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Title: Dynamic cardiac PET imaging: Technological improvements advancing future cardiac health

Abstract

Here PET, in conjunction with CT,1 has been an important tool in the management of oncology patients, accounting for 86% of PET scans by 2016,2 PET with attenuation and motion correction has significant potential for future cardiac applications, especially with the ability of PET to perform dynamic imaging to measure myocardial perfusion—myocardial blood flow (MBF) and coronary flow reserve (CFR), integrity of neural transmitters of the autonomic nervous system, and connecting cardiac efficiency with metabolism of myocardial substrates.

Authors:
 [1];  [1];  [1]
  1. Univ. of California, San Francisco, CA (United States)
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1477265
Grant/Contract Number:  
AC02-05CH11231
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Nuclear Cardiology
Additional Journal Information:
Journal Volume: 26; Journal Issue: 4; Journal ID: ISSN 1071-3581
Publisher:
Springer Nature
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Gullberg, Grant T., Shrestha, Uttam M., and Seo, Youngho. Dynamic cardiac PET imaging: Technological improvements advancing future cardiac health. United States: N. p., 2018. Web. https://doi.org/10.1007/s12350-018-1201-3.
Gullberg, Grant T., Shrestha, Uttam M., & Seo, Youngho. Dynamic cardiac PET imaging: Technological improvements advancing future cardiac health. United States. https://doi.org/10.1007/s12350-018-1201-3
Gullberg, Grant T., Shrestha, Uttam M., and Seo, Youngho. Wed . "Dynamic cardiac PET imaging: Technological improvements advancing future cardiac health". United States. https://doi.org/10.1007/s12350-018-1201-3. https://www.osti.gov/servlets/purl/1477265.
@article{osti_1477265,
title = {Dynamic cardiac PET imaging: Technological improvements advancing future cardiac health},
author = {Gullberg, Grant T. and Shrestha, Uttam M. and Seo, Youngho},
abstractNote = {Here PET, in conjunction with CT,1 has been an important tool in the management of oncology patients, accounting for 86% of PET scans by 2016,2 PET with attenuation and motion correction has significant potential for future cardiac applications, especially with the ability of PET to perform dynamic imaging to measure myocardial perfusion—myocardial blood flow (MBF) and coronary flow reserve (CFR), integrity of neural transmitters of the autonomic nervous system, and connecting cardiac efficiency with metabolism of myocardial substrates.},
doi = {10.1007/s12350-018-1201-3},
journal = {Journal of Nuclear Cardiology},
number = 4,
volume = 26,
place = {United States},
year = {2018},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Figures / Tables:

Figure 1 Figure 1: Figure 1 in the paper of Renaud and colleagues showing the anthropomorphic torso phantom used for the measurements (A) with cardiac insert (B). The volume of interest (red) (C) is drawn over the cardiac insert. An illustration of the acquired data shows the measured time– activity curve (D)more » increasing with time as the paralysis of the system deceases with a decrease in activity due to decay. The measured data approaches asymptotically equal to the true activity. Dotted (vertical) line shows the time when the accurate and inaccurate measured activity is less than 1%. This figure was originally published in Journal of Nuclear Medicine.© by the Society of Nuclear Medicine and Molecular Imaging, Inc.« less

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Works referenced in this record:

Benefit of Time-of-Flight in PET: Experimental and Clinical Results
journal, February 2008

  • Karp, J. S.; Surti, S.; Daube-Witherspoon, M. E.
  • Journal of Nuclear Medicine, Vol. 49, Issue 3
  • DOI: 10.2967/jnumed.107.044834

Improved Intrinsic Motion Detection Using Time-of-Flight PET
journal, October 2015

  • Xu, Jingyan; Tsui, Benjamin M. W.
  • IEEE Transactions on Medical Imaging, Vol. 34, Issue 10
  • DOI: 10.1109/TMI.2015.2423976

Application of Silicon Photomultipliers to Positron Emission Tomography
journal, February 2011


Preclinical and Translational PET/MR Imaging
journal, May 2014

  • Wehrl, H. F.; Wiehr, S.; Divine, M. R.
  • Journal of Nuclear Medicine, Vol. 55, Issue Supplement_2
  • DOI: 10.2967/jnumed.113.129221

Recent Advances and Future Progress in PET Instrumentation
journal, January 2016


Studies of a Next-Generation Silicon-Photomultiplier–Based Time-of-Flight PET/CT System
journal, April 2017

  • Hsu, David F. C.; Ilan, Ezgi; Peterson, William T.
  • Journal of Nuclear Medicine, Vol. 58, Issue 9
  • DOI: 10.2967/jnumed.117.189514

Imaging of myocardial fatty acid oxidation
journal, October 2016

  • Mather, Kieren J.; DeGrado, Timothy R.
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1861, Issue 10
  • DOI: 10.1016/j.bbalip.2016.02.019

Hypertensive left ventricular hypertrophy is associated with abnormal myocardial fatty acid metabolism and myocardial efficiency
journal, June 2006


Free Fatty Acid Depletion Acutely Decreases Cardiac Work and Efficiency in Cardiomyopathic Heart Failure
journal, November 2006


System models for PET statistical iterative reconstruction: A review
journal, March 2016


Recent Advances and Clinical Applications of PET Cardiac Autonomic Nervous System Imaging
journal, March 2017


Selective improvement in Seattle Heart Failure Model risk stratification using iodine-123 meta-iodobenzylguanidine imaging
journal, September 2012

  • Ketchum, Eric S.; Jacobson, Arnold F.; Caldwell, James H.
  • Journal of Nuclear Cardiology, Vol. 19, Issue 5
  • DOI: 10.1007/s12350-012-9603-0

Approaches to Reducing Radiation Dose from Radionuclide Myocardial Perfusion Imaging
journal, March 2015


Pushing the Limits in Time-of-Flight PET Imaging
journal, November 2017


Study of a high-resolution, 3D positioning cadmium zinc telluride detector for PET
journal, February 2011


Relationship Between Carbohydrate and Lipid Metabolism and the Energy Balance of Heart Muscle
journal, March 1974


Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents
journal, February 2010

  • Haim, Todd E.; Wang, Wei; Flagg, Thomas P.
  • Journal of Molecular and Cellular Cardiology, Vol. 48, Issue 2
  • DOI: 10.1016/j.yjmcc.2009.10.004

Time-of-flight PET data determine the attenuation sinogram up to a constant
journal, January 2012

  • Defrise, Michel; Rezaei, Ahmadreza; Nuyts, Johan
  • Physics in Medicine and Biology, Vol. 57, Issue 4
  • DOI: 10.1088/0031-9155/57/4/885

Characterization of 3-Dimensional PET Systems for Accurate Quantification of Myocardial Blood Flow
journal, August 2016

  • Renaud, Jennifer M.; Yip, Kathy; Guimond, Jean
  • Journal of Nuclear Medicine, Vol. 58, Issue 1
  • DOI: 10.2967/jnumed.116.174565

Journey in Evolution of Nuclear Cardiology
journal, December 2012


Improving Depth, Energy and Timing Estimation in PET Detectors with Deconvolution and Maximum Likelihood Pulse Shape Discrimination
journal, November 2016

  • Berg, Eric; Roncali, Emilie; Hutchcroft, Will
  • IEEE Transactions on Medical Imaging, Vol. 35, Issue 11
  • DOI: 10.1109/TMI.2016.2577539

Quantitative accuracy of PET/CT for image-based kinetic analysis: Quantitative accuracy of PET/CT
journal, June 2008

  • Seo, Youngho; Teo, Boon-Keng; Hadi, Mohiuddin
  • Medical Physics, Vol. 35, Issue 7Part1
  • DOI: 10.1118/1.2937439

Cardiac-gated parametric images from 82 Rb PET from dynamic frames and direct 4D reconstruction
journal, December 2017

  • Germino, Mary; Carson, Richard E.
  • Medical Physics, Vol. 45, Issue 2
  • DOI: 10.1002/mp.12710

Image Quality and Diagnostic Performance of a Digital PET Prototype in Patients with Oncologic Diseases: Initial Experience and Comparison with Analog PET
journal, July 2015

  • Nguyen, N. C.; Vercher-Conejero, J. L.; Sattar, A.
  • Journal of Nuclear Medicine, Vol. 56, Issue 9
  • DOI: 10.2967/jnumed.114.148338

Performance evaluation of the Ingenuity TF PET/CT scanner with a focus on high count-rate conditions
journal, June 2014


Retention Kinetics of the 18F-Labeled Sympathetic Nerve PET Tracer LMI1195: Comparison with 11C-Hydroxyephedrine and 123I-MIBG
journal, July 2015


Iterative reconstruction techniques in emission computed tomography
journal, July 2006


Using convolutional neural networks to estimate time-of-flight from PET detector waveforms
journal, January 2018


Time-of-flight PET
journal, July 1998


    Figures / Tables found in this record:

      Figures/Tables have been extracted from DOE-funded journal article accepted manuscripts.