Complete validation of a continuous and blood-correlated sweat biosensing device with integrated sweat stimulation

Hauke, A.; Simmers, P.; Ojha, Y. R.; Cameron, B. D.; Ballweg, R.; Zhang, T.; Twine, N.; Brothers, M.; Gomez, E.; Heikenfeld, J.

doi:10.1039/C8LC01082J

Title: Complete validation of a continuous and blood-correlated sweat biosensing device with integrated sweat stimulation

Journal Article · 03 December 2018 · Lab on a chip (Print)

DOI: https://doi.org/10.1039/C8LC01082J · OSTI ID:1482408

^[1];

^[1]; Ojha, Y. R. ^[2]; Cameron, B. D. ^[2]; Ballweg, R. ^[3]; Zhang, T. ^[3];

^[1]; Brothers, M. ^[4];

^[1]; Heikenfeld, J. ^[1]

Novel Devices Laboratory, College of Engineering, University of Cincinnati, Cincinnati, USA
Biomedical Optics and Sensing Laboratory, Department of Bioengineering, University of Toledo, Toledo, USA
College of Medicine, University of Cincinnati, Cincinnati, USA
UES, Inc., Dayton, USA

A wearable sweat biosensing device is demonstrated that stimulates sweat and continuously measures sweat ethanol concentrations at 25 s intervals, which is then correlated with blood ethanol during a >3 hour testing phase.

View Accepted Manuscript (Publisher)

Cite

Export

Save

Sponsoring Organization:: USDOE

OSTI ID:: 1482408

Journal Information:: Lab on a chip (Print), Journal Name: Lab on a chip (Print) Journal Issue: 24 Vol. 18; ISSN LCAHAM; ISSN 1473-0197

Publisher:: Royal Society of Chemistry (RSC)Copyright Statement

Country of Publication:: France

Language:: English

References (33)

Methylxanthine Drug Monitoring with Wearable Sweat Sensors Tai, Li-Chia; Gao, Wei; Chao, Minghan Advanced Materials, Vol. 30, Issue 23 https://doi.org/10.1002/adma.201707442	journal	April 2018
Simultaneous Monitoring of Sweat and Interstitial Fluid Using a Single Wearable Biosensor Platform Kim, Jayoung; Sempionatto, Juliane R.; Imani, Somayeh Advanced Science, Vol. 5, Issue 10 https://doi.org/10.1002/advs.201800880	journal	August 2018
Non-invasive Analyte Access and Sensing through Eccrine Sweat: Challenges and Outlook circa 2016 Heikenfeld, Jason Electroanalysis, Vol. 28, Issue 6 https://doi.org/10.1002/elan.201600018	journal	March 2016
Stretchable, Wireless Sensors and Functional Substrates for Epidermal Characterization of Sweat Huang, Xian; Liu, Yuhao; Chen, Kaile Small, Vol. 10, Issue 15 https://doi.org/10.1002/smll.201400483	journal	April 2014
Novel instrumentation for determination of ethanol concentrations in human perspiration by gas chromatography and a good interrelationship between ethanol concentrations in sweat and blood Kamei, Tomoya; Tsuda, Takao; Mibu, Yuuko Analytica Chimica Acta, Vol. 365, Issue 1-3 https://doi.org/10.1016/S0003-2670(97)00673-9	journal	June 1998
A novel non-invasive electrochemical biosensing device for in situ determination of the alcohol content in blood by monitoring ethanol in sweat Gamella, M.; Campuzano, S.; Manso, J. Analytica Chimica Acta, Vol. 806 https://doi.org/10.1016/j.aca.2013.09.020	journal	January 2014
Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring Bandodkar, Amay J.; Molinnus, Denise; Mirza, Omar Biosensors and Bioelectronics, Vol. 54 https://doi.org/10.1016/j.bios.2013.11.039	journal	April 2014
Superwetting and aptamer functionalized shrink-induced high surface area electrochemical sensors Hauke, A.; Kumar, L. S. Selva; Kim, M. Y. Biosensors and Bioelectronics, Vol. 94 https://doi.org/10.1016/j.bios.2017.03.024	journal	August 2017
Prolonged and localized sweat stimulation by iontophoretic delivery of the slowly-metabolized cholinergic agent carbachol Simmers, Phillip; Li, S. Kevin; Kasting, Gerald Journal of Dermatological Science, Vol. 89, Issue 1 https://doi.org/10.1016/j.jdermsci.2017.10.013	journal	January 2018
Bio-sensing textile based patch with integrated optical detection system for sweat monitoring Morris, Deirdre; Coyle, Shirley; Wu, Yanzhe Sensors and Actuators B: Chemical, Vol. 139, Issue 1 https://doi.org/10.1016/j.snb.2009.02.032	journal	May 2009
Electrochemical Tattoo Biosensors for Real-Time Noninvasive Lactate Monitoring in Human Perspiration Jia, Wenzhao; Bandodkar, Amay J.; Valdés-Ramírez, Gabriela Analytical Chemistry, Vol. 85, Issue 14, p. 6553-6560 https://doi.org/10.1021/ac401573r	journal	July 2013
Skin-Attachable, Stretchable Electrochemical Sweat Sensor for Glucose and pH Detection Oh, Seung Yun; Hong, Soo Yeong; Jeong, Yu Ra ACS Applied Materials & Interfaces, Vol. 10, Issue 16 https://doi.org/10.1021/acsami.8b03342	journal	April 2018
Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System Kim, Jayoung; Jeerapan, Itthipon; Imani, Somayeh ACS Sensors, Vol. 1, Issue 8 https://doi.org/10.1021/acssensors.6b00356	journal	July 2016
Epidermal Microfluidic Electrochemical Detection System: Enhanced Sweat Sampling and Metabolite Detection Martín, Aida; Kim, Jayoung; Kurniawan, Jonas F. ACS Sensors, Vol. 2, Issue 12 https://doi.org/10.1021/acssensors.7b00729	journal	December 2017
A Wearable Microfluidic Sensing Patch for Dynamic Sweat Secretion Analysis Nyein, Hnin Yin Yin; Tai, Li-Chia; Ngo, Quynh Phuong ACS Sensors, Vol. 3, Issue 5 https://doi.org/10.1021/acssensors.7b00961	journal	May 2018
Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis Gao, Wei; Emaminejad, Sam; Nyein, Hnin Yin Yin Nature, Vol. 529, Issue 7587 https://doi.org/10.1038/nature16521	journal	January 2016
A wearable chemical–electrophysiological hybrid biosensing system for real-time health and fitness monitoring Imani, Somayeh; Bandodkar, Amay J.; Mohan, A. M. Vinu Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms11650	journal	May 2016
A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy Lee, Hyunjae; Choi, Tae Kyu; Lee, Young Bum Nature Nanotechnology, Vol. 11, Issue 6 https://doi.org/10.1038/nnano.2016.38	journal	March 2016
Advances in non-enzymatic glucose sensors based on metal oxides Zhu, Hua; Li, Li; Zhou, Wei Journal of Materials Chemistry B, Vol. 4, Issue 46 https://doi.org/10.1039/C6TB02037B	journal	January 2016
Integrated sudomotor axon reflex sweat stimulation for continuous sweat analyte analysis with individuals at rest Sonner, Zachary; Wilder, Eliza; Gaillard, Trudy Lab on a Chip, Vol. 17, Issue 15 https://doi.org/10.1039/C7LC00364A	journal	January 2017
Wearable sensors: modalities, challenges, and prospects Heikenfeld, J.; Jajack, A.; Rogers, J. Lab on a Chip, Vol. 18, Issue 2 https://doi.org/10.1039/C7LC00914C	journal	January 2018
Open nanofluidic films with rapid transport and no analyte exchange for ultra-low sample volumes Twine, N. B.; Norton, R. M.; Brothers, M. C. Lab on a Chip, Vol. 18, Issue 18 https://doi.org/10.1039/C8LC00186C	journal	January 2018
A wearable patch for continuous monitoring of sweat electrolytes during exertion Alizadeh, Azar; Burns, Andrew; Lenigk, Ralf Lab on a Chip, Vol. 18, Issue 17 https://doi.org/10.1039/C8LC00510A	journal	January 2018
A wearable electrochemical sensor for the real-time measurement of sweat sodium concentration Schazmann, Benjamin; Morris, Deirdre; Slater, Conor Analytical Methods, Vol. 2, Issue 4 https://doi.org/10.1039/b9ay00184k	journal	January 2010
Lactate and Ammonia Concentration in Blood and Sweat During Incremental Cycle Ergometer Exercise Ament, W.; Huizenga, J.; Mook, G. International Journal of Sports Medicine, Vol. 18, Issue 01 https://doi.org/10.1055/s-2007-972592	journal	January 1997
The microfluidics of the eccrine sweat gland, including biomarker partitioning, transport, and biosensing implications Sonner, Z.; Wilder, E.; Heikenfeld, J. Biomicrofluidics, Vol. 9, Issue 3 https://doi.org/10.1063/1.4921039	journal	May 2015
Membrane isolation of repeated-use sweat stimulants for mitigating both direct dermal contact and sweat dilution Simmers, P.; Yuan, Y.; Sonner, Z. Biomicrofluidics, Vol. 12, Issue 3 https://doi.org/10.1063/1.5023396	journal	May 2018
Time Delays in Transdermal Alcohol Concentrations Relative to Breath Alcohol Concentrations Karns-Wright, Tara E.; Roache, John D.; Hill-Kapturczak, Nathalie Alcohol and Alcoholism, Vol. 52, Issue 1 https://doi.org/10.1093/alcalc/agw058	journal	August 2016
Stability of Enzymatic Biosensors for Wearable Applications Sonawane, Apurva; Manickam, Pandiaraj; Bhansali, Shekhar IEEE Reviews in Biomedical Engineering, Vol. 10 https://doi.org/10.1109/RBME.2017.2706661	journal	January 2017
Adhesive RFID Sensor Patch for Monitoring of Sweat Electrolytes Rose, Daniel P.; Ratterman, Michael E.; Griffin, Daniel K. IEEE Transactions on Biomedical Engineering, Vol. 62, Issue 6 https://doi.org/10.1109/TBME.2014.2369991	journal	June 2015
Sweat Ethanol Concentrations are Highly Correlated with Co-Existing Blood Values in Humans Buono, Michael J. Experimental Physiology, Vol. 84, Issue 2 https://doi.org/10.1111/j.1469-445X.1999.01798.x	journal	March 1999
Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module Lee, Hyunjae; Song, Changyeong; Hong, Yong Seok Science Advances, Vol. 3, Issue 3 https://doi.org/10.1126/sciadv.1601314	journal	March 2017
A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat Koh, A.; Kang, D.; Xue, Y. Science Translational Medicine, Vol. 8, Issue 366 https://doi.org/10.1126/scitranslmed.aaf2593	journal	November 2016

Similar Records

A Fully Integrated and Self-Powered Smartwatch for Continuous Sweat Glucose Monitoring

Journal Article · 2019 · ACS Sensors · OSTI ID:1638991

Zhao, Jiangqi; Lin, Yuanjing; Wu, Jingbo; +8 more

Regional and correlative sweat analysis using high-throughput microfluidic sensing patches toward decoding sweat

Journal Article · 2019 · Science Advances · OSTI ID:1638993

Nyein, Hnin Yin Yin; Bariya, Mallika; Kivimäki, Liisa; +14 more

Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform

Journal Article · 2017 · Proceedings of the National Academy of Sciences of the United States of America · OSTI ID:1351925

Emaminejad, Sam; Gao, Wei; Wu, Eric; +11 more

Title: Complete validation of a continuous and blood-correlated sweat biosensing device with integrated sweat stimulation

Citation Formats

References (33)

Similar Records

Related Subjects