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Title: Going the Distance: Long-Range Conductivity in Protein and Peptide Bioelectronic Materials

Abstract

Bioelectronic materials interface biomolecules, cells, organs, or organisms with electronic devices, and they represent an active and growing field of materials research. Protein and peptide nanostructures are ideal bioelectronic materials. They possess many of the properties required for biocompatibility across scales from enzymatic to organismal interfaces, and recent examples of supramolecular protein and peptide nanostructures exhibit impressive electronic properties. The ability of such natural and synthetic protein and peptide materials to conduct electricity over micrometer to centimeter length scales, however, is not readily understood from a conventional view of their amino acid building blocks. Distinct in structure and properties from solid-state inorganic and synthetic organic metals and semiconductors, supramolecular conductive proteins and peptides require careful theoretical treatment and experimental characterization methods to understand their electronic structure. In this review, we discuss theory and experimental evidence from recent literature describing the long-range conduction of electronic charge in protein and peptide materials. Electron transfer across proteins has been studied extensively, but application of models for such short-range charge transport to longer distances relevant to bioelectronic materials are less well-understood. Implementation of electronic band structure and electron transfer formulations in extended biomolecular systems will be covered in the context of recent materials discoveriesmore » and efforts at characterization of electronic transport mechanisms.« less

Authors:
 [1]; ORCiD logo [2]; ORCiD logo [3]
  1. Univ. of California, Irvine, CA (United States). Dept. of Chemical Engineering and Materials Science
  2. Univ. of Southern California, Los Angeles, CA (United States). Dept. of Biological Sciences, Dept. of Chemistry, and Dept. of Physics and Astronomy
  3. Univ. of California, Irvine, CA (United States). Dept. of Chemical Engineering and Materials Science, and Dept. of Chemistry
Publication Date:
Research Org.:
Univ. of California, Irvine, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
OSTI Identifier:
1477516
Alternate Identifier(s):
OSTI ID: 1508738
Grant/Contract Number:  
FG02-13ER16415; SC0010609
Resource Type:
Published Article
Journal Name:
Journal of Physical Chemistry. B, Condensed Matter, Materials, Surfaces, Interfaces and Biophysical Chemistry
Additional Journal Information:
Journal Volume: 122; Journal Issue: 46; Journal ID: ISSN 1520-6106
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Ing, Nicole L., El-Naggar, Mohamed Y., and Hochbaum, Allon I. Going the Distance: Long-Range Conductivity in Protein and Peptide Bioelectronic Materials. United States: N. p., 2018. Web. doi:10.1021/acs.jpcb.8b07431.
Ing, Nicole L., El-Naggar, Mohamed Y., & Hochbaum, Allon I. Going the Distance: Long-Range Conductivity in Protein and Peptide Bioelectronic Materials. United States. doi:10.1021/acs.jpcb.8b07431.
Ing, Nicole L., El-Naggar, Mohamed Y., and Hochbaum, Allon I. Fri . "Going the Distance: Long-Range Conductivity in Protein and Peptide Bioelectronic Materials". United States. doi:10.1021/acs.jpcb.8b07431.
@article{osti_1477516,
title = {Going the Distance: Long-Range Conductivity in Protein and Peptide Bioelectronic Materials},
author = {Ing, Nicole L. and El-Naggar, Mohamed Y. and Hochbaum, Allon I.},
abstractNote = {Bioelectronic materials interface biomolecules, cells, organs, or organisms with electronic devices, and they represent an active and growing field of materials research. Protein and peptide nanostructures are ideal bioelectronic materials. They possess many of the properties required for biocompatibility across scales from enzymatic to organismal interfaces, and recent examples of supramolecular protein and peptide nanostructures exhibit impressive electronic properties. The ability of such natural and synthetic protein and peptide materials to conduct electricity over micrometer to centimeter length scales, however, is not readily understood from a conventional view of their amino acid building blocks. Distinct in structure and properties from solid-state inorganic and synthetic organic metals and semiconductors, supramolecular conductive proteins and peptides require careful theoretical treatment and experimental characterization methods to understand their electronic structure. In this review, we discuss theory and experimental evidence from recent literature describing the long-range conduction of electronic charge in protein and peptide materials. Electron transfer across proteins has been studied extensively, but application of models for such short-range charge transport to longer distances relevant to bioelectronic materials are less well-understood. Implementation of electronic band structure and electron transfer formulations in extended biomolecular systems will be covered in the context of recent materials discoveries and efforts at characterization of electronic transport mechanisms.},
doi = {10.1021/acs.jpcb.8b07431},
journal = {Journal of Physical Chemistry. B, Condensed Matter, Materials, Surfaces, Interfaces and Biophysical Chemistry},
number = 46,
volume = 122,
place = {United States},
year = {2018},
month = {9}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1021/acs.jpcb.8b07431

Citation Metrics:
Cited by: 8 works
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