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Title: Determinant of receptor-preference switch in influenza hemagglutinin

Abstract

Influenza pandemic occurs when a new strain from other animal species overcomes the inter-species barriers and supports rapid human-to-human transmission. A critical prerequisite to this process is that hemagglutinin (HA) acquires a few key mutations to switch from avian receptors to human receptors. Previous studies suggest that H1 and H2/H3 HAs use different sets of mutations for the switch. This report shows that HA from the 1918 H1N1 pandemic virus (1918H1 HA) adopts the set of mutations used by H2/H3 HAs in receptor-preference switch when its 130-loop is made similar to those of H2/H3 HAs. Thus, the 130-loop appears to be the key determinant for the different mutations employed by pandemic H1 or H2/H3 HA. We conclude the correlation of the mutational routes and the 130-loop as unraveled in this study opens the door for efficient investigation of mutations required by other HA subtypes for inter-human airborne transmission.

Authors:
; ;
Publication Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Org.:
USDOE Office of Science (SC); National Institutes of Health (NIH); Welch Foundation; Michigan Economic Development Corporation and the Michigan Technology Tri-Corridor
OSTI Identifier:
1489174
Alternate Identifier(s):
OSTI ID: 1439616
Grant/Contract Number:  
AC02-06CH11357; R01-AI067839; R01-GM116280; Q-1826; 085P1000817
Resource Type:
Published Article
Journal Name:
Virology
Additional Journal Information:
Journal Name: Virology Journal Volume: 513 Journal Issue: C; Journal ID: ISSN 0042-6822
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; Human adaptation; Inter-human airborne transmission; Influenza pandemics; Receptor binding; The 130-loop

Citation Formats

Ni, Fengyun, Kondrashkina, Elena, and Wang, Qinghua. Determinant of receptor-preference switch in influenza hemagglutinin. United States: N. p., 2017. Web. doi:10.1016/j.virol.2017.10.010.
Ni, Fengyun, Kondrashkina, Elena, & Wang, Qinghua. Determinant of receptor-preference switch in influenza hemagglutinin. United States. doi:10.1016/j.virol.2017.10.010.
Ni, Fengyun, Kondrashkina, Elena, and Wang, Qinghua. Wed . "Determinant of receptor-preference switch in influenza hemagglutinin". United States. doi:10.1016/j.virol.2017.10.010.
@article{osti_1489174,
title = {Determinant of receptor-preference switch in influenza hemagglutinin},
author = {Ni, Fengyun and Kondrashkina, Elena and Wang, Qinghua},
abstractNote = {Influenza pandemic occurs when a new strain from other animal species overcomes the inter-species barriers and supports rapid human-to-human transmission. A critical prerequisite to this process is that hemagglutinin (HA) acquires a few key mutations to switch from avian receptors to human receptors. Previous studies suggest that H1 and H2/H3 HAs use different sets of mutations for the switch. This report shows that HA from the 1918 H1N1 pandemic virus (1918H1 HA) adopts the set of mutations used by H2/H3 HAs in receptor-preference switch when its 130-loop is made similar to those of H2/H3 HAs. Thus, the 130-loop appears to be the key determinant for the different mutations employed by pandemic H1 or H2/H3 HA. We conclude the correlation of the mutational routes and the 130-loop as unraveled in this study opens the door for efficient investigation of mutations required by other HA subtypes for inter-human airborne transmission.},
doi = {10.1016/j.virol.2017.10.010},
journal = {Virology},
number = C,
volume = 513,
place = {United States},
year = {2017},
month = {10}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1016/j.virol.2017.10.010

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Cited by: 3 works
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