Type I collagen–targeted PET probe for pulmonary fibrosis detection and staging in preclinical models

Désogère, Pauline; Tapias, Luis F.; Hariri, Lida P.; Rotile, Nicholas J.; Rietz, Tyson A.; Probst, Clemens K.; Blasi, Francesco; Day, Helen; Mino-Kenudson, Mari; Weinreb, Paul; Violette, Shelia M.; Fuchs, Bryan C.; Tager, Andrew M.; Lanuti, Michael; Caravan, Peter

doi:10.1126/scitranslmed.aaf4696

Title: Type I collagen–targeted PET probe for pulmonary fibrosis detection and staging in preclinical models

Journal Article · 04 April 2017 · Science Translational Medicine

DOI: https://doi.org/10.1126/scitranslmed.aaf4696 · OSTI ID:1477818

^[1];

^[2]; Hariri, Lida P. ^[3]; Rotile, Nicholas J. ^[1];

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^[4]; Blasi, Francesco ^[1]; Day, Helen ^[1];

^[5];

^[6]; Violette, Shelia M. ^[6]; Fuchs, Bryan C. ^[7];

^[4]; Lanuti, Michael ^[2];

^[1]

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Division of Thoracic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA., Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Biogen, Cambridge, MA 02142, USA.
Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Positron emission tomography with a probe targeting type I collagen enables detection, staging, and treatment response monitoring in lung fibrosis.

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Sponsoring Organization:: USDOE

OSTI ID:: 1477818

Alternate ID(s):: OSTI ID: 1536853

Journal Information:: Science Translational Medicine, Journal Name: Science Translational Medicine Journal Issue: 384 Vol. 9; ISSN 1946-6234

Publisher:: American Association for the Advancement of Science (AAAS)Copyright Statement

Country of Publication:: United States

Language:: English

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