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Title: Regulation of Lignin Biosynthesis and Its Role in Growth-Defense Tradeoffs

Abstract

Plant growth-defense tradeoffs are fundamental for optimizing plant performance and fitness in a changing biotic/abiotic environment. This process is thought to involve readjusting resource allocation to different pathways. It has been frequently observed that among secondary cell wall components, alteration in lignin biosynthesis results in changes in both growth and defense. How this process is regulated, leading to growth or defense, remains largely elusive. In this article, we review the canonical lignin biosynthesis pathway, the recently discovered tyrosine shortcut pathway, and the biosynthesis of unconventional C-lignin. We summarize the current model of the hierarchical transcriptional regulation of lignin biosynthesis. Moreover, the interface between recently identified transcription factors and the hierarchical model are also discussed. We propose the existence of a transcriptional co-regulation mechanism coordinating energy allowance among growth, defense and lignin biosynthesis.

Authors:
 [1];  [2];  [2];  [2];  [2];  [2]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)
  2. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
OSTI Identifier:
1474522
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Frontiers in Plant Science
Additional Journal Information:
Journal Volume: 9; Journal Issue: N/A; Journal ID: ISSN 1664-462X
Publisher:
Frontiers Research Foundation
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Xie, Meng, Zhang, Jin, Tschaplinski, Timothy J., Tuskan, Gerald A., Chen, Jin-Gui, and Muchero, Wellington. Regulation of Lignin Biosynthesis and Its Role in Growth-Defense Tradeoffs. United States: N. p., 2018. Web. doi:10.3389/fpls.2018.01427.
Xie, Meng, Zhang, Jin, Tschaplinski, Timothy J., Tuskan, Gerald A., Chen, Jin-Gui, & Muchero, Wellington. Regulation of Lignin Biosynthesis and Its Role in Growth-Defense Tradeoffs. United States. doi:10.3389/fpls.2018.01427.
Xie, Meng, Zhang, Jin, Tschaplinski, Timothy J., Tuskan, Gerald A., Chen, Jin-Gui, and Muchero, Wellington. Fri . "Regulation of Lignin Biosynthesis and Its Role in Growth-Defense Tradeoffs". United States. doi:10.3389/fpls.2018.01427. https://www.osti.gov/servlets/purl/1474522.
@article{osti_1474522,
title = {Regulation of Lignin Biosynthesis and Its Role in Growth-Defense Tradeoffs},
author = {Xie, Meng and Zhang, Jin and Tschaplinski, Timothy J. and Tuskan, Gerald A. and Chen, Jin-Gui and Muchero, Wellington},
abstractNote = {Plant growth-defense tradeoffs are fundamental for optimizing plant performance and fitness in a changing biotic/abiotic environment. This process is thought to involve readjusting resource allocation to different pathways. It has been frequently observed that among secondary cell wall components, alteration in lignin biosynthesis results in changes in both growth and defense. How this process is regulated, leading to growth or defense, remains largely elusive. In this article, we review the canonical lignin biosynthesis pathway, the recently discovered tyrosine shortcut pathway, and the biosynthesis of unconventional C-lignin. We summarize the current model of the hierarchical transcriptional regulation of lignin biosynthesis. Moreover, the interface between recently identified transcription factors and the hierarchical model are also discussed. We propose the existence of a transcriptional co-regulation mechanism coordinating energy allowance among growth, defense and lignin biosynthesis.},
doi = {10.3389/fpls.2018.01427},
journal = {Frontiers in Plant Science},
number = N/A,
volume = 9,
place = {United States},
year = {2018},
month = {9}
}

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Cited by: 9 works
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Works referenced in this record:

Elicitor-induced transcription factors for metabolic reprogramming of secondary metabolism in Medicago truncatula
journal, January 2008

  • Naoumkina, Marina A.; He, XianZhi; Dixon, Richard A.
  • BMC Plant Biology, Vol. 8, Issue 1
  • DOI: 10.1186/1471-2229-8-132

Lignin Biosynthesis
journal, June 2003


A polymer of caffeyl alcohol in plant seeds
journal, January 2012

  • Chen, F.; Tobimatsu, Y.; Havkin-Frenkel, D.
  • Proceedings of the National Academy of Sciences, Vol. 109, Issue 5
  • DOI: 10.1073/pnas.1120992109

Expansion and Diversification of the Populus R2R3-MYB Family of Transcription Factors
journal, December 2008

  • Wilkins, Olivia; Nahal, Hardeep; Foong, Justin
  • Plant Physiology, Vol. 149, Issue 2
  • DOI: 10.1104/pp.108.132795

Current Models for Transcriptional Regulation of Secondary Cell Wall Biosynthesis in Grasses
journal, April 2018


Growth-defense tradeoffs for two major anti-herbivore traits of the common milkweed Asclepias syriaca
journal, February 2015

  • Züst, Tobias; Rasmann, Sergio; Agrawal, Anurag A.
  • Oikos, Vol. 124, Issue 10
  • DOI: 10.1111/oik.02075

Novel seed coat lignins in the Cactaceae: structure, distribution and implications for the evolution of lignin diversity
journal, November 2012

  • Chen, Fang; Tobimatsu, Yuki; Jackson, Lisa
  • The Plant Journal, Vol. 73, Issue 2
  • DOI: 10.1111/tpj.12012

The MYB46 Transcription Factor Is a Direct Target of SND1 and Regulates Secondary Wall Biosynthesis in Arabidopsis
journal, September 2007

  • Zhong, R.; Richardson, E. A.; Ye, Z.-H.
  • The Plant Cell Online, Vol. 19, Issue 9, p. 2776-2792
  • DOI: 10.1105/tpc.107.053678

Caffeoyl Shikimate Esterase (CSE) Is an Enzyme in the Lignin Biosynthetic Pathway in Arabidopsis
journal, August 2013


The Phenylpropanoid Pathway in Arabidopsis
journal, January 2011

  • Fraser, Christopher M.; Chapple, Clint
  • The Arabidopsis Book, Vol. 9
  • DOI: 10.1199/tab.0152

Transcriptional Activation of Secondary Wall Biosynthesis by Rice and Maize NAC and MYB Transcription Factors
journal, September 2011

  • Zhong, R.; Lee, C.; McCarthy, R. L.
  • Plant and Cell Physiology, Vol. 52, Issue 10
  • DOI: 10.1093/pcp/pcr123

Salicylic acid mediates the reduced growth of lignin down-regulated plants
journal, November 2011

  • Gallego-Giraldo, L.; Escamilla-Trevino, L.; Jackson, L. A.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 51
  • DOI: 10.1073/pnas.1117873108

NAC-MYB-based transcriptional regulation of secondary cell wall biosynthesis in land plants
journal, May 2015

  • Nakano, Yoshimi; Yamaguchi, Masatoshi; Endo, Hitoshi
  • Frontiers in Plant Science, Vol. 6
  • DOI: 10.3389/fpls.2015.00288

miR156-Regulated SPL Transcription Factors Define an Endogenous Flowering Pathway in Arabidopsis thaliana
journal, August 2009


Improving wood properties for wood utilization through multi-omics integration in lignin biosynthesis
journal, April 2018


Tyrosine and Phenylalanine Ammonia Lyase Activities during Shoot Initiation in Tobacco Callus Cultures
journal, July 1985

  • Beaudoin-Eagan, Lynda D.; Thorpe, Trevor A.
  • Plant Physiology, Vol. 78, Issue 3
  • DOI: 10.1104/pp.78.3.438

Mutation of WRKY transcription factors initiates pith secondary wall formation and increases stem biomass in dicotyledonous plants
journal, December 2010

  • Wang, H.; Avci, U.; Nakashima, J.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 51, p. 22338-22343
  • DOI: 10.1073/pnas.1016436107

A Battery of Transcription Factors Involved in the Regulation of Secondary Cell Wall Biosynthesis in Arabidopsis
journal, October 2008


Selective lignin downregulation leads to constitutive defense response expression in alfalfa (Medicago sativa L.)
journal, January 2011


LACCASE Is Necessary and Nonredundant with PEROXIDASE for Lignin Polymerization during Vascular Development in Arabidopsis
journal, October 2013


The genetic control of lignin deposition during plant growth and development: Tansley review
journal, July 2004


The NAC Transcription Factors NST1 and NST2 of Arabidopsis Regulate Secondary Wall Thickenings and Are Required for Anther Dehiscence
journal, October 2005

  • Mitsuda, Nobutaka; Seki, Motoaki; Shinozaki, Kazuo
  • The Plant Cell, Vol. 17, Issue 11
  • DOI: 10.1105/tpc.105.036004

On–Off Switches for Secondary Cell Wall Biosynthesis
journal, March 2012

  • Wang, Huan-Zhong; Dixon, Richard A.
  • Molecular Plant, Vol. 5, Issue 2
  • DOI: 10.1093/mp/ssr098

Silencing CAFFEOYL SHIKIMATE ESTERASE Affects Lignification and Improves Saccharification in Poplar
journal, September 2017

  • Saleme, Marina de Lyra Soriano; Cesarino, Igor; Vargas, Lívia
  • Plant Physiology, Vol. 175, Issue 3
  • DOI: 10.1104/pp.17.00920

Fungal pretreatment of lignocellulosic biomass
journal, November 2012


AtMYB32 is required for normal pollen development in Arabidopsis thaliana
journal, December 2004


Value-adding to cellulosic ethanol: Lignin polymers
journal, March 2011

  • Doherty, William O. S.; Mousavioun, Payam; Fellows, Christopher M.
  • Industrial Crops and Products, Vol. 33, Issue 2
  • DOI: 10.1016/j.indcrop.2010.10.022

Coexistence but Independent Biosynthesis of Catechyl and Guaiacyl/Syringyl Lignin Polymers in Seed Coats
journal, July 2013


A Genomics Approach to Deciphering Lignin Biosynthesis in Switchgrass
journal, November 2013


SND1, a NAC Domain Transcription Factor, Is a Key Regulator of Secondary Wall Synthesis in Fibers of Arabidopsis
journal, November 2006


Transcription switches for protoxylem and metaxylem vessel formation
journal, August 2005


A 5-Enolpyruvylshikimate 3-Phosphate Synthase Functions as a Transcriptional Repressor in Populus
journal, June 2018

  • Xie, Meng; Muchero, Wellington; Bryan, Anthony C.
  • The Plant Cell, Vol. 30, Issue 7
  • DOI: 10.1105/tpc.18.00168

The Poplar MYB Transcription Factors, PtrMYB3 and PtrMYB20, are Involved in the Regulation of Secondary Wall Biosynthesis
journal, April 2010

  • McCarthy, Ryan L.; Zhong, Ruiqin; Fowler, Scott
  • Plant and Cell Physiology, Vol. 51, Issue 6
  • DOI: 10.1093/pcp/pcq064

The Poplar MYB Master Switches Bind to the SMRE Site and Activate the Secondary Wall Biosynthetic Program during Wood Formation
journal, July 2013


ASYMMETRIC LEAVES2-LIKE19/LATERAL ORGAN BOUNDARIES DOMAIN30 and ASL20/LBD18 Regulate Tracheary Element Differentiation in Arabidopsis
journal, December 2008

  • Soyano, Takashi; Thitamadee, Siripong; Machida, Yasunori
  • The Plant Cell, Vol. 20, Issue 12
  • DOI: 10.1105/tpc.108.061796

Lignin content in natural Populus variants affects sugar release
journal, March 2011

  • Studer, M. H.; DeMartini, J. D.; Davis, M. F.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 15, p. 6300-6305
  • DOI: 10.1073/pnas.1009252108

Studies on Tyrosine Ammonia Lyase Activity in Castor Bean Endosperm
journal, February 1976


Rewiring of jasmonate and phytochrome B signalling uncouples plant growth-defense tradeoffs
journal, August 2016

  • Campos, Marcelo L.; Yoshida, Yuki; Major, Ian T.
  • Nature Communications, Vol. 7, Issue 1
  • DOI: 10.1038/ncomms12570

NMR Characterization of C3H and HCT Down-Regulated Alfalfa Lignin
journal, October 2009


Simultaneously disrupting AtPrx2 , AtPrx25 and AtPrx71 alters lignin content and structure in Arabidopsis stem : Lignin alteration by simultaneous disruption of
journal, March 2015

  • Shigeto, Jun; Itoh, Yoshitaka; Hirao, Sakie
  • Journal of Integrative Plant Biology, Vol. 57, Issue 4
  • DOI: 10.1111/jipb.12334

Role of bifunctional ammonia-lyase in grass cell wall biosynthesis
journal, May 2016


Modifying lignin to improve bioenergy feedstocks: strengthening the barrier against pathogens?†
journal, January 2013


Disruption of LACCASE4 and 17 Results in Tissue-Specific Alterations to Lignification of Arabidopsis thaliana Stems
journal, March 2011

  • Berthet, Serge; Demont-Caulet, Nathalie; Pollet, Brigitte
  • The Plant Cell, Vol. 23, Issue 3
  • DOI: 10.1105/tpc.110.082792

Arabidopsis MYB26/MALE STERILE35 Regulates Secondary Thickening in the Endothecium and Is Essential for Anther Dehiscence
journal, February 2007


EgMYB2, a new transcriptional activator from Eucalyptus xylem, regulates secondary cell wall formation and lignin biosynthesis
journal, July 2005


NAC domain function and transcriptional control of a secondary cell wall master switch: NST1 function and regulation
journal, October 2011


Multiple Classes of Transcription Factors Regulate the Expression of VASCULAR-RELATED NAC-DOMAIN7, a Master Switch of Xylem Vessel Differentiation
journal, September 2014

  • Endo, Hitoshi; Yamaguchi, Masatoshi; Tamura, Taizo
  • Plant and Cell Physiology, Vol. 56, Issue 2
  • DOI: 10.1093/pcp/pcu134

Expression of the Floral Repressor miRNA156 is Positively Regulated by the AGAMOUS-like Proteins AGL15 and AGL18
journal, January 2015


Differential Regulation of β-1,3-Glucanase Messenger RNAs in Response to Pathogen Infection
journal, June 1991

  • Ward, Eric R.; Payne, George B.; Moyer, Mary B.
  • Plant Physiology, Vol. 96, Issue 2
  • DOI: 10.1104/pp.96.2.390

MYB46 and MYB83 Bind to the SMRE Sites and Directly Activate a Suite of Transcription Factors and Secondary Wall Biosynthetic Genes
journal, December 2011

  • Zhong, Ruiqin; Ye, Zheng-Hua
  • Plant and Cell Physiology, Vol. 53, Issue 2
  • DOI: 10.1093/pcp/pcr185

Characterisation of a pine MYB that regulates lignification
journal, December 2003


NAC Transcription Factors, NST1 and NST3, Are Key Regulators of the Formation of Secondary Walls in Woody Tissues of Arabidopsis
journal, January 2007

  • Mitsuda, N.; Iwase, A.; Yamamoto, H.
  • The Plant Cell, Vol. 19, Issue 1, p. 270-280
  • DOI: 10.1105/tpc.106.047043

Flavonoid Accumulation in Arabidopsis Repressed in Lignin Synthesis Affects Auxin Transport and Plant Growth
journal, January 2007

  • Besseau, S.; Hoffmann, L.; Geoffroy, P.
  • THE PLANT CELL ONLINE, Vol. 19, Issue 1, p. 148-162
  • DOI: 10.1105/tpc.106.044495

Enhanced disease resistance to Botrytis cinerea in myb46 Arabidopsis plants is associated to an early down-regulation of CesA genes
journal, June 2011

  • Ramírez, Vicente; García-Andrade, Javier; Vera, Pablo
  • Plant Signaling & Behavior, Vol. 6, Issue 6
  • DOI: 10.4161/psb.6.6.15354

Challenging/interesting lignin times
journal, August 2016

  • Ragauskas, Arthur J.
  • Biofuels, Bioproducts and Biorefining, Vol. 10, Issue 5
  • DOI: 10.1002/bbb.1714

Insect Herbivores Drive Real-Time Ecological and Evolutionary Change in Plant Populations
journal, October 2012

  • Agrawal, Anurag A.; Hastings, Amy P.; Johnson, Marc T. J.
  • Science, Vol. 338, Issue 6103
  • DOI: 10.1126/science.1225977

An Arabidopsis gene regulatory network for secondary cell wall synthesis
journal, December 2014

  • Taylor-Teeples, M.; Lin, L.; de Lucas, M.
  • Nature, Vol. 517, Issue 7536
  • DOI: 10.1038/nature14099

Disruption of Mediator rescues the stunted growth of a lignin-deficient Arabidopsis mutant
journal, March 2014

  • Bonawitz, Nicholas D.; Kim, Jeong Im; Tobimatsu, Yuki
  • Nature, Vol. 509, Issue 7500, p. 376-380
  • DOI: 10.1038/nature13084

An essential role of caffeoyl shikimate esterase in monolignol biosynthesis in Medicago truncatula
journal, June 2016

  • Ha, Chan Man; Escamilla-Trevino, Luis; Yarce, Juan Carlos Serrani
  • The Plant Journal, Vol. 86, Issue 5
  • DOI: 10.1111/tpj.13177

REF4 and RFR1, Subunits of the Transcriptional Coregulatory Complex Mediator, Are Required for Phenylpropanoid Homeostasis in Arabidopsis
journal, December 2011

  • Bonawitz, Nicholas D.; Soltau, Whitney L.; Blatchley, Michael R.
  • Journal of Biological Chemistry, Vol. 287, Issue 8
  • DOI: 10.1074/jbc.M111.312298

Lignin engineering
journal, June 2008

  • Vanholme, R.; Morreel, K.; Ralph, J.
  • Current Opinion in Plant Biology, Vol. 11, Issue 3, p. 278-285
  • DOI: 10.1016/j.pbi.2008.03.005

The cell biology of lignification in higher plants
journal, April 2015

  • Barros, Jaime; Serk, Henrik; Granlund, Irene
  • Annals of Botany, Vol. 115, Issue 7
  • DOI: 10.1093/aob/mcv046

CINNAMYL ALCOHOL DEHYDROGENASE-C and -D Are the Primary Genes Involved in Lignin Biosynthesis in the Floral Stem of Arabidopsis
journal, June 2005

  • Sibout, Richard; Eudes, Aymerick; Mouille, Gregory
  • The Plant Cell, Vol. 17, Issue 7
  • DOI: 10.1105/tpc.105.030767

MYB58 and MYB63 Are Transcriptional Activators of the Lignin Biosynthetic Pathway during Secondary Cell Wall Formation in Arabidopsis
journal, January 2009


Arabidopsis miR156 Regulates Tolerance to Recurring Environmental Stress through SPL Transcription Factors
journal, April 2014


A Systems Biology View of Responses to Lignin Biosynthesis Perturbations in Arabidopsis
journal, September 2012

  • Vanholme, Ruben; Storme, Véronique; Vanholme, Bartel
  • The Plant Cell, Vol. 24, Issue 9
  • DOI: 10.1105/tpc.112.102574

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