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Title: Testing a Cherenkov neutron time-of-flight detector on OMEGA

Abstract

To establish a rat model of blood stasis with adrenaline (Adr) subcutaneous injection and ice bath stimulation. The effects of different doses on the blood viscosity of blood stasis model rats were observed. The rats were randomly divided into 6 groups: blank control group (no model), model group, positive control group, high, middle and low dose group. The whole blood viscosity and plasma viscosity were detected by blood viscosity instrument. Compared with the blank group, model group, high shear, low shear whole blood viscosity and plasma viscosity were significantly increased, TT PT significantly shortened, APTT was significantly prolonged, FIB increased significantly, indicating that the model was successful. Compared with the model group, can significantly reduce the Naoluotong group (cut, low cut). Qingnaopian high dose group (low cut), middle dose group (cut, low shear blood viscosity) (P<0.01), Can significantly reduce Naoluotong qingnaopian group, high dose group (P<0.01), plasma viscosity decreased qingnaopian plasma viscosity in low dose group (P<0.05). Conclusion: qingnaopian could improve the blood rheology of blood stasis mice abnormal index, decrease the blood viscosity, blood stasis has certain hemostatic effect.

Authors:
 [1];  [2];  [1];  [2]; ORCiD logo [2];  [2];  [1];  [2];  [1]; ORCiD logo [1]; ORCiD logo [2];  [1]
+ Show Author Affiliations
  1. Univ. of Rochester, NY (United States). Lab. for Laser Energetics
  2. Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Publication Date:
Research Org.:
Univ. of Rochester, NY (United States). Lab. for Laser Energetics; Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1477167
Alternate Identifier(s):
OSTI ID: 1476843; OSTI ID: 1876986
Report Number(s):
2017-264, 1439; LLNL-JRNL-823172
Journal ID: ISSN 0034-6748; 2017-264, 1439, 2397
Grant/Contract Number:  
NA0001944; AC52-07NA27344
Resource Type:
Accepted Manuscript
Journal Name:
Review of Scientific Instruments
Additional Journal Information:
Journal Volume: 89; Journal Issue: 10; Conference: 22nd Topical Conference on High Temperature Plasma Diagnostics, San Diego, CA, 16-19 April 2018; Journal ID: ISSN 0034-6748
Publisher:
American Institute of Physics (AIP)
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; 70 PLASMA PHYSICS AND FUSION TECHNOLOGY

Citation Formats

Glebov, V. Yu., Eckart, M. J., Forrest, C. J., Grim, G. P., Hartouni, E. P., Hatarik, R., Knauer, J. P., Moore, A. S., Regan, S. P., Sangster, T. C., Schlossberg, D. J., and Stoeckl, C. Testing a Cherenkov neutron time-of-flight detector on OMEGA. United States: N. p., 2018. Web. doi:10.1063/1.5035289.
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Glebov, V. Yu., Eckart, M. J., Forrest, C. J., Grim, G. P., Hartouni, E. P., Hatarik, R., Knauer, J. P., Moore, A. S., Regan, S. P., Sangster, T. C., Schlossberg, D. J., & Stoeckl, C. Testing a Cherenkov neutron time-of-flight detector on OMEGA. United States. https://doi.org/10.1063/1.5035289
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Glebov, V. Yu., Eckart, M. J., Forrest, C. J., Grim, G. P., Hartouni, E. P., Hatarik, R., Knauer, J. P., Moore, A. S., Regan, S. P., Sangster, T. C., Schlossberg, D. J., and Stoeckl, C. Tue . "Testing a Cherenkov neutron time-of-flight detector on OMEGA". United States. https://doi.org/10.1063/1.5035289. https://www.osti.gov/servlets/purl/1477167.
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@article{osti_1477167,
title = {Testing a Cherenkov neutron time-of-flight detector on OMEGA},
author = {Glebov, V. Yu. and Eckart, M. J. and Forrest, C. J. and Grim, G. P. and Hartouni, E. P. and Hatarik, R. and Knauer, J. P. and Moore, A. S. and Regan, S. P. and Sangster, T. C. and Schlossberg, D. J. and Stoeckl, C.},
abstractNote = {To establish a rat model of blood stasis with adrenaline (Adr) subcutaneous injection and ice bath stimulation. The effects of different doses on the blood viscosity of blood stasis model rats were observed. The rats were randomly divided into 6 groups: blank control group (no model), model group, positive control group, high, middle and low dose group. The whole blood viscosity and plasma viscosity were detected by blood viscosity instrument. Compared with the blank group, model group, high shear, low shear whole blood viscosity and plasma viscosity were significantly increased, TT PT significantly shortened, APTT was significantly prolonged, FIB increased significantly, indicating that the model was successful. Compared with the model group, can significantly reduce the Naoluotong group (cut, low cut). Qingnaopian high dose group (low cut), middle dose group (cut, low shear blood viscosity) (P<0.01), Can significantly reduce Naoluotong qingnaopian group, high dose group (P<0.01), plasma viscosity decreased qingnaopian plasma viscosity in low dose group (P<0.05). Conclusion: qingnaopian could improve the blood rheology of blood stasis mice abnormal index, decrease the blood viscosity, blood stasis has certain hemostatic effect.},
doi = {10.1063/1.5035289},
journal = {Review of Scientific Instruments},
number = 10,
volume = 89,
place = {United States},
year = {Tue Oct 09 00:00:00 EDT 2018},
month = {Tue Oct 09 00:00:00 EDT 2018}
}
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Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1063/1.5035289
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Cited by: 5 works
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Figures / Tables:

FIG. 1 FIG. 1: A photograph of the Cherenkov neutron time-of-flight (nTOF) detector at 13 m from TCC together with the Petal and 8 x 4 nTOF detectors in a collimated LOS on OMEGA.
All figures and tables (11 total)
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Works referenced in this record:

Calibration of a neutron time-of-flight detector with a rapid instrument response function for measurements of bulk fluid motion on OMEGA
journal, October 2018

  • Mannion, O. M.; Glebov, V. Yu.; Forrest, C. J.
  • Review of Scientific Instruments, Vol. 89, Issue 10
  • DOI: 10.1063/1.5037324

The National Ignition Facility neutron time-of-flight system and its initial performance (invited)
journal, October 2010

  • Glebov, V. Yu.; Sangster, T. C.; Stoeckl, C.
  • Review of Scientific Instruments, Vol. 81, Issue 10
  • DOI: 10.1063/1.3492351

Interpretation of neutron time-of-flight signals from current-mode detectors
journal, January 1997

  • Murphy, T. J.; Chrien, R. E.; Klare, K. A.
  • Review of Scientific Instruments, Vol. 68, Issue 1
  • DOI: 10.1063/1.1147763

A fused silica Cherenkov radiator for high precision time-of-flight measurement of DT γ and neutron spectra (invited)
journal, October 2018

  • Moore, A. S.; Schlossberg, D. J.; Hartouni, E. P.
  • Review of Scientific Instruments, Vol. 89, Issue 10
  • DOI: 10.1063/1.5039322

A new neutron time-of-flight detector for fuel-areal-density measurements on OMEGA
journal, November 2014

  • Glebov, V. Yu.; Forrest, C. J.; Marshall, K. L.
  • Review of Scientific Instruments, Vol. 85, Issue 11
  • DOI: 10.1063/1.4886428

Prototypes of National Ignition Facility neutron time-of-flight detectors tested on OMEGA
journal, October 2004

  • Glebov, V. Yu.; Stoeckl, C.; Sangster, T. C.
  • Review of Scientific Instruments, Vol. 75, Issue 10
  • DOI: 10.1063/1.1788875

High-resolution spectroscopy used to measure inertial confinement fusion neutron spectra on Omega (invited)
journal, October 2012

  • Forrest, C. J.; Radha, P. B.; Glebov, V. Yu.
  • Review of Scientific Instruments, Vol. 83, Issue 10
  • DOI: 10.1063/1.4742926
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    Works referencing / citing this record:

    The National Direct-Drive Inertial Confinement Fusion Program
    journal, December 2018

    Nuclear diagnostics for Inertial Confinement Fusion (ICF) plasmas
    journal, January 2020

    A fused silica Cherenkov radiator for high precision time-of-flight measurement of DT γ and neutron spectra (invited)
    journal, October 2018

    • Moore, A. S.; Schlossberg, D. J.; Hartouni, E. P.
    • Review of Scientific Instruments, Vol. 89, Issue 10
    • DOI: 10.1063/1.5039322

    Ab initio response functions for Cherenkov-based neutron detectors
    journal, October 2018

    • Schlossberg, D. J.; Moore, A. S.; Beeman, B. V.
    • Review of Scientific Instruments, Vol. 89, Issue 10
    • DOI: 10.1063/1.5039399
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      Figures / Tables found in this record:

      FIG. 1 (p. 2)figure
      FIG. 2 (p. 2)figure
      FIG. 3 (p. 2)figure
      FIG. 4 (p. 3)figure
      FIG. 5 (p. 3)figure
      FIG. 6 (p. 3)figure
      FIG. 7 (p. 3)figure
      FIG. 10 (p. 4)figure
      FIG. 11 (p. 4)figure
      FIG. 8 (p. 4)figure
      FIG. 9 (p. 4)figure
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