The intrinsically disordered nature of the peroxisomal protein translocation machinery

Barros‐Barbosa, Aurora; Rodrigues, Tony A.; Ferreira, Maria J.; Pedrosa, Ana G.; Teixeira, Nélson R.; Francisco, Tânia; Azevedo, Jorge E.

doi:10.1111/febs.14704

Title: The intrinsically disordered nature of the peroxisomal protein translocation machinery

Journal Article · 30 November 2018 · Federation of European Biochemical Societies (FEBS) Journal

DOI: https://doi.org/10.1111/febs.14704 · OSTI ID:1484307

Barros‐Barbosa, Aurora ^[1]; Rodrigues, Tony A. ^[1]; Ferreira, Maria J. ^[1]; Pedrosa, Ana G. ^[1]; Teixeira, Nélson R. ^[1]; Francisco, Tânia ^[1]; Azevedo, Jorge E. ^[1]

Instituto de Investigação e Inovação em Saúde (i3S) Universidade do Porto Portugal, Instituto de Biologia Molecular e Celular (IBMC) Universidade do Porto Portugal, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS) Universidade do Porto Portugal

Despite having a membrane that is impermeable to all but the smallest of metabolites, peroxisomes acquire their newly synthesized (cytosolic) matrix proteins in an already folded conformation. In some cases, even oligomeric proteins have been reported to translocate the organelle membrane. The protein sorting machinery that accomplishes this feat must be rather flexible and, unsurprisingly, several of its key components have large intrinsically disordered domains. Here, we provide an overview on these domains and their interactions trying to infer their functional roles in this protein sorting pathway.

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Sponsoring Organization:: USDOE

OSTI ID:: 1484307

Journal Information:: Federation of European Biochemical Societies (FEBS) Journal, Journal Name: Federation of European Biochemical Societies (FEBS) Journal Journal Issue: 1 Vol. 286; ISSN 1742-464X

Publisher:: Wiley-BlackwellCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Pex9p is a new yeast peroxisomal import receptor for PTS1-containing proteins Effelsberg, Daniel; Cruz-Zaragoza, Luis Daniel; Schliebs, Wolfgang Journal of Cell Science, Vol. 129, Issue 21 https://doi.org/10.1242/jcs.195271	journal	November 2016
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A Peroxisomal Lon Protease and Peroxisome Degradation by Autophagy Play Key Roles in Vitality of Hansenula polymorpha Cells Aksam, Eda Bener; Koek, Anne; Jourdan, Stefanie Autophagy, Vol. 3, Issue 2 https://doi.org/10.4161/auto.3534	journal	March 2007

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