Bacterial microcompartments

Kerfeld, Cheryl A.; Aussignargues, Clement; Zarzycki, Jan; Cai, Fei; Sutter, Markus

doi:10.1038/nrmicro.2018.10

Title: Bacterial microcompartments

Journal Article · 05 March 2018 · Nature Reviews Microbiology

DOI: https://doi.org/10.1038/nrmicro.2018.10 · OSTI ID:1485085

Kerfeld, Cheryl A. ^[1]; Aussignargues, Clement ^[2]; Zarzycki, Jan ^[3]; Cai, Fei ^[4]; Sutter, Markus ^[1]

Michigan State Univ., East Lansing, MI (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Michigan State Univ., East Lansing, MI (United States)
Max Planck Institute for Terrestrial Microbiology, Marburg (Germany)
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

We report that bacterial microcompartments (BMCs) are self-assembling organelles that consist of an enzymatic core that is encapsulated by a selectively permeable protein shell. The potential to form BMCs is widespread and found across the kingdom Bacteria. BMCs have crucial roles in carbon dioxide fixation in autotrophs and the catabolism of organic substrates in heterotrophs. They contribute to the metabolic versatility of bacteria, providing a competitive advantage in specific environmental niches. Although BMCs were first visualized more than 60 years ago, it is mainly in the past decade that progress has been made in understanding their metabolic diversity and the structural basis of their assembly and function. This progress has not only heightened our understanding of their role in microbial metabolism but is also beginning to enable their use in a variety of applications in synthetic biology. In this work, we focus on recent insights into the structure, assembly, diversity and function of BMCs.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Michigan State Univ., East Lansing, MI (United States). MSU-DOE Plant Research Laboratory

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-05CH11231; FG02-91ER20021

OSTI ID:: 1485085

Alternate ID(s):: OSTI ID: 1687379

Journal Information:: Nature Reviews Microbiology, Vol. 16, Issue 5; ISSN 1740-1526

Publisher:: Springer NatureCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 224 works

Citation information provided by
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