Multifunctional GdVO4: Eu core–shell nanoparticles containing 225Ac for targeted alpha therapy and molecular imaging

Toro-González, Miguel T.; Copping, Roy; Mirzadeh, Saed; Rojas, Jessika V.

doi:10.1039/C8TB02173B

Title: Multifunctional GdVO₄: Eu core–shell nanoparticles containing ²²⁵Ac for targeted alpha therapy and molecular imaging

Journal Article · 12 November 2018 · Journal of Materials Chemistry. B

DOI: https://doi.org/10.1039/C8TB02173B · OSTI ID:1486950

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Virginia Commonwealth Univ., Richmond, VA (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Gadolinium vanadate nanoparticles (NPs) doped with europium, in concentrations between 5–40%, were synthesized via an aqueous route to prove their multimodal imaging functionalities and their performance as radionuclide carriers for targeted alpha therapy. Core–shell Gd_0.8Eu_0.2VO₄ NPs were doped with the α-emitting actinium-225 to assess the in vitro retention of ²²⁵Ac and its decay daughters; francium-221 and bismuth-213. Gd_0.8Eu_0.2VO₄ core–shell NPs were obtained using a precipitation synthesis route having a tetragonal system, a spherical morphology, and a uniform particle size distribution. Gd_0.8Eu_0.2VO₄ core–shell NPs displayed the characteristic intense emission at 618 nm (red) and paramagnetic behavior of Eu and Gd cations, respectively. Partial retention of radionuclides was obtained with Gd_0.8Eu_0.2VO₄ core NPs, while deposition of two nonradioactive Gd_0.8Eu_0.2VO₄ shells significantly decreased the leakage of both ²²⁵Ac and ²²¹Fr. As a result, the luminescence and magnetic functionalities as well as radionuclide retention capabilities of Gd_0.8Eu_0.2VO₄ core–shell NPs demonstrate their potential for biomedical applications.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1486950

Journal Information:: Journal of Materials Chemistry. B, Journal Name: Journal of Materials Chemistry. B Journal Issue: 47 Vol. 6; ISSN 2050-750X; ISSN JMCBDV

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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Title: Multifunctional GdVO₄: Eu core–shell nanoparticles containing ²²⁵Ac for targeted alpha therapy and molecular imaging