Transplanted human multipotent stromal cells reduce acute tongue fibrosis in rats
[1];
[2];
[3]
- Department of Surgery, Division of Otolaryngology UC San Diego Health La Jolla CA
- From the Department of Head and Neck Surgery, UCLA David Geffen School of Medicine Los Angeles California U.S.A.
- From the Department of Head and Neck Surgery, UCLA David Geffen School of Medicine Los Angeles California U.S.A., Research Service Greater Los Angeles VA Healthcare System Los Angeles California U.S.A.
Background Tongue fibrosis resulting from head and neck cancer, surgery, radiation, chemotherapy, or a combination thereof devastates one's quality of life. Therapeutic options are limited. Here we investigate human bone marrow–derived multipotent stromal cells (MSC) as a novel injectable treatment for post‐injury tongue fibrosis. Methods MSCs were grown in culture. Eighteen athymic rats underwent unilateral partial glossectomy. After two weeks for scar formation, a single injection was performed in the tongue scar. Three treatment groups were studied: low and high concentration MSC, and control media injection. Tongues were harvested for evaluation at three weeks post‐treatment. Results Dense fibrosis was achieved in control animals at five weeks. High concentration MSC reduced cross sectional scar burden ( P = .007) and pathologic score for inflammation and fibrosis. Conclusion This study establishes the feasibility of a novel rodent tongue fibrosis model, and begins to assess the utility of human MSCs to reduce scar burden. Level of Evidence N/a
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 1481436
- Journal Information:
- Laryngoscope Investigative Otolaryngology, Journal Name: Laryngoscope Investigative Otolaryngology Journal Issue: 6 Vol. 3; ISSN 2378-8038
- Publisher:
- Wiley Blackwell (John Wiley & Sons)Copyright Statement
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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