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Title: Reducing t1 noise through rapid scanning

Abstract

The so-called t 1 noise, which arises due to random instabilities in the spectrometer hardware, remains the primary source of noise that limits the sensitivity of most 2D NMR experiments, particularly in the expanding group of solid-state NMR methods that utilize dipolar-recoupling. Here in this communication we revisit the relationship between the signal intensity and the t 1 noise produced. It is shown that since the latter scales linearly with the signal strength, the use of a conventional relaxation delay of 1.3T 1 may prove far from optimal. In cases where the fluctuations occur on a shorter timescale than the recycle delay, a considerably faster repetition rate should be used to maximize the time sensitivity in a 2D experiment than what is used to maximize the sensitivity in 1D. This is demonstrated with the acquisition of 1H{ 13C} Dipolar-mediated Heteronuclear Multiple-Quantum Correlation (D-HMQC) type spectra in which the sensitivity could be nearly doubled by choosing a very short relaxation delay corresponding to 0.2T 1.

Authors:
 [1]; ORCiD logo [2]
  1. Ames Lab., Ames, IA (United States)
  2. Iowa State Univ., Ames, IA (United States). Dept. of Chemistry
Publication Date:
Research Org.:
Ames Laboratory (AMES), Ames, IA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1487222
Report Number(s):
IS-J-9831
Journal ID: ISSN 1090-7807; PII: S1090780718303173
Grant/Contract Number:  
AC02-07CH11358
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Magnetic Resonance
Additional Journal Information:
Journal Volume: 298; Journal Issue: C; Journal ID: ISSN 1090-7807
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 2D NMR; t1 noise; Spin-lattice relaxation; D-HMQC; Solid-state NMR

Citation Formats

Perras, Frédéric A., and Pruski, Marek. Reducing t1 noise through rapid scanning. United States: N. p., 2018. Web. doi:10.1016/j.jmr.2018.11.008.
Perras, Frédéric A., & Pruski, Marek. Reducing t1 noise through rapid scanning. United States. doi:10.1016/j.jmr.2018.11.008.
Perras, Frédéric A., and Pruski, Marek. Mon . "Reducing t1 noise through rapid scanning". United States. doi:10.1016/j.jmr.2018.11.008. https://www.osti.gov/servlets/purl/1487222.
@article{osti_1487222,
title = {Reducing t1 noise through rapid scanning},
author = {Perras, Frédéric A. and Pruski, Marek},
abstractNote = {The so-called t1 noise, which arises due to random instabilities in the spectrometer hardware, remains the primary source of noise that limits the sensitivity of most 2D NMR experiments, particularly in the expanding group of solid-state NMR methods that utilize dipolar-recoupling. Here in this communication we revisit the relationship between the signal intensity and the t1 noise produced. It is shown that since the latter scales linearly with the signal strength, the use of a conventional relaxation delay of 1.3T1 may prove far from optimal. In cases where the fluctuations occur on a shorter timescale than the recycle delay, a considerably faster repetition rate should be used to maximize the time sensitivity in a 2D experiment than what is used to maximize the sensitivity in 1D. This is demonstrated with the acquisition of 1H{13C} Dipolar-mediated Heteronuclear Multiple-Quantum Correlation (D-HMQC) type spectra in which the sensitivity could be nearly doubled by choosing a very short relaxation delay corresponding to 0.2T1.},
doi = {10.1016/j.jmr.2018.11.008},
journal = {Journal of Magnetic Resonance},
number = C,
volume = 298,
place = {United States},
year = {2018},
month = {11}
}

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