DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Photocrosslinked methacrylated poly(vinyl alcohol)/hydroxyapatite nanocomposite hydrogels with enhanced mechanical strength and cell adhesion

Abstract

ABSTRACT Poly(vinyl alcohol) (PVA) hydrogels with high water content, good load‐bearing property, low frictional behavior as well as excellent biocompatibility have been considered as promising cartilage replacement materials. However, the lack of sufficient mechanical properties and cell adhesion are two critical barriers for their application as cartilage substitutes. To address these problems, herein, methacrylated PVA with low degree of substitution of methacryloyl group has been synthesized first. Then, methacrylated PVA‐glycidyl methacrylate/hydroxyapatite (PVA‐GMA/Hap) nanocomposite hydrogels have been developed by the photopolymerization approach subsequently. Markedly, both pure PVA‐GMA hydrogel and PVA‐GMA/Hap nanocomposite hydrogels exhibit excellent performance in compressive tests, and they are undamaged during compressive stress–strain tests. Moreover, compared to pure PVA‐GMA hydrogels, 8.5‐fold, 7.4‐fold, and 14.2‐fold increase in fracture stress, Young's modulus and toughness, respectively, can be obtained for PVA‐GMA/Hap nanocomposite hydrogels with 10 wt % Hap nanoparticles. These enhancements can be ascribed to the intrinsic property of PVA‐GMA and strong hydrogen bonding interactions between PVA‐GMA chain and Hap nanoparticles. More interestingly, significant improvement in the cell adhesion can also be successfully achieved by incorporation of Hap nanoparticles. These biocompatible nanocomposite hydrogels have great potential to be used as cartilage substitutes. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A:more » Polym. Chem. 2019, 57, 1882–1889« less

Authors:
 [1];  [1];  [1];  [1];  [2]; ORCiD logo [3]
  1. Key Laboratory of Green Processing and Functional Textiles of New Textile Materials, Ministry of Education Wuhan Textile University Wuhan 430073 People's Republic of China
  2. Key Laboratory of Green Processing and Functional Textiles of New Textile Materials, Ministry of Education Wuhan Textile University Wuhan 430073 People's Republic of China, College of Materials Science and Engineering Wuhan Textile University Wuhan 430073 People's Republic of China
  3. Research School of Chemistry Australian National University Canberra ACT 2601 Australia
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1479826
Resource Type:
Publisher's Accepted Manuscript
Journal Name:
Journal of Polymer Science. Part A, Polymer Chemistry
Additional Journal Information:
Journal Name: Journal of Polymer Science. Part A, Polymer Chemistry Journal Volume: 57 Journal Issue: 18; Journal ID: ISSN 0887-624X
Publisher:
Wiley Blackwell (John Wiley & Sons)
Country of Publication:
United States
Language:
English

Citation Formats

Zhou, Ding, Dong, Qi, Liang, Kaili, Xu, Weilin, Zhou, Yingshan, and Xiao, Pu. Photocrosslinked methacrylated poly(vinyl alcohol)/hydroxyapatite nanocomposite hydrogels with enhanced mechanical strength and cell adhesion. United States: N. p., 2018. Web. doi:10.1002/pola.29263.
Zhou, Ding, Dong, Qi, Liang, Kaili, Xu, Weilin, Zhou, Yingshan, & Xiao, Pu. Photocrosslinked methacrylated poly(vinyl alcohol)/hydroxyapatite nanocomposite hydrogels with enhanced mechanical strength and cell adhesion. United States. https://doi.org/10.1002/pola.29263
Zhou, Ding, Dong, Qi, Liang, Kaili, Xu, Weilin, Zhou, Yingshan, and Xiao, Pu. Mon . "Photocrosslinked methacrylated poly(vinyl alcohol)/hydroxyapatite nanocomposite hydrogels with enhanced mechanical strength and cell adhesion". United States. https://doi.org/10.1002/pola.29263.
@article{osti_1479826,
title = {Photocrosslinked methacrylated poly(vinyl alcohol)/hydroxyapatite nanocomposite hydrogels with enhanced mechanical strength and cell adhesion},
author = {Zhou, Ding and Dong, Qi and Liang, Kaili and Xu, Weilin and Zhou, Yingshan and Xiao, Pu},
abstractNote = {ABSTRACT Poly(vinyl alcohol) (PVA) hydrogels with high water content, good load‐bearing property, low frictional behavior as well as excellent biocompatibility have been considered as promising cartilage replacement materials. However, the lack of sufficient mechanical properties and cell adhesion are two critical barriers for their application as cartilage substitutes. To address these problems, herein, methacrylated PVA with low degree of substitution of methacryloyl group has been synthesized first. Then, methacrylated PVA‐glycidyl methacrylate/hydroxyapatite (PVA‐GMA/Hap) nanocomposite hydrogels have been developed by the photopolymerization approach subsequently. Markedly, both pure PVA‐GMA hydrogel and PVA‐GMA/Hap nanocomposite hydrogels exhibit excellent performance in compressive tests, and they are undamaged during compressive stress–strain tests. Moreover, compared to pure PVA‐GMA hydrogels, 8.5‐fold, 7.4‐fold, and 14.2‐fold increase in fracture stress, Young's modulus and toughness, respectively, can be obtained for PVA‐GMA/Hap nanocomposite hydrogels with 10 wt % Hap nanoparticles. These enhancements can be ascribed to the intrinsic property of PVA‐GMA and strong hydrogen bonding interactions between PVA‐GMA chain and Hap nanoparticles. More interestingly, significant improvement in the cell adhesion can also be successfully achieved by incorporation of Hap nanoparticles. These biocompatible nanocomposite hydrogels have great potential to be used as cartilage substitutes. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 1882–1889},
doi = {10.1002/pola.29263},
journal = {Journal of Polymer Science. Part A, Polymer Chemistry},
number = 18,
volume = 57,
place = {United States},
year = {2018},
month = {10}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1002/pola.29263

Citation Metrics:
Cited by: 23 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Analysis of friction between articular cartilage and polyvinyl alcohol hydrogel artificial cartilage
journal, March 2016

  • Li, Feng; Wang, Anmin; Wang, Chengtao
  • Journal of Materials Science: Materials in Medicine, Vol. 27, Issue 5
  • DOI: 10.1007/s10856-016-5700-y

Fabrication of injectable high strength hydrogel based on 4-arm star PEG for cartilage tissue engineering
journal, March 2017


Photopolymerized maleilated chitosan/methacrylated silk fibroin micro/nanocomposite hydrogels as potential scaffolds for cartilage tissue engineering
journal, March 2018


The effect of hydroxyapatite in biopolymer-based scaffolds on release of naproxen sodium: CHITOSAN-graft-POLY(ACRYLIC ACID)/n-HAP AS DRUG CARRIER FOR BONE TISSUE ENGINEERING
journal, August 2016

  • Asadian-Ardakani, Vahid; Saber-Samandari, Samaneh; Saber-Samandari, Saeed
  • Journal of Biomedical Materials Research Part A, Vol. 104, Issue 12
  • DOI: 10.1002/jbm.a.35838

Preparation and characterization of PVA-PEEK/PVA-β-TCP bilayered hydrogels for articular cartilage tissue repair
journal, May 2016


High-Performance Photopolymerized Poly(vinyl alcohol)/Silica Nanocomposite Hydrogels with Enhanced Cell Adhesion
journal, July 2018

  • Zhang, Can; Liang, Kaili; Zhou, Ding
  • ACS Applied Materials & Interfaces, Vol. 10, Issue 33
  • DOI: 10.1021/acsami.8b09026

Hydrothermal synthesis of porous hydroxyapatite ceramics composed of rod-shaped particles and evaluation of their fracture behavior
journal, March 2012


Photopolymerization of biocompatible phosphorus-containing vinyl esters and vinyl carbamates
journal, July 2010

  • Dworak, Claudia; Koch, Thomas; Varga, Franz
  • Journal of Polymer Science Part A: Polymer Chemistry, Vol. 48, Issue 13
  • DOI: 10.1002/pola.24072

An effective approach for the fabrication of reinforced composite hydrogel engineered with SWNTs, polypyrrole and PEGDA hydrogel
journal, January 2012

  • Xiao, Yinghong; He, Lei; Che, Jianfei
  • Journal of Materials Chemistry, Vol. 22, Issue 16
  • DOI: 10.1039/c2jm30601h

Transparent, elastomeric and tough hydrogels from poly(ethylene glycol) and silicate nanoparticles
journal, December 2011


Development of artificial articular cartilage
journal, January 2000

  • Oka, M.; Ushio, K.; Kumar, P.
  • Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, Vol. 214, Issue 1
  • DOI: 10.1243/0954411001535246

Compressive mechanical properties and microstructure of PVA–HA hydrogels for cartilage repair
journal, January 2016


An in situ phototriggered-imine-crosslink composite hydrogel for bone defect repair
journal, January 2016

  • Zhang, Jieyuan; Yang, Yunlong; Chen, Yunfeng
  • Journal of Materials Chemistry B, Vol. 4, Issue 5
  • DOI: 10.1039/C5TB02377G

Osteochondral defect repair using a polyvinyl alcohol-polyacrylic acid (PVA-PAAc) hydrogel
journal, July 2014


Rheology and Photo-Cross-Linking of Thiol−Ene Polymers
journal, January 1996

  • Chiou, Bor-Sen; English, Robert J.; Khan, Saad A.
  • Macromolecules, Vol. 29, Issue 16
  • DOI: 10.1021/ma960383e

Biomimetic composite scaffolds based mineralization of hydroxyapatite on electrospun calcium-containing poly(vinyl alcohol) nanofibers
journal, October 2013


A two year in vivo study of polyvinyl alcohol-hydrogel (PVA-H) artificial meniscus
journal, June 2005


Hydrogels for the Repair of Articular Cartilage Defects
journal, August 2011

  • Spiller, Kara L.; Maher, Suzanne A.; Lowman, Anthony M.
  • Tissue Engineering Part B: Reviews, Vol. 17, Issue 4
  • DOI: 10.1089/ten.teb.2011.0077

Three-dimensional microfabrication of protein hydrogels via two-photon-excited thiol-vinyl ester photopolymerization
journal, September 2013

  • Qin, Xiao-Hua; Torgersen, Jan; Saf, Robert
  • Journal of Polymer Science Part A: Polymer Chemistry, Vol. 51, Issue 22
  • DOI: 10.1002/pola.26903

Photopolymerization of hydroxyethylmethacrylate in the formation of organic-inorganic hybrid sol-gel matrices
journal, November 1996


High-water-content graphene oxide/polyvinyl alcohol hydrogel with excellent mechanical properties
journal, January 2014

  • Huang, Yifu; Zhang, Mingqiu; Ruan, Wenhong
  • J. Mater. Chem. A, Vol. 2, Issue 27
  • DOI: 10.1039/C4TA01464B

Effect of stereoregularity and molecular weight on the mechanical properties of poly(vinyl alcohol) hydrogel
journal, October 2010

  • Fukae, Ryohei; Yoshimura, Miki; Yamamoto, Tohei
  • Journal of Applied Polymer Science, Vol. 120, Issue 1
  • DOI: 10.1002/app.33187

Synthesis and characterization of novel biodegradable unsaturated poly(ester amide)/poly(ethylene glycol) diacrylate hydrogels
journal, January 2005

  • Guo, Kai; Chu, C. C.
  • Journal of Polymer Science Part A: Polymer Chemistry, Vol. 43, Issue 17
  • DOI: 10.1002/pola.20781

Mechanical Properties of Cellularly Responsive Hydrogels and Their Experimental Determination
journal, May 2010

  • Kloxin, April M.; Kloxin, Christopher J.; Bowman, Christopher N.
  • Advanced Materials, Vol. 22, Issue 31
  • DOI: 10.1002/adma.200904179

A novel chitosan- tussah silk fibroin/nano-hydroxyapatite composite bone scaffold platform with tunable mechanical strength in a wide range
journal, December 2016


Stiff, strong, and tough hydrogels with good chemical stability
journal, January 2014

  • Li, Jianyu; Suo, Zhigang; Vlassak, Joost J.
  • J. Mater. Chem. B, Vol. 2, Issue 39
  • DOI: 10.1039/C4TB01194E

The impact of functionalized CNT in the network of sodium alginate-based nanocomposite beads on the removal of Co(II) ions from aqueous solutions
journal, July 2016

  • Karkeh-abadi, Fatemeh; Saber-Samandari, Samaneh; Saber-Samandari, Saeed
  • Journal of Hazardous Materials, Vol. 312
  • DOI: 10.1016/j.jhazmat.2016.03.074

Study of microporous PVA/PVC composite polymer membrane and it application to MnO2 capacitors
journal, April 2009


PVA-based hydrogels for tissue engineering: A review
journal, June 2016

  • Kumar, Anuj; Han, Sung Soo
  • International Journal of Polymeric Materials and Polymeric Biomaterials, Vol. 66, Issue 4
  • DOI: 10.1080/00914037.2016.1190930

Evaluation of a superior lubrication mechanism with biphasic hydrogels for artificial cartilage
journal, September 2015


Modular material system for the microfabrication of biocompatible hydrogels based on thiol-ene-modified poly(vinyl alcohol)
journal, March 2016

  • Baudis, Stefan; Bomze, Daniel; Markovic, Marica
  • Journal of Polymer Science Part A: Polymer Chemistry, Vol. 54, Issue 13
  • DOI: 10.1002/pola.28073

Microgel-Reinforced Hydrogel Films with High Mechanical Strength and Their Visible Mesoscale Fracture Structure
journal, October 2011

  • Hu, Jian; Hiwatashi, Kenta; Kurokawa, Takayuki
  • Macromolecules, Vol. 44, Issue 19
  • DOI: 10.1021/ma2016248

Defining the Role of Matrix Compliance and Proteolysis in Three-Dimensional Cell Spreading and Remodeling
journal, April 2008


High strength graphene oxide/polyvinyl alcohol composite hydrogels
journal, January 2011

  • Zhang, Lu; Wang, Zhipeng; Xu, Chen
  • Journal of Materials Chemistry, Vol. 21, Issue 28
  • DOI: 10.1039/c0jm04043f

Photocrosslinked Poly(vinyl alcohol) Nanofibrous Scaffolds
journal, January 2016

  • Chen, Shaohua; Liu, Yuansen; Dong, Qi
  • Journal of Photopolymer Science and Technology, Vol. 29, Issue 6
  • DOI: 10.2494/photopolymer.29.841