Reversible self-assembly of superstructured networks
Abstract
The dynamic reorganization of some cellular biopolymers in response to signals has inspired efforts to create artificial materials with similar properties. Freeman et al. created hydrogels based on peptide amphiphiles that can bear DNA strands that assemble into superstructures and that disassemble in response to chemical triggers. The addition of DNA conjugates induced transitions from micelles to fibers and bundles of fibers. The resulting hydrogels were used as an extracellular matrix mimic for cultured cells. Switching the hydrogel between states also switched astrocytes between their reactive and naïve phenotypes.
- Publication Date:
- Research Org.:
- Energy Frontier Research Centers (EFRC) (United States). Center for Bio-Inspired Energy Science (CBES)
- Sponsoring Org.:
- USDOE Office of Science (SC), Basic Energy Sciences (BES)
- OSTI Identifier:
- 1482288
- Alternate Identifier(s):
- OSTI ID: 1822197; OSTI ID: 1846778
- Grant/Contract Number:
- FG02-00ER45810; SC0000989; 2014 BP-A 00007
- Resource Type:
- Published Article
- Journal Name:
- Science
- Additional Journal Information:
- Journal Name: Science Journal Volume: 362 Journal Issue: 6416; Journal ID: ISSN 0036-8075
- Publisher:
- American Association for the Advancement of Science (AAAS)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 99 GENERAL AND MISCELLANEOUS
Citation Formats
Freeman, Ronit, Han, Ming, Álvarez, Zaida, Lewis, Jacob A., Wester, James R., Stephanopoulos, Nicholas, McClendon, Mark T., Lynsky, Cheyenne, Godbe, Jacqueline M., Sangji, Hussain, Luijten, Erik, and Stupp, Samuel I. Reversible self-assembly of superstructured networks. United States: N. p., 2018.
Web. doi:10.1126/science.aat6141.
Freeman, Ronit, Han, Ming, Álvarez, Zaida, Lewis, Jacob A., Wester, James R., Stephanopoulos, Nicholas, McClendon, Mark T., Lynsky, Cheyenne, Godbe, Jacqueline M., Sangji, Hussain, Luijten, Erik, & Stupp, Samuel I. Reversible self-assembly of superstructured networks. United States. https://doi.org/10.1126/science.aat6141
Freeman, Ronit, Han, Ming, Álvarez, Zaida, Lewis, Jacob A., Wester, James R., Stephanopoulos, Nicholas, McClendon, Mark T., Lynsky, Cheyenne, Godbe, Jacqueline M., Sangji, Hussain, Luijten, Erik, and Stupp, Samuel I. Thu .
"Reversible self-assembly of superstructured networks". United States. https://doi.org/10.1126/science.aat6141.
@article{osti_1482288,
title = {Reversible self-assembly of superstructured networks},
author = {Freeman, Ronit and Han, Ming and Álvarez, Zaida and Lewis, Jacob A. and Wester, James R. and Stephanopoulos, Nicholas and McClendon, Mark T. and Lynsky, Cheyenne and Godbe, Jacqueline M. and Sangji, Hussain and Luijten, Erik and Stupp, Samuel I.},
abstractNote = {The dynamic reorganization of some cellular biopolymers in response to signals has inspired efforts to create artificial materials with similar properties. Freeman et al. created hydrogels based on peptide amphiphiles that can bear DNA strands that assemble into superstructures and that disassemble in response to chemical triggers. The addition of DNA conjugates induced transitions from micelles to fibers and bundles of fibers. The resulting hydrogels were used as an extracellular matrix mimic for cultured cells. Switching the hydrogel between states also switched astrocytes between their reactive and naïve phenotypes.},
doi = {10.1126/science.aat6141},
journal = {Science},
number = 6416,
volume = 362,
place = {United States},
year = {Thu Oct 04 00:00:00 EDT 2018},
month = {Thu Oct 04 00:00:00 EDT 2018}
}
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https://doi.org/10.1126/science.aat6141
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