Reducing t1 noise through rapid scanning

Perras, Frédéric A.; Pruski, Marek

doi:10.1016/j.jmr.2018.11.008

Title: Reducing t1 noise through rapid scanning

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Abstract

The so-called t₁ noise, which arises due to random instabilities in the spectrometer hardware, remains the primary source of noise that limits the sensitivity of most 2D NMR experiments, particularly in the expanding group of solid-state NMR methods that utilize dipolar-recoupling. Here in this communication we revisit the relationship between the signal intensity and the t₁ noise produced. It is shown that since the latter scales linearly with the signal strength, the use of a conventional relaxation delay of 1.3T₁ may prove far from optimal. In cases where the fluctuations occur on a shorter timescale than the recycle delay, a considerably faster repetition rate should be used to maximize the time sensitivity in a 2D experiment than what is used to maximize the sensitivity in 1D. This is demonstrated with the acquisition of ¹H{¹³C} Dipolar-mediated Heteronuclear Multiple-Quantum Correlation (D-HMQC) type spectra in which the sensitivity could be nearly doubled by choosing a very short relaxation delay corresponding to 0.2T₁.

Authors:

Perras, Frédéric A. ^[1];

^[2]

Ames Lab., Ames, IA (United States)
Iowa State Univ., Ames, IA (United States). Dept. of Chemistry

Publication Date:: Mon Nov 26 00:00:00 EST 2018

Research Org.:: Ames Lab., Ames, IA (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

OSTI Identifier:: 1487222

Alternate Identifier(s):: OSTI ID: 1636931

Report Number(s):: IS-J-9831
Journal ID: ISSN 1090-7807; PII: S1090780718303173

Grant/Contract Number:: AC02-07CH11358

Resource Type:: Accepted Manuscript

Journal Name:: Journal of Magnetic Resonance

Additional Journal Information:: Journal Volume: 298; Journal Issue: C; Journal ID: ISSN 1090-7807

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Subject:: 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 2D NMR; t1 noise; Spin-lattice relaxation; D-HMQC; Solid-state NMR

Citation Formats


                    Perras, Frédéric A., and Pruski, Marek. Reducing t1 noise through rapid scanning.  United States: N. p., 2018. 
Web.  doi:10.1016/j.jmr.2018.11.008.

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                    Perras, Frédéric A., & Pruski, Marek. Reducing t1 noise through rapid scanning.  United States.  https://doi.org/10.1016/j.jmr.2018.11.008

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                    Perras, Frédéric A., and Pruski, Marek. Mon .  
"Reducing t1 noise through rapid scanning".  United States.  https://doi.org/10.1016/j.jmr.2018.11.008.  https://www.osti.gov/servlets/purl/1487222.

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@article{osti_1487222,

  title        = {Reducing t1 noise through rapid scanning},

  author       = {Perras, Frédéric A. and Pruski, Marek},

  abstractNote = {The so-called t1 noise, which arises due to random instabilities in the spectrometer hardware, remains the primary source of noise that limits the sensitivity of most 2D NMR experiments, particularly in the expanding group of solid-state NMR methods that utilize dipolar-recoupling. Here in this communication we revisit the relationship between the signal intensity and the t1 noise produced. It is shown that since the latter scales linearly with the signal strength, the use of a conventional relaxation delay of 1.3T1 may prove far from optimal. In cases where the fluctuations occur on a shorter timescale than the recycle delay, a considerably faster repetition rate should be used to maximize the time sensitivity in a 2D experiment than what is used to maximize the sensitivity in 1D. This is demonstrated with the acquisition of 1H{13C} Dipolar-mediated Heteronuclear Multiple-Quantum Correlation (D-HMQC) type spectra in which the sensitivity could be nearly doubled by choosing a very short relaxation delay corresponding to 0.2T1.},

  doi          = {10.1016/j.jmr.2018.11.008},

  journal      = {Journal of Magnetic Resonance},

  number       = C,

  volume       = 298,

  place        = {United States},

  year         = {Mon Nov 26 00:00:00 EST 2018},

  month        = {Mon Nov 26 00:00:00 EST 2018}

}

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