Clearing the Brain's Amyloid Cobwebs
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October 2001 |
Free R value: a novel statistical quantity for assessing the accuracy of crystal structures
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January 1992 |
Degradation of the Amyloid β-Protein by the Novel Mitochondrial Peptidasome, PreP
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July 2006 |
The amyloid hypothesis of Alzheimer's disease at 25 years
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March 2016 |
Structure of human neutral endopeptidase (neprilysin) complexed with phosphoramidon 1 1Edited by R. Huber
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February 2000 |
Overexpression of Neprilysin Reduces Alzheimer Amyloid-β42 (Aβ42)-induced Neuron Loss and Intraneuronal Aβ42 Deposits but Causes a Reduction in cAMP-responsive Element-binding Protein-mediated Transcription, Age-dependent Axon Pathology, and Premature Death in Drosophila
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May 2008 |
Crystal Structure of the Amyloid- p3 Fragment Provides a Model for Oligomer Formation in Alzheimer's Disease
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January 2011 |
Features and development of Coot
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March 2010 |
Neprilysin Degrades Both Amyloid β Peptides 1–40 and 1–42 Most Rapidly and Efficiently among Thiorphan- and Phosphoramidon-sensitive Endopeptidases
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March 2001 |
Clearance of Extracellular and Cell-Associated Amyloid Peptide through Viral Expression of Neprilysin in Primary Neurons
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December 2001 |
A New Structural Model of Aβ 40 Fibrils
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October 2011 |
Physiological roles for amyloid β peptides: Physiological roles for amyloid β peptides
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August 2006 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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January 2010 |
Gantenerumab: A Novel Human Anti-Aβ Antibody Demonstrates Sustained Cerebral Amyloid-β Binding and Elicits Cell-Mediated Removal of Human Amyloid-β
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January 2012 |
Molecular Basis of Substrate Recognition and Degradation by Human Presequence Protease
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July 2014 |
Thermolysin in the absence of substrate has an open conformation
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May 2002 |
Neprilysin-sensitive Synapse-associated Amyloid-β Peptide Oligomers Impair Neuronal Plasticity and Cognitive Function
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April 2006 |
Peripherally expressed neprilysin reduces brain amyloid burden: A novel approach for treating Alzheimer's disease
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May 2009 |
Plasminogen and plasmin in Alzheimer's disease
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October 2010 |
Phaser crystallographic software
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July 2007 |
Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation
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February 2013 |
Structure of amyloid beta fragments in aqueous environments
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January 2006 |
A coiled conformation of amyloid-β recognized by antibody C706
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August 2017 |
Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition
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February 2000 |
Solvent content of protein crystals
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April 1968 |
Structural Basis of C-terminal β-Amyloid Peptide Binding by the Antibody Ponezumab for the Treatment of Alzheimer's Disease
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August 2012 |
Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce β-amyloid related to Alzheimer's disease
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August 2010 |
Structural studies of the tethered N-terminus of the Alzheimer's disease amyloid-β peptide: Aβ N-Terminal Structural Studies
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July 2013 |
Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid β-related Behavioral Deficits in a Mouse Model of Alzheimer Disease
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November 2009 |
Antiamyloidogenic and Neuroprotective Functions of Cathepsin B: Implications for Alzheimer's Disease
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September 2006 |
Neutral endopeptidase can hydrolyze β-amyloid(1–40) but shows no effect on β-amyloid precursor protein metabolism
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January 1995 |
Molecular basis for mid-region amyloid-β capture by leading Alzheimer's disease immunotherapies
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April 2015 |
Matrix Metalloproteinase-9 (MMP-9) Is Synthesized in Neurons of the Human Hippocampus and Is Capable of Degrading the Amyloid-β Peptide (1–40)
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December 1996 |
Amyloid-β–Anti-Amyloid-β Complex Structure Reveals an Extended Conformation in the Immunodominant B-Cell Epitope
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March 2008 |
Effect of Glu-143 and His-231 substitutions on the catalytic activity and secretion of Bacillus subtilis neutral protease
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January 1989 |
Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin
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December 2016 |
Amyloid beta: structure, biology and structure-based therapeutic development
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July 2017 |
Kidney neutral endopeptidase and the hydrolysis of enkephalin by synaptic membranes show similar sensitivity to inhibitors
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May 1982 |
Elucidating the Origin of Long Residence Time Binding for Inhibitors of the Metalloprotease Thermolysin
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December 2016 |
Kinetics of Amyloid β-Protein Degradation Determined by Novel Fluorescence- and Fluorescence Polarization-based Assays
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July 2003 |
Structural analysis of zinc substitutions in the active site of thermolysin
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October 1995 |
Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis
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November 2011 |
Interprotofilament interactions between Alzheimer's A 1-42 peptides in amyloid fibrils revealed by cryoEM
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March 2009 |
Does Aβ 42 Have a Function Related to Blood Homeostasis?
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December 2006 |
Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants
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December 1993 |
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism
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October 2006 |
The Plasmin System Is Induced by and Degrades Amyloid-β Aggregates
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June 2000 |
Self-Propagating, Molecular-Level Polymorphism in Alzheimer's -Amyloid Fibrils
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January 2005 |
Alzheimer's disease drug development pipeline: 2017
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September 2017 |
Molecular basis for passive immunotherapy of Alzheimer's disease
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September 2007 |
Molecular basis for amyloid- polymorphism
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September 2011 |
Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice
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March 2003 |
Kinetic and structural characterization of amyloid-β peptide hydrolysis by human angiotensin-1-converting enzyme
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February 2016 |
Matrix Metalloproteinase-9 Degrades Amyloid-β Fibrils in Vitro and Compact Plaques in Situ
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June 2006 |