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Title: Efficient Cytosolic Delivery Using Crystalline Nanoflowers Assembled from Fluorinated Peptoids

Authors:
 [1];  [2];  [1];  [2];  [1];  [1];  [1];  [2]; ORCiD logo [1]
  1. Department of Mechanical and Materials Engineering, Washington State University, Pullman WA 99164 USA
  2. Division of Physical Sciences, Pacific Northwest National Laboratory, Richland WA 99352 USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1488353
Grant/Contract Number:  
AC05-76RL01830; AC02-05CH11231
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Small
Additional Journal Information:
Journal Name: Small Journal Volume: 14 Journal Issue: 52; Journal ID: ISSN 1613-6810
Publisher:
Wiley Blackwell (John Wiley & Sons)
Country of Publication:
Germany
Language:
English

Citation Formats

Song, Yang, Wang, Mingming, Li, Suiqiong, Jin, Haibao, Cai, Xiaoli, Du, Dan, Li, He, Chen, Chun-Long, and Lin, Yuehe. Efficient Cytosolic Delivery Using Crystalline Nanoflowers Assembled from Fluorinated Peptoids. Germany: N. p., 2018. Web. doi:10.1002/smll.201803544.
Song, Yang, Wang, Mingming, Li, Suiqiong, Jin, Haibao, Cai, Xiaoli, Du, Dan, Li, He, Chen, Chun-Long, & Lin, Yuehe. Efficient Cytosolic Delivery Using Crystalline Nanoflowers Assembled from Fluorinated Peptoids. Germany. doi:10.1002/smll.201803544.
Song, Yang, Wang, Mingming, Li, Suiqiong, Jin, Haibao, Cai, Xiaoli, Du, Dan, Li, He, Chen, Chun-Long, and Lin, Yuehe. Thu . "Efficient Cytosolic Delivery Using Crystalline Nanoflowers Assembled from Fluorinated Peptoids". Germany. doi:10.1002/smll.201803544.
@article{osti_1488353,
title = {Efficient Cytosolic Delivery Using Crystalline Nanoflowers Assembled from Fluorinated Peptoids},
author = {Song, Yang and Wang, Mingming and Li, Suiqiong and Jin, Haibao and Cai, Xiaoli and Du, Dan and Li, He and Chen, Chun-Long and Lin, Yuehe},
abstractNote = {},
doi = {10.1002/smll.201803544},
journal = {Small},
number = 52,
volume = 14,
place = {Germany},
year = {2018},
month = {11}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1002/smll.201803544

Citation Metrics:
Cited by: 1 work
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Works referenced in this record:

Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles
journal, May 2008

  • Verma, Ayush; Uzun, Oktay; Hu, Yuhua
  • Nature Materials, Vol. 7, Issue 7
  • DOI: 10.1038/nmat2202

Cell-specific targeting of nanoparticles by multivalent attachment of small molecules
journal, October 2005

  • Weissleder, Ralph; Kelly, Kimberly; Sun, Eric Yi
  • Nature Biotechnology, Vol. 23, Issue 11, p. 1418-1423
  • DOI: 10.1038/nbt1159

Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides
journal, February 2008

  • Chongsiriwatana, N. P.; Patch, J. A.; Czyzewski, A. M.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 8
  • DOI: 10.1073/pnas.0708254105

Self-assembly of crystalline nanotubes from monodisperse amphiphilic diblock copolypeptoid tiles
journal, March 2016

  • Sun, Jing; Jiang, Xi; Lund, Reidar
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 15
  • DOI: 10.1073/pnas.1517169113

RNA interference in the clinic: challenges and future directions
journal, December 2010

  • Pecot, Chad V.; Calin, George A.; Coleman, Robert L.
  • Nature Reviews Cancer, Vol. 11, Issue 1
  • DOI: 10.1038/nrc2966

Polarized endosome dynamics by spindle asymmetry during asymmetric cell division
journal, December 2015

  • Derivery, Emmanuel; Seum, Carole; Daeden, Alicia
  • Nature, Vol. 528, Issue 7581
  • DOI: 10.1038/nature16443

Enhanced delivery of cell-penetrating peptide–peptide nucleic acid conjugates by endosomal disruption
journal, June 2006


Virus-Inspired Polymer for Efficient In Vitro and In Vivo Gene Delivery
journal, August 2016

  • Cheng, Yilong; Yumul, Roma C.; Pun, Suzie H.
  • Angewandte Chemie, Vol. 128, Issue 39
  • DOI: 10.1002/ange.201605958

Overcoming cellular barriers for RNA therapeutics
journal, February 2017


Direct Cytosolic Delivery of CRISPR/Cas9-Ribonucleoprotein for Efficient Gene Editing
journal, January 2017


Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery
journal, December 2011

  • Zhou, Jiangbing; Liu, Jie; Cheng, Christopher J.
  • Nature Materials, Vol. 11, Issue 1
  • DOI: 10.1038/nmat3187

Fluoropolymers for intracellular and in vivo protein delivery
journal, November 2018


Functional nanoparticles for molecular imaging guided gene delivery
journal, December 2010


Quantum dot-loaded monofunctionalized DNA icosahedra for single-particle tracking of endocytic pathways
journal, August 2016

  • Bhatia, Dhiraj; Arumugam, Senthil; Nasilowski, Michel
  • Nature Nanotechnology, Vol. 11, Issue 12
  • DOI: 10.1038/nnano.2016.150

Peptoid nanotubes: an oligomer macrocycle that reversibly sequesters water via single-crystal-to-single-crystal transformations
journal, January 2013

  • Vollrath, Sidonie B. L.; Hu, Chunhua; Bräse, Stefan
  • Chemical Communications, Vol. 49, Issue 23
  • DOI: 10.1039/c3cc37163h

Highly fluorinated amphiphiles as drug and gene carrier and delivery systems
journal, February 2001


Single-Layer MoS 2 -Based Nanoprobes for Homogeneous Detection of Biomolecules
journal, April 2013

  • Zhu, Changfeng; Zeng, Zhiyuan; Li, Hai
  • Journal of the American Chemical Society, Vol. 135, Issue 16
  • DOI: 10.1021/ja4019572

Toxicity of cationic lipids and cationic polymers in gene delivery
journal, August 2006


Thermo-triggered Release of CRISPR-Cas9 System by Lipid-Encapsulated Gold Nanoparticles for Tumor Therapy
journal, January 2018

  • Wang, Peng; Zhang, Lingmin; Zheng, Wenfu
  • Angewandte Chemie International Edition, Vol. 57, Issue 6
  • DOI: 10.1002/anie.201708689

Single-Particle Tracking and Modulation of Cell Entry Pathways of a Tetrahedral DNA Nanostructure in Live Cells
journal, May 2014


In vitro and ex vivo strategies for intracellular delivery
journal, October 2016

  • Stewart, Martin P.; Sharei, Armon; Ding, Xiaoyun
  • Nature, Vol. 538, Issue 7624
  • DOI: 10.1038/nature19764

Proton-Sponge Coated Quantum Dots for siRNA Delivery and Intracellular Imaging
journal, July 2008

  • Yezhelyev, Maksym V.; Qi, Lifeng; O’Regan, Ruth M.
  • Journal of the American Chemical Society, Vol. 130, Issue 28
  • DOI: 10.1021/ja800086u

Hydrogel nanoparticles in drug delivery
journal, December 2008


Oligonucleotide Delivery by Cell-Penetrating “Striped” Nanoparticles
journal, October 2011

  • Jewell, Christopher M.; Jung, Jin-Mi; Atukorale, Prabhani U.
  • Angewandte Chemie International Edition, Vol. 50, Issue 51
  • DOI: 10.1002/anie.201104514

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression
journal, December 2017


Perfluoroarene–Based Peptide Macrocycles to Enhance Penetration Across the Blood–Brain Barrier
journal, October 2017

  • Fadzen, Colin M.; Wolfe, Justin M.; Cho, Choi-Fong
  • Journal of the American Chemical Society, Vol. 139, Issue 44
  • DOI: 10.1021/jacs.7b09790

Motivating endosome motility
journal, October 1999

  • Pfeffer, Suzanne R.
  • Nature Cell Biology, Vol. 1, Issue 6
  • DOI: 10.1038/14097

Self-Assembled Fluorodendrimers Combine the Features of Lipid and Polymeric Vectors in Gene Delivery
journal, August 2015

  • Wang, Hui; Wang, Yitong; Wang, Yu
  • Angewandte Chemie International Edition, Vol. 54, Issue 40
  • DOI: 10.1002/anie.201501461

Probing short-range protein Brownian motion in the cytoplasm of living cells
journal, December 2014

  • Di Rienzo, Carmine; Piazza, Vincenzo; Gratton, Enrico
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms6891

Water insoluble and soluble lipids for gene delivery
journal, April 2005


Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide
journal, May 2017

  • Akishiba, Misao; Takeuchi, Toshihide; Kawaguchi, Yoshimasa
  • Nature Chemistry, Vol. 9, Issue 8
  • DOI: 10.1038/nchem.2779

Activatable Fluorescence/MRI Bimodal Platform for Tumor Cell Imaging via MnO 2 Nanosheet–Aptamer Nanoprobe
journal, July 2014

  • Zhao, Zilong; Fan, Huanhuan; Zhou, Gaofeng
  • Journal of the American Chemical Society, Vol. 136, Issue 32
  • DOI: 10.1021/ja5029364

Long-distance endosome trafficking drives fungal effector production during plant infection
journal, October 2014

  • Bielska, Ewa; Higuchi, Yujiro; Schuster, Martin
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms6097

Free-floating ultrathin two-dimensional crystals from sequence-specific peptoid polymers
journal, April 2010

  • Nam, Ki Tae; Shelby, Sarah A.; Choi, Philip H.
  • Nature Materials, Vol. 9, Issue 5
  • DOI: 10.1038/nmat2742

Design and development of polymers for gene delivery
journal, July 2005

  • Pack, Daniel W.; Hoffman, Allan S.; Pun, Suzie
  • Nature Reviews Drug Discovery, Vol. 4, Issue 7
  • DOI: 10.1038/nrd1775

In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
journal, December 2007

  • Qian, Ximei; Peng, Xiang-Hong; Ansari, Dominic O.
  • Nature Biotechnology, Vol. 26, Issue 1
  • DOI: 10.1038/nbt1377

Highly stable and self-repairing membrane-mimetic 2D nanomaterials assembled from lipid-like peptoids
journal, July 2016

  • Jin, Haibao; Jiao, Fang; Daily, Michael D.
  • Nature Communications, Vol. 7, Issue 1
  • DOI: 10.1038/ncomms12252

Cell Penetrating Peptides: Intracellular Pathways and Pharmaceutical Perspectives
journal, April 2007

  • Patel, Leena N.; Zaro, Jennica L.; Shen, Wei-Chiang
  • Pharmaceutical Research, Vol. 24, Issue 11
  • DOI: 10.1007/s11095-007-9303-7

Chemical Basis of Interactions Between Engineered Nanoparticles and Biological Systems
journal, June 2014

  • Mu, Qingxin; Jiang, Guibin; Chen, Lingxin
  • Chemical Reviews, Vol. 114, Issue 15
  • DOI: 10.1021/cr400295a

Designable and dynamic single-walled stiff nanotubes assembled from sequence-defined peptoids
journal, January 2018


Efficient Delivery of Quantum Dots into the Cytosol of Cells Using Cell-Penetrating Poly(disulfide)s
journal, July 2017

  • Derivery, Emmanuel; Bartolami, Eline; Matile, Stefan
  • Journal of the American Chemical Society, Vol. 139, Issue 30
  • DOI: 10.1021/jacs.7b02952

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
journal, January 2012

  • Kamaly, Nazila; Xiao, Zeyu; Valencia, Pedro M.
  • Chemical Society Reviews, Vol. 41, Issue 7
  • DOI: 10.1039/c2cs15344k

Synthetic DNA delivery systems
journal, January 2000

  • Luo, Dan; Saltzman, W. Mark
  • Nature Biotechnology, Vol. 18, Issue 1
  • DOI: 10.1038/71889

Movement of myosin-coated fluorescent beads on actin cables in vitro
journal, May 1983

  • Sheetz, Michael P.; Spudich, James A.
  • Nature, Vol. 303, Issue 5912
  • DOI: 10.1038/303031a0

The fluorination effect of fluoroamphiphiles in cytosolic protein delivery
journal, April 2018


Brownian Motion: A Theoretical Explanation for the Movement of Vesicles across the Endothelium
journal, October 1966

  • Shea, Stephen M.; Karnovsky, Morris J.
  • Nature, Vol. 212, Issue 5060
  • DOI: 10.1038/212353a0

The effect of fluorination on the transfection efficacy of surface-engineered dendrimers
journal, August 2014


Peptoids: a modular approach to drug discovery.
journal, October 1992

  • Simon, R. J.; Kania, R. S.; Zuckermann, R. N.
  • Proceedings of the National Academy of Sciences, Vol. 89, Issue 20
  • DOI: 10.1073/pnas.89.20.9367

Tug-of-war between dissimilar teams of microtubule motors regulates transport and fission of endosomes
journal, October 2009

  • Soppina, V.; Rai, A. K.; Ramaiya, A. J.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 46
  • DOI: 10.1073/pnas.0906524106

Biopharmaceutical benchmarks 2014
journal, October 2014


Fluorine makes a difference
journal, November 2003


Engineered Biocompatible Nanoparticles for in Vivo Imaging Applications
journal, October 2010

  • Chen, Shu; Wang, Lijun; Duce, Suzanne L.
  • Journal of the American Chemical Society, Vol. 132, Issue 42
  • DOI: 10.1021/ja106543j

Surface-Engineered Dendrimers in Gene Delivery
journal, May 2015

  • Yang, Jiepin; Zhang, Qiang; Chang, Hong
  • Chemical Reviews, Vol. 115, Issue 11
  • DOI: 10.1021/cr500542t

DNA Amplification in Neutral Liposomes for Safe and Efficient Gene Delivery
journal, April 2014

  • Lee, Sangmin; Koo, Heebeom; Na, Jin Hee
  • ACS Nano, Vol. 8, Issue 5
  • DOI: 10.1021/nn501106a

In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis
journal, March 2003


A fluorinated dendrimer achieves excellent gene transfection efficacy at extremely low nitrogen to phosphorus ratios
journal, January 2014

  • Wang, Mingming; Liu, Hongmei; Li, Lei
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms4053