Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae
Abstract
The substantial research efforts into lignocellulosic biofuels have generated an abundance of valuable knowledge and technologies for metabolic engineering. In particular, these investments have led to a vast growth in proficiency of engineering the yeast Saccharomyces cerevisiae for consuming lignocellulosic sugars, enabling the simultaneous assimilation of multiple carbon sources, and producing a large variety of value-added products by introduction of heterologous metabolic pathways. While microbial conversion of cellulosic sugars into large-volume low-value biofuels is not currently economically feasible, there may still be opportunities to produce other value-added chemicals as regulation of cellulosic sugar metabolism is quite different from glucose metabolism. Furthermore, this review summarizes these recent advances with an emphasis on employing engineered yeast for the bioconversion of lignocellulosic sugars into a variety of non-ethanol value-added products.
- Authors:
-
- Univ. of Illinois at Urbana-Champaign, Urbana, IL (United States)
- Publication Date:
- Research Org.:
- Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), Urbana, IL (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC), Biological and Environmental Research (BER)
- OSTI Identifier:
- 1489217
- Alternate Identifier(s):
- OSTI ID: 1991832
- Grant/Contract Number:
- SC0018420
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Bioresource Technology
- Additional Journal Information:
- Journal Volume: 260; Journal Issue: C; Journal ID: ISSN 0960-8524
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; Saccharomyces cerevisiae; metabolic engineering; synthetic biology; fermentation; lignocellulosic biofuels
Citation Formats
Lane, Stephan, Dong, Jia, and Jin, Yong -Su. Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae. United States: N. p., 2018.
Web. doi:10.1016/j.biortech.2018.04.013.
Lane, Stephan, Dong, Jia, & Jin, Yong -Su. Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae. United States. https://doi.org/10.1016/j.biortech.2018.04.013
Lane, Stephan, Dong, Jia, and Jin, Yong -Su. Sat .
"Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae". United States. https://doi.org/10.1016/j.biortech.2018.04.013. https://www.osti.gov/servlets/purl/1489217.
@article{osti_1489217,
title = {Value-added biotransformation of cellulosic sugars by engineered Saccharomyces cerevisiae},
author = {Lane, Stephan and Dong, Jia and Jin, Yong -Su},
abstractNote = {The substantial research efforts into lignocellulosic biofuels have generated an abundance of valuable knowledge and technologies for metabolic engineering. In particular, these investments have led to a vast growth in proficiency of engineering the yeast Saccharomyces cerevisiae for consuming lignocellulosic sugars, enabling the simultaneous assimilation of multiple carbon sources, and producing a large variety of value-added products by introduction of heterologous metabolic pathways. While microbial conversion of cellulosic sugars into large-volume low-value biofuels is not currently economically feasible, there may still be opportunities to produce other value-added chemicals as regulation of cellulosic sugar metabolism is quite different from glucose metabolism. Furthermore, this review summarizes these recent advances with an emphasis on employing engineered yeast for the bioconversion of lignocellulosic sugars into a variety of non-ethanol value-added products.},
doi = {10.1016/j.biortech.2018.04.013},
journal = {Bioresource Technology},
number = C,
volume = 260,
place = {United States},
year = {2018},
month = {4}
}
Web of Science
Figures / Tables:

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Works referencing / citing this record:
Combined Cell Surface Display of β‐ d ‐Glucosidase (BGL), Maltose Transporter (MAL11), and Overexpression of Cytosolic Xylose Reductase (XR) in Saccharomyces cerevisiae Enhance Cellobiose/Xylose Coutilization for Xylitol Bioproduction from Lignocellulosic Biomass
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Exploiting the NADPH pool for xylitol production using recombinant Saccharomyces cerevisiae
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Xylose utilization stimulates mitochondrial production of isobutanol and 2-methyl-1-butanol in Saccharomyces cerevisiae
journal, September 2019
- Zhang, Yanfei; Lane, Stephan; Chen, Jhong-Min
- Biotechnology for Biofuels, Vol. 12, Issue 1
Xylose assimilation enhances the production of isobutanol in engineered Saccharomyces cerevisiae
journal, November 2019
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Xylose utilization stimulates mitochondrial production of isobutanol and 2-methyl-1-butanol in Saccharomyces cerevisiae
journal, September 2019
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- Biotechnology for Biofuels, Vol. 12, Issue 1
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