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Title: Rapidly moving new bacteria to model-organism status

Abstract

The paradigm of large research communities collectively working on a small number of model bacteria such as Escherichia coli and Bacillus subtilis is changing. While these classic model bacteria will continue to be important for advanced systems biology and new technology development, we envision that increasingly small research teams will be deeply investigating their own favorite strains, for example as new hosts for metabolic engineering or as key members of a complex microbiome. Given the lack of a research community and the sheer number of possible bacteria to interrogate, the development and application of technologies to rapidly and inexpensively advance these unstudied strains to ‘model-organism’ status is imperative. Here, we discuss the minimal information and tools necessary to develop a new model bacterium and how existing approaches can bring this power into the hands of a single investigator.

Authors:
 [1];  [1]
  1. Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1477301
Alternate Identifier(s):
OSTI ID: 1548819
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Accepted Manuscript
Journal Name:
Current Opinion in Biotechnology
Additional Journal Information:
Journal Volume: 51; Journal Issue: C; Journal ID: ISSN 0958-1669
Publisher:
Elsevier
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Liu, Hualan, and Deutschbauer, Adam M. Rapidly moving new bacteria to model-organism status. United States: N. p., 2018. Web. doi:10.1016/j.copbio.2017.12.006.
Liu, Hualan, & Deutschbauer, Adam M. Rapidly moving new bacteria to model-organism status. United States. doi:10.1016/j.copbio.2017.12.006.
Liu, Hualan, and Deutschbauer, Adam M. Sat . "Rapidly moving new bacteria to model-organism status". United States. doi:10.1016/j.copbio.2017.12.006. https://www.osti.gov/servlets/purl/1477301.
@article{osti_1477301,
title = {Rapidly moving new bacteria to model-organism status},
author = {Liu, Hualan and Deutschbauer, Adam M.},
abstractNote = {The paradigm of large research communities collectively working on a small number of model bacteria such as Escherichia coli and Bacillus subtilis is changing. While these classic model bacteria will continue to be important for advanced systems biology and new technology development, we envision that increasingly small research teams will be deeply investigating their own favorite strains, for example as new hosts for metabolic engineering or as key members of a complex microbiome. Given the lack of a research community and the sheer number of possible bacteria to interrogate, the development and application of technologies to rapidly and inexpensively advance these unstudied strains to ‘model-organism’ status is imperative. Here, we discuss the minimal information and tools necessary to develop a new model bacterium and how existing approaches can bring this power into the hands of a single investigator.},
doi = {10.1016/j.copbio.2017.12.006},
journal = {Current Opinion in Biotechnology},
number = C,
volume = 51,
place = {United States},
year = {2018},
month = {1}
}

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