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Title: An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery

Abstract

Simulation of blood flows in the pulmonary artery provides some insight into certain diseases by examining the relationship between some continuum metrics, eg, the wall shear stress acting on the vascular endothelium, which responds to flow-induced mechanical forces by releasing vasodilators/constrictors. V. Kheyfets, in his previous work, studies numerically a patient-specific pulmonary circulation to show that decreasing wall shear stress is correlated with increasing pulmonary vascular impedance. We develop a scalable parallel algorithm based on domain decomposition methods to investigate an unsteady model with patient-specific pulsatile waveforms as the inlet boundary condition. The unsteady model offers tremendously more information about the dynamic behavior of the flow field, but computationally speaking, the simulation is a lot more expensive since a problem which is similar to the steady-state problem has to be solved many times, and therefore, the traditional sequential approach is not suitable anymore. We show computationally that simulations using the proposed parallel approach with up to 10 000 processor cores can be obtained with much reduced compute time. Finally, this makes the technology potentially usable for the routine study of the dynamic behavior of blood flows in the pulmonary artery, in particular, the changes of the blood flows and themore » wall shear stress in the spatial and temporal dimensions.« less

Authors:
 [1];  [2];  [3]; ORCiD logo [4]
  1. Idaho National Lab. (INL), Idaho Falls, ID (United States). Modeling and Simulation
  2. Univ. of Colorado, Denver, CO (United States). School of Medicine
  3. Univ. of Texas, San Antonio, TX (United States). Dept. of Mechanical Engineering
  4. Univ. of Colorado, Boulder, CO (United States). Dept. of Computer Science
Publication Date:
Research Org.:
Idaho National Lab. (INL), Idaho Falls, ID (United States)
Sponsoring Org.:
USDOE; National Science Foundation (NSF)
OSTI Identifier:
1484705
Alternate Identifier(s):
OSTI ID: 1419356
Report Number(s):
INL/JOU-17-42412-Rev001
Journal ID: ISSN 2040-7939
Grant/Contract Number:  
AC07-05ID14517; DMS-1720366
Resource Type:
Accepted Manuscript
Journal Name:
International Journal for Numerical Methods in Biomedical Engineering
Additional Journal Information:
Journal Volume: 34; Journal Issue: 4; Journal ID: ISSN 2040-7939
Publisher:
Wiley
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; unsteady blood flows; patient-specific pulmonary artery; finite element; domain decomposition; parallel processing

Citation Formats

Kong, Fande, Kheyfets, Vitaly, Finol, Ender, and Cai, Xiao-Chuan. An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery. United States: N. p., 2017. Web. doi:10.1002/cnm.2952.
Kong, Fande, Kheyfets, Vitaly, Finol, Ender, & Cai, Xiao-Chuan. An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery. United States. doi:10.1002/cnm.2952.
Kong, Fande, Kheyfets, Vitaly, Finol, Ender, and Cai, Xiao-Chuan. Fri . "An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery". United States. doi:10.1002/cnm.2952. https://www.osti.gov/servlets/purl/1484705.
@article{osti_1484705,
title = {An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery},
author = {Kong, Fande and Kheyfets, Vitaly and Finol, Ender and Cai, Xiao-Chuan},
abstractNote = {Simulation of blood flows in the pulmonary artery provides some insight into certain diseases by examining the relationship between some continuum metrics, eg, the wall shear stress acting on the vascular endothelium, which responds to flow-induced mechanical forces by releasing vasodilators/constrictors. V. Kheyfets, in his previous work, studies numerically a patient-specific pulmonary circulation to show that decreasing wall shear stress is correlated with increasing pulmonary vascular impedance. We develop a scalable parallel algorithm based on domain decomposition methods to investigate an unsteady model with patient-specific pulsatile waveforms as the inlet boundary condition. The unsteady model offers tremendously more information about the dynamic behavior of the flow field, but computationally speaking, the simulation is a lot more expensive since a problem which is similar to the steady-state problem has to be solved many times, and therefore, the traditional sequential approach is not suitable anymore. We show computationally that simulations using the proposed parallel approach with up to 10 000 processor cores can be obtained with much reduced compute time. Finally, this makes the technology potentially usable for the routine study of the dynamic behavior of blood flows in the pulmonary artery, in particular, the changes of the blood flows and the wall shear stress in the spatial and temporal dimensions.},
doi = {10.1002/cnm.2952},
journal = {International Journal for Numerical Methods in Biomedical Engineering},
number = 4,
volume = 34,
place = {United States},
year = {2017},
month = {12}
}

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    Works referencing / citing this record:

    Simulation of unsteady blood flows in a patient‐specific compliant pulmonary artery with a highly parallel monolithically coupled fluid‐structure interaction algorithm
    journal, May 2019

    • Kong, Fande; Kheyfets, Vitaly; Finol, Ender
    • International Journal for Numerical Methods in Biomedical Engineering, Vol. 35, Issue 7
    • DOI: 10.1002/cnm.3208

    Simulation of unsteady blood flows in a patient‐specific compliant pulmonary artery with a highly parallel monolithically coupled fluid‐structure interaction algorithm
    journal, May 2019

    • Kong, Fande; Kheyfets, Vitaly; Finol, Ender
    • International Journal for Numerical Methods in Biomedical Engineering, Vol. 35, Issue 7
    • DOI: 10.1002/cnm.3208