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Title: Inositol phosphates are assembly co-factors for HIV-1

Abstract

A short, 14-amino-acid segment called SP1, located in the Gag structural protein, has a critical role during the formation of the HIV-1 virus particle. During virus assembly, the SP1 peptide and seven preceding residues fold into a six-helix bundle, which holds together the Gag hexamer and facilitates the formation of a curved immature hexagonal lattice underneath the viral membrane. Upon completion of assembly and budding, proteolytic cleavage of Gag leads to virus maturation, in which the immature lattice is broken down; the liberated CA domain of Gag then re-assembles into the mature conical capsid that encloses the viral genome and associated enzymes. Folding and proteolysis of the six-helix bundle are crucial rate-limiting steps of both Gag assembly and disassembly, and the six-helix bundle is an established target of HIV-1 inhibitors. Here, using a combination of structural and functional analyses, we show that inositol hexakisphosphate (InsP6, also known as IP6) facilitates the formation of the six-helix bundle and assembly of the immature HIV-1 Gag lattice. IP6 makes ionic contacts with two rings of lysine residues at the centre of the Gag hexamer. Proteolytic cleavage then unmasks an alternative binding site, where IP6 interaction promotes the assembly of the mature capsid lattice.more » Furthermore, these studies identify IP6 as a naturally occurring small molecule that promotes both assembly and maturation of HIV-1.« less

Authors:
 [1];  [2];  [3];  [4];  [5];  [5];  [2];  [3];  [2];  [5];  [2];  [1]
+ Show Author Affiliations
  1. Cornell Univ., Ithaca, NY (United States)
  2. Univ. of Virginia, Charlottesville, VA (United States)
  3. Univ. of Delaware, Newport, DE (United States)
  4. EMBL, Heidelberg (Germany); Inst. of Science and Technology Austria, Klosterneuburg (Austria)
  5. Univ. of Missouri, Columbia, MO (United States)
Publication Date:
Research Org.:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Org.:
National Inst. of Health; German Research Foundation (DFG); National Science Foundation (NSF)
OSTI Identifier:
1474170
Grant/Contract Number:  
R01-GM116961; OCI-1053575; ACI-1445606; R01-GM107013; R01-GM105684; P30-GM110758; P50-GM082251; R01-AI129678; U54-GM103297; R01-GM110776; BR 3635/2-1
Resource Type:
Accepted Manuscript
Journal Name:
Nature (London)
Additional Journal Information:
Journal Name: Nature (London); Journal Volume: 560; Journal Issue: 7719; Journal ID: ISSN 0028-0836
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH
Subject:
59 BASIC BIOLOGICAL SCIENCES; biochemistry; molecular biology

Citation Formats

Dick, Robert A., Zadrozny, Kaneil K., Xu, Chaoyi, Schur, Florian K. M., Lyddon, Terri D., Ricana, Clifton L., Wagner, Jonathan M., Perilla, Juan R., Ganser-Pornillos, Barbie K., Johnson, Marc C., Pornillos, Owen, and Vogt, Volker M. Inositol phosphates are assembly co-factors for HIV-1. United States: N. p., 2018. Web. doi:10.1038/s41586-018-0396-4.
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Dick, Robert A., Zadrozny, Kaneil K., Xu, Chaoyi, Schur, Florian K. M., Lyddon, Terri D., Ricana, Clifton L., Wagner, Jonathan M., Perilla, Juan R., Ganser-Pornillos, Barbie K., Johnson, Marc C., Pornillos, Owen, & Vogt, Volker M. Inositol phosphates are assembly co-factors for HIV-1. United States. https://doi.org/10.1038/s41586-018-0396-4
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Dick, Robert A., Zadrozny, Kaneil K., Xu, Chaoyi, Schur, Florian K. M., Lyddon, Terri D., Ricana, Clifton L., Wagner, Jonathan M., Perilla, Juan R., Ganser-Pornillos, Barbie K., Johnson, Marc C., Pornillos, Owen, and Vogt, Volker M. Wed . "Inositol phosphates are assembly co-factors for HIV-1". United States. https://doi.org/10.1038/s41586-018-0396-4. https://www.osti.gov/servlets/purl/1474170.
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@article{osti_1474170,
title = {Inositol phosphates are assembly co-factors for HIV-1},
author = {Dick, Robert A. and Zadrozny, Kaneil K. and Xu, Chaoyi and Schur, Florian K. M. and Lyddon, Terri D. and Ricana, Clifton L. and Wagner, Jonathan M. and Perilla, Juan R. and Ganser-Pornillos, Barbie K. and Johnson, Marc C. and Pornillos, Owen and Vogt, Volker M.},
abstractNote = {A short, 14-amino-acid segment called SP1, located in the Gag structural protein, has a critical role during the formation of the HIV-1 virus particle. During virus assembly, the SP1 peptide and seven preceding residues fold into a six-helix bundle, which holds together the Gag hexamer and facilitates the formation of a curved immature hexagonal lattice underneath the viral membrane. Upon completion of assembly and budding, proteolytic cleavage of Gag leads to virus maturation, in which the immature lattice is broken down; the liberated CA domain of Gag then re-assembles into the mature conical capsid that encloses the viral genome and associated enzymes. Folding and proteolysis of the six-helix bundle are crucial rate-limiting steps of both Gag assembly and disassembly, and the six-helix bundle is an established target of HIV-1 inhibitors. Here, using a combination of structural and functional analyses, we show that inositol hexakisphosphate (InsP6, also known as IP6) facilitates the formation of the six-helix bundle and assembly of the immature HIV-1 Gag lattice. IP6 makes ionic contacts with two rings of lysine residues at the centre of the Gag hexamer. Proteolytic cleavage then unmasks an alternative binding site, where IP6 interaction promotes the assembly of the mature capsid lattice. Furthermore, these studies identify IP6 as a naturally occurring small molecule that promotes both assembly and maturation of HIV-1.},
doi = {10.1038/s41586-018-0396-4},
journal = {Nature (London)},
number = 7719,
volume = 560,
place = {United States},
year = {Wed Aug 01 00:00:00 EDT 2018},
month = {Wed Aug 01 00:00:00 EDT 2018}
}
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https://doi.org/10.1038/s41586-018-0396-4
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Works referenced in this record:

Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics
journal, April 2016

Function minimization by conjugate gradients
journal, February 1964

myo-Inositol metabolism in plants
journal, January 2000

Interactions between HIV-1 Gag Molecules in Solution: An Inositol Phosphate-mediated Switch
journal, January 2007

  • Datta, Siddhartha A. K.; Zhao, Zhuojun; Clark, Patrick K.
  • Journal of Molecular Biology, Vol. 365, Issue 3
  • DOI: 10.1016/j.jmb.2006.10.072

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis
journal, August 2016

  • Jacques, David A.; McEwan, William A.; Hilditch, Laura
  • Nature, Vol. 536, Issue 7616
  • DOI: 10.1038/nature19098

An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation
journal, July 2016

Accurate and efficient integration for molecular dynamics simulations at constant temperature and pressure
journal, October 2013

  • Lippert, Ross A.; Predescu, Cristian; Ierardi, Douglas J.
  • The Journal of Chemical Physics, Vol. 139, Issue 16
  • DOI: 10.1063/1.4825247

Assembly Properties of the Human Immunodeficiency Virus Type 1 CA Protein
journal, February 2004

Scalable molecular dynamics with NAMD
journal, January 2005

  • Phillips, James C.; Braun, Rosemary; Wang, Wei
  • Journal of Computational Chemistry, Vol. 26, Issue 16, p. 1781-1802
  • DOI: 10.1002/jcc.20289

Extreme Genetic Fragility of the HIV-1 Capsid
journal, June 2013

Molecular dynamics with coupling to an external bath
journal, October 1984

  • Berendsen, H. J. C.; Postma, J. P. M.; van Gunsteren, W. F.
  • The Journal of Chemical Physics, Vol. 81, Issue 8
  • DOI: 10.1063/1.448118

Functional Surfaces of the Human Immunodeficiency Virus Type 1 Capsid Protein
journal, May 2003

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ 1 and χ 2 Dihedral Angles
journal, August 2012

  • Best, Robert B.; Zhu, Xiao; Shim, Jihyun
  • Journal of Chemical Theory and Computation, Vol. 8, Issue 9
  • DOI: 10.1021/ct300400x

Modulation of HIV-like particle assembly in vitro by inositol phosphates
journal, August 2001

  • Campbell, S.; Fisher, R. J.; Towler, E. M.
  • Proceedings of the National Academy of Sciences, Vol. 98, Issue 19
  • DOI: 10.1073/pnas.191224698

Improved vectors and genome-wide libraries for CRISPR screening
journal, July 2014

  • Sanjana, Neville E.; Shalem, Ophir; Zhang, Feng
  • Nature Methods, Vol. 11, Issue 8
  • DOI: 10.1038/nmeth.3047

Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes
journal, March 1977

  • Ryckaert, Jean-Paul; Ciccotti, Giovanni; Berendsen, Herman J. C.
  • Journal of Computational Physics, Vol. 23, Issue 3
  • DOI: 10.1016/0021-9991(77)90098-5

Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly
journal, March 1998

PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

2dx—User-friendly image processing for 2D crystals
journal, January 2007

  • Gipson, Bryant; Zeng, Xiangyan; Zhang, Zi Yan
  • Journal of Structural Biology, Vol. 157, Issue 1
  • DOI: 10.1016/j.jsb.2006.07.020

Interaction of GAPR-1 with lipid bilayers is regulated by alternative homodimerization
journal, September 2012

  • van Galen, Josse; Olrichs, Nick K.; Schouten, Arie
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1818, Issue 9
  • DOI: 10.1016/j.bbamem.2012.04.016

A conformational switch controlling HIV-1 morphogenesis
journal, January 2000

X-Ray Structures of the Hexameric Building Block of the HIV Capsid
journal, June 2009

Constant pressure molecular dynamics simulation: The Langevin piston method
journal, September 1995

  • Feller, Scott E.; Zhang, Yuhong; Pastor, Richard W.
  • The Journal of Chemical Physics, Vol. 103, Issue 11
  • DOI: 10.1063/1.470648

Efficacy and safety analyses of a recombinant human immunodeficiency virus type 1 derived vector system
journal, May 1999

Disulfide Bond Stabilization of the Hexameric Capsomer of Human Immunodeficiency Virus
journal, September 2010

  • Pornillos, Owen; Ganser-Pornillos, Barbie K.; Banumathi, Sankaran
  • Journal of Molecular Biology, Vol. 401, Issue 5
  • DOI: 10.1016/j.jmb.2010.06.042

Quenching protein dynamics interferes with HIV capsid maturation
journal, November 2017

Mutations in Capsid Major Homology Region Affect Assembly and Membrane Affinity of HIV-1 Gag
journal, July 2007

  • Chang, Yu-Fen; Wang, Shiu-Mei; Huang, Kuo-Jung
  • Journal of Molecular Biology, Vol. 370, Issue 3
  • DOI: 10.1016/j.jmb.2007.05.020

Structure of Full-Length HIV-1 CA: A Model for the Mature Capsid Lattice
journal, October 2007

Constant pressure molecular dynamics algorithms
journal, September 1994

  • Martyna, Glenn J.; Tobias, Douglas J.; Klein, Michael L.
  • The Journal of Chemical Physics, Vol. 101, Issue 5
  • DOI: 10.1063/1.467468

Inositol Hexakisphosphate Is Bound in the ADAR2 Core and Required for RNA Editing
journal, September 2005

[20] Processing of X-ray diffraction data collected in oscillation mode
book, January 1997

Atomic-level modelling of the HIV capsid
journal, January 2011

  • Pornillos, Owen; Ganser-Pornillos, Barbie K.; Yeager, Mark
  • Nature, Vol. 469, Issue 7330
  • DOI: 10.1038/nature09640

VMD: Visual molecular dynamics
journal, February 1996

Gaussian split Ewald: A fast Ewald mesh method for molecular simulation
journal, February 2005

  • Shan, Yibing; Klepeis, John L.; Eastwood, Michael P.
  • The Journal of Chemical Physics, Vol. 122, Issue 5
  • DOI: 10.1063/1.1839571

PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome
journal, December 2019

Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation
journal, February 2021

Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly
journal, May 2000

  • von Schwedler, Uta K.; Stemmler, Timothy L.; Klishko, Victor Y.
  • The EMBO Journal, Vol. 19, Issue 10
  • DOI: 10.1038/sj.emboj.7593063

PHENIX: a comprehensive Python-based system for macromolecular structure solution.
text, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Apollo - University of Cambridge Repository
  • DOI: 10.17863/cam.45787

Scalable molecular dynamics with NAMD
journal, January 2005

  • Phillips, James C.; Braun, Rosemary; Wang, Wei
  • Journal of Computational Chemistry, Vol. 26, Issue 16, p. 1781-1802
  • DOI: 10.1002/jcc.20289

CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields
journal, January 2009

  • Vanommeslaeghe, K.; Hatcher, E.; Acharya, C.
  • Journal of Computational Chemistry
  • DOI: 10.1002/jcc.21367

Interaction of GAPR-1 with lipid bilayers is regulated by alternative homodimerization
journal, September 2012

  • van Galen, Josse; Olrichs, Nick K.; Schouten, Arie
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1818, Issue 9
  • DOI: 10.1016/j.bbamem.2012.04.016

How to Assemble a Capsid
journal, October 2007

X-Ray Structures of the Hexameric Building Block of the HIV Capsid
journal, June 2009

Interactions between HIV-1 Gag Molecules in Solution: An Inositol Phosphate-mediated Switch
journal, January 2007

  • Datta, Siddhartha A. K.; Zhao, Zhuojun; Clark, Patrick K.
  • Journal of Molecular Biology, Vol. 365, Issue 3
  • DOI: 10.1016/j.jmb.2006.10.072

Mutations in Capsid Major Homology Region Affect Assembly and Membrane Affinity of HIV-1 Gag
journal, July 2007

  • Chang, Yu-Fen; Wang, Shiu-Mei; Huang, Kuo-Jung
  • Journal of Molecular Biology, Vol. 370, Issue 3
  • DOI: 10.1016/j.jmb.2007.05.020

Disulfide Bond Stabilization of the Hexameric Capsomer of Human Immunodeficiency Virus
journal, September 2010

  • Pornillos, Owen; Ganser-Pornillos, Barbie K.; Banumathi, Sankaran
  • Journal of Molecular Biology, Vol. 401, Issue 5
  • DOI: 10.1016/j.jmb.2010.06.042

2dx—User-friendly image processing for 2D crystals
journal, January 2007

  • Gipson, Bryant; Zeng, Xiangyan; Zhang, Zi Yan
  • Journal of Structural Biology, Vol. 157, Issue 1
  • DOI: 10.1016/j.jsb.2006.07.020

Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics
journal, April 2016

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ 1 and χ 2 Dihedral Angles
journal, August 2012

  • Best, Robert B.; Zhu, Xiao; Shim, Jihyun
  • Journal of Chemical Theory and Computation, Vol. 8, Issue 9
  • DOI: 10.1021/ct300400x

SUMO fusions and SUMO-specific protease for efficient expression and purification of proteins
journal, March 2004

Atomic-level modelling of the HIV capsid
journal, January 2011

  • Pornillos, Owen; Ganser-Pornillos, Barbie K.; Yeager, Mark
  • Nature, Vol. 469, Issue 7330
  • DOI: 10.1038/nature09640

Proteolytic refolding of the HIV-1 capsid protein amino-terminus facilitates viral core assembly
journal, May 2000

  • von Schwedler, Uta K.; Stemmler, Timothy L.; Klishko, Victor Y.
  • The EMBO Journal, Vol. 19, Issue 10
  • DOI: 10.1038/sj.emboj.7593063

Do mammals make all their own inositol hexakisphosphate?
journal, November 2008

  • Letcher, Andrew J.; Schell, Michael J.; Irvine, Robin F.
  • Biochemical Journal, Vol. 416, Issue 2
  • DOI: 10.1042/bj20081417

Gaussian split Ewald: A fast Ewald mesh method for molecular simulation
journal, February 2005

  • Shan, Yibing; Klepeis, John L.; Eastwood, Michael P.
  • The Journal of Chemical Physics, Vol. 122, Issue 5
  • DOI: 10.1063/1.1839571

Constant pressure molecular dynamics algorithms
journal, September 1994

  • Martyna, Glenn J.; Tobias, Douglas J.; Klein, Michael L.
  • The Journal of Chemical Physics, Vol. 101, Issue 5
  • DOI: 10.1063/1.467468

Accurate and efficient integration for molecular dynamics simulations at constant temperature and pressure
journal, October 2013

  • Lippert, Ross A.; Predescu, Cristian; Ierardi, Douglas J.
  • The Journal of Chemical Physics, Vol. 139, Issue 16
  • DOI: 10.1063/1.4825247

Modulation of HIV-like particle assembly in vitro by inositol phosphates
journal, August 2001

  • Campbell, S.; Fisher, R. J.; Towler, E. M.
  • Proceedings of the National Academy of Sciences, Vol. 98, Issue 19
  • DOI: 10.1073/pnas.191224698

A conformational switch controlling HIV-1 morphogenesis
journal, January 2000

Inositol Hexakisphosphate Is Bound in the ADAR2 Core and Required for RNA Editing
journal, September 2005

An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation
journal, July 2016

HIV-1 Maturation Inhibitor Bevirimat Stabilizes the Immature Gag Lattice
journal, November 2010

  • Keller, P. W.; Adamson, C. S.; Heymann, J. B.
  • Journal of Virology, Vol. 85, Issue 4
  • DOI: 10.1128/jvi.01926-10

A Conformational Transition Observed in Single HIV-1 Gag Molecules during In Vitro Assembly of Virus-Like Particles
journal, January 2014

  • Munro, J. B.; Nath, A.; Farber, M.
  • Journal of Virology, Vol. 88, Issue 6
  • DOI: 10.1128/jvi.03353-13

Extreme genetic fragility of the HIV-1 capsid
journal, September 2013

PHENIX: a comprehensive Python-based system for macromolecular structure solution.
text, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Apollo - University of Cambridge Repository
  • DOI: 10.17863/cam.45787

Crystal structure of an HIV assembly and maturation switch
journal, July 2016

  • Wagner, Jonathan M.; Zadrozny, Kaneil K.; Chrustowicz, Jakub
  • eLife, Vol. 5
  • DOI: 10.7554/elife.17063
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    The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export
    journal, June 2019

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    Nucleic acid–induced dimerization of HIV-1 Gag protein
    journal, September 2019

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    • Journal of Biological Chemistry, Vol. 294, Issue 45
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    Hierarchical assembly governs TRIM5α recognition of HIV-1 and retroviral capsids
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