Title: Long-Term in Situ Reduction in Soil Lead Bioavailability Measured in a Mouse Model

Journal Article · · Environmental Science and Technology
ORCiD logo [1];  [2];  [1];  [3];  [3];  [1];  [4];  [5]; ORCiD logo [1]
  1. US Environmental Protection Agency (EPA), Research Triangle Park, NC (United States)
  2. SRC, Inc., North Syracuse, NY (United States)
  3. US Environmental Protection Agency (EPA), Cincinnati, OH (United States)
  4. USDA-ARS-Adaptive Cropping Systems Lab, Beltsville, MD (United States)
  5. Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS), DND-CAT, Synchrotron Research Center-Northwestern Univ.
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In this study, effects of different treatments on the bioavailability of lead (Pb) in soil from a smelter emission contaminated site in Joplin, Missouri, were evaluated in a mouse model. Similar estimates of relative bioavailability for Pb in untreated or treated soil were obtained in mice and in the well-established juvenile swine model. In the mouse model, treatments that used phosphate (phosphoric acid or triple superphosphate) combined with iron oxide or biosolids compost significantly reduced soil Pb bioavailability. Notably, effects of these remediation procedures were persistent, given that up to 16 years had elapsed between soil treatment and sample collection. Remediation of soils was associated with changes in Pb species present in soil. Differences in Pb species in ingested soil and in feces from treated mice indicated that changes in Pb speciation occurred during transit through the gastrointestinal tract. Use of the mouse model facilitates evaluation of remediation procedures and allows monitoring of the performance of procedures under laboratory and field conditions.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
E.I. DuPont de Nemours & Co.; Strategic Environmental Research and Development Program (SERDP); The Dow Chemical Company; USDOE Office of Science (SC); USEPA
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
1488946
Journal Information:
Environmental Science and Technology, Journal Name: Environmental Science and Technology Journal Issue: 23 Vol. 52; ISSN 0013-936X
Publisher:
American Chemical Society (ACS)Copyright Statement
Country of Publication:
United States
Language:
ENGLISH

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Related Subjects

54 ENVIRONMENTAL SCIENCES
Anatomy
Bioavailability
Remediation
Rodent models
Soils