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Title: Detection of long-lived contaminants in cyclotron-produced radiopharmaceuticals by large area plastic scintillators

Abstract

In the USA during 2015 over 1,718,500 clinical PET scans were performed in 2380 centers. Patients undergoing these studies will alarm homeland security monitors at borders, ports, and some airports for up to 2 days due to the positron-annihilation photons (0.511 MeV) from the imaging isotope 18F (110 min half-life). In some radiopharmaceuticals, long-lived contaminants generated from the activation and spallation of elements in the HAVAR window of the cyclotron target may also be present in the patient dose. In this work, we have modeled a typical homeland security portal monitor in MCNP, and determined its sensitivity to each of the possible contaminating isotopes found in PET radiopharmaceuticals when distributed in patient phantoms. Furthermore, these data were combined with the time-dependent uptake/retention functions for the contaminating isotopes, to identify the isotopes that can cause alarms for substantial periods of time after the short-lived imaging agent has decayed away.

Authors:
ORCiD logo [1];  [2];  [3]; ORCiD logo [4]
  1. RSE, Inc., Chandler, AZ (United States)
  2. White Rock Science, White Rock, NM (United States)
  3. Eastern Scientific, Oak Ridge, TN (United States)
  4. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1474858
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Journal of Radioanalytical and Nuclear Chemistry
Additional Journal Information:
Journal Volume: 318; Journal Issue: 1; Journal ID: ISSN 0236-5731
Publisher:
Springer
Country of Publication:
United States
Language:
English
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; Radiopharmaceuticals; Portal monitors; MCNP; PET

Citation Formats

Metzger, Robert L., Van Riper, Kenneth A., Eckerman, Keith F., and Leggett, Richard Wayne. Detection of long-lived contaminants in cyclotron-produced radiopharmaceuticals by large area plastic scintillators. United States: N. p., 2018. Web. doi:10.1007/s10967-018-5971-5.
Metzger, Robert L., Van Riper, Kenneth A., Eckerman, Keith F., & Leggett, Richard Wayne. Detection of long-lived contaminants in cyclotron-produced radiopharmaceuticals by large area plastic scintillators. United States. doi:10.1007/s10967-018-5971-5.
Metzger, Robert L., Van Riper, Kenneth A., Eckerman, Keith F., and Leggett, Richard Wayne. Fri . "Detection of long-lived contaminants in cyclotron-produced radiopharmaceuticals by large area plastic scintillators". United States. doi:10.1007/s10967-018-5971-5. https://www.osti.gov/servlets/purl/1474858.
@article{osti_1474858,
title = {Detection of long-lived contaminants in cyclotron-produced radiopharmaceuticals by large area plastic scintillators},
author = {Metzger, Robert L. and Van Riper, Kenneth A. and Eckerman, Keith F. and Leggett, Richard Wayne},
abstractNote = {In the USA during 2015 over 1,718,500 clinical PET scans were performed in 2380 centers. Patients undergoing these studies will alarm homeland security monitors at borders, ports, and some airports for up to 2 days due to the positron-annihilation photons (0.511 MeV) from the imaging isotope 18F (110 min half-life). In some radiopharmaceuticals, long-lived contaminants generated from the activation and spallation of elements in the HAVAR window of the cyclotron target may also be present in the patient dose. In this work, we have modeled a typical homeland security portal monitor in MCNP, and determined its sensitivity to each of the possible contaminating isotopes found in PET radiopharmaceuticals when distributed in patient phantoms. Furthermore, these data were combined with the time-dependent uptake/retention functions for the contaminating isotopes, to identify the isotopes that can cause alarms for substantial periods of time after the short-lived imaging agent has decayed away.},
doi = {10.1007/s10967-018-5971-5},
journal = {Journal of Radioanalytical and Nuclear Chemistry},
number = 1,
volume = 318,
place = {United States},
year = {2018},
month = {6}
}

Journal Article:
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