schothorst, Joep; Kankipati, Harish Nag FEMS Microbiology Reviews, Vol. 38, Issue 2 https://doi.org/10.1111/1574-6976.12065	journal	March 2014
Switchgrass as an energy crop for biofuel production: A review of its ligno-cellulosic chemical properties David, Kasi; Ragauskas, Arthur J. Energy & Environmental Science, Vol. 3, Issue 9 https://doi.org/10.1039/b926617h	journal	January 2010
Anaerobic poly-3-d-hydroxybutyrate production from xylose in recombinant Saccharomyces cerevisiae using a NADH-dependent acetoacetyl-CoA reductase de las Heras, Alejandro Muñoz; Portugal-Nunes, Diogo J.; Rizza, Nathasha Microbial Cell Factories, Vol. 15, Issue 1 https://doi.org/10.1186/s12934-016-0598-0	journal	November 2016
The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression Diaz-Ruiz, Rodrigo; Rigoulet, Michel; Devin, Anne Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol. 1807, Issue 6 https://doi.org/10.1016/j.bbabio.2010.08.010	journal	June 2011
Synthetic protein scaffolds provide modular control over metabolic flux Dueber, John E.; Wu, Gabriel C.; Malmirchegini, G. Reza Nature Biotechnology, Vol. 27, Issue 8, p. 753-759 https://doi.org/10.1038/nbt.1557	journal	August 2009
Anaerobic Xylose Fermentation by Recombinant Saccharomyces cerevisiae Carrying XYL1, XYL2, and XKS1 in Mineral Medium Chemostat Cultures Eliasson, A.; Christensson, C.; Wahlbom, C. F. Applied and Environmental Microbiology, Vol. 66, Issue 8 https://doi.org/10.1128/AEM.66.8.3381-3386.2000	journal	August 2000
Galactose metabolic genes in yeast respond to a ratio of galactose and glucose Escalante-Chong, Renan; Savir, Yonatan; Carroll, Sean M. Proceedings of the National Academy of Sciences, Vol. 112, Issue 5 https://doi.org/10.1073/pnas.1418058112	journal	January 2015
Engineering of yeast hexose transporters to transport D-xylose without inhibition by D-glucose Farwick, A.; Bruder, S.; Schadeweg, V. Proceedings of the National Academy of Sciences, Vol. 111, Issue 14 https://doi.org/10.1073/pnas.1323464111	journal	March 2014
Metabolic engineering of Saccharomyces cerevisiae to improve 1-hexadecanol production Feng, Xueyang; Lian, Jiazhang; Zhao, Huimin Metabolic Engineering, Vol. 27 https://doi.org/10.1016/j.ymben.2014.10.001	journal	January 2015
Cellodextrin Transport in Yeast for Improved Biofuel Production Galazka, J. M.; Tian, C.; Beeson, W. T. Science, Vol. 330, Issue 6000 https://doi.org/10.1126/science.1192838	journal	September 2010
Functional profiling of the Saccharomyces cerevisiae genome Giaever, Guri; Chu, Angela M.; Ni, Li Nature, Vol. 418, Issue 6896 https://doi.org/10.1038/nature00935	journal	July 2002
Cell surface engineering of Saccharomyces cerevisiae combined with membrane separation technology for xylitol production from rice straw hydrolysate Guirimand, Gregory; Sasaki, Kengo; Inokuma, Kentaro Applied Microbiology and Biotechnology, Vol. 100, Issue 8 https://doi.org/10.1007/s00253-015-7179-8	journal	December 2015
Metabolic engineering of Saccharomyces cerevisiae to produce 1-hexadecanol from xylose Guo, Weihua; Sheng, Jiayuan; Zhao, Huimin Microbial Cell Factories, Vol. 15, Issue 1 https://doi.org/10.1186/s12934-016-0423-9	journal	February 2016
Dynamic regulation of metabolic flux in engineered bacteria using a pathway-independent quorum-sensing circuit Gupta, Apoorv; Reizman, Irene M. Brockman; Reisch, Christopher R. Nature Biotechnology, Vol. 35, Issue 3 https://doi.org/10.1038/nbt.3796	journal	February 2017
Engineered Saccharomyces cerevisiae capable of simultaneous cellobiose and xylose fermentation Ha, S. -J.; Galazka, J. M.; Rin Kim, S. Proceedings of the National Academy of Sciences, Vol. 108, Issue 2 https://doi.org/10.1073/pnas.1010456108	journal	December 2010
Energetic benefits and rapid cellobiose fermentation by Saccharomyces cerevisiae expressing cellobiose phosphorylase and mutant cellodextrin transporters Ha, Suk-Jin; Galazka, Jonathan M.; Joong Oh, Eun Metabolic Engineering, Vol. 15 https://doi.org/10.1016/j.ymben.2012.11.005	journal	January 2013
Harnessing yeast organelles for metabolic engineering Hammer, Sarah K.; Avalos, José L. Nature Chemical Biology, Vol. 13, Issue 8 https://doi.org/10.1038/nchembio.2429	journal	July 2017
Development of yeast cell factories for consolidated bioprocessing of lignocellulose to bioethanol through cell surface engineering Hasunuma, Tomohisa; Kondo, Akihiko Biotechnology Advances, Vol. 30, Issue 6 https://doi.org/10.1016/j.biotechadv.2011.10.011	journal	November 2012
Chemical profiles of switchgrass Hu, Zhoujian; Sykes, Robert; Davis, Mark F. Bioresource Technology, Vol. 101, Issue 9 https://doi.org/10.1016/j.biortech.2009.12.033	journal	May 2010
High level secretion of cellobiohydrolases by Saccharomyces cerevisiae Ilmén, Marja; den Haan, Riaan; Brevnova, Elena Biotechnology for Biofuels, Vol. 4, Issue 1 https://doi.org/10.1186/1754-6834-4-30	journal	January 2011
Dual utilization of NADPH and NADH cofactors enhances xylitol production in engineered Saccharomyces cerevisiae Jo, Jung-Hyun; Oh, Sun-Young; Lee, Hyeun-Soo Biotechnology Journal, Vol. 10, Issue 12 https://doi.org/10.1002/biot.201500068	journal	November 2015
Glucose repression in Saccharomyces cerevisiae Kayikci, Ömur; Nielsen, Jens FEMS Yeast Research, Vol. 15, Issue 6 https://doi.org/10.1093/femsyr/fov068	journal	July 2015
Production of 3-hydroxypropionic acid from glucose and xylose by metabolically engineered Saccharomyces cerevisiae Kildegaard, Kanchana R.; Wang, Zheng; Chen, Yun Metabolic Engineering Communications, Vol. 2 https://doi.org/10.1016/j.meteno.2015.10.001	journal	December 2015
Analysis of cellodextrin transporters from Neurospora crassa in Saccharomyces cerevisiae for cellobiose fermentation Kim, Heejin; Lee, Won-Heong; Galazka, Jonathan M. Applied Microbiology and Biotechnology, Vol. 98, Issue 3 https://doi.org/10.1007/s00253-013-5339-2	journal	November 2013
Composition of sugar cane, energy cane, and sweet sorghum suitable for ethanol production at Louisiana sugar mills Kim, Misook; Day, Donal F. Journal of Industrial Microbiology & Biotechnology, Vol. 38, Issue 7 https://doi.org/10.1007/s10295-010-0812-8	journal	August 2010
Production of 2,3-butanediol from xylose by engineered Saccharomyces cerevisiae Kim, Soo-Jung; Seo, Seung-Oh; Park, Yong-Cheol Journal of Biotechnology, Vol. 192 https://doi.org/10.1016/j.jbiotec.2013.12.017	journal	December 2014
Enhanced production of 2,3-butanediol from xylose by combinatorial engineering of xylose metabolic pathway and cofactor regeneration in pyruvate decarboxylase-deficient Saccharomyces cerevisiae Kim, Soo-Jung; Sim, Hee-Jin; Kim, Jin-Woo Bioresource Technology, Vol. 245 https://doi.org/10.1016/j.biortech.2017.06.034	journal	December 2017
Metabolic engineering of Saccharomyces cerevisiae for production of spermidine under optimal culture conditions Kim, Sun-Ki; Jo, Jung-Hyun; Park, Yong-Cheol Enzyme and Microbial Technology, Vol. 101 https://doi.org/10.1016/j.enzmictec.2017.03.008	journal	June 2017
Xylitol production by Saccharomyces cerevisiae overexpressing different xylose reductases using non-detoxified hemicellulosic hydrolysate of corncob Kogje, Anushree; Ghosalkar, Anand 3 Biotech, Vol. 6, Issue 2 https://doi.org/10.1007/s13205-016-0444-4	journal	June 2016
Xylitol production by genetically modified industrial strain of Saccharomyces cerevisiae using glycerol as co-substrate Kogje, Anushree B.; Ghosalkar, Anand Journal of Industrial Microbiology and Biotechnology, Vol. 44, Issue 6 https://doi.org/10.1007/s10295-017-1914-3	journal	June 2017
Glycolic acid production in the engineered yeasts Saccharomyces cerevisiae and Kluyveromyces lactis Koivistoinen, Outi M.; Kuivanen, Joosu; Barth, Dorothee Microbial Cell Factories, Vol. 12, Issue 1 https://doi.org/10.1186/1475-2859-12-82	journal	January 2013
Catabolite inactivation of the high-affinity hexose transporters Hxt6 and Hxt7 of Saccharomyces cerevisiae occurs in the vacuole after internalization by endocytosis ¹ Krampe, Stefanie; Stamm, Olaf; Hollenberg, Cornelis P. FEBS Letters, Vol. 441, Issue 3 https://doi.org/10.1016/S0014-5793(98)01583-X	journal	December 1998
Properties of Sugar-Free Cookies with Xylitol, Sucralose, Acesulfame K and Their Blends: Sugar-Free Cookies with Xylitol, Sucralose and Acesulfame K Kutyła-Kupidura, Edyta Maja; Sikora, Marek; Krystyjan, Magdalena Journal of Food Process Engineering, Vol. 39, Issue 4 https://doi.org/10.1111/jfpe.12222	journal	April 2015
Metabolic engineering of a xylose-isomerase-expressing strain for rapid anaerobic xylose fermentation Kuyper, Marko; Hartog, Miranda; Toirkens, Maurice FEMS Yeast Research, Vol. 5, Issue 4-5, p. 399-409 https://doi.org/10.1016/j.femsyr.2004.09.010	journal	February 2005
Production of fuels and chemicals from xylose by engineered Saccharomyces cerevisiae: a review and perspective Kwak, Suryang; Jin, Yong-Su Microbial Cell Factories, Vol. 16, Issue 1 https://doi.org/10.1186/s12934-017-0694-9	journal	May 2017
Enhanced isoprenoid production from xylose by engineered Saccharomyces cerevisiae : Enhanced Yeast Isoprenoid Production from Xylose Kwak, Suryang; Kim, Soo Rin; Xu, Haiqing Biotechnology and Bioengineering, Vol. 114, Issue 11 https://doi.org/10.1002/bit.26369	journal	July 2017
Glucose repression can be alleviated by reducing glucose phosphorylation rate in Saccharomyces cerevisiae Lane, Stephan; Xu, Haiqing; Oh, Eun Joong Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-20804-4	journal	February 2018
Two glucose/xylose transporter genes from the yeast Candida intermedia: first molecular characterization of a yeast xylose–H⁺ symporter Leandro, Maria José; Gonçalves, Paula; Spencer-Martins, Isabel Biochemical Journal, Vol. 395, Issue 3, p. 543-549 https://doi.org/10.1042/BJ20051465	journal	May 2006
Effect of harvesting date on the composition and saccharification of Miscanthus x giganteus Le Ngoc Huyen, T.; Rémond, C.; Dheilly, R. M. Bioresource Technology, Vol. 101, Issue 21 https://doi.org/10.1016/j.biortech.2010.05.087	journal	November 2010
Simultaneous saccharification and fermentation by engineered Saccharomyces cerevisiae without supplementing extracellular β-glucosidase Lee, Won-Heong; Nan, Hong; Kim, Hyo Jin Journal of Biotechnology, Vol. 167, Issue 3 https://doi.org/10.1016/j.jbiotec.2013.06.016	journal	September 2013
Enabling glucose/xylose co-transport in yeast through the directed evolution of a sugar transporter Li, Haibo; Schmitz, Olivia; Alper, Hal S. Applied Microbiology and Biotechnology, Vol. 100, Issue 23 https://doi.org/10.1007/s00253-016-7879-8	journal	October 2016
Comparison of xylose fermentation by two high-performance engineered strains of Saccharomyces cerevisiae Li, Xin; Park, Annsea; Estrela, Raissa Biotechnology Reports, Vol. 9 https://doi.org/10.1016/j.btre.2016.01.003	journal	March 2016
Direct and efficient xylitol production from xylan by Saccharomyces cerevisiae through transcriptional level and fermentation processing optimizations Li, Zhe; Qu, Hongnan; Li, Chun Bioresource Technology, Vol. 149 https://doi.org/10.1016/j.biortech.2013.09.101	journal	December 2013
Metabolic engineering of a Saccharomyces cerevisiae strain capable of simultaneously utilizing glucose and galactose to produce enantiopure (2R,3R)-butanediol Lian, Jiazhang; Chao, Ran; Zhao, Huimin Metabolic Engineering, Vol. 23 https://doi.org/10.1016/j.ymben.2014.02.003	journal	May 2014
Elucidating Xylose Metabolism of Scheffersomyces stipitis for Lignocellulosic Ethanol Production Liang, Meng; Damiani, Andrew; He, Q. Peter ACS Sustainable Chemistry & Engineering, Vol. 2, Issue 1 https://doi.org/10.1021/sc400265g	journal	November 2013
Improvement of ethanol production from crystalline cellulose via optimizing cellulase ratios in cellulolytic Saccharomyces cerevisiae : Higher Ethanol Yield in Cellulase-Displaying Yeast Liu, Zhuo; Inokuma, Kentaro; Ho, Shih-Hsin Biotechnology and Bioengineering, Vol. 114, Issue 6 https://doi.org/10.1002/bit.26252	journal	March 2017
Combined cell-surface display- and secretion-based strategies for production of cellulosic ethanol with Saccharomyces cerevisiae Liu, Zhuo; Inokuma, Kentaro; Ho, Shih-Hsin Biotechnology for Biofuels, Vol. 8, Issue 1 https://doi.org/10.1186/s13068-015-0344-6	journal	September 2015
The grand challenge of cellulosic biofuels Lynd, Lee R. Nature Biotechnology, Vol. 35, Issue 10 https://doi.org/10.1038/nbt.3976	journal	October 2017
A review of thermal–chemical conversion of lignocellulosic biomass in China Ma, Longlong; Wang, Tiejun; Liu, Qiying Biotechnology Advances, Vol. 30, Issue 4 https://doi.org/10.1016/j.biotechadv.2012.01.016	journal	July 2012
Transcriptome of Saccharomyces cerevisiae during production of D-xylonate Mojzita, Dominik; Oja, Merja; Rintala, Eija BMC Genomics, Vol. 15, Issue 1 https://doi.org/10.1186/1471-2164-15-763	journal	January 2014
Overexpression of yeast spermidine synthase impacts ripening, senescence and decay symptoms in tomato: Polyamines enhance shelf life in tomato Nambeesan, Savithri; Datsenka, Tatsiana; Ferruzzi, Mario G. The Plant Journal, Vol. 63, Issue 5 https://doi.org/10.1111/j.1365-313X.2010.04286.x	journal	August 2010
2,3-Butanediol production from cellobiose by engineered Saccharomyces cerevisiae Nan, Hong; Seo, Seung-Oh; Oh, Eun Joong Applied Microbiology and Biotechnology, Vol. 98, Issue 12 https://doi.org/10.1007/s00253-014-5683-x	journal	April 2014
Metabolic engineering of yeast for production of fuels and chemicals Nielsen, Jens; Larsson, Christer; van Maris, Antonius Current Opinion in Biotechnology, Vol. 24, Issue 3 https://doi.org/10.1016/j.copbio.2013.03.023	journal	June 2013
Engineering of an endogenous hexose transporter into a specific D-xylose transporter facilitates glucose-xylose co-consumption in Saccharomyces cerevisiae Nijland, Jeroen G.; Shin, Hyun Yong; de Jong, René M. Biotechnology for Biofuels, Vol. 7, Issue 1 https://doi.org/10.1186/s13068-014-0168-9	journal	November 2014
Improving pentose fermentation by preventing ubiquitination of hexose transporters in Saccharomyces cerevisiae Nijland, Jeroen G.; Vos, Erwin; Shin, Hyun Yong Biotechnology for Biofuels, Vol. 9, Issue 1 https://doi.org/10.1186/s13068-016-0573-3	journal	July 2016
Single cell and in vivo analyses elucidate the effect of xylC lactonase during production of D-xylonate in Saccharomyces cerevisiae Nygård, Yvonne; Maaheimo, Hannu; Mojzita, Dominik Metabolic Engineering, Vol. 25 https://doi.org/10.1016/j.ymben.2014.07.005	journal	September 2014
Effects of overexpression of acetaldehyde dehydrogenase 6 and acetyl-CoA synthetase 1 on xylitol production in recombinant Saccharomyces cerevisiae Oh, Eun-Joong; Bae, Yi-Hyun; Kim, Kyoung-Heon Biocatalysis and Agricultural Biotechnology, Vol. 1, Issue 1 https://doi.org/10.1016/j.bcab.2011.08.011	journal	January 2012
Enhanced xylitol production through simultaneous co-utilization of cellobiose and xylose by engineered Saccharomyces cerevisiae Oh, Eun Joong; Ha, Suk-Jin; Rin Kim, Soo Metabolic Engineering, Vol. 15 https://doi.org/10.1016/j.ymben.2012.09.003	journal	January 2013
Recent progress in consolidated bioprocessing Olson, Daniel G.; McBride, John E.; Joe Shaw, A. Current Opinion in Biotechnology, Vol. 23, Issue 3, p. 396-405 https://doi.org/10.1016/j.copbio.2011.11.026	journal	June 2012
The sedoheptulose 7-phosphate cyclases and their emerging roles in biology and ecology Osborn, Andrew R.; Kean, Kelsey M.; Karplus, P. Andrew Natural Product Reports, Vol. 34, Issue 8 https://doi.org/10.1039/C7NP00017K	journal	January 2017
Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose. Ozcan, S.; Johnston, M. Molecular and Cellular Biology, Vol. 15, Issue 3 https://doi.org/10.1128/MCB.15.3.1564	journal	March 1995
Function and Regulation of Yeast Hexose Transporters Özcan, Sabire; Johnston, Mark Microbiology and Molecular Biology Reviews, Vol. 63, Issue 3 https://doi.org/10.1128/MMBR.63.3.554-569.1999	journal	September 1999
Lactic acid production in Saccharomyces cerevisiae is modulated by expression of the monocarboxylate transporters Jen1 and Ady2 Pacheco, António; Talaia, Gabriel; Sá-Pessoa, Joana FEMS Yeast Research, Vol. 12, Issue 3 https://doi.org/10.1111/j.1567-1364.2012.00790.x	journal	February 2012
Glucose-induced Ubiquitylation and Endocytosis of the Yeast Jen1 Transporter Paiva, Sandra; Vieira, Neide; Nondier, Isabelle Journal of Biological Chemistry, Vol. 284, Issue 29 https://doi.org/10.1074/jbc.M109.008318	journal	July 2009
Scheffersomyces stipitis: a comparative systems biology study with the Crabtree positive yeast Saccharomyces cerevisiae Papini, Marta; Nookaew, Intawat; Uhlén, Mathias Microbial Cell Factories, Vol. 11, Issue 1 https://doi.org/10.1186/1475-2859-11-136	journal	January 2012
Spermidine may decrease ER stress in pancreatic beta cells and may reduce apoptosis via activating AMPK dependent autophagy pathway Tirupathi Pichiah, P. B.; Suriyakalaa, U.; Kamalakkannan, S. Medical Hypotheses, Vol. 77, Issue 4 https://doi.org/10.1016/j.mehy.2011.07.014	journal	October 2011
Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions Ramot, Yuval; Tiede, Stephan; Bíró, Tamás PLoS ONE, Vol. 6, Issue 7 https://doi.org/10.1371/journal.pone.0022564	journal	July 2011
Improved xylose uptake in Saccharomyces cerevisiae due to directed evolution of galactose permease Gal2 for sugar co-consumption Reznicek, O.; Facey, S. J.; de Waal, P. P. Journal of Applied Microbiology, Vol. 119, Issue 1 https://doi.org/10.1111/jam.12825	journal	May 2015
Cloning and Expression of a Fungal l-Arabinitol 4-Dehydrogenase Gene Richard, Peter; Londesborough, John; Putkonen, Mikko Journal of Biological Chemistry, Vol. 276, Issue 44 https://doi.org/10.1074/jbc.M104022200	journal	August 2001
Glucose starvation-induced turnover of the yeast glucose transporter Hxt1 Roy, Adhiraj; Kim, Yong-Bae; Cho, Kyu Hong Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1840, Issue 9 https://doi.org/10.1016/j.bbagen.2014.05.004	journal	September 2014
Hydrothermal pretreatment and enzymatic saccharification of corn stover for efficient ethanol production Saha, Badal C.; Yoshida, Tsuyoshi; Cotta, Michael A. Industrial Crops and Products, Vol. 44 https://doi.org/10.1016/j.indcrop.2012.11.025	journal	January 2013
Xylose transport studies with xylose-utilizing Saccharomyces cerevisiae strains expressing heterologous and homologous permeases Saloheimo, Anu; Rauta, Jenita; Stasyk, Oleh V. Applied Microbiology and Biotechnology, Vol. 74, Issue 5, p. 1041-1052 https://doi.org/10.1007/s00253-006-0747-1	journal	December 2006
Production of ethylene glycol or glycolic acid from D-xylose in Saccharomyces cerevisiae Salusjärvi, Laura; Toivari, Mervi; Vehkomäki, Maija-Leena Applied Microbiology and Biotechnology, Vol. 101, Issue 22 https://doi.org/10.1007/s00253-017-8547-3	journal	October 2017
Improved xylose and arabinose utilization by an industrial recombinant Saccharomyces cerevisiae strain using evolutionary engineering Garcia Sanchez, Rosa; Karhumaa, Kaisa; Fonseca, César Biotechnology for Biofuels, Vol. 3, Issue 1 https://doi.org/10.1186/1754-6834-3-13	journal	January 2010
Engineering of Saccharomyces cerevisiae for the production of poly-3-d-hydroxybutyrate from xylose Sandström, Anders G.; Muñoz de las Heras, Alejandro; Portugal-Nunes, Diogo AMB Express, Vol. 5, Issue 1 https://doi.org/10.1186/s13568-015-0100-0	journal	February 2015
Morphological and Chemical Composition of Pith and Fibers from Mexican Sugarcane Bagasse Sanjuán, R.; Anzaldo, J.; Vargas, J. Holz als Roh- und Werkstoff, Vol. 59, Issue 6 https://doi.org/10.1007/s001070100236	journal	December 2001
Expression of E. coli araBAD operon encoding enzymes for metabolizing L-arabinose in Saccharomyces cerevisiae Sedlak, Miroslav; Ho, Nancy W. Y. Enzyme and Microbial Technology, Vol. 28, Issue 1 https://doi.org/10.1016/S0141-0229(00)00282-9	journal	January 2001
An engineered cryptic Hxt11 sugar transporter facilitates glucose–xylose co-consumption in Saccharomyces cerevisiae Shin, Hyun Yong; Nijland, Jeroen G.; de Waal, Paul P. Biotechnology for Biofuels, Vol. 8, Issue 1 https://doi.org/10.1186/s13068-015-0360-6	journal	November 2015
The amino-terminal tail of Hxt11 confers membrane stability to the Hxt2 sugar transporter and improves xylose fermentation in the presence of acetic acid: Amino-Terminal Tail of Hxt11 Shin, Hyun Yong; Nijland, Jeroen G.; de Waal, Paul P. Biotechnology and Bioengineering, Vol. 114, Issue 9 https://doi.org/10.1002/bit.26322	journal	May 2017
Lactic acid production by Saccharomyces cerevisiae expressing a Rhizopus oryzae lactate dehydrogenase gene Skory, Christopher D. Journal of Industrial Microbiology & Biotechnology, Vol. 30, Issue 1 https://doi.org/10.1007/s10295-002-0004-2	journal	January 2003
Intensification of Enzymatic Hydrolysis of Lignocellulose Using Ultrasound for Efficient Bioethanol Production: A Review Subhedar, Preeti B.; Gogate, Parag R. Industrial & Engineering Chemistry Research, Vol. 52, Issue 34 https://doi.org/10.1021/ie401286z	journal	August 2013
Competition between pentoses and glucose during uptake and catabolism in recombinant Saccharomyces cerevisiae Subtil, Thorsten; Boles, Eckhard Biotechnology for Biofuels, Vol. 5, Issue 1 https://doi.org/10.1186/1754-6834-5-14	journal	January 2012
Hydrolysis of lignocellulosic materials for ethanol production: a review Sun, Ye; Cheng, Jiayang Bioresource Technology, Vol. 83, Issue 1, p. 1-11 https://doi.org/10.1016/S0960-8524(01)00212-7	journal	May 2002
Biological production of 2,3-butanediol Syu, M. -J. Applied Microbiology and Biotechnology, Vol. 55, Issue 1 https://doi.org/10.1007/s002530000486	journal	January 2001
Controlling Central Carbon Metabolism for Improved Pathway Yields in Saccharomyces cerevisiae Tan, Sue Zanne; Manchester, Shawn; Prather, Kristala L. J. ACS Synthetic Biology, Vol. 5, Issue 2 https://doi.org/10.1021/acssynbio.5b00164	journal	November 2015
Conversion of an inactive xylose isomerase into a functional enzyme by co-expression of GroEL-GroES chaperonins in Saccharomyces cerevisiae Temer, Beatriz; dos Santos, Leandro Vieira; Negri, Victor Augusti BMC Biotechnology, Vol. 17, Issue 1 https://doi.org/10.1186/s12896-017-0389-7	journal	September 2017
Metabolic engineering of Saccharomyces cerevisiae for bioconversion of d-xylose to d-xylonate Toivari, Mervi; Nygård, Yvonne; Kumpula, Esa-Pekka Metabolic Engineering, Vol. 14, Issue 4 https://doi.org/10.1016/j.ymben.2012.03.002	journal	July 2012
Conversion of Xylose to Ethanol by Recombinant Saccharomyces cerevisiae: Importance of Xylulokinase (XKS1) and Oxygen Availability Toivari, Mervi H.; Aristidou, Aristos; Ruohonen, Laura Metabolic Engineering, Vol. 3, Issue 3 https://doi.org/10.1006/mben.2000.0191	journal	July 2001
Saccharomyces cerevisiae engineered to produce D-xylonate Toivari, Mervi H.; Ruohonen, Laura; Richard, Peter Applied Microbiology and Biotechnology, Vol. 88, Issue 3 https://doi.org/10.1007/s00253-010-2787-9	journal	August 2010
Lactic acid production from xylose by engineered Saccharomyces cerevisiae without PDC or ADH deletion Turner, Timothy L.; Zhang, Guo-Chang; Kim, Soo Rin Applied Microbiology and Biotechnology, Vol. 99, Issue 19 https://doi.org/10.1007/s00253-015-6701-3	journal	June 2015
Lactic acid production from cellobiose and xylose by engineered Saccharomyces cerevisiae: Xylose/Cellobiose to Lactic Acid by S. cerevisiae Turner, Timothy L.; Zhang, Guo-Chang; Oh, Eun Joong Biotechnology and Bioengineering, Vol. 113, Issue 5 https://doi.org/10.1002/bit.25875	journal	November 2015
Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity Urlinger, S.; Baron, U.; Thellmann, M. Proceedings of the National Academy of Sciences, Vol. 97, Issue 14 https://doi.org/10.1073/pnas.130192197	journal	June 2000
A review of lignocellulose bioconversion using enzymatic hydrolysis and synergistic cooperation between enzymes—Factors affecting enzymes, conversion and synergy Van Dyk, J. S.; Pletschke, B. I. Biotechnology Advances, Vol. 30, Issue 6 https://doi.org/10.1016/j.biotechadv.2012.03.002	journal	November 2012
Directed Evolution of Pyruvate Decarboxylase-Negative Saccharomyces cerevisiae, Yielding a C2-Independent, Glucose-Tolerant, and Pyruvate-Hyperproducing Yeast van Maris, A. J. A.; Geertman, J. -M. A.; Vermeulen, A. Applied and Environmental Microbiology, Vol. 70, Issue 1 https://doi.org/10.1128/AEM.70.1.159-166.2004	journal	January 2004
A Novel NADH-linked L-Xylulose Reductase in the L-Arabinose Catabolic Pathway of Yeast Verho, Ritva; Putkonen, Mikko; Londesborough, John Journal of Biological Chemistry, Vol. 279, Issue 15 https://doi.org/10.1074/jbc.M312533200	journal	January 2004
Data set for cloning and characterization of heterologous transporters in Saccharomyces cerevisiae and identification of important amino acids for xylose utilization Wang, Chengqiang; Bao, Xiaoming; Li, Yanwei Data in Brief, Vol. 4 https://doi.org/10.1016/j.dib.2015.05.005	journal	September 2015
Directed evolution of xylose specific transporters to facilitate glucose-xylose co-utilization: Engineering Xylose Specific Transporters Wang, Meng; Yu, Chenzhao; Zhao, Huimin Biotechnology and Bioengineering, Vol. 113, Issue 3 https://doi.org/10.1002/bit.25724	journal	September 2015
Simultaneous Utilization of Cellobiose, Xylose, and Acetic Acid from Lignocellulosic Biomass for Biofuel Production by an Engineered Yeast Platform Wei, Na; Oh, Eun Joong; Million, Gyver ACS Synthetic Biology, Vol. 4, Issue 6 https://doi.org/10.1021/sb500364q	journal	November 2014
Enhanced biofuel production through coupled acetic acid and xylose consumption by engineered yeast Wei, Na; Quarterman, Josh; Kim, Soo Rin Nature Communications, Vol. 4, Issue 1 https://doi.org/10.1038/ncomms3580	journal	October 2013
Yeast Surface Display of Trifunctional Minicellulosomes for Simultaneous Saccharification and Fermentation of Cellulose to Ethanol Wen, F.; Sun, J.; Zhao, H. Applied and Environmental Microbiology, Vol. 76, Issue 4 https://doi.org/10.1128/AEM.01687-09	journal	December 2009
Saccharomyces cerevisiae Is Capable of de Novo Pantothenic Acid Biosynthesis Involving a Novel Pathway of β-Alanine Production from Spermine White, W. Hunter; Gunyuzlu, Paul L.; Toyn, Jeremy H. Journal of Biological Chemistry, Vol. 276, Issue 14 https://doi.org/10.1074/jbc.M009804200	journal	April 2001
A novel aldose-aldose oxidoreductase for co-production of D-xylonate and xylitol from D-xylose with Saccharomyces cerevisiae Wiebe, Marilyn G.; Nygård, Yvonne; Oja, Merja Applied Microbiology and Biotechnology, Vol. 99, Issue 22 https://doi.org/10.1007/s00253-015-6878-5	journal	August 2015
Codon-Optimized Bacterial Genes Improve l -Arabinose Fermentation in Recombinant Saccharomyces cerevisiae Wiedemann, Beate; Boles, Eckhard Applied and Environmental Microbiology, Vol. 74, Issue 7 https://doi.org/10.1128/AEM.02395-07	journal	April 2008
GroE chaperonins assisted functional expression of bacterial enzymes in Saccharomyces cerevisiae : Chaperonins Facilitated Enzyme Expression Xia, Peng-Fei; Zhang, Guo-Chang; Liu, Jing-Jing Biotechnology and Bioengineering, Vol. 113, Issue 10 https://doi.org/10.1002/bit.25980	journal	April 2016
The mammalian AMP-activated protein kinase complex mediates glucose regulation of gene expression in the yeast Saccharomyces cerevisiae Ye, Tian; Bendrioua, Loubna; Carmena, David FEBS Letters, Vol. 588, Issue 12 https://doi.org/10.1016/j.febslet.2014.04.039	journal	May 2014
Growth landscape formed by perception and import of glucose in yeast Youk, Hyun; van Oudenaarden, Alexander Nature, Vol. 462, Issue 7275 https://doi.org/10.1038/nature08653	journal	December 2009
Rewiring yeast sugar transporter preference through modifying a conserved protein motif Young, E. M.; Tong, A.; Bui, H. Proceedings of the National Academy of Sciences, Vol. 111, Issue 1 https://doi.org/10.1073/pnas.1311970111	journal	December 2013
Dynamic control of ERG9 expression for improved amorpha-4,11-diene production in Saccharomyces cerevisiae Yuan, Jifeng; Ching, Chi-Bun Microbial Cell Factories, Vol. 14, Issue 1 https://doi.org/10.1186/s12934-015-0220-x	journal	March 2015
Optimization of CDT-1 and XYL1 Expression for Balanced Co-Production of Ethanol and Xylitol from Cellobiose and Xylose by Engineered Saccharomyces cerevisiae Zha, Jian; Li, Bing-Zhi; Shen, Ming-Hua PLoS ONE, Vol. 8, Issue 7 https://doi.org/10.1371/journal.pone.0068317	journal	July 2013
Optimization of an acetate reduction pathway for producing cellulosic ethanol by engineered yeast: Optimization of the Acetate Reduction Pathway in Yeast Zhang, Guo-Chang; Kong, In Iok; Wei, Na Biotechnology and Bioengineering, Vol. 113, Issue 12 https://doi.org/10.1002/bit.26021	journal	September 2016
Xylose isomerase overexpression along with engineering of the pentose phosphate pathway and evolutionary engineering enable rapid xylose utilization and ethanol production by Saccharomyces cerevisiae Zhou, Hang; Cheng, Jing-sheng; Wang, Benjamin L. Metabolic Engineering, Vol. 14, Issue 6, p. 611-622 https://doi.org/10.1016/j.ymben.2012.07.011	journal	November 2012

Cited By (5)

Combined Cell Surface Display of β‐ d ‐Glucosidase (BGL), Maltose Transporter (MAL11), and Overexpression of Cytosolic Xylose Reductase (XR) in Saccharomyces cerevisiae Enhance Cellobiose/Xylose Coutilization for Xylitol Bioproduction from Lignocellulosic Biomass Guirimand, Gregory G. Y.; Bamba, Takahiro; Matsuda, Mami Biotechnology Journal, Vol. 14, Issue 9 https://doi.org/10.1002/biot.201800704	journal	July 2019
Exploiting the NADPH pool for xylitol production using recombinant Saccharomyces cerevisiae Reshamwala, Shamlan M. S.; Lali, Arvind M. Biotechnology Progress, Vol. 36, Issue 3 https://doi.org/10.1002/btpr.2972	journal	February 2020
Xylose utilization stimulates mitochondrial production of isobutanol and 2-methyl-1-butanol in Saccharomyces cerevisiae Zhang, Yanfei; Lane, Stephan; Chen, Jhong-Min Biotechnology for Biofuels, Vol. 12, Issue 1 https://doi.org/10.1186/s13068-019-1560-2	journal	September 2019
Xylose assimilation enhances the production of isobutanol in engineered Saccharomyces cerevisiae Lane, Stephan; Zhang, Yanfei; Yun, Eun Ju Biotechnology and Bioengineering, Vol. 117, Issue 2 https://doi.org/10.1002/bit.27202	journal	November 2019
Xylose utilization stimulates mitochondrial production of isobutanol and 2-methyl-1-butanol in Saccharomyces cerevisiae Zhang, Yanfei; Lane, Stephan; Chen, Jhong-Min Biotechnology for Biofuels, Vol. 12, Issue 1 https://doi.org/10.1186/s13068-019-1560-2	journal	September 2019