Examination of lutetium(III)-DOTA and copper(II)-NOTA solution structures using EXAFS

Journal Article · 01 October 2018 · Inorganica Chimica Acta

DOI: https://doi.org/10.1016/j.ica.2018.05.031 · OSTI ID:1477458

Alex Brown, M. ^[1]; Brossard, Thomas ^[1]; Rotsch, David A. ^[1]

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1. Argonne National Lab. (ANL), Lemont, IL (United States). Nuclear Engineering Division

Targeted radionuclide therapy generally relies on the chelation of select short-lived isotopes such as ¹⁷⁷Lu and ⁶⁷Cu. The majority of Lu(III) and Cu(II) chelate structural information is derived from solid state diffraction data. Herein, the complexes Lu(DOTA)^-, Cu(NOTA)^- were examined in solution using EXAFS for the first time. Both ligands were fully deprotonated and coordinated to the metal with four and three carboxylic sites for Lu(DOTA)^- and Cu(NOTA)^-, respectively. Near-neighbor correlations from nitrogen atoms on the macrocyclic cages were also visible in the spectra in addition to the adjacent carbon backbones. Coordination numbers, bond distances, and Debye-Waller factors are reported and discussed alongside differences with known crystal structures.

• Research Organization: Argonne National Laboratory (ANL), Argonne, IL (United States)
• Sponsoring Organization: USDOE Office of Science (SC)
• Grant/Contract Number: AC02-06CH11357; DEAC02-06CH11357
• OSTI ID: 1477458
• Alternate ID(s): OSTI ID: 1601298
• Journal Information: Inorganica Chimica Acta, Vol. 482, Issue C; ISSN 0020-1693
• Publisher: ElsevierCopyright Statement
• Country of Publication: United States
• Language: English