Dynamic cardiac PET imaging: Technological improvements advancing future cardiac health
Abstract
Here PET, in conjunction with CT,1 has been an important tool in the management of oncology patients, accounting for 86% of PET scans by 2016,2 PET with attenuation and motion correction has significant potential for future cardiac applications, especially with the ability of PET to perform dynamic imaging to measure myocardial perfusion—myocardial blood flow (MBF) and coronary flow reserve (CFR), integrity of neural transmitters of the autonomic nervous system, and connecting cardiac efficiency with metabolism of myocardial substrates.
- Authors:
-
- Univ. of California, San Francisco, CA (United States)
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1477265
- Grant/Contract Number:
- AC02-05CH11231
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Journal of Nuclear Cardiology
- Additional Journal Information:
- Journal Volume: 26; Journal Issue: 4; Journal ID: ISSN 1071-3581
- Publisher:
- Springer Nature
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Gullberg, Grant T., Shrestha, Uttam M., and Seo, Youngho. Dynamic cardiac PET imaging: Technological improvements advancing future cardiac health. United States: N. p., 2018.
Web. doi:10.1007/s12350-018-1201-3.
Gullberg, Grant T., Shrestha, Uttam M., & Seo, Youngho. Dynamic cardiac PET imaging: Technological improvements advancing future cardiac health. United States. https://doi.org/10.1007/s12350-018-1201-3
Gullberg, Grant T., Shrestha, Uttam M., and Seo, Youngho. Wed .
"Dynamic cardiac PET imaging: Technological improvements advancing future cardiac health". United States. https://doi.org/10.1007/s12350-018-1201-3. https://www.osti.gov/servlets/purl/1477265.
@article{osti_1477265,
title = {Dynamic cardiac PET imaging: Technological improvements advancing future cardiac health},
author = {Gullberg, Grant T. and Shrestha, Uttam M. and Seo, Youngho},
abstractNote = {Here PET, in conjunction with CT,1 has been an important tool in the management of oncology patients, accounting for 86% of PET scans by 2016,2 PET with attenuation and motion correction has significant potential for future cardiac applications, especially with the ability of PET to perform dynamic imaging to measure myocardial perfusion—myocardial blood flow (MBF) and coronary flow reserve (CFR), integrity of neural transmitters of the autonomic nervous system, and connecting cardiac efficiency with metabolism of myocardial substrates.},
doi = {10.1007/s12350-018-1201-3},
journal = {Journal of Nuclear Cardiology},
number = 4,
volume = 26,
place = {United States},
year = {2018},
month = {1}
}
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Works referenced in this record:
Benefit of Time-of-Flight in PET: Experimental and Clinical Results
journal, February 2008
- Karp, J. S.; Surti, S.; Daube-Witherspoon, M. E.
- Journal of Nuclear Medicine, Vol. 49, Issue 3
Improved Intrinsic Motion Detection Using Time-of-Flight PET
journal, October 2015
- Xu, Jingyan; Tsui, Benjamin M. W.
- IEEE Transactions on Medical Imaging, Vol. 34, Issue 10
Myocardial flow reserve (MFR) with positron emission tomography (PET)/computed tomography (CT): clinical impact in diagnosis and prognosis
journal, April 2017
- Ziadi, Maria Cecilia
- Cardiovascular Diagnosis and Therapy, Vol. 7, Issue 2
Application of Silicon Photomultipliers to Positron Emission Tomography
journal, February 2011
- Roncali, Emilie; Cherry, Simon R.
- Annals of Biomedical Engineering, Vol. 39, Issue 4
Preclinical and Translational PET/MR Imaging
journal, May 2014
- Wehrl, H. F.; Wiehr, S.; Divine, M. R.
- Journal of Nuclear Medicine, Vol. 55, Issue Supplement_2
Recent Advances and Future Progress in PET Instrumentation
journal, January 2016
- Slomka, Piotr J.; Pan, Tinsu; Germano, Guido
- Seminars in Nuclear Medicine, Vol. 46, Issue 1
Studies of a Next-Generation Silicon-Photomultiplier–Based Time-of-Flight PET/CT System
journal, April 2017
- Hsu, David F. C.; Ilan, Ezgi; Peterson, William T.
- Journal of Nuclear Medicine, Vol. 58, Issue 9
Imaging of myocardial fatty acid oxidation
journal, October 2016
- Mather, Kieren J.; DeGrado, Timothy R.
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1861, Issue 10
Hypertensive left ventricular hypertrophy is associated with abnormal myocardial fatty acid metabolism and myocardial efficiency
journal, June 2006
- Delasfuentes, L.; Soto, P.; Cupps, B.
- Journal of Nuclear Cardiology, Vol. 13, Issue 3
Free Fatty Acid Depletion Acutely Decreases Cardiac Work and Efficiency in Cardiomyopathic Heart Failure
journal, November 2006
- Tuunanen, Helena; Engblom, Erik; Naum, Alexandru
- Circulation, Vol. 114, Issue 20
System models for PET statistical iterative reconstruction: A review
journal, March 2016
- Iriarte, A.; Marabini, R.; Matej, S.
- Computerized Medical Imaging and Graphics, Vol. 48
Recent Advances and Clinical Applications of PET Cardiac Autonomic Nervous System Imaging
journal, March 2017
- Boutagy, Nabil E.; Sinusas, Albert J.
- Current Cardiology Reports, Vol. 19, Issue 4
Selective improvement in Seattle Heart Failure Model risk stratification using iodine-123 meta-iodobenzylguanidine imaging
journal, September 2012
- Ketchum, Eric S.; Jacobson, Arnold F.; Caldwell, James H.
- Journal of Nuclear Cardiology, Vol. 19, Issue 5
Approaches to Reducing Radiation Dose from Radionuclide Myocardial Perfusion Imaging
journal, March 2015
- Dorbala, S.; Blankstein, R.; Skali, H.
- Journal of Nuclear Medicine, Vol. 56, Issue 4
Pushing the Limits in Time-of-Flight PET Imaging
journal, November 2017
- Lecoq, P.
- IEEE Transactions on Radiation and Plasma Medical Sciences, Vol. 1, Issue 6
Study of a high-resolution, 3D positioning cadmium zinc telluride detector for PET
journal, February 2011
- Gu, Y.; Matteson, J. L.; Skelton, R. T.
- Physics in Medicine and Biology, Vol. 56, Issue 6
Relationship Between Carbohydrate and Lipid Metabolism and the Energy Balance of Heart Muscle
journal, March 1974
- Neely, J. R.; Morgan, H. E.
- Annual Review of Physiology, Vol. 36, Issue 1
Palmitate attenuates myocardial contractility through augmentation of repolarizing Kv currents
journal, February 2010
- Haim, Todd E.; Wang, Wei; Flagg, Thomas P.
- Journal of Molecular and Cellular Cardiology, Vol. 48, Issue 2
Time-of-flight PET data determine the attenuation sinogram up to a constant
journal, January 2012
- Defrise, Michel; Rezaei, Ahmadreza; Nuyts, Johan
- Physics in Medicine and Biology, Vol. 57, Issue 4
Characterization of 3-Dimensional PET Systems for Accurate Quantification of Myocardial Blood Flow
journal, August 2016
- Renaud, Jennifer M.; Yip, Kathy; Guimond, Jean
- Journal of Nuclear Medicine, Vol. 58, Issue 1
Journey in Evolution of Nuclear Cardiology
journal, December 2012
- Dilsizian, Vasken; Taillefer, Raymond
- JACC: Cardiovascular Imaging, Vol. 5, Issue 12
Improving Depth, Energy and Timing Estimation in PET Detectors with Deconvolution and Maximum Likelihood Pulse Shape Discrimination
journal, November 2016
- Berg, Eric; Roncali, Emilie; Hutchcroft, Will
- IEEE Transactions on Medical Imaging, Vol. 35, Issue 11
Quantitative accuracy of PET/CT for image-based kinetic analysis: Quantitative accuracy of PET/CT
journal, June 2008
- Seo, Youngho; Teo, Boon-Keng; Hadi, Mohiuddin
- Medical Physics, Vol. 35, Issue 7Part1
Cardiac-gated parametric images from 82 Rb PET from dynamic frames and direct 4D reconstruction
journal, December 2017
- Germino, Mary; Carson, Richard E.
- Medical Physics, Vol. 45, Issue 2
Ultralow dose computed tomography attenuation correction for pediatric PET CT using adaptive statistical iterative reconstruction: Ultra-low dose PET CT attenuation correction
journal, January 2015
- Brady, Samuel L.; Shulkin, Barry L.
- Medical Physics, Vol. 42, Issue 2
Longitudinal Evaluation of Sympathetic Nervous System and Perfusion in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic Single-Photon Emission Computed Tomography
journal, July 2015
- Zan, Yunlong; Boutchko, Rostyslav; Huang, Qiu
- Molecular Imaging, Vol. 14, Issue 7
Image Quality and Diagnostic Performance of a Digital PET Prototype in Patients with Oncologic Diseases: Initial Experience and Comparison with Analog PET
journal, July 2015
- Nguyen, N. C.; Vercher-Conejero, J. L.; Sattar, A.
- Journal of Nuclear Medicine, Vol. 56, Issue 9
Performance evaluation of the Ingenuity TF PET/CT scanner with a focus on high count-rate conditions
journal, June 2014
- Kolthammer, Jeffrey A.; Su, Kuan-Hao; Grover, Anu
- Physics in Medicine and Biology, Vol. 59, Issue 14
Retention Kinetics of the 18F-Labeled Sympathetic Nerve PET Tracer LMI1195: Comparison with 11C-Hydroxyephedrine and 123I-MIBG
journal, July 2015
- Werner, R. A.; Rischpler, C.; Onthank, D.
- Journal of Nuclear Medicine, Vol. 56, Issue 9
Longitudinal Evaluation of Left Ventricular Substrate Metabolism, Perfusion, and Dysfunction in the Spontaneously Hypertensive Rat Model of Hypertrophy Using Small-Animal PET/CT Imaging
journal, October 2013
- Hernandez, A. M.; Huber, J. S.; Murphy, S. T.
- Journal of Nuclear Medicine, Vol. 54, Issue 11
Iterative reconstruction techniques in emission computed tomography
journal, July 2006
- Qi, Jinyi; Leahy, Richard M.
- Physics in Medicine and Biology, Vol. 51, Issue 15
Using convolutional neural networks to estimate time-of-flight from PET detector waveforms
journal, January 2018
- Berg, Eric; Cherry, Simon R.
- Physics in Medicine & Biology, Vol. 63, Issue 2
Time-of-flight PET
journal, July 1998
- Lewellen, Tom K.
- Seminars in Nuclear Medicine, Vol. 28, Issue 3
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