skip to main content
DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: 3D-Printed Hydrogel Composites for Predictive Temporal (4D) Cellular Organizations and Patterned Biogenic Mineralization

Authors:
ORCiD logo [1];  [1];  [1]; ORCiD logo [2]; ORCiD logo [3]; ORCiD logo [1];  [3];  [4];  [2]; ORCiD logo [5]
  1. Department of Chemistry, University of Illinois-Urbana Champaign, 600 S. Matthews, Avenue Urbana IL 61801 USA
  2. Department of Electrical and Computer Engineering, 4055 Beckman Institute, MC 251, 405 N. Mathews Urbana IL 61801 USA
  3. Frederick Seitz Materials Research Laboratory and Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana IL 61801 USA
  4. Department of Chemical and Biomolecular Engineering, University of Illinois-Urbana Champaign, 600 S. Matthews Avenue Urbana IL 61801 USA
  5. Department of Chemistry, University of Illinois-Urbana Champaign, 600 S. Matthews, Avenue Urbana IL 61801 USA, Frederick Seitz Materials Research Laboratory and Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana IL 61801 USA, Surface and Corrosion Science, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Drottning Kristinasväg 51 100 44 Stockholm Sweden
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1488354
Grant/Contract Number:  
FG02-07ER46471
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Advanced Healthcare Materials
Additional Journal Information:
Journal Name: Advanced Healthcare Materials Journal Volume: 8 Journal Issue: 1; Journal ID: ISSN 2192-2640
Publisher:
Wiley Blackwell (John Wiley & Sons)
Country of Publication:
Germany
Language:
English

Citation Formats

McCracken, Joselle M., Rauzan, Brittany M., Kjellman, Jacob C. E., Kandel, Mikhail E., Liu, Yu Hao, Badea, Adina, Miller, Lou Ann, Rogers, Simon A., Popescu, Gabriel, and Nuzzo, Ralph G. 3D-Printed Hydrogel Composites for Predictive Temporal (4D) Cellular Organizations and Patterned Biogenic Mineralization. Germany: N. p., 2018. Web. doi:10.1002/adhm.201800788.
McCracken, Joselle M., Rauzan, Brittany M., Kjellman, Jacob C. E., Kandel, Mikhail E., Liu, Yu Hao, Badea, Adina, Miller, Lou Ann, Rogers, Simon A., Popescu, Gabriel, & Nuzzo, Ralph G. 3D-Printed Hydrogel Composites for Predictive Temporal (4D) Cellular Organizations and Patterned Biogenic Mineralization. Germany. doi:10.1002/adhm.201800788.
McCracken, Joselle M., Rauzan, Brittany M., Kjellman, Jacob C. E., Kandel, Mikhail E., Liu, Yu Hao, Badea, Adina, Miller, Lou Ann, Rogers, Simon A., Popescu, Gabriel, and Nuzzo, Ralph G. Thu . "3D-Printed Hydrogel Composites for Predictive Temporal (4D) Cellular Organizations and Patterned Biogenic Mineralization". Germany. doi:10.1002/adhm.201800788.
@article{osti_1488354,
title = {3D-Printed Hydrogel Composites for Predictive Temporal (4D) Cellular Organizations and Patterned Biogenic Mineralization},
author = {McCracken, Joselle M. and Rauzan, Brittany M. and Kjellman, Jacob C. E. and Kandel, Mikhail E. and Liu, Yu Hao and Badea, Adina and Miller, Lou Ann and Rogers, Simon A. and Popescu, Gabriel and Nuzzo, Ralph G.},
abstractNote = {},
doi = {10.1002/adhm.201800788},
journal = {Advanced Healthcare Materials},
number = 1,
volume = 8,
place = {Germany},
year = {2018},
month = {11}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1002/adhm.201800788

Save / Share:

Works referenced in this record:

Hierarchical architecture influences calcium dynamics in engineered cardiac muscle
journal, March 2011

  • Pong, Terrence; Adams, William J.; Bray, Mark-Anthony
  • Experimental Biology and Medicine, Vol. 236, Issue 3
  • DOI: 10.1258/ebm.2010.010239

Investigation of Four Different Laponite Clays as Stabilizers in Pickering Emulsion Polymerization
journal, June 2016


Osteogenic Responses to Zirconia with Hydroxyapatite Coating by Aerosol Deposition
journal, December 2014


Clay enriched silk biomaterials for bone formation
journal, August 2011

  • Mieszawska, Aneta J.; Llamas, Jabier Gallego; Vaiana, Christopher A.
  • Acta Biomaterialia, Vol. 7, Issue 8
  • DOI: 10.1016/j.actbio.2011.04.016

The role of HEMA in one-step self-etch adhesives
journal, October 2008


Engineering Substrate Topography at the Micro- and Nanoscale to Control Cell Function
journal, July 2009

  • Bettinger, Christopher J.; Langer, Robert; Borenstein, Jeffrey T.
  • Angewandte Chemie International Edition, Vol. 48, Issue 30
  • DOI: 10.1002/anie.200805179

Polymer-layered silicate nanocomposites: Synthesis, properties and applications
journal, October 1998


Easy fabrication of aligned PLLA nanofibers-based 2D scaffolds suitable for cell contact guidance studies
journal, May 2016


Bioactive Glass Stimulates In Vitro Osteoblast Differentiation and Creates a Favorable Template for Bone Tissue Formation
journal, February 2001


Review: Polymeric-Based 3D Printing for Tissue Engineering
journal, June 2015


Multiphase Intrafibrillar Mineralization of Collagen
journal, April 2013

  • Niu, Li-na; Jiao, Kai; Ryou, Heonjune
  • Angewandte Chemie International Edition, Vol. 52, Issue 22
  • DOI: 10.1002/anie.201210259

The making of filopodia
journal, February 2006


Three-dimensionally printed biological machines powered by skeletal muscle
journal, June 2014

  • Cvetkovic, C.; Raman, R.; Chan, V.
  • Proceedings of the National Academy of Sciences, Vol. 111, Issue 28
  • DOI: 10.1073/pnas.1401577111

Enhancing the Gelation and Bioactivity of Injectable Silk Fibroin Hydrogel with Laponite Nanoplatelets
journal, April 2016

  • Su, Dihan; Jiang, Libo; Chen, Xin
  • ACS Applied Materials & Interfaces, Vol. 8, Issue 15
  • DOI: 10.1021/acsami.6b00891

Engineered hybrid cardiac patches with multifunctional electronics for online monitoring and regulation of tissue function
journal, March 2016

  • Feiner, Ron; Engel, Leeya; Fleischer, Sharon
  • Nature Materials, Vol. 15, Issue 6
  • DOI: 10.1038/nmat4590

Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems
journal, February 2000

  • Chiu, D. T.; Jeon, N. L.; Huang, S.
  • Proceedings of the National Academy of Sciences, Vol. 97, Issue 6
  • DOI: 10.1073/pnas.040562297

Self-assembled monolayers with different terminating groups as model substrates for cell adhesion studies
journal, June 2004


Simultaneous optical measurements of cell motility and growth
journal, January 2011

  • Sridharan, Shamira; Mir, Mustafa; Popescu, Gabriel
  • Biomedical Optics Express, Vol. 2, Issue 10
  • DOI: 10.1364/BOE.2.002815

High-Resolution, High-Aspect Ratio Conductive Wires Embedded in Plastic Substrates
journal, January 2015

  • Mahajan, Ankit; Hyun, Woo Jin; Walker, S. Brett
  • ACS Applied Materials & Interfaces, Vol. 7, Issue 3
  • DOI: 10.1021/am507539a

Microfabricated Biomaterials for Engineering 3D Tissues
journal, March 2012

  • Zorlutuna, Pinar; Annabi, Nasim; Camci-Unal, Gulden
  • Advanced Materials, Vol. 24, Issue 14
  • DOI: 10.1002/adma.201104631

Gigahertz Electromagnetic Structures via Direct Ink Writing for Radio-Frequency Oscillator and Transmitter Applications
journal, February 2017

  • Zhou, Nanjia; Liu, Chengye; Lewis, Jennifer A.
  • Advanced Materials, Vol. 29, Issue 15
  • DOI: 10.1002/adma.201605198

Three-dimensional printing of complex biological structures by freeform reversible embedding of suspended hydrogels
journal, October 2015

  • Hinton, Thomas J.; Jallerat, Quentin; Palchesko, Rachelle N.
  • Science Advances, Vol. 1, Issue 9
  • DOI: 10.1126/sciadv.1500758

Cellular Microcultures: Programming Mechanical and Physicochemical Properties of 3D Hydrogel Cellular Microcultures via Direct Ink Writing (Adv. Healthcare Mater. 9/2016)
journal, May 2016

  • McCracken, Joselle M.; Badea, Adina; Kandel, Mikhail E.
  • Advanced Healthcare Materials, Vol. 5, Issue 9
  • DOI: 10.1002/adhm.201670043

Bioactive Nanoengineered Hydrogels for Bone Tissue Engineering: A Growth-Factor-Free Approach
journal, February 2015

  • Xavier, Janet R.; Thakur, Teena; Desai, Prachi
  • ACS Nano, Vol. 9, Issue 3
  • DOI: 10.1021/nn507488s

The extracellular matrix at a glance
journal, December 2010

  • Frantz, C.; Stewart, K. M.; Weaver, V. M.
  • Journal of Cell Science, Vol. 123, Issue 24
  • DOI: 10.1242/jcs.023820

Effects of synthetic micro- and nano-structured surfaces on cell behavior
journal, March 1999


Insight into molecular interactions between constituents in polymer clay nanocomposites
journal, June 2006


Taking Cell-Matrix Adhesions to the Third Dimension
journal, November 2001


Antifouling Potential of Lubricious, Micro-engineered, PDMS Elastomers against Zoospores of the Green Fouling Alga Ulva (Enteromorpha)
journal, February 2004


3D-Printed pHEMA Materials for Topographical and Biochemical Modulation of Dorsal Root Ganglion Cell Response
journal, August 2017

  • Badea, Adina; McCracken, Joselle M.; Tillmaand, Emily G.
  • ACS Applied Materials & Interfaces, Vol. 9, Issue 36
  • DOI: 10.1021/acsami.7b06742

3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs
journal, February 2014

  • Kolesky, David B.; Truby, Ryan L.; Gladman, A. Sydney
  • Advanced Materials, Vol. 26, Issue 19
  • DOI: 10.1002/adma.201305506

The Blood Vascular Supply of the Dental Pulp with Emphasis on Capillary Circulation
journal, March 1958


Evaluation of alternative monomers to HEMA for dental applications
journal, July 2017


Tissue engineering
journal, May 1993


Additive manufacturing technologies: state of the art and trends
journal, November 2015


Three-Dimensional Fabrication at Small Size Scales
journal, April 2010

  • Leong, Timothy G.; Zarafshar, Aasiyeh M.; Gracias, David H.
  • Small, Vol. 6, Issue 7
  • DOI: 10.1002/smll.200901704

Engineered antifouling microtopographies – correlating wettability with cell attachment
journal, January 2006


Silicone rubber substrata: a new wrinkle in the study of cell locomotion
journal, April 1980


Exploring and Engineering the Cell Surface Interface
journal, November 2005


Particle-Free Emulsions for 3D Printing Elastomers
journal, March 2018

  • Rauzan, Brittany M.; Nelson, Arif Z.; Lehman, Sean E.
  • Advanced Functional Materials, Vol. 28, Issue 21
  • DOI: 10.1002/adfm.201707032

The osteogenic, inflammatory and osteo-immunomodulatory performances of biomedical Ti-Ta metal–metal composite with Ca- and Si-containing bioceramic coatings
journal, September 2018


Photo-patterning of porous hydrogels for tissue engineering
journal, July 2007


Exploring Cellular Contact Guidance Using Gradient Nanogratings
journal, November 2010

  • Sun, Jirun; Ding, Yifu; Lin, Nancy J.
  • Biomacromolecules, Vol. 11, Issue 11
  • DOI: 10.1021/bm100883m

Effects of multigrooved surfaces on fibroblast behavior
journal, May 2003

  • Yoshinari, M.; Matsuzaka, K.; Inoue, T.
  • Journal of Biomedical Materials Research, Vol. 65A, Issue 3
  • DOI: 10.1002/jbm.a.10521

3D Microperiodic Hydrogel Scaffolds for Robust Neuronal Cultures
journal, November 2010

  • Hanson Shepherd, Jennifer N.; Parker, Sara T.; Shepherd, Robert F.
  • Advanced Functional Materials, Vol. 21, Issue 1
  • DOI: 10.1002/adfm.201001746

3D-printed spherical dipole antenna integrated on small RF node
journal, April 2015

  • Adams, J. J.; Slimmer, S. C.; Bernhard, J. T.
  • Electronics Letters, Vol. 51, Issue 9
  • DOI: 10.1049/el.2015.0256

Microtopographic Cues for Settlement of Zoospores of the Green Fouling Alga Enteromorpha
journal, January 2002


A Printing-Centric Approach to the Electrostatic Modification of Polymer/Clay Composites for Use in 3D Direct-Ink Writing
journal, February 2018

  • Rauzan, Brittany M.; Lehman, Sean E.; McCracken, Joselle M.
  • Advanced Materials Interfaces, Vol. 5, Issue 8
  • DOI: 10.1002/admi.201701579

A Simple, Low-Cost Conductive Composite Material for 3D Printing of Electronic Sensors
journal, November 2012


Laponite Nanodisks as an Efficient Platform for Doxorubicin Delivery to Cancer Cells
journal, February 2013

  • Wang, Shige; Wu, Yilun; Guo, Rui
  • Langmuir, Vol. 29, Issue 16
  • DOI: 10.1021/la4001363

Functionally graded Nylon-11/silica nanocomposites produced by selective laser sintering
journal, July 2008


A Self-Aligned Strategy for Printed Electronics: Exploiting Capillary Flow on Microstructured Plastic Surfaces
journal, August 2015

  • Mahajan, Ankit; Hyun, Woo Jin; Walker, S. Brett
  • Advanced Electronic Materials, Vol. 1, Issue 9
  • DOI: 10.1002/aelm.201500137

Three-dimensional mapping and regulation of action potential propagation in nanoelectronics-innervated tissues
journal, June 2016

  • Dai, Xiaochuan; Zhou, Wei; Gao, Teng
  • Nature Nanotechnology, Vol. 11, Issue 9
  • DOI: 10.1038/nnano.2016.96

Rapid-prototyped PLGA/β-TCP/hydroxyapatite nanocomposite scaffolds in a rabbit femoral defect model
journal, March 2012


Biomimetic 4D printing
journal, January 2016

  • Sydney Gladman, A.; Matsumoto, Elisabetta A.; Nuzzo, Ralph G.
  • Nature Materials, Vol. 15, Issue 4
  • DOI: 10.1038/nmat4544

Topographical control of cells
journal, December 1997


Evaluation of 3D Printing and Its Potential Impact on Biotechnology and the Chemical Sciences
journal, January 2014

  • Gross, Bethany C.; Erkal, Jayda L.; Lockwood, Sarah Y.
  • Analytical Chemistry, Vol. 86, Issue 7
  • DOI: 10.1021/ac403397r

High-Performance Biodegradable/Transient Electronics on Biodegradable Polymers
journal, April 2014

  • Hwang, Suk-Won; Song, Jun-Kyul; Huang, Xian
  • Advanced Materials, Vol. 26, Issue 23
  • DOI: 10.1002/adma.201306050

Use of nanotopography to study mechanotransduction in fibroblasts ? methods and perspectives
journal, January 2004


Cell-ECM traction force modulates endogenous tension at cell-cell contacts
journal, March 2011

  • Maruthamuthu, V.; Sabass, B.; Schwarz, U. S.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 12
  • DOI: 10.1073/pnas.1011123108

Mechanisms of magnesium-stimulated adhesion of osteoblastic cells to commonly used orthopaedic implants
journal, August 2002

  • Zreiqat, H.; Howlett, C. R.; Zannettino, A.
  • Journal of Biomedical Materials Research, Vol. 62, Issue 2
  • DOI: 10.1002/jbm.10270

Chemically well-defined self-assembled monolayers for cell culture: toward mimicking the natural ECM
journal, January 2011

  • Hudalla, Gregory A.; Murphy, William L.
  • Soft Matter, Vol. 7, Issue 20
  • DOI: 10.1039/c1sm05596h

Effects of HEMA/Solvent Combinations on Bond Strength to Dentin
journal, August 2003


3D Printing of Interdigitated Li-Ion Microbattery Architectures
journal, June 2013

  • Sun, Ke; Wei, Teng-Sing; Ahn, Bok Yeop
  • Advanced Materials, Vol. 25, Issue 33, p. 4539-4543
  • DOI: 10.1002/adma.201301036

Clay: New Opportunities for Tissue Regeneration and Biomaterial Design
journal, May 2013

  • Dawson, Jonathan I.; Oreffo, Richard O. C.
  • Advanced Materials, Vol. 25, Issue 30
  • DOI: 10.1002/adma.201301034

Three-dimensional micro/nanoscale architectures: fabrication and applications
journal, January 2015


Engineered antifouling microtopographies – effect of feature size, geometry, and roughness on settlement of zoospores of the green alga Ulva
journal, January 2007


A histologic comparison of Hydron and zinc oxide—eugenol as endodontic filling materials in the primary teeth of dogs
journal, July 1984

  • Woods, Robin L.; Kildea, Patrick M.; Gabriel, Samir A.
  • Oral Surgery, Oral Medicine, Oral Pathology, Vol. 58, Issue 1
  • DOI: 10.1016/0030-4220(84)90369-4

Mechanical Properties of the Sodium Montmorillonite Interlayer Intercalated with Amino Acids
journal, November 2005

  • Katti, Dinesh R.; Ghosh, Pijush; Schmidt, Steven
  • Biomacromolecules, Vol. 6, Issue 6
  • DOI: 10.1021/bm0503219

Label-Free Characterization of Emerging Human Neuronal Networks
journal, March 2014

  • Mir, Mustafa; Kim, Taewoo; Majumder, Anirban
  • Scientific Reports, Vol. 4, Issue 1
  • DOI: 10.1038/srep04434

Quantitative analysis of fibroblast morphology on microgrooved surfaces with various groove and ridge dimensions
journal, November 1996


Three-dimensional printed electronics
journal, February 2015

  • Lewis, Jennifer A.; Ahn, Bok Y.
  • Nature, Vol. 518, Issue 7537
  • DOI: 10.1038/518042a

On the History and Mechanism of Alizarin and Alizarin red s Stains for Calcium
journal, February 1969

  • Puchtler, Holde; Meloan, Susan N.; Terry, Mary S.
  • Journal of Histochemistry & Cytochemistry, Vol. 17, Issue 2
  • DOI: 10.1177/17.2.110

Cell Origami: Self-Folding of Three-Dimensional Cell-Laden Microstructures Driven by Cell Traction Force
journal, December 2012


Cardiomyocyte Imaging Using Real-Time Spatial Light Interference Microscopy (SLIM)
journal, February 2013


Basement Membrane Proteins: Structure, Assembly, and Cellular Interactions
journal, January 1992

  • M., Mats Paulsson
  • Critical Reviews in Biochemistry and Molecular Biology, Vol. 27, Issue 1-2
  • DOI: 10.3109/10409239209082560

Design of yield-stress fluids: a rheology-to-structure inverse problem
journal, January 2017

  • Nelson, Arif Z.; Ewoldt, Randy H.
  • Soft Matter, Vol. 13, Issue 41
  • DOI: 10.1039/C7SM00758B

Synthesis and characterization of nylon 1012/clay nanocomposite
journal, January 2002

  • Wu, Zenggang; Zhou, Chixing; Qi, Rongrong
  • Journal of Applied Polymer Science, Vol. 83, Issue 11
  • DOI: 10.1002/app.10198

A bioengineered microenvironment to quantitatively measure the tumorigenic properties of cancer-associated fibroblasts in human prostate cancer
journal, July 2013


Influence of HEMA content on the mechanical and bonding properties of experimental HEMA-added glass ionomer cements
journal, August 2009


Spatial light interference microscopy (SLIM)
journal, January 2011

  • Wang, Zhuo; Millet, Larry; Mir, Mustafa
  • Optics Express, Vol. 19, Issue 2
  • DOI: 10.1364/OE.19.001016

Printing soft matter in three dimensions
journal, December 2016


Geometric Control of Cell Life and Death
journal, May 1997


An integrated design and fabrication strategy for entirely soft, autonomous robots
journal, August 2016

  • Wehner, Michael; Truby, Ryan L.; Fitzgerald, Daniel J.
  • Nature, Vol. 536, Issue 7617
  • DOI: 10.1038/nature19100

Muscular Thin Films for Building Actuators and Powering Devices
journal, September 2007


The Effect of Sympathetic Nerve Stimulation on the Rate of Disappearance of Tracers from Various Oral Tissues
journal, January 1971


Embedded 3D Printing of Strain Sensors within Highly Stretchable Elastomers
journal, June 2014

  • Muth, Joseph T.; Vogt, Daniel M.; Truby, Ryan L.
  • Advanced Materials, Vol. 26, Issue 36, p. 6307-6312
  • DOI: 10.1002/adma.201400334

A tissue-engineered jellyfish with biomimetic propulsion
journal, July 2012

  • Nawroth, Janna C.; Lee, Hyungsuk; Feinberg, Adam W.
  • Nature Biotechnology, Vol. 30, Issue 8
  • DOI: 10.1038/nbt.2269

Bioprinting of 3D hydrogels
journal, January 2015

  • Stanton, M. M.; Samitier, J.; Sánchez, S.
  • Lab on a Chip, Vol. 15, Issue 15
  • DOI: 10.1039/C5LC90069G

Three-dimensional bioprinting of thick vascularized tissues
journal, March 2016

  • Kolesky, David B.; Homan, Kimberly A.; Skylar-Scott, Mark A.
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 12
  • DOI: 10.1073/pnas.1521342113

Preparation of Laponite Bioceramics for Potential Bone Tissue Engineering Applications
journal, June 2014


Push it, pull it
journal, February 2011

  • Hersen, Pascal; Ladoux, Benoît
  • Nature, Vol. 470, Issue 7334
  • DOI: 10.1038/470340a

Monomer-Solvent Phase Separation in One-step Self-etch Adhesives
journal, February 2005


Additive Manufacturing of Optically Transparent Glass
journal, September 2015

  • Klein, John; Stern, Michael; Franchin, Giorgia
  • 3D Printing and Additive Manufacturing, Vol. 2, Issue 3
  • DOI: 10.1089/3dp.2015.0021

The Structural Biology of the Developing Dental Enamel Matrix
journal, June 1999

  • Fincham, A. G.; Moradian-Oldak, J.; Simmer, J. P.
  • Journal of Structural Biology, Vol. 126, Issue 3
  • DOI: 10.1006/jsbi.1999.4130

3D Printing of Shear-Thinning Hyaluronic Acid Hydrogels with Secondary Cross-Linking
journal, May 2016

  • Ouyang, Liliang; Highley, Christopher B.; Rodell, Christopher B.
  • ACS Biomaterials Science & Engineering, Vol. 2, Issue 10
  • DOI: 10.1021/acsbiomaterials.6b00158