Causes and Consequences of Spatial Within-Host Viral Spread
Abstract
The spread of viral pathogens both between and within hosts is inherently a spatial process. While the spatial aspects of viral spread at the epidemiological level have been increasingly well characterized, the spatial aspects of viral spread within infected hosts are still understudied. Here, with a focus on influenza A viruses (IAVs), we first review experimental studies that have shed light on the mechanisms and spatial dynamics of viral spread within hosts. These studies provide strong empirical evidence for highly localized IAV spread within hosts. Since mathematical and computational within-host models have been increasingly used to gain a quantitative understanding of observed viral dynamic patterns, we then review the (relatively few) computational modeling studies that have shed light on possible factors that structure the dynamics of spatial within-host IAV spread. These factors include the dispersal distance of virions, the localization of the immune response, and heterogeneity in host cell phenotypes across the respiratory tract. While informative, we find in these studies a striking absence of theoretical expectations of how spatial dynamics may impact the dynamics of viral populations. To mitigate this, we turn to the extensive ecological and evolutionary literature on range expansions to provide informed theoretical expectations. We findmore »
- Authors:
-
- Emory Univ., Atlanta, GA (United States). Dept. of Biology
- Univ. of Illinois, Champaign, IL (United States). Dept. of Microbiology. Carl R. Woese Inst. for Genomic Biology
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Publication Date:
- Research Org.:
- Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE; Defense Advanced Research Projects Agency (DARPA) (United States); National Inst. of Health (NIH) (United States)
- OSTI Identifier:
- 1483551
- Report Number(s):
- LA-UR-18-29454
Journal ID: ISSN 1999-4915
- Grant/Contract Number:
- 89233218CNA000001; W911NF-17-2-0034; U54-GM111274
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Viruses
- Additional Journal Information:
- Journal Volume: 10; Journal Issue: 11; Journal ID: ISSN 1999-4915
- Publisher:
- MDPI
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; influenza virus; within-host viral dynamics; spatial spread; within-host evolution
Citation Formats
Gallagher, Molly E., Brooke, Christopher B., Ke, Ruian, and Koelle, Katia. Causes and Consequences of Spatial Within-Host Viral Spread. United States: N. p., 2018.
Web. doi:10.3390/v10110627.
Gallagher, Molly E., Brooke, Christopher B., Ke, Ruian, & Koelle, Katia. Causes and Consequences of Spatial Within-Host Viral Spread. United States. doi:10.3390/v10110627.
Gallagher, Molly E., Brooke, Christopher B., Ke, Ruian, and Koelle, Katia. Tue .
"Causes and Consequences of Spatial Within-Host Viral Spread". United States. doi:10.3390/v10110627. https://www.osti.gov/servlets/purl/1483551.
@article{osti_1483551,
title = {Causes and Consequences of Spatial Within-Host Viral Spread},
author = {Gallagher, Molly E. and Brooke, Christopher B. and Ke, Ruian and Koelle, Katia},
abstractNote = {The spread of viral pathogens both between and within hosts is inherently a spatial process. While the spatial aspects of viral spread at the epidemiological level have been increasingly well characterized, the spatial aspects of viral spread within infected hosts are still understudied. Here, with a focus on influenza A viruses (IAVs), we first review experimental studies that have shed light on the mechanisms and spatial dynamics of viral spread within hosts. These studies provide strong empirical evidence for highly localized IAV spread within hosts. Since mathematical and computational within-host models have been increasingly used to gain a quantitative understanding of observed viral dynamic patterns, we then review the (relatively few) computational modeling studies that have shed light on possible factors that structure the dynamics of spatial within-host IAV spread. These factors include the dispersal distance of virions, the localization of the immune response, and heterogeneity in host cell phenotypes across the respiratory tract. While informative, we find in these studies a striking absence of theoretical expectations of how spatial dynamics may impact the dynamics of viral populations. To mitigate this, we turn to the extensive ecological and evolutionary literature on range expansions to provide informed theoretical expectations. We find that factors such as the type of density dependence, the frequency of long-distance dispersal, specific life history characteristics, and the extent of spatial heterogeneity are critical factors affecting the speed of population spread and the genetic composition of spatially expanding populations. For each factor that we identified in the theoretical literature, we draw parallels to its analog in viral populations. We end by discussing current knowledge gaps related to the spatial component of within-host IAV spread and the potential for within-host spatial considerations to inform the development of disease control strategies.},
doi = {10.3390/v10110627},
journal = {Viruses},
number = 11,
volume = 10,
place = {United States},
year = {2018},
month = {11}
}
Other availability
Search WorldCat to find libraries that may hold this journal
Cited by: 7 works
Citation information provided by
Web of Science
Web of Science
Figures / Tables:
Figure 1: Experimental findings of within-host influenza virus spread. (A) Influenza virus spread visualized through bioluminescent imaging. The figure shows fluorescence from excised lungs of infected mice. Figure reproduced from [31]; (B) The genome and proteins of influenza virus can be transferred between cells via intercellular pathways called tunneling nanotubes.more »
All figures and tables
(4 total)
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Influenza Virus Receptor Specificity and Cell Tropism in Mouse and Human Airway Epithelial Cells
journal, July 2006
- Ibricevic, A.; Pekosz, A.; Walter, M. J.
- Journal of Virology, Vol. 80, Issue 15
Bronchotracheal Response in Human Influenza: Type A, Asian Strain, as Studied by Light and Electron Microscopic Examination of Bronchoscopic Biopsies
journal, September 1961
- Walsh, John J.
- Archives of Internal Medicine, Vol. 108, Issue 3
A spatial model of the efficiency of T cell search in the influenza-infected lung
journal, June 2016
- Levin, Drew; Forrest, Stephanie; Banerjee, Soumya
- Journal of Theoretical Biology, Vol. 398
The Fate of Mutations Surfing on the Wave of a Range Expansion
journal, November 2005
- Klopfstein, Seraina; Currat, Mathias; Excoffier, Laurent
- Molecular Biology and Evolution, Vol. 23, Issue 3
Within-Host Evolution of Human Influenza Virus
journal, September 2018
- Xue, Katherine S.; Moncla, Louise H.; Bedford, Trevor
- Trends in Microbiology, Vol. 26, Issue 9
Molecular Diversity After a Range Expansion in Heterogeneous Environments
journal, October 2006
- Wegmann, Daniel; Currat, Mathias; Excoffier, Laurent
- Genetics, Vol. 174, Issue 4
Influenza A Virus Transmission Bottlenecks Are Defined by Infection Route and Recipient Host
journal, November 2014
- Varble, Andrew; Albrecht, Randy A.; Backes, Simone
- Cell Host & Microbe, Vol. 16, Issue 5
Synchrony, Waves, and Spatial Hierarchies in the Spread of Influenza
journal, March 2006
- Viboud, C.; Bjornstad, O. N.; Smith, D. L.
- Science, Vol. 312, Issue 5772
Locally Produced IL-10 Limits Cutaneous Vaccinia Virus Spread
journal, March 2016
- Cush, Stephanie S.; Reynoso, Glennys V.; Kamenyeva, Olena
- PLOS Pathogens, Vol. 12, Issue 3
Seasonal and Pandemic Human Influenza Viruses Attach Better to Human Upper Respiratory Tract Epithelium than Avian Influenza Viruses
journal, April 2010
- van Riel, Debby; den Bakker, Michael A.; Leijten, Lonneke M. E.
- The American Journal of Pathology, Vol. 176, Issue 4
Rapid Intrahost Evolution of Human Cytomegalovirus Is Shaped by Demography and Positive Selection
journal, September 2013
- Renzette, Nicholas; Gibson, Laura; Bhattacharjee, Bornali
- PLoS Genetics, Vol. 9, Issue 9
Comparison of Temporal and Spatial Dynamics of Seasonal H3N2, Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Virus Infections in Ferrets
journal, August 2012
- van den Brand, Judith M. A.; Stittelaar, Koert J.; van Amerongen, Geert
- PLoS ONE, Vol. 7, Issue 8
Collective Infectious Units in Viruses
journal, May 2017
- Sanjuán, Rafael
- Trends in Microbiology, Vol. 25, Issue 5
Immunohistochemical and In Situ Hybridization Studies of Influenza A Virus Infection in Human Lungs
journal, August 2000
- Guarner, Jeannette; Shieh, Wun-Ju; Dawson, Jacqueline
- American Journal of Clinical Pathology, Vol. 114, Issue 2
Allee Dynamics and the Spread of Invading Organisms
journal, April 1993
- Lewis, M. A.; Kareiva, P.
- Theoretical Population Biology, Vol. 43, Issue 2
Characterization of temperature sensitive influenza virus mutants defective in neuraminidase
journal, October 1974
- Palese, Peter; Tobita, Kiyotake; Ueda, Masahiro
- Virology, Vol. 61, Issue 2
Expansion Load and the Evolutionary Dynamics of a Species Range
journal, April 2015
- Peischl, Stephan; Kirkpatrick, Mark; Excoffier, Laurent
- The American Naturalist, Vol. 185, Issue 4
Viruses Roll the Dice: The Stochastic Behavior of Viral Genome Molecules Accelerates Viral Adaptation at the Cell and Tissue Levels
journal, March 2015
- Miyashita, Shuhei; Ishibashi, Kazuhiro; Kishino, Hirohisa
- PLOS Biology, Vol. 13, Issue 3
Colonization with long-distance seed dispersal and genetic structure of maternally inherited genes in forest trees: a simulation study
journal, April 1997
- Le Corre, ValÉRie; Machon, Nathalie; Petit, RÉMy J.
- Genetical Research, Vol. 69, Issue 2
Spatial evolutionary epidemiology of spreading epidemics
journal, October 2016
- Lion, S.; Gandon, S.
- Proceedings of the Royal Society B: Biological Sciences, Vol. 283, Issue 1841
Cloned Defective Interfering Influenza Virus Protects Ferrets from Pandemic 2009 Influenza A Virus and Allows Protective Immunity to Be Established
journal, December 2012
- Dimmock, Nigel J.; Dove, Brian K.; Scott, Paul D.
- PLoS ONE, Vol. 7, Issue 12
Evolution of Coalescence Times, Genetic Diversity and Structure during Colonization
journal, April 1997
- Austerlitz, Frédéric; Jung-Muller, Bernard; Godelle, Bernard
- Theoretical Population Biology, Vol. 51, Issue 2
Life at the Front of an Expanding Population
journal, January 2010
- Hallatschek, Oskar; Nelson, David R.
- Evolution, Vol. 64, Issue 1
Purification, characterization, and localization of a novel trypsin-like protease found in the human airway.
journal, March 1997
- Yasuoka, S.; Ohnishi, T.; Kawano, S.
- American Journal of Respiratory Cell and Molecular Biology, Vol. 16, Issue 3
Rabies Epizootics Among Raccoons Vary Along a North–South Gradient in the Eastern United States
journal, December 2001
- Childs, James E.; Curns, Aaron T.; Dey, Meghan E.
- Vector-Borne and Zoonotic Diseases, Vol. 1, Issue 4
Most Influenza A Virions Fail To Express at Least One Essential Viral Protein
journal, January 2013
- Brooke, C. B.; Ince, W. L.; Wrammert, J.
- Journal of Virology, Vol. 87, Issue 6
Inferring Viral Dynamics in Chronically HCV Infected Patients from the Spatial Distribution of Infected Hepatocytes
journal, November 2014
- Graw, Frederik; Balagopal, Ashwin; Kandathil, Abraham J.
- PLoS Computational Biology, Vol. 10, Issue 11
Human and Avian Influenza Viruses Target Different Cells in the Lower Respiratory Tract of Humans and Other Mammals
journal, October 2007
- van Riel, Debby; Munster, Vincent J.; de Wit, Emmie
- The American Journal of Pathology, Vol. 171, Issue 4
On the Spatial Spread of the Grey Squirrel in Britain
journal, November 1989
- Okubo, A.; Maini, P. K.; Williamson, M. H.
- Proceedings of the Royal Society B: Biological Sciences, Vol. 238, Issue 1291
Spatial models of virus-immune dynamics
journal, March 2005
- Funk, Georg A.; Jansen, Vincent A. A.; Bonhoeffer, Sebastian
- Journal of Theoretical Biology, Vol. 233, Issue 2
Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus
journal, June 2010
- Manicassamy, B.; Manicassamy, S.; Belicha-Villanueva, A.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 25
House-to-house human movement drives dengue virus transmission
journal, December 2012
- Stoddard, S. T.; Forshey, B. M.; Morrison, A. C.
- Proceedings of the National Academy of Sciences, Vol. 110, Issue 3
Attachment of infectious influenza A viruses of various subtypes to live mammalian and avian cells as measured by flow cytometry
journal, November 2007
- Rimmelzwaan, Guus F.; Nieuwkoop, Nella J.; de Mutsert, Gerrie
- Virus Research, Vol. 129, Issue 2
Anatomically Restricted Synergistic Antiviral Activities of Innate and Adaptive Immune Cells in the Skin
journal, February 2013
- Hickman, Heather D.; Reynoso, Glennys V.; Ngudiankama, Barbara F.
- Cell Host & Microbe, Vol. 13, Issue 2
Models of Spatial Spread: Is the Theory Complete?
journal, September 1996
- Hastings, Alan
- Ecology, Vol. 77, Issue 6
Genomic variation of human immunodeficiency virus type 1 (HIV-1): molecular analyses of HIV-1 in sequential blood samples and various organs obtained at autopsy
journal, April 1994
- Ball, J. K.; Holmes, E. C.; Whitwell, H.
- Journal of General Virology, Vol. 75, Issue 4
Human mobility and the spatial transmission of influenza in the United States
journal, February 2017
- Charu, Vivek; Zeger, Scott; Gog, Julia
- PLOS Computational Biology, Vol. 13, Issue 2
Limits and patterns of cytomegalovirus genomic diversity in humans
journal, July 2015
- Renzette, Nicholas; Pokalyuk, Cornelia; Gibson, Laura
- Proceedings of the National Academy of Sciences, Vol. 112, Issue 30
Analysis of IAV Replication and Co-infection Dynamics by a Versatile RNA Viral Genome Labeling Method
journal, July 2017
- Dou, Dan; Hernández-Neuta, Iván; Wang, Hao
- Cell Reports, Vol. 20, Issue 1
Mapping global environmental suitability for Zika virus
journal, April 2016
- Messina, Jane P.; Kraemer, Moritz UG; Brady, Oliver J.
- eLife, Vol. 5
Synaptic transmission and the susceptibility of HIV infection to anti-viral drugs
journal, July 2013
- Komarova, Natalia L.; Levy, David N.; Wodarz, Dominik
- Scientific Reports, Vol. 3, Issue 1
Long term trends in the evolution of H(3) HA1 human influenza type A
journal, July 1997
- Fitch, W. M.; Bush, R. M.; Bender, C. A.
- Proceedings of the National Academy of Sciences, Vol. 94, Issue 15
Barrier function of airway tract epithelium
journal, May 2013
- Ganesan, Shyamala; Comstock, Adam T.; Sajjan, Uma S.
- Tissue Barriers, Vol. 1, Issue 4
Modeling the intracellular replication of influenza A virus in the presence of defective interfering RNAs
journal, February 2016
- Laske, Tanja; Heldt, Frank Stefan; Hoffmann, Helene
- Virus Research, Vol. 213
Random Dispersal in Theoretical Populations
journal, June 1951
- Skellam, J. G.
- Biometrika, Vol. 38, Issue 1/2
Dynamics of Influenza Virus Infection and Pathology
journal, February 2010
- Saenz, R. A.; Quinlivan, M.; Elton, D.
- Journal of Virology, Vol. 84, Issue 8
Defective Interfering Viruses
journal, October 1973
- Huang, A. S.
- Annual Review of Microbiology, Vol. 27, Issue 1
Highly Sensitive Real-Time In Vivo Imaging of an Influenza Reporter Virus Reveals Dynamics of Replication and Spread
journal, October 2013
- Tran, V.; Moser, L. A.; Poole, D. S.
- Journal of Virology, Vol. 87, Issue 24
Global Transmission Dynamics of Measles in the Measles Elimination Era
journal, April 2017
- Furuse, Yuki; Oshitani, Hitoshi
- Viruses, Vol. 9, Issue 4
Modeling Stratified Diffusion in Biological Invasions
journal, August 1995
- Shigesada, Nanako; Kawasaki, Kohkichi; Takeda, Yasuhiko
- The American Naturalist, Vol. 146, Issue 2
The effects of a deleterious mutation load on patterns of influenza A/H3N2's antigenic evolution in humans
journal, September 2015
- Koelle, Katia; Rasmussen, David A.
- eLife, Vol. 4
A mathematical model of cell-to-cell spread of HIV-1 that includes a time delay
journal, May 2003
- Culshaw, Rebecca V.; Ruan, Shigui; Webb, Glenn
- Journal of Mathematical Biology, Vol. 46, Issue 5
Phylogenetic Evidence for Deleterious Mutation Load in RNA Viruses and Its Contribution to Viral Evolution
journal, January 2007
- Pybus, Oliver G.; Rambaut, Andrew; Belshaw, Robert
- Molecular Biology and Evolution, Vol. 24, Issue 3
Human Mobility Networks, Travel Restrictions, and the Global Spread of 2009 H1N1 Pandemic
journal, January 2011
- Bajardi, Paolo; Poletto, Chiara; Ramasco, Jose J.
- PLoS ONE, Vol. 6, Issue 1
Kinetics of Influenza A Virus Infection in Humans
journal, July 2006
- Baccam, P.; Beauchemin, C.; Macken, C. A.
- Journal of Virology, Vol. 80, Issue 15
Visualizing influenza virus infection in living mice
journal, September 2013
- Pan, Weiqi; Dong, Zhenyuan; Li, Feng
- Nature Communications, Vol. 4, Issue 1
Dengue diversity across spatial and temporal scales: Local structure and the effect of host population size
journal, March 2017
- Salje, Henrik; Lessler, Justin; Maljkovic Berry, Irina
- Science, Vol. 355, Issue 6331
Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs
journal, September 2012
- Ehre, C.; Worthington, E. N.; Liesman, R. M.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 41
Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies
journal, March 2015
- Fukuyama, Satoshi; Katsura, Hiroaki; Zhao, Dongming
- Nature Communications, Vol. 6, Issue 1
Tropism of Dengue Virus in Mice and Humans Defined by Viral Nonstructural Protein 3-Specific Immunostaining
journal, March 2009
- Flores, Diana; Coloma, Josefina; Beatty, P. Robert
- The American Journal of Tropical Medicine and Hygiene, Vol. 80, Issue 3
Influenza A virus infection kinetics: quantitative data and models: Modeling influenza kinetics
journal, December 2010
- Smith, Amber M.; Perelson, Alan S.
- Wiley Interdisciplinary Reviews: Systems Biology and Medicine, Vol. 3, Issue 4
Random Dispersal in Theoretical Populations
journal, January 1951
- Skellam, J. G.
- Biometrika, Vol. 38, Issue 1-2
The spatial spread of invasions: new developments in theory and evidence: Spatial spread of invasions
journal, November 2004
- Hastings, Alan; Cuddington, Kim; Davies, Kendi F.
- Ecology Letters, Vol. 8, Issue 1
Analysing the Velocity of Animal Range Expansion
journal, March 1992
- van den Bosch, F.; Hengeveld, R.; Metz, J. A. J.
- Journal of Biogeography, Vol. 19, Issue 2
Genetic Consequences of Range Expansions
journal, December 2009
- Excoffier, Laurent; Foll, Matthieu; Petit, Rémy J.
- Annual Review of Ecology, Evolution, and Systematics, Vol. 40, Issue 1
Influenza Virus Reassortment Occurs with High Frequency in the Absence of Segment Mismatch
journal, June 2013
- Marshall, Nicolle; Priyamvada, Lalita; Ende, Zachary
- PLoS Pathogens, Vol. 9, Issue 6
Time Lines of Infection and Disease in Human Influenza: A Review of Volunteer Challenge Studies
journal, January 2008
- Carrat, Fabrice; Vergu, Elisabeta; Ferguson, Neil M.
- American Journal of Epidemiology, Vol. 167, Issue 7
Multiscale modeling of virus replication and spread
journal, March 2016
- Kumberger, Peter; Frey, Felix; Schwarz, Ulrich S.
- FEBS Letters, Vol. 590, Issue 13
Spatial structure inhibits the rate of invasion of beneficial mutations in asexual populations
journal, June 2007
- Habets, Michelle G. J. L.; Czárán, Tamás; Hoekstra, Rolf F.
- Proceedings of the Royal Society B: Biological Sciences, Vol. 274, Issue 1622
A spatial model for the spread of invading organisms subject to competition
journal, September 1997
- Hart, Deborah R.; Gardner, Robert H.
- Journal of Mathematical Biology, Vol. 35, Issue 8
Allee effect promotes diversity in traveling waves of colonization
journal, May 2012
- Roques, L.; Garnier, J.; Hamel, F.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 23
Partial Differential Equations in Ecology: Spatial Interactions and Population Dynamics
journal, January 1994
- Holmes, E. E.; Lewis, M. A.; Banks, J. E.
- Ecology, Vol. 75, Issue 1
Big city, small world: density, contact rates, and transmission of dengue across Pakistan
journal, October 2015
- Kraemer, M. U. G.; Perkins, T. A.; Cummings, D. A. T.
- Journal of The Royal Society Interface, Vol. 12, Issue 111
Higher Level of Replication Efficiency of 2009 (H1N1) Pandemic Influenza Virus than Those of Seasonal and Avian Strains: Kinetics from Epithelial Cell Culture and Computational Modeling
journal, November 2010
- Mitchell, H.; Levin, D.; Forrest, S.
- Journal of Virology, Vol. 85, Issue 2
A Single Amino Acid Substitution in the Hemagglutinin of H3N2 Subtype Influenza A Viruses Is Associated with Resistance to the Long Pentraxin PTX3 and Enhanced Virulence in Mice
journal, December 2013
- Job, Emma R.; Bottazzi, Barbara; Short, Kirsty R.
- The Journal of Immunology, Vol. 192, Issue 1
Linking Influenza Virus Tissue Tropism to Population-Level Reproductive Fitness
journal, August 2012
- Reperant, Leslie A.; Kuiken, Thijs; Grenfell, Bryan T.
- PLoS ONE, Vol. 7, Issue 8
Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver
journal, April 2014
- Wieland, Stefan; Makowska, Zuzanna; Campana, Benedetta
- Hepatology, Vol. 59, Issue 6
Spatial patterns of genetic variation generated by different forms of dispersal during range expansion
journal, September 1996
- Ibrahim, Kamal M.; Nichols, Richard A.; Hewitt, Godfrey M.
- Heredity, Vol. 77, Issue 3
Mutations arising in the wave front of an expanding population
journal, January 2004
- Edmonds, C. A.; Lillie, A. S.; Cavalli-Sforza, L. L.
- Proceedings of the National Academy of Sciences, Vol. 101, Issue 4
Early Alterations of the Receptor-Binding Properties of H1, H2, and H3 Avian Influenza Virus Hemagglutinins after Their Introduction into Mammals
journal, September 2000
- Matrosovich, M.; Tuzikov, A.; Bovin, N.
- Journal of Virology, Vol. 74, Issue 18
Gene surfing in expanding populations
journal, February 2008
- Hallatschek, Oskar; Nelson, David R.
- Theoretical Population Biology, Vol. 73, Issue 1
The approach of solutions of nonlinear diffusion equations to travelling front solutions
journal, December 1977
- Fife, Paul C.; McLeod, J. B.
- Archive for Rational Mechanics and Analysis, Vol. 65, Issue 4
Molecular Imaging Reveals a Progressive Pulmonary Inflammation in Lower Airways in Ferrets Infected with 2009 H1N1 Pandemic Influenza Virus
journal, July 2012
- Jonsson, Colleen B.; Camp, Jeremy V.; Wu, Albert
- PLoS ONE, Vol. 7, Issue 7
Probing the effects of the well-mixed assumption on viral infection dynamics
journal, September 2006
- Beauchemin, Catherine
- Journal of Theoretical Biology, Vol. 242, Issue 2
On the accumulation of deleterious mutations during range expansions
journal, November 2013
- Peischl, S.; Dupanloup, I.; Kirkpatrick, M.
- Molecular Ecology, Vol. 22, Issue 24
Role of receptor binding specificity in influenza A virus transmission and pathogenesis
journal, March 2014
- de Graaf, M.; Fouchier, R. A. M.
- The EMBO Journal, Vol. 33, Issue 8
Influenza virus receptors in the human airway
journal, March 2006
- Shinya, Kyoko; Ebina, Masahito; Yamada, Shinya
- Nature, Vol. 440, Issue 7083
Surfing during population expansions promotes genetic revolutions and structuration
journal, July 2008
- Excoffier, Laurent; Ray, Nicolas
- Trends in Ecology & Evolution, Vol. 23, Issue 7
In Vivo HIV-1 Cell-to-Cell Transmission Promotes Multicopy Micro-compartmentalized Infection
journal, June 2016
- Law, Kenneth M.; Komarova, Natalia L.; Yewdall, Alice W.
- Cell Reports, Vol. 15, Issue 12
Proteolytic Activation of Influenza Viruses by Serine Proteases TMPRSS2 and HAT from Human Airway Epithelium
journal, September 2006
- Bottcher, E.; Matrosovich, T.; Beyerle, M.
- Journal of Virology, Vol. 80, Issue 19
Influenza Virus Infection Model With Density Dependence Supports Biphasic Viral Decay
journal, July 2018
- Smith, Amanda P.; Moquin, David J.; Bernhauerova, Veronika
- Frontiers in Microbiology, Vol. 9
The Fate of Cooperation during Range Expansions
journal, March 2013
- Korolev, Kirill S.
- PLoS Computational Biology, Vol. 9, Issue 3
Biological activities of 'noninfectious' influenza A virus particles
journal, January 2014
- Brooke, Christopher B.
- Future Virology, Vol. 9, Issue 1
Stochastic processes constrain the within and between host evolution of influenza virus
journal, May 2018
- McCrone, John T.; Woods, Robert J.; Martin, Emily T.
- eLife, Vol. 7
The Role of Human Transportation Networks in Mediating the Genetic Structure of Seasonal Influenza in the United States
journal, June 2015
- Bozick, Brooke A.; Real, Leslie A.
- PLOS Pathogens, Vol. 11, Issue 6
In Vivo Imaging of Influenza Virus Infection in Immunized Mice
journal, May 2017
- Czakó, Rita; Vogel, Leatrice; Lamirande, Elaine W.
- mBio, Vol. 8, Issue 3
Immune history and influenza virus susceptibility
journal, February 2017
- Cobey, Sarah; Hensley, Scott E.
- Current Opinion in Virology, Vol. 22
Model of Slowing the Spread of Gypsy moth (Lepidoptera: Lymantriidae) with a Barrier zone
journal, November 1998
- Sharov, Alexei A.; Liebhold, Andrew M.
- Ecological Applications, Vol. 8, Issue 4
Transient virulence of emerging pathogens
journal, October 2009
- Bolker, Benjamin M.; Nanda, Arjun; Shah, Dharmini
- Journal of The Royal Society Interface, Vol. 7, Issue 46
Host-pathogen kinetics during influenza infection and coinfection: insights from predictive modeling
journal, August 2018
- Smith, Amber M.
- Immunological Reviews, Vol. 285, Issue 1
Contrasting effects of long distance seed dispersal on genetic diversity during range expansion
journal, January 2006
- Bialozyt, R.; Ziegenhagen, B.; Petit, R. J.
- Journal of Evolutionary Biology, Vol. 19, Issue 1
(In)validating experimentally derived knowledge about influenza A defective interfering particles
journal, November 2016
- Liao, Laura E.; Iwami, Shingo; Beauchemin, Catherine A. A.
- Journal of The Royal Society Interface, Vol. 13, Issue 124
A simple cellular automaton model for influenza A viral infections
journal, January 2005
- Beauchemin, Catherine; Samuel, John; Tuszynski, Jack
- Journal of Theoretical Biology, Vol. 232, Issue 2
Glycan array analysis of influenza H1N1 binding and release
journal, February 2014
- Gulati, Shelly; Lasanajak, Yi; Smith, David F.
- Cancer Biomarkers, Vol. 14, Issue 1
Visualizing real-time influenza virus infection, transmission and protection in ferrets
journal, March 2015
- Karlsson, Erik A.; Meliopoulos, Victoria A.; Savage, Chandra
- Nature Communications, Vol. 6, Issue 1
Dispersal Data and the Spread of Invading Organisms
journal, October 1996
- Kot, Mark; Lewis, Mark A.; van den Driessche, P.
- Ecology, Vol. 77, Issue 7
Human and avian influenza viruses target different cell types in cultures of human airway epithelium
journal, March 2004
- Matrosovich, M. N.; Matrosovich, T. Y.; Gray, T.
- Proceedings of the National Academy of Sciences, Vol. 101, Issue 13
Influenza virus exploits tunneling nanotubes for cell-to-cell spread
journal, January 2017
- Kumar, Amrita; Kim, Jin Hyang; Ranjan, Priya
- Scientific Reports, Vol. 7, Issue 1
Quantification of Hepatitis C Virus Cell-to-Cell Spread Using a Stochastic Modeling Approach
journal, April 2015
- Graw, Frederik; Martin, Danyelle N.; Perelson, Alan S.
- Journal of Virology, Vol. 89, Issue 13
Modeling Within-Host Dynamics of Influenza Virus Infection Including Immune Responses
journal, June 2012
- Pawelek, Kasia A.; Huynh, Giao T.; Quinlivan, Michelle
- PLoS Computational Biology, Vol. 8, Issue 6
The Mutational Robustness of Influenza A Virus
journal, August 2016
- Visher, Elisa; Whitefield, Shawn E.; McCrone, John T.
- PLOS Pathogens, Vol. 12, Issue 8
Agent-based modeling of host–pathogen systems: The successes and challenges
journal, April 2009
- Bauer, Amy L.; Beauchemin, Catherine A. A.; Perelson, Alan S.
- Information Sciences, Vol. 179, Issue 10
Sociovirology: Conflict, Cooperation, and Communication among Viruses
journal, October 2017
- Díaz-Muñoz, Samuel L.; Sanjuán, Rafael; West, Stuart
- Cell Host & Microbe, Vol. 22, Issue 4
Progress and trends in mathematical modelling of influenza A virus infections
journal, December 2018
- Handel, Andreas; Liao, Laura E.; Beauchemin, Catherine A. A.
- Current Opinion in Systems Biology, Vol. 12
The soft palate is an important site of adaptation for transmissible influenza viruses
journal, September 2015
- Lakdawala, Seema S.; Jayaraman, Akila; Halpin, Rebecca A.
- Nature, Vol. 526, Issue 7571
Continuous Influenza Virus Production in Cell Culture Shows a Periodic Accumulation of Defective Interfering Particles
journal, September 2013
- Frensing, Timo; Heldt, Frank Stefan; Pflugmacher, Antje
- PLoS ONE, Vol. 8, Issue 9
In Vivo Bioluminescent Imaging of Influenza A Virus Infection and Characterization of Novel Cross-Protective Monoclonal Antibodies
journal, May 2013
- Heaton, N. S.; Leyva-Grado, V. H.; Tan, G. S.
- Journal of Virology, Vol. 87, Issue 15
A review of mathematical models of influenza A infections within a host or cell culture: lessons learned and challenges ahead
journal, January 2011
- Beauchemin, Catherine AA; Handel, Andreas
- BMC Public Health, Vol. 11, Issue Suppl 1
Deleterious Mutations Can Surf to High Densities on the Wave Front of an Expanding Population
journal, July 2007
- Travis, J. M. J.; Munkemuller, T.; Burton, O. J.
- Molecular Biology and Evolution, Vol. 24, Issue 10
Dynamics of the 2001 UK Foot and Mouth Epidemic: Stochastic Dispersal in a Heterogeneous Landscape
journal, October 2001
- Keeling, M. J.
- Science, Vol. 294, Issue 5543
Inverse density dependence and the Allee effect
journal, October 1999
- Courchamp, Franck; Clutton-Brock, Tim; Grenfell, Bryan
- Trends in Ecology & Evolution, Vol. 14, Issue 10
Influenza A Virus Uses Intercellular Connections To Spread to Neighboring Cells
journal, November 2014
- Roberts, Kari L.; Manicassamy, Balaji; Lamb, Robert A.
- Journal of Virology, Vol. 89, Issue 3
Spatiotemporal Dynamics of HIV Propagation
journal, September 2002
- Strain, M. C.; Richman, D. D.; Wong, J. K.
- Journal of Theoretical Biology, Vol. 218, Issue 1
Mathematical Model of Antiviral Immune Response III. Influenza A Virus Infection
journal, April 1994
- Bocharov, G. A.; Romanyukha, A. A.
- Journal of Theoretical Biology, Vol. 167, Issue 4
Genetic differences between blood- and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: evidence of conserved elements in the V3 region of the envelope protein of brain-derived sequences.
journal, January 1994
- Korber, B. T.; Kunstman, K. J.; Patterson, B. K.
- Journal of Virology, Vol. 68, Issue 11
Influenza type A virus neuraminidase does not play a role in viral entry, replication, assembly, or budding.
journal, January 1995
- Liu, C.; Eichelberger, M. C.; Compans, R. W.
- Journal of virology, Vol. 69, Issue 2
Localization of human airway trypsin-like protease in the airway: an immunohistochemical study
journal, March 2001
- Takahashi, Masako; Sano, Toshiaki; Yamaoka, Kazuyoshi
- Histochemistry and Cell Biology, Vol. 115, Issue 3
Works referencing / citing this record:
Within-host infectious disease models accommodating cellular coinfection, with an application to influenza†
journal, July 2019
- Koelle, Katia; Farrell, Alex P.; Brooke, Christopher B.
- Virus Evolution, Vol. 5, Issue 2
Within-host infectious disease models accommodating cellular coinfection, with an application to influenza†
journal, July 2019
- Koelle, Katia; Farrell, Alex P.; Brooke, Christopher B.
- Virus Evolution, Vol. 5, Issue 2
The rate of viral transfer between upper and lower respiratory tracts determines RSV illness duration
journal, April 2019
- González-Parra, Gilberto; Dobrovolny, Hana M.
- Journal of Mathematical Biology, Vol. 79, Issue 2
A Parameter Estimation Method for Multiscale Models of Hepatitis C Virus Dynamics
journal, July 2019
- Reinharz, Vladimir; Churkin, Alexander; Lewkiewicz, Stephanie
- Bulletin of Mathematical Biology, Vol. 81, Issue 10
Incomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spread
journal, August 2019
- Jacobs, Nathan T.; Onuoha, Nina O.; Antia, Alice
- Nature Communications, Vol. 10, Issue 1
Figures / Tables found in this record:
Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.